DOI: 10.1523/jneurosci.21-11-04066.2001. Calcineurin Links Ca<sup>2+</sup>Dysregulation with Brain Aging

Calcineurin Links Ca2+Dysregulation with Brain Aging

10.1523/jneurosci.21-11-04066.2001

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Brain aging is associated with altered Ca2+regulation. However, many Ca2+signal transduction mechanisms have not been explored in the aged brain. Here, we report that cytosolic expression and activity of the Ca2+-dependent protein phosphatase calcineurin (CaN) increases in the hippocampus during aging. CaN changes were paralleled by increased activation, but not expression, of CaN-regulated protein phosphatase 1 and a reduction in the phosphorylation state of CaN substrates involved in cell survival (i.e., Bcl-2-associated death protein and cAMP response element-binding protein). The age-related increase in CaN activity was not attributable to the inability of CaN to translocate to the membrane and was reduced by blocking L-type Ca2+channels. Finally, increased CaN activity correlated with memory function as measured with the Morris water escape task. The results suggest that altered regulation of CaN is one of the processes that could link Ca2+dyshomeostasis to age-related changes in neural function and cognition.

Bibliography

Foster, T. C., Sharrow, K. M., Masse, J. R., Norris, C. M., & Kumar, A. (2001). Calcineurin Links Ca2+Dysregulation with Brain Aging. The Journal of Neuroscience, 21(11), 4066â4073.

Authors 5

Thomas C. Foster (first)
Keith M. Sharrow (additional)
James R. Masse (additional)
Christopher M. Norris (additional)
Ashok Kumar (additional)

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Dates

Type	When
Created	7 years, 4 months ago (April 4, 2018, 9:30 p.m.)
Deposited	1 year, 1 month ago (July 5, 2024, 3:06 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:46 a.m.)
Issued	24 years, 3 months ago (June 1, 2001)
Published	24 years, 3 months ago (June 1, 2001)
Published Online	24 years, 3 months ago (June 1, 2001)
Published Print	24 years, 3 months ago (June 1, 2001)

Funders 0

None

BibTeX

@article{Foster_2001, title={Calcineurin Links Ca2+Dysregulation with Brain Aging}, volume={21}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.21-11-04066.2001}, DOI={10.1523/jneurosci.21-11-04066.2001}, number={11}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Foster, Thomas C. and Sharrow, Keith M. and Masse, James R. and Norris, Christopher M. and Kumar, Ashok}, year={2001}, month=jun, pages={4066–4073} }

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