DOI: 10.2337/diacare.25.2.347. Continuous Subcutaneous Glucose Monitoring in Diabetic Patients

Continuous Subcutaneous Glucose Monitoring in Diabetic Patients

10.2337/diacare.25.2.347

Crossref journal-article

American Diabetes Association

Diabetes Care (1167)

Abstract

OBJECTIVE—To evaluate the accuracy of a new subcutaneous glucose sensor (Glucoday; A. Menarini Diagnostics) compared with venous blood glucose measurement in type 1 and type 2 diabetic patients. RESEARCH DESIGN—A multicenter study was performed in 70 diabetic patients. A microdialysis fiber was inserted subcutaneously into the periumbelical region and perfused with a buffer solution. Glucose concentrations in the dialysate were then measured every 3 min by the glucose sensor over a 24-h period, during which nine venous blood samples were also collected throughout the day. RESULTS—Both the insertion of the fiber and the wearing of the device were well tolerated by the patients. Subcutaneous glucose levels were well correlated with venous glucose measurements (r = 0.9, P &lt; 0.001) over a wide range (40–400 mg/dl) for up to 24 h, with a single-point calibration. An analysis of 381 data pairs showed a linear relationship between the GlucoDay and serial venous blood glucose levels, and 97% of the data fell in the A and B regions of the error grid analysis. Percentage bias between the GlucoDay and the blood venous levels was −2.0% in the hypoglycemic range (&lt;70 mg/dl), 6.9% in the euglycemic range (70–180 mg/dl), and 11.2% in the hyperglycemic range (&gt;180 mg/dl). CONCLUSIONS—The GlucoDay system demonstrated high reliability and reported values that closely agreed with venous blood glucose measurements. The system was well tolerated and thus constitutes a relatively easy method to monitor glucose excursions in diabetic patients.

Bibliography

Maran, A., Crepaldi, C., Tiengo, A., Grassi, G., Vitali, E., Pagano, G., Bistoni, S., Calabrese, G., Santeusanio, F., Leonetti, F., Ribaudo, M., Di Mario, U., Annuzzi, G., Genovese, S., Riccardi, G., Previti, M., Cucinotta, D., Giorgino, F., Bellomo, A., â¦ Varalli, M. (2002). Continuous Subcutaneous Glucose Monitoring in Diabetic Patients. Diabetes Care, 25(2), 347â352.

Authors 22

Alberto Maran (first)
Cristina Crepaldi (additional)
Antonio Tiengo (additional)
Giorgio Grassi (additional)
Emanuela Vitali (additional)
Gianfranco Pagano (additional)
Sergio Bistoni (additional)
Giuseppe Calabrese (additional)
Fausto Santeusanio (additional)
Frida Leonetti (additional)
Maria Ribaudo (additional)
Umberto Di Mario (additional)
Giovanni Annuzzi (additional)
Salvatore Genovese (additional)
Gabriele Riccardi (additional)
Marcello Previti (additional)
Domenico Cucinotta (additional)
Francesco Giorgino (additional)
Aurelia Bellomo (additional)
Riccardo Giorgino (additional)
Alessandro Poscia (additional)
Maurizio Varalli (additional)

References 14 Referenced 167

Dates

Type	When
Created	18 years, 6 months ago (March 5, 2007, 5:51 p.m.)
Deposited	3 years, 5 months ago (March 12, 2022, 11:25 a.m.)
Indexed	1 month, 1 week ago (July 30, 2025, 10:38 a.m.)
Issued	23 years, 7 months ago (Feb. 1, 2002)
Published	23 years, 7 months ago (Feb. 1, 2002)
Published Print	23 years, 7 months ago (Feb. 1, 2002)

Funders 0

None

BibTeX

@article{Maran_2002, title={Continuous Subcutaneous Glucose Monitoring in Diabetic Patients}, volume={25}, ISSN={1935-5548}, url={http://dx.doi.org/10.2337/diacare.25.2.347}, DOI={10.2337/diacare.25.2.347}, number={2}, journal={Diabetes Care}, publisher={American Diabetes Association}, author={Maran, Alberto and Crepaldi, Cristina and Tiengo, Antonio and Grassi, Giorgio and Vitali, Emanuela and Pagano, Gianfranco and Bistoni, Sergio and Calabrese, Giuseppe and Santeusanio, Fausto and Leonetti, Frida and Ribaudo, Maria and Di Mario, Umberto and Annuzzi, Giovanni and Genovese, Salvatore and Riccardi, Gabriele and Previti, Marcello and Cucinotta, Domenico and Giorgino, Francesco and Bellomo, Aurelia and Giorgino, Riccardo and Poscia, Alessandro and Varalli, Maurizio}, year={2002}, month=feb, pages={347–352} }

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