DOI: 10.2337/diabetes.53.8.1937. Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia

Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia

10.2337/diabetes.53.8.1937

Crossref journal-article

American Diabetes Association

Diabetes (1167)

Abstract

Resistin is an adipocyte-secreted protein that circulates at increased levels in obesity. Acute administration of resistin impairs glucose tolerance, but the effects of chronic hyperresistinemia have not been established. Here we describe the generation and characterization of transgenic mice that have high circulating levels of resistin in the setting of normal weight. Fasted blood glucose was higher in resistin-transgenic mice than in their nontransgenic littermates, and glucose tolerance was impaired in the hyperresistinemic mice. Metabolic studies in the setting of a hyperinsulinemic-euglycemic clamp protocol revealed that chronically hyperresistinemic mice have elevated glucose production. This increase in glucose production may be partly explained by increased expression of hepatic phosphoenolpyruvate carboxykinase. Thus, chronic hyperresistinemia impairs normal glucose metabolism.

Bibliography

Rangwala, S. M., Rich, A. S., Rhoades, B., Shapiro, J. S., Obici, S., Rossetti, L., & Lazar, M. A. (2004). Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia. Diabetes, 53(8), 1937â1941.

Authors 7

Shamina M. Rangwala (first)
A. Sophie Rich (additional)
Ben Rhoades (additional)
Jennifer S. Shapiro (additional)
Silvana Obici (additional)
Luciano Rossetti (additional)
Mitchell A. Lazar (additional)

References 22 Referenced 151

Dates

Type	When
Created	18 years, 5 months ago (March 6, 2007, 2:04 p.m.)
Deposited	2 years, 10 months ago (Nov. 2, 2022, 12:22 p.m.)
Indexed	4 months, 2 weeks ago (April 22, 2025, 3:29 a.m.)
Issued	21 years, 1 month ago (Aug. 1, 2004)
Published	21 years, 1 month ago (Aug. 1, 2004)
Published Print	21 years, 1 month ago (Aug. 1, 2004)

Funders 0

None

BibTeX

@article{Rangwala_2004, title={Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia}, volume={53}, ISSN={1939-327X}, url={http://dx.doi.org/10.2337/diabetes.53.8.1937}, DOI={10.2337/diabetes.53.8.1937}, number={8}, journal={Diabetes}, publisher={American Diabetes Association}, author={Rangwala, Shamina M. and Rich, A. Sophie and Rhoades, Ben and Shapiro, Jennifer S. and Obici, Silvana and Rossetti, Luciano and Lazar, Mitchell A.}, year={2004}, month=aug, pages={1937–1941} }

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