DOI: 10.1523/jneurosci.4406-06.2007. Removal of GABA within Adult Modulatory Systems Alters Electrical Coupling and Allows Expression of an Embryonic-Like Network

Removal of GABA within Adult Modulatory Systems Alters Electrical Coupling and Allows Expression of an Embryonic-Like Network

10.1523/jneurosci.4406-06.2007

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

The maturation and operation of neural networks are known to depend on modulatory neurons. However, whether similar mechanisms may control both adult and developmental plasticity remains poorly investigated. To examine this issue, we have used the lobster stomatogastric nervous system (STNS) to investigate the ontogeny and role of GABAergic modulatory neurons projecting to small pattern generating networks. Using immunocytochemistry, we found that modulatory input neurons to the stomatogastric ganglion (STG) express GABA only after metamorphosis, a time that coincides with the developmental switch from a single to multiple pattern generating networks within the STNS. We demonstrate that blocking GABA synthesis with 3-mercapto-propionic acid within the adult modulatory neurons results in the reconfiguration of the distinct STG networks into a single network that generates a unified embryonic-like motor pattern. Using dye-coupling experiments, we also found that gap-junctional coupling is greater in embryos and GABA-deprived adults exhibiting the unified motor pattern compared with control adults. Furthermore, GABA was found to diminish directly the extent and strength of electrical coupling within adult STG networks. Together, these observations suggest the acquisition of a GABAergic phenotype by modulatory neurons after metamorphosis may induce the reconfiguration of the single embryonic network into multiple adult networks by directly decreasing electrical coupling. The findings also suggest that adult neural networks retain the ability to express typical embryonic characteristics, indicating that network ontogeny can be reversed and that changes in electrical coupling during development may allow the segregation of multiple distinct functional networks from a single large embryonic network.

Bibliography

Ducret, E., Le Feuvre, Y., Meyrand, P., & FÃ©nelon, V. S. (2007). Removal of GABA within Adult Modulatory Systems Alters Electrical Coupling and Allows Expression of an Embryonic-Like Network. The Journal of Neuroscience, 27(14), 3626â3638.

Authors 4

Eric Ducret (first)
Yves Le Feuvre (additional)
Pierre Meyrand (additional)
Valérie S. Fénelon (additional)

References 53 Referenced 10

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10.1523/JNEUROSCI.19-13-05449.1999 / J Neurosci / Different proctolin neurons elicit distinct motor patterns from a multifunctional neuronal network by Blitz (1999)
10.1523/JNEUROSCI.15-08-05703.1995 / J Neurosci / Functional differentiation of adult neural circuits from a single embryonic network by Casasnovas (1995)
10.1523/JNEUROSCI.07-09-02884.1987 / J Neurosci / Suppression of oscillatory activity in crustacean pyloric neurons: implication of GABAergic inputs by Cazalets (1987)
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Faumont S (1999) Mécanismes cellulaires impliqués dans la sélection de programmes moteurs multiples par un même système de contrôle descendant: approches électrophysiologique, pharmacologique et immunohistochimique. PhD thesis (Université Bordeaux I).
10.1111/j.1460-9568.2005.04442.x / Eur J Neurosci / Reconfiguration of multiple motor networks by short- and long-term actions of an identified modulatory neuron by Faumont (2005)
10.1002/(SICI)1096-9861(19980928)399:3<289::AID-CNE1>3.0.CO;2-X
10.1152/jn.1996.75.5.2089 / J Neurophysiol / Block of glutamate decarboxylase decreases GABAergic inhibition at the crayfish synapses: possible role of presynaptic metabotropic mechanisms by Golan (1996)
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10.2307/1542337 / Biol Bull / Embryonic development of the American lobster (Homarus americanus): quantitative staging and characterization of an embryonic molt cycle by Helluy (1991)
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{'key': '2023041303243882000_27.14.3626.50', 'first-page': '367', 'article-title': 'Expression of embryonic-like motor patterns in an adult system: a role for histaminergic transmission', 'volume': '32', 'author': 'Sullivan', 'year': '2002', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Expression of embryonic-like motor patterns in an adult system: a role for histaminergic transmission by Sullivan (2002)
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Dates

Type	When
Created	18 years, 5 months ago (April 4, 2007, 1:02 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 1:57 p.m.)
Indexed	1 year, 3 months ago (May 7, 2024, 1:57 a.m.)
Issued	18 years, 5 months ago (April 4, 2007)
Published	18 years, 5 months ago (April 4, 2007)
Published Online	18 years, 5 months ago (April 4, 2007)
Published Print	18 years, 5 months ago (April 4, 2007)

Funders 0

None

BibTeX

@article{Ducret_2007, title={Removal of GABA within Adult Modulatory Systems Alters Electrical Coupling and Allows Expression of an Embryonic-Like Network}, volume={27}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.4406-06.2007}, DOI={10.1523/jneurosci.4406-06.2007}, number={14}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Ducret, Eric and Le Feuvre, Yves and Meyrand, Pierre and Fénelon, Valérie S.}, year={2007}, month=apr, pages={3626–3638} }

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