DOI: 10.1529/biophysj.105.076455. Gas Phase Characterization of the Noncovalent Quaternary Structure of Cholera Toxin and the Cholera Toxin B Subunit Pentamer

Gas Phase Characterization of the Noncovalent Quaternary Structure of Cholera Toxin and the Cholera Toxin B Subunit Pentamer

10.1529/biophysj.105.076455

Crossref journal-article

Elsevier BV

Biophysical Journal (78)

Bibliography

Williams, J. P., Smith, D. C., Green, B. N., Marsden, B. D., Jennings, K. R., Roberts, L. M., & Scrivens, J. H. (2006). Gas Phase Characterization of the Noncovalent Quaternary Structure of Cholera Toxin and the Cholera Toxin B Subunit Pentamer. Biophysical Journal, 90(9), 3246â3254.

Authors 7

Jonathan P. Williams (first)
Daniel C. Smith (additional)
Brian N. Green (additional)
Brian D. Marsden (additional)
Keith R. Jennings (additional)
Lynne M. Roberts (additional)
James H. Scrivens (additional)

References 51 Referenced 5

10.1016/0264-410X(93)90002-F / Vaccine / Epidemiology of diarrhoeal disease: implications for control by vaccines by Black (1993)
10.1016/j.tips.2005.02.003 / Trends Pharmacol. Sci. / New drug targets for cholera therapy by Thiagarajah (2005)
10.1016/S0140-6736(03)15328-7 / Lancet / Cholera by Sack (2004)
{'key': '10.1529/biophysj.105.076455_bib4', 'first-page': '269', 'article-title': 'Cholera', 'volume': '78', 'year': '2003', 'journal-title': 'Wkly. Epidemiol. Rec.'} / Wkly. Epidemiol. Rec. / Cholera (2003)
United Nations. 1993. Convention on the prohibition of the development, production, stockpiling and use of chemical weapons and on their destruction. Paris, France.
10.1006/jmbi.1995.0455 / J. Mol. Biol. / The 2.4Å crystal structure of cholera toxin B subunit pentamer: choleragenoid by Zhang (1995)
10.1006/jmbi.1995.0456 / J. Mol. Biol. / The three-dimensional crystal structure of cholera toxin by Zhang (1995)
10.1006/jmbi.1998.2076 / J. Mol. Biol. / The 1.25Å resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site by Merritt (1998)
10.1080/09687680410001663267 / Mol. Membr. Biol. / Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review) by De Haan (2004)
10.1038/229266a0 / Nature / Stimulation of intestinal adenyl cyclase by cholera toxin by Sharp (1971)
10.1093/infdis/125.4.377 / J. Infect. Dis. / Intestinal adenyl-cyclase activity in canine cholera: correlation with fluid accumulation by Guerrant (1972)
10.1016/S0021-9258(17)34469-1 / J. Biol. Chem. / Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase by Johnson (1978)
10.1172/JCI106874 / J. Clin. Invest / Effect of cholera enterotoxin on ion transport across isolated ileal mucosa by Field (1972)
10.1111/j.1749-6632.1971.tb45263.x / Ann. N. Y. Acad. Sci. / The possible role of cyclic AMP in some actions of cholera toxin by Schafer (1971)
10.1073/pnas.67.2.851 / Proc. Natl. Acad. Sci. USA / Elevated concentration of adenosine 3′:5′-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin by Schafer (1970)
10.1056/NEJM198909283211307 / N. Engl. J. Med. / Intestinal electrolyte transport and diarrheal disease (2) by Field (1989)
10.1016/0092-8674(91)90446-6 / Cell / Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel by Cheng (1991)
{'key': '10.1529/biophysj.105.076455_bib18', 'first-page': '765', 'article-title': 'Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line', 'volume': '244', 'author': 'Burch', 'year': '1988', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line by Burch (1988)
10.1126/science.183.4125.656 / Science / Cholera toxin: interaction of subunits with ganglioside GM1 by Heyningen (1974)
10.1042/bj2380313 / Biochem. J. / Characterization of the receptor for cholera toxin and Escherichia coli heat-labile toxin in rabbit intestinal brush borders by Griffiths (1986)
10.1016/S0021-9258(18)51619-7 / J. Biol. Chem. / Binding of Vibrio cholera toxin and the heat-labile enterotoxin of Escherichia coli to GM1, derivatives of GM1, and nonlipid oligosaccharide polyvalent ligands by Schengrund (1989)
10.1016/j.semcdb.2004.03.005 / Semin. Cell Dev. Biol. / Glycosphingolipids as toxin receptors by Smith (2004)
10.1078/1438-4221-00294 / Int. J. Med. Microbiol. / Pathways followed by protein toxins into cells by Sandvig (2004)
10.1091/mbc.e04-04-0283 / Mol. Biol. Cell / Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways by Massol (2004)
10.1078/1438-4221-00293 / Int. J. Med. Microbiol. / Retrograde transport of cholera toxin into the ER of host cells by Lencer (2004)
