DOI: 10.1542/peds.50.2.246. NINE YEARS' EXPERIENCE WITH "TOTAL THERAPY" OF CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA

NINE YEARS' EXPERIENCE WITH "TOTAL THERAPY" OF CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA

10.1542/peds.50.2.246

Crossref journal-article

American Academy of Pediatrics (AAP)

Pediatrics (417)

Abstract

Experience with combined chemotherapy and radiotherapy of acute lymphocytic leukemia (ALL) in children is reviewed. Multiple anti-metabolite chemotherapy is effective in prolonging duration of continuous hematological remission. Craniospinal irradiation or cranial irradiation combined with intrathecal methotrexate in adequate doses inhibits relapse in the central nervous system. The high frequency of lengthy continuous complete remission achieved with "total therapy" indicates that ALL in children cannot be considered an incurable disease. Palliation is no longer an acceptable approach to its initial treatment.

Bibliography

Pinkel, D., Simone, J., Hustu, H. O., & Aur, R. J. A. (1972). NINE YEARSâ EXPERIENCE WITH âTOTAL THERAPYâ OF CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA. Pediatrics, 50(2), 246â251.

Authors 4

Donald Pinkel (first)
Joseph Simone (additional)
H. Omar Hustu (additional)
Rhomes J. A. Aur (additional)

References 0 Referenced 102

None

Dates

Type	When
Created	3 years, 8 months ago (Dec. 10, 2021, 8:46 a.m.)
Deposited	3 years, 8 months ago (Dec. 10, 2021, 8:46 a.m.)
Indexed	3 months, 3 weeks ago (May 8, 2025, 10:30 a.m.)
Issued	53 years, 1 month ago (Aug. 1, 1972)
Published	53 years, 1 month ago (Aug. 1, 1972)
Published Online	53 years, 1 month ago (Aug. 1, 1972)
Published Print	53 years, 1 month ago (Aug. 1, 1972)

Funders 0

None

BibTeX

@article{Pinkel_1972, title={NINE YEARS’ EXPERIENCE WITH “TOTAL THERAPY” OF CHILDHOOD ACUTE LYMPHOCYTIC LEUKEMIA}, volume={50}, ISSN={1098-4275}, url={http://dx.doi.org/10.1542/peds.50.2.246}, DOI={10.1542/peds.50.2.246}, number={2}, journal={Pediatrics}, publisher={American Academy of Pediatrics (AAP)}, author={Pinkel, Donald and Simone, Joseph and Hustu, H. Omar and Aur, Rhomes J. A.}, year={1972}, month=aug, pages={246–251} }

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