DOI: 10.1523/jneurosci.2761-05.2006. Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine

Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine

10.1523/jneurosci.2761-05.2006

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

In this study, we investigated the role of orexinergic systems in dopamine-related behaviors induced by the μ-opioid receptor agonist morphine in rodents. Extensive coexpression of tyrosine hydroxylase with orexin receptors was observed in the mouse ventral tegmental area (VTA). The levels of dopamine and its major metabolites in the nucleus accumbens were markedly increased by the microinjection of orexin A and orexin B into the VTA. The subcutaneous morphine-induced place preference and hyperlocomotion observed in wild-type mice were abolished in mice that lacked the prepro-orexin gene. An intra-VTA injection of a selective orexin receptor antagonist SB334867A [1-(2-methylbenzoxazol-6-yl)-3-[1.5]naphthyridin-4-yl urea] significantly suppressed the morphine-induced place preference in rats. Furthermore, the increased level of dialysate dopamine produced by morphine in the mouse brain was significantly decreased by deletion of the prepro-orexin gene. These findings provide new evidence that orexin-containing neurons in the VTA are directly implicated in the rewarding effect and hyperlocomotion induced by morphine through activation of the mesolimbic dopamine pathway in rodents.

Bibliography

Narita, M., Nagumo, Y., Hashimoto, S., Narita, M., Khotib, J., Miyatake, M., Sakurai, T., Yanagisawa, M., Nakamachi, T., Shioda, S., & Suzuki, T. (2006). Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine. The Journal of Neuroscience, 26(2), 398â405.

Authors 11

Minoru Narita (first)
Yasuyuki Nagumo (additional)
Seiko Hashimoto (additional)
Michiko Narita (additional)
Junaidi Khotib (additional)
Mayumi Miyatake (additional)
Takeshi Sakurai (additional)
Masashi Yanagisawa (additional)
Tomoya Nakamachi (additional)
Seiji Shioda (additional)
Tsutomu Suzuki (additional)

References 40 Referenced 430

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{'key': '2023041303161864000_26.2.398.3', 'first-page': '489', 'volume': '264', 'year': '1993', 'journal-title': 'J Pharmacol Exp Ther'} / J Pharmacol Exp Ther (1993)
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10.1016/S0165-0173(98)00019-8
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Dates

Type	When
Created	19 years, 7 months ago (Jan. 11, 2006, 5:20 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 1:09 p.m.)
Indexed	58 minutes ago (Sept. 4, 2025, 2:49 a.m.)
Issued	19 years, 7 months ago (Jan. 11, 2006)
Published	19 years, 7 months ago (Jan. 11, 2006)
Published Online	19 years, 7 months ago (Jan. 11, 2006)
Published Print	19 years, 7 months ago (Jan. 11, 2006)

Funders 0

None

BibTeX

@article{Narita_2006, title={Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine}, volume={26}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.2761-05.2006}, DOI={10.1523/jneurosci.2761-05.2006}, number={2}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Narita, Minoru and Nagumo, Yasuyuki and Hashimoto, Seiko and Narita, Michiko and Khotib, Junaidi and Miyatake, Mayumi and Sakurai, Takeshi and Yanagisawa, Masashi and Nakamachi, Tomoya and Shioda, Seiji and Suzuki, Tsutomu}, year={2006}, month=jan, pages={398–405} }

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