10.1038/sj.embor.7400152 / EMBO Rep. / Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells by Feng (2004)
10.1016/j.tibs.2003.10.002 / Trends Biochem. Sci. / The intracellular voyage of cholera toxin: going retro by Lencer (2003)
10.1091/mbc.e03-06-0354 / Mol. Biol. Cell / Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulum by Fujinaga (2003)
10.1034/j.1600-0854.2003.00070.x / Traffic / A class of mutant CHO cells resistant to cholera toxin rapidly degrades the catalytic polypeptide of cholera toxin and exhibits increased endoplasmic reticulum-associated degradation by Teter (2003)
10.1016/S0092-8674(01)00289-6 / Cell / Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin by Tsai (2001)
10.1083/jcb.200207120 / J. Cell Biol. / Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1 by Tsai (2002)
10.1038/nrm780 / Nat. Rev. Mol. Cell Biol. / Retro-translocation of proteins from the endoplasmic reticulum into the cytosol by Tsai (2002)
10.1078/1438-4221-00163 / Int. J. Med. Microbiol. / New insights into the structure-function relationships and therapeutic applications of cholera-like enterotoxins by Hirst (2002)
10.1111/j.1432-1033.1985.tb08680.x / Eur. J. Biochem. / Facile identification of protein sequences by mass spectrometry. B subunit of Vibrio cholerae classical biotype Inaba 569B toxin by Takao (1985)
10.1016/S0041-0101(98)00136-6 / Toxicon / Characterisation of cholera toxin by liquid chromatography—electrospray mass spectrometry by van Baar (1999)
10.1093/glycob/11.7.605 / Glycobiology / The observation of multivalent complexes of Shiga-like toxin with globotriaoside and the determination of their stoichiometry by nanoelectrospray Fourier-transform ion cyclotron resonance mass spectrometry by Kitova (2001)
10.1021/bi0503706 / Biochemistry / Noncovalent Shiga-like toxin assemblies: characterization by means of mass spectrometry and tandem mass spectrometry by Williams (2005)
10.1021/ac0103975 / Anal. Chem. / Thermal decomposition of a gaseous multiprotein complex studied by blackbody infrared radiative dissociation. Investigating the origin of the asymmetric dissociation behavior by Felitsyn (2001)
10.1093/nar/28.1.235 / Nucleic Acids Res. / The protein data bank by Berman (2000)
10.1002/jcc.540150503 / J. Comput. Chem. / ICM—a new method for protein modeling and design: applications to docking and structure prediction from the distorted native conformation by Abagyan (1994)
10.1128/jb.177.11.3128-3132.1995 / J. Bacteriol. / Analysis of Shiga toxin subunit association by using hybrid A polypeptides and site-specific mutagenesis by Jemal (1995)
10.1038/nsb0194-59 / Nat. Struct. Biol. / Crystal structure of the holotoxin from Shigella dysenteriae at 2.5Å resolution by Fraser (1994)
10.1111/j.1432-1033.1982.tb05885.x / Eur. J. Biochem. / Conformational changes in subunit A of cholera toxin following the binding of ganglioside to subunit B by van Heyningen (1982)
10.1021/bi00406a035 / Biochemistry / Thermal stability and intersubunit interactions of cholera toxin in solution and in association with its cell-surface receptor ganglioside GM1 by Goins (1988)
10.1021/bi00487a017 / Biochemistry / Structure, stability, and receptor interaction of cholera toxin as studied by Fourier-transform infrared spectroscopy by Surewicz (1990)
10.1016/j.toxicon.2004.12.014 / Toxicon / Cholera and Shiga toxin B-subunits: thermodynamic and structural considerations for function and biomedical applications by Pina (2005)
10.1021/bi962996p / Biochemistry / Conformational changes in cholera toxin B subunit-ganglioside GM1 complexes are elicited by environmental pH and evoke changes in membrane structure by McCann (1997)
10.1016/0167-4838(94)00208-X / Biochim. Biophys. Acta / Fluorescence analysis of the interaction between ganglioside GM1-containing phospholipid vesicles and the B subunit of cholera toxin by Picking (1995)
10.1021/bi034591s / Biochemistry / Thermodynamic analysis of the structural stability of the Shiga toxin B-subunit by Pina (2003)
10.1021/bi00052a025 / Biochemistry / Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity by Sixma (1993)
{'key': '10.1529/biophysj.105.076455_bib51', 'first-page': '748', 'article-title': 'Crystal structure of the cell-binding B oligomer of verotoxin-1 from', 'volume': '355', 'author': 'Stein', 'year': '1992', 'journal-title': 'E. coli. Nature'} / E. coli. Nature / Crystal structure of the cell-binding B oligomer of verotoxin-1 from by Stein (1992)

