DOI: 10.1523/jneurosci.4070-05.2005. Endogenous Neurogenesis Replaces Oligodendrocytes and Astrocytes after Primate Spinal Cord Injury

Endogenous Neurogenesis Replaces Oligodendrocytes and Astrocytes after Primate Spinal Cord Injury

10.1523/jneurosci.4070-05.2005

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Neurogenesis has been described in various regions of the CNS throughout life. We examined the extent of natural cell division and replacement from 7 weeks to 7 months after cervical spinal cord injury in four adult rhesus monkeys. Bromodeoxyuridine (BrdU) injections revealed an increase of >80-fold in the number of newly divided cells in the primate spinal cord after injury, with an average of 725,000 BrdU-labeled cells identified per monkey in the immediate injury zone. By 7 months after injury, 15% of these new cells expressed mature markers of oligodendrocytes and 12% expressed mature astrocytic markers. Newly born oligodendrocytes were present in zones of injury-induced demyelination and appeared to ensheath or remyelinate host axons. Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement.

Bibliography

Yang, H., Lu, P., McKay, H. M., Bernot, T., Keirstead, H., Steward, O., Gage, F. H., Edgerton, V. R., & Tuszynski, M. H. (2006). Endogenous Neurogenesis Replaces Oligodendrocytes and Astrocytes after Primate Spinal Cord Injury. The Journal of Neuroscience, 26(8), 2157â2166.

Authors 9

Hong Yang (first)
Paul Lu (additional)
Heather M. McKay (additional)
Tim Bernot (additional)
Hans Keirstead (additional)
Oswald Steward (additional)
Fred H. Gage (additional)
V. Reggie Edgerton (additional)
Mark H. Tuszynski (additional)

References 48 Referenced 132

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Dates

Type	When
Created	19 years, 6 months ago (Feb. 22, 2006, 3:18 p.m.)
Deposited	1 year, 7 months ago (Feb. 2, 2024, 9:18 p.m.)
Indexed	1 day, 3 hours ago (Sept. 3, 2025, 5:52 a.m.)
Issued	19 years, 6 months ago (Feb. 22, 2006)
Published	19 years, 6 months ago (Feb. 22, 2006)
Published Online	19 years, 6 months ago (Feb. 22, 2006)
Published Print	19 years, 6 months ago (Feb. 22, 2006)

Funders 0

None

BibTeX

@article{Yang_2006, title={Endogenous Neurogenesis Replaces Oligodendrocytes and Astrocytes after Primate Spinal Cord Injury}, volume={26}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.4070-05.2005}, DOI={10.1523/jneurosci.4070-05.2005}, number={8}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Yang, Hong and Lu, Paul and McKay, Heather M. and Bernot, Tim and Keirstead, Hans and Steward, Oswald and Gage, Fred H. and Edgerton, V. Reggie and Tuszynski, Mark H.}, year={2006}, month=feb, pages={2157–2166} }

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