DOI: 10.1523/jneurosci.2850-06.2006. A Progressive and Cell Non-Autonomous Increase in Striatal Neural Stem Cells in the Huntington's Disease R6/2 Mouse

A Progressive and Cell Non-Autonomous Increase in Striatal Neural Stem Cells in the Huntington's Disease R6/2 Mouse

10.1523/jneurosci.2850-06.2006

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Neural stem and progenitor cells are located in the subependyma of the adult forebrain. An increase in adult subependymal cell proliferation is reported after various kinds of brain injury. We demonstrate an expansion of neural precursor cells in the postnatal subependyma in a murine genetic disease model of Huntington's disease (HD), the R6/2 mouse. We used thein vitroneurosphere assay as an index of the number of neural stem cellsin vivoand to assess proliferation kineticsin vitroandin vivobromodeoxyuridine labeling to assess the progenitor cell population and their fates. Disease progression in this model leads to an increase in the numbers of neural stem cells in the adult striatal subependyma. This increase is produced cell non-autonomously by events in the R6/2 brains as the mice become increasingly symptomatic. Once the neural stem cell increase is inducedin vivo, it is maintained duringin vitropassaging of neural stem cells, but the neural stem cell increase is not reproduced duringin vitropassaging of neural stem cells from presymptomatic R6/2 mice. In addition, we show that some of the R6/2 neural progenitor cells show a change from their normal migration destiny toward the olfactory bulb. Instead, some of these cells migrate into the striatum, one of the main affected areas in HD. Our findings demonstrate that HD damage recruits precursor cells in two ways: expansion of neural stem cells and altered migration of progenitor cells.

Bibliography

Batista, C. M. C., Kippin, T. E., Willaime-Morawek, S., Shimabukuro, M. K., Akamatsu, W., & van der Kooy, D. (2006). A Progressive and Cell Non-Autonomous Increase in Striatal Neural Stem Cells in the Huntingtonâs Disease R6/2 Mouse. The Journal of Neuroscience, 26(41), 10452â10460.

Authors 6

Claudia M. C. Batista (first)
Tod E. Kippin (additional)
Sandrine Willaime-Morawek (additional)
Marília Kimie Shimabukuro (additional)
Wado Akamatsu (additional)
Derek van der Kooy (additional)

References 50 Referenced 46

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 11, 2006, 1:30 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 1:39 p.m.)
Indexed	1 year ago (Aug. 12, 2024, 11:14 a.m.)
Issued	18 years, 10 months ago (Oct. 11, 2006)
Published	18 years, 10 months ago (Oct. 11, 2006)
Published Online	18 years, 10 months ago (Oct. 11, 2006)
Published Print	18 years, 10 months ago (Oct. 11, 2006)

Funders 0

None

BibTeX

@article{Batista_2006, title={A Progressive and Cell Non-Autonomous Increase in Striatal Neural Stem Cells in the Huntington’s Disease R6/2 Mouse}, volume={26}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.2850-06.2006}, DOI={10.1523/jneurosci.2850-06.2006}, number={41}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Batista, Claudia M. C. and Kippin, Tod E. and Willaime-Morawek, Sandrine and Shimabukuro, Marília Kimie and Akamatsu, Wado and van der Kooy, Derek}, year={2006}, month=oct, pages={10452–10460} }

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  "alternative-id": [
    "10.1523/JNEUROSCI.2850-06.2006"
  ],
  "URL": "http://dx.doi.org/10.1523/JNEUROSCI.2850-06.2006",
  "relation": {},
  "ISSN": [
    "0270-6474",
    "1529-2401"
  ],
  "subject": [],
  "container-title-short": "J. Neurosci.",
  "published": {
    "date-parts": [
      [
        2006,
        10,
        11
      ]
    ]
  }
}