DOI: 10.1523/jneurosci.23-15-06245.2003. Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons

Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons

10.1523/jneurosci.23-15-06245.2003

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

By stimulating distinct receptor subtypes, dopamine (DA) exerts presynaptic and postsynaptic actions on both large aspiny (LA) cholinergic and fast-spiking (FS) parvalbumin-positive interneurons of the striatum. Lack of receptor- and isoform-specific pharmacological agents, however, has hampered the progress toward a detailed identification of the specific DA receptors involved in these actions.To overcome this issue, in the present study we used four different mutant mice in which the expression of specific DA receptors was ablated. In D1 receptor null mice, D1R-/-, DA dose-dependently depolarized both LA and FS interneurons. Interestingly, SCH 233390 (10 μm), a D1-like (D1 and D5) receptor antagonist, but notl-sulpiride (3–10 μm), a D2-like (D2, D3, D4) receptor blocker, prevented this effect, implying D5 receptors in this action. Accordingly, immunohistochemical analyses in both wild-type and D1R-/- mice confirmed the expression of D5 receptors in both cholinergic and parvalbumin-positive interneurons of the striatum.In mice lacking D2 receptors, D2R-/-, the DA-dependent inhibition of GABA transmission was lost in both interneuron populations. Both isoforms of D2 receptor, D2L and D2S, were very likely involved in this inhibitory action, as revealed by the electrophysiological analysis of the effect of the DA D2-like receptor agonist quinpirole in two distinct mutants lacking D2L receptors and expressing variable contents of D2S receptors.The identification of the receptor subtypes involved in the actions of DA on different populations of striatal cells is essential to understand the circuitry of the basal ganglia and to develop pharmacological strategies able to interfere selectively with specific neuronal functions.

Bibliography

Centonze, D., Grande, C., Usiello, A., Gubellini, P., Erbs, E., MartÃn, A. B., Pisani, A., Tognazzi, N., Bernardi, G., Moratalla, R., Borrelli, E., & Calabresi, P. (2003). Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons. The Journal of Neuroscience, 23(15), 6245â6254.

Authors 12

Diego Centonze (first)
Cristina Grande (additional)
Alessandro Usiello (additional)
Paolo Gubellini (additional)
Eric Erbs (additional)
Ana B. Martín (additional)
Antonio Pisani (additional)
Nadia Tognazzi (additional)
Giorgio Bernardi (additional)
Rosario Moratalla (additional)
Emiliana Borrelli (additional)
Paolo Calabresi (additional)

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Dates

Type	When
Created	7 years, 4 months ago (April 13, 2018, 6:30 p.m.)
Deposited	2 years, 6 months ago (Feb. 23, 2023, 11:07 a.m.)
Indexed	2 months, 2 weeks ago (June 16, 2025, 10:31 a.m.)
Issued	22 years, 1 month ago (July 16, 2003)
Published	22 years, 1 month ago (July 16, 2003)
Published Online	22 years, 1 month ago (July 16, 2003)
Published Print	22 years, 1 month ago (July 16, 2003)

Funders 0

None

BibTeX

@article{Centonze_2003, title={Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons}, volume={23}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.23-15-06245.2003}, DOI={10.1523/jneurosci.23-15-06245.2003}, number={15}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Centonze, Diego and Grande, Cristina and Usiello, Alessandro and Gubellini, Paolo and Erbs, Eric and Martín, Ana B. and Pisani, Antonio and Tognazzi, Nadia and Bernardi, Giorgio and Moratalla, Rosario and Borrelli, Emiliana and Calabresi, Paolo}, year={2003}, month=jul, pages={6245–6254} }

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