DOI: 10.1534/genetics.111.137760. Prions in Yeast

Prions in Yeast

10.1534/genetics.111.137760

Crossref journal-article

Oxford University Press (OUP)

Genetics (286)

Abstract

AbstractThe concept of a prion as an infectious self-propagating protein isoform was initially proposed to explain certain mammalian diseases. It is now clear that yeast also has heritable elements transmitted via protein. Indeed, the “protein only” model of prion transmission was first proven using a yeast prion. Typically, known prions are ordered cross-β aggregates (amyloids). Recently, there has been an explosion in the number of recognized prions in yeast. Yeast continues to lead the way in understanding cellular control of prion propagation, prion structure, mechanisms of de novo prion formation, specificity of prion transmission, and the biological roles of prions. This review summarizes what has been learned from yeast prions.

Bibliography

Liebman, S. W., & Chernoff, Y. O. (2012). Prions in Yeast. Genetics, 191(4), 1041â1072.

Authors 2

Susan W Liebman (first)
Yury O Chernoff (additional)

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Dates

Type	When
Created	13 years ago (Aug. 9, 2012, 9:23 a.m.)
Deposited	1 year, 4 months ago (April 28, 2024, 4:42 a.m.)
Indexed	3 weeks, 3 days ago (Aug. 5, 2025, 8:54 a.m.)
Issued	13 years ago (Aug. 1, 2012)
Published	13 years ago (Aug. 1, 2012)
Published Online	13 years ago (Aug. 1, 2012)
Published Print	13 years ago (Aug. 1, 2012)

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@article{Liebman_2012, title={Prions in Yeast}, volume={191}, ISSN={1943-2631}, url={http://dx.doi.org/10.1534/genetics.111.137760}, DOI={10.1534/genetics.111.137760}, number={4}, journal={Genetics}, publisher={Oxford University Press (OUP)}, author={Liebman, Susan W and Chernoff, Yury O}, year={2012}, month=aug, pages={1041–1072} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>The concept of a prion as an infectious self-propagating protein isoform was initially proposed to explain certain mammalian diseases. It is now clear that yeast also has heritable elements transmitted via protein. Indeed, the \u201cprotein only\u201d model of prion transmission was first proven using a yeast prion. Typically, known prions are ordered cross-\u03b2 aggregates (amyloids). Recently, there has been an explosion in the number of recognized prions in yeast. Yeast continues to lead the way in understanding cellular control of prion propagation, prion structure, mechanisms of de novo prion formation, specificity of prion transmission, and the biological roles of prions. This review summarizes what has been learned from yeast prions.</jats:p>",
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  "title": "Prions in Yeast",
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