Dates

Type	When
Created	19 years, 6 months ago (Feb. 3, 2006, 8:33 p.m.)
Deposited	1 year, 5 months ago (March 4, 2024, 3:37 p.m.)
Indexed	6 months ago (Feb. 21, 2025, 7:18 a.m.)
Issued	19 years, 3 months ago (May 1, 2006)
Published	19 years, 3 months ago (May 1, 2006)
Published Print	19 years, 3 months ago (May 1, 2006)

Funders 1

Wellcome Trust 10.13039/100010269
Region: Europe
pri (Trusts, charities, foundations (both public and private))
Labels2
1. Wellcome
2. WT
Awards1
1. 063058/Z/00/Z

BibTeX

@article{Williams_2006, title={Gas Phase Characterization of the Noncovalent Quaternary Structure of Cholera Toxin and the Cholera Toxin B Subunit Pentamer}, volume={90}, ISSN={0006-3495}, url={http://dx.doi.org/10.1529/biophysj.105.076455}, DOI={10.1529/biophysj.105.076455}, number={9}, journal={Biophysical Journal}, publisher={Elsevier BV}, author={Williams, Jonathan P. and Smith, Daniel C. and Green, Brian N. and Marsden, Brian D. and Jennings, Keith R. and Roberts, Lynne M. and Scrivens, James H.}, year={2006}, month=may, pages={3246–3254} }

