DOI: 10.1523/jneurosci.5252-03.2004. The Classical Receptive Field Surround of Primate Parasol Ganglion Cells Is Mediated Primarily by a Non-GABAergic Pathway

The Classical Receptive Field Surround of Primate Parasol Ganglion Cells Is Mediated Primarily by a Non-GABAergic Pathway

10.1523/jneurosci.5252-03.2004

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Although the center-surround receptive field is a fundamental property of retinal ganglion cells, the circuitry that mediates surround inhibition remains controversial. We examined the contribution of horizontal cells and amacrine cells to the surround of parasol ganglion cells of macaque and baboon retina by measuring receptive field structure before and during the application of drugs that have been shown previously to affect surrounds in a range of mammalian and nonmammalian species. Carbenoxolone and cobalt, thought to attenuate feedback from horizontal cells to cones, severely reduced the surround. Tetrodotoxin, which blocks sodium spiking in amacrine cells, and picrotoxin, which blocks the inhibitory action of GABA, only slightly reduced the surround. These data are consistent with the hypothesis that the surrounds of light-adapted parasol ganglion cells are generated primarily by non-GABAergic horizontal cell feedback in the outer retina, with a small contribution from GABAergic amacrine cells of the inner retina.

Bibliography

McMahon, M. J., Packer, O. S., & Dacey, D. M. (2004). The Classical Receptive Field Surround of Primate Parasol Ganglion Cells Is Mediated Primarily by a Non-GABAergic Pathway. The Journal of Neuroscience, 24(15), 3736â3745.

Authors 3

Matthew J. McMahon (first)
Orin S. Packer (additional)
Dennis M. Dacey (additional)

References 55 Referenced 95

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Dates

Type	When
Created	21 years, 4 months ago (April 14, 2004, 1:33 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 12:04 p.m.)
Indexed	4 months, 2 weeks ago (April 12, 2025, 8:51 p.m.)
Issued	21 years, 4 months ago (April 14, 2004)
Published	21 years, 4 months ago (April 14, 2004)
Published Online	21 years, 4 months ago (April 14, 2004)
Published Print	21 years, 4 months ago (April 14, 2004)

Funders 0

None

BibTeX

@article{McMahon_2004, title={The Classical Receptive Field Surround of Primate Parasol Ganglion Cells Is Mediated Primarily by a Non-GABAergic Pathway}, volume={24}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.5252-03.2004}, DOI={10.1523/jneurosci.5252-03.2004}, number={15}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={McMahon, Matthew J. and Packer, Orin S. and Dacey, Dennis M.}, year={2004}, month=apr, pages={3736–3745} }

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