DOI: 10.2337/diab.39.6.647. Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes [Penn]

Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes

10.2337/diab.39.6.647

Crossref journal-article

American Diabetes Association

Diabetes (1167)

Abstract

This article reviews evidence for a pivotal role of glucokinase as glucose sensor of the pancreatic β-cells. Glucokinase explains the capacity, hexose specificity, affinities, sigmoidicity, and anomeric preference of pancreatic islet glycolysis, and because stimulation of glucose metabolism is a prerequisite of glucose stimulation of insulin release, glucokinase also explains many characteristics of this β-cell function. Glucokinase of the β-cell is induced or activated by glucose in contrast to liver glucokinase, which is regulated by insulin. Tissue-specific regulation corresponds with observations that liver and pancreatic β-cell glucokinase are structurally distinct. Glucokinase could play a glucose-sensor role in hepatocytes as well, and certain forms of diabetes mellitus might be due to glucokinase deficiencies in pancreatic β-cells, hepatocytes, or both.

Bibliography

Matschinsky, F. M. (1990). Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic Î²-Cells and Hepatocytes. Diabetes, 39(6), 647â652.

Authors 1

Franz M Matschinsky (first)

References 0 Referenced 376

None

Dates

Type	When
Created	11 years, 11 months ago (Sept. 19, 2013, 1:22 p.m.)
Deposited	2 years, 10 months ago (Nov. 2, 2022, 12:14 p.m.)
Indexed	25 minutes ago (Sept. 2, 2025, 3:55 p.m.)
Issued	35 years, 3 months ago (June 1, 1990)
Published	35 years, 3 months ago (June 1, 1990)
Published Print	35 years, 3 months ago (June 1, 1990)

Funders 0

None

BibTeX

@article{Matschinsky_1990, title={Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes}, volume={39}, ISSN={1939-327X}, url={http://dx.doi.org/10.2337/diab.39.6.647}, DOI={10.2337/diab.39.6.647}, number={6}, journal={Diabetes}, publisher={American Diabetes Association}, author={Matschinsky, Franz M}, year={1990}, month=jun, pages={647–652} }

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