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      "article-title": "New drug targets for cholera therapy",
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      "author": "Thiagarajah",
      "year": "2005",
      "journal-title": "Trends Pharmacol. Sci."
    },
    {
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      "first-page": "223",
      "DOI": "10.1016/S0140-6736(03)15328-7",
      "article-title": "Cholera",
      "volume": "363",
      "author": "Sack",
      "year": "2004",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib4",
      "first-page": "269",
      "article-title": "Cholera",
      "volume": "78",
      "year": "2003",
      "journal-title": "Wkly. Epidemiol. Rec."
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      "first-page": "550",
      "DOI": "10.1006/jmbi.1995.0455",
      "article-title": "The 2.4\u00c5 crystal structure of cholera toxin B subunit pentamer: choleragenoid",
      "volume": "251",
      "author": "Zhang",
      "year": "1995",
      "journal-title": "J. Mol. Biol."
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      "article-title": "The three-dimensional crystal structure of cholera toxin",
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      "author": "Zhang",
      "year": "1995",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "1043",
      "DOI": "10.1006/jmbi.1998.2076",
      "article-title": "The 1.25\u00c5 resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site",
      "volume": "282",
      "author": "Merritt",
      "year": "1998",
      "journal-title": "J. Mol. Biol."
    },
    {
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      "doi-asserted-by": "crossref",
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      "author": "Schafer",
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      "author": "Schafer",
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      "volume": "238",
      "author": "Griffiths",
      "year": "1986",
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      "first-page": "13233",
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      "volume": "264",
      "author": "Schengrund",
      "year": "1989",
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      "first-page": "397",
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      "article-title": "Glycosphingolipids as toxin receptors",
      "volume": "15",
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      "year": "2004",
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    },
    {
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      "first-page": "483",
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      "volume": "293",
      "author": "Sandvig",
      "year": "2004",
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    },
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      "volume": "293",
      "author": "Lencer",
      "year": "2004",
      "journal-title": "Int. J. Med. Microbiol."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "596",
      "DOI": "10.1038/sj.embor.7400152",
      "article-title": "Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells",
      "volume": "5",
      "author": "Feng",
      "year": "2004",
      "journal-title": "EMBO Rep."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "639",
      "DOI": "10.1016/j.tibs.2003.10.002",
      "article-title": "The intracellular voyage of cholera toxin: going retro",
      "volume": "28",
      "author": "Lencer",
      "year": "2003",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "4783",
      "DOI": "10.1091/mbc.e03-06-0354",
      "article-title": "Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulum",
      "volume": "14",
      "author": "Fujinaga",
      "year": "2003",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "232",
      "DOI": "10.1034/j.1600-0854.2003.00070.x",
      "article-title": "A class of mutant CHO cells resistant to cholera toxin rapidly degrades the catalytic polypeptide of cholera toxin and exhibits increased endoplasmic reticulum-associated degradation",
      "volume": "4",
      "author": "Teter",
      "year": "2003",
      "journal-title": "Traffic"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "937",
      "DOI": "10.1016/S0092-8674(01)00289-6",
      "article-title": "Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin",
      "volume": "104",
      "author": "Tsai",
      "year": "2001",
      "journal-title": "Cell"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "207",
      "DOI": "10.1083/jcb.200207120",
      "article-title": "Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1",
      "volume": "159",
      "author": "Tsai",
      "year": "2002",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "246",
      "DOI": "10.1038/nrm780",
      "article-title": "Retro-translocation of proteins from the endoplasmic reticulum into the cytosol",
      "volume": "3",
      "author": "Tsai",
      "year": "2002",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "531",
      "DOI": "10.1078/1438-4221-00163",
      "article-title": "New insights into the structure-function relationships and therapeutic applications of cholera-like enterotoxins",
      "volume": "291",
      "author": "Hirst",
      "year": "2002",
      "journal-title": "Int. J. Med. Microbiol."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "503",
      "DOI": "10.1111/j.1432-1033.1985.tb08680.x",
      "article-title": "Facile identification of protein sequences by mass spectrometry. B subunit of Vibrio cholerae classical biotype Inaba 569B toxin",
