DOI: 10.1557/proc-978-0978-gg10-05. Hierarchical nanomechanics of vimentin alpha helical coiled-coil proteins

Hierarchical nanomechanics of vimentin alpha helical coiled-coil proteins

10.1557/proc-978-0978-gg10-05

Crossref journal-article

Springer Science and Business Media LLC

MRS Proceedings (297)

Abstract

AbstractCoiled-coil alpha-helical dimers are the elementary building blocks of intermediate filaments (IFs), an important component of the cell's cytoskeleton. Therefore, IFs play a leading role in the mechanical integrity of the cells. Here we use atomistic simulation to carry out tensile tests on coiled-coils as well as on single alpha-helices of the 2B segment of the vimentin dimer that has been shown to control the large-deformation behavior of cells. We compare the characteristic force-strain curves of both structures and suggest explanations for the differences on this fundamental level of hierarchical assembly. We further systematically explore the strain rate dependence of the mechanical properties of the vimentin coiled-coil protein. We develop a simple continuum model capable of reproducing the atomistic modeling results. The model enables us to extrapolate to much lower deformation rates approaching those used in experiment.

Authors 2

Theodor Ackbarow (first)
Markus J. Buehler (additional)

References 19 Referenced 1

5. Herrmann H. , Aebi U. , Intermediate Filaments: Molecular Structure, Assembly Mechanism, and Integration into Functionally distinct Intracellular Scaffolds. Annu. Rev. Biochem.,
10.1098/rsta.2004.1395 / Phil. Trans. R. Soc. Lond. by Akkermans (2004)
10.1083/jcb.113.1.155
10.1038/nature03521
10.1021/jp973084f
10.1016/0263-7855(96)00018-5
10.1023/A:1023470709071
10.1016/S0006-3495(98)77556-3
{'key': 'S1946427400058498_ref003', 'first-page': '2342', 'volume': '355', 'author': 'Mücke', 'year': '2004', 'journal-title': 'J. Mol. Biol.'} / J. Mol. Biol. by Mücke (2004)
{'key': 'S1946427400058498_ref013', 'volume-title': 'Mechanical Behavior of Materials.', 'author': 'Courtney', 'year': '1990'} / Mechanical Behavior of Materials. by Courtney (1990)
10.1002/bies.10246
10.1016/j.jsb.2006.03.020
10.1242/jcs.00936
10.1016/j.jmb.2005.09.092
{'key': 'S1946427400058498_ref019', 'first-page': '618', 'volume': '200', 'author': 'Bell', 'year': '1978', 'journal-title': 'Models for the Specific Adhesion of Cells to Cells, Science'} / Models for the Specific Adhesion of Cells to Cells, Science by Bell (1978)
{'key': 'S1946427400058498_ref001', 'volume-title': 'Molecular Biology of the Cell', 'author': 'Alberts', 'year': '2002'} / Molecular Biology of the Cell by Alberts (2002)
2004. 73: p. 749–789
10.1016/j.jmb.2004.04.039
10.1038/nmat776

Dates

Type	When
Created	6 years, 2 months ago (June 6, 2019, 7:18 p.m.)
Deposited	6 years, 2 months ago (June 6, 2019, 7:19 p.m.)
Indexed	3 years, 4 months ago (April 2, 2022, 2:27 a.m.)
Issued	19 years, 7 months ago (Jan. 1, 2006)
Published	19 years, 7 months ago (Jan. 1, 2006)
Published Online	14 years, 6 months ago (Feb. 26, 2011)
Published Print	19 years, 7 months ago (Jan. 1, 2006)

Funders 0

None

BibTeX

@article{Ackbarow_2006, title={Hierarchical nanomechanics of vimentin alpha helical coiled-coil proteins}, volume={978}, ISSN={1946-4274}, url={http://dx.doi.org/10.1557/proc-978-0978-gg10-05}, DOI={10.1557/proc-978-0978-gg10-05}, journal={MRS Proceedings}, publisher={Springer Science and Business Media LLC}, author={Ackbarow, Theodor and Buehler, Markus J.}, year={2006} }

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