DOI: 10.1523/jneurosci.23-21-07727.2003. NMDA-Dependent Proteolysis of Presynaptic Adhesion Molecule L1 in the Hippocampus by Neuropsin

NMDA-Dependent Proteolysis of Presynaptic Adhesion Molecule L1 in the Hippocampus by Neuropsin

10.1523/jneurosci.23-21-07727.2003

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Synaptic plasticity requires an activity-dependent, rapid, and long-lasting modification of synaptic character, including morphology and coupling strength. Here we show that a serine protease, neuropsin, directly and specifically modifies the synaptic adhesion molecule L1, which was localized to the presynaptic site of the asymmetric synapse in the mouse hippocampus. Increased neural activity triggered the rapid, transient activation of the precursor form of neuropsin in an NMDA receptor-dependent manner. The activated neuropsin immediately cleaved L1 and released a neuropsin-specific extracellular 180 kDa fragment. This neuropsin-specific L1-cleaving system is involved in NMDA receptor-dependent synaptic plasticity, such as the Schaffer collateral long-term potentiation.

Bibliography

Matsumoto-Miyai, K., Ninomiya, A., Yamasaki, H., Tamura, H., Nakamura, Y., & Shiosaka, S. (2003). NMDA-Dependent Proteolysis of Presynaptic Adhesion Molecule L1 in the Hippocampus by Neuropsin. The Journal of Neuroscience, 23(21), 7727â7736.

Authors 6

Kazumasa Matsumoto-Miyai (first)
Ayako Ninomiya (additional)
Hironobu Yamasaki (additional)
Hideki Tamura (additional)
Yukiko Nakamura (additional)
Sadao Shiosaka (additional)

References 50 Referenced 119

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{'key': '2023022307583618000_23.21.7727.50', 'first-page': '405', 'volume': '3', 'year': '1999', 'journal-title': 'Int J Mol Med'} / Int J Mol Med (1999)

Dates

Type	When
Created	7 years, 4 months ago (April 12, 2018, 7:25 p.m.)
Deposited	2 years, 6 months ago (Feb. 23, 2023, 11:09 a.m.)
Indexed	1 month, 1 week ago (July 30, 2025, 10:47 a.m.)
Issued	22 years ago (Aug. 27, 2003)
Published	22 years ago (Aug. 27, 2003)
Published Online	22 years ago (Aug. 27, 2003)
Published Print	22 years ago (Aug. 27, 2003)

Funders 0

None

BibTeX

@article{Matsumoto_Miyai_2003, title={NMDA-Dependent Proteolysis of Presynaptic Adhesion Molecule L1 in the Hippocampus by Neuropsin}, volume={23}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.23-21-07727.2003}, DOI={10.1523/jneurosci.23-21-07727.2003}, number={21}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Matsumoto-Miyai, Kazumasa and Ninomiya, Ayako and Yamasaki, Hironobu and Tamura, Hideki and Nakamura, Yukiko and Shiosaka, Sadao}, year={2003}, month=aug, pages={7727–7736} }

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