      "volume": "146",
      "author": "Takao",
      "year": "1985",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1016/S0041-0101(98)00136-6",
      "article-title": "Characterisation of cholera toxin by liquid chromatography\u2014electrospray mass spectrometry",
      "volume": "37",
      "author": "van Baar",
      "year": "1999",
      "journal-title": "Toxicon"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "605",
      "DOI": "10.1093/glycob/11.7.605",
      "article-title": "The observation of multivalent complexes of Shiga-like toxin with globotriaoside and the determination of their stoichiometry by nanoelectrospray Fourier-transform ion cyclotron resonance mass spectrometry",
      "volume": "11",
      "author": "Kitova",
      "year": "2001",
      "journal-title": "Glycobiology"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "8282",
      "DOI": "10.1021/bi0503706",
      "article-title": "Noncovalent Shiga-like toxin assemblies: characterization by means of mass spectrometry and tandem mass spectrometry",
      "volume": "44",
      "author": "Williams",
      "year": "2005",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "4647",
      "DOI": "10.1021/ac0103975",
      "article-title": "Thermal decomposition of a gaseous multiprotein complex studied by blackbody infrared radiative dissociation. Investigating the origin of the asymmetric dissociation behavior",
      "volume": "73",
      "author": "Felitsyn",
      "year": "2001",
      "journal-title": "Anal. Chem."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1093/nar/28.1.235",
      "article-title": "The protein data bank",
      "volume": "28",
      "author": "Berman",
      "year": "2000",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "488",
      "DOI": "10.1002/jcc.540150503",
      "article-title": "ICM\u2014a new method for protein modeling and design: applications to docking and structure prediction from the distorted native conformation",
      "volume": "15",
      "author": "Abagyan",
      "year": "1994",
      "journal-title": "J. Comput. Chem."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "3128",
      "DOI": "10.1128/jb.177.11.3128-3132.1995",
      "article-title": "Analysis of Shiga toxin subunit association by using hybrid A polypeptides and site-specific mutagenesis",
      "volume": "177",
      "author": "Jemal",
      "year": "1995",
      "journal-title": "J. Bacteriol."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1038/nsb0194-59",
      "article-title": "Crystal structure of the holotoxin from Shigella dysenteriae at 2.5\u00c5 resolution",
      "volume": "1",
      "author": "Fraser",
      "year": "1994",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1111/j.1432-1033.1982.tb05885.x",
      "article-title": "Conformational changes in subunit A of cholera toxin following the binding of ganglioside to subunit B",
      "volume": "122",
      "author": "van Heyningen",
      "year": "1982",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "10.1529/biophysj.105.076455_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "2046",
      "DOI": "10.1021/bi00406a035",
      "article-title": "Thermal stability and intersubunit interactions of cholera toxin in solution and in association with its cell-surface receptor ganglioside GM1",
      "volume": "27",
      "author": "Goins",
      "year": "1988",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "8106",
      "DOI": "10.1021/bi00487a017",
      "article-title": "Structure, stability, and receptor interaction of cholera toxin as studied by Fourier-transform infrared spectroscopy",
      "volume": "29",
      "author": "Surewicz",
      "year": "1990",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "389",
      "DOI": "10.1016/j.toxicon.2004.12.014",
      "article-title": "Cholera and Shiga toxin B-subunits: thermodynamic and structural considerations for function and biomedical applications",
      "volume": "45",
      "author": "Pina",
      "year": "2005",
      "journal-title": "Toxicon"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "9169",
      "DOI": "10.1021/bi962996p",
      "article-title": "Conformational changes in cholera toxin B subunit-ganglioside GM1 complexes are elicited by environmental pH and evoke changes in membrane structure",
      "volume": "36",
      "author": "McCann",
      "year": "1997",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "65",
      "DOI": "10.1016/0167-4838(94)00208-X",
      "article-title": "Fluorescence analysis of the interaction between ganglioside GM1-containing phospholipid vesicles and the B subunit of cholera toxin",
      "volume": "1247",
      "author": "Picking",
      "year": "1995",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "9498",
      "DOI": "10.1021/bi034591s",
      "article-title": "Thermodynamic analysis of the structural stability of the Shiga toxin B-subunit",
      "volume": "42",
      "author": "Pina",
      "year": "2003",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "191",
      "DOI": "10.1021/bi00052a025",
      "article-title": "Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity",
      "volume": "32",
      "author": "Sixma",
      "year": "1993",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1529/biophysj.105.076455_bib51",
      "first-page": "748",
      "article-title": "Crystal structure of the cell-binding B oligomer of verotoxin-1 from",
      "volume": "355",
      "author": "Stein",
      "year": "1992",
      "journal-title": "E. coli. Nature"
    }
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