DOI: 10.1523/jneurosci.21-11-03904.2001. Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements

Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements

10.1523/jneurosci.21-11-03904.2001

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown. We found that cultured neurons from a key forebrain structure, the dorsal thalamus, develop a need for survival factors including brain-derived neurotrophic factor (BDNF) from their major target, the cerebral cortex, at the age at which they innervate it. Experimentsin vivohave shown that rates of dorsal thalamic cell death are reduced by increasing cortical levels of BDNF and are increased in mutant mice lacking functional BDNF receptors or thalamocortical projections; these experiments have also shown that an increase in the rates of dorsal thalamic cell death can be achieved by blocking BDNF in the cortex. We suggest that the onset of a requirement for cortex-derived neurotrophic factors initiates a competitive mechanism regulating programmed cell death among dorsal thalamic neurons.

Bibliography

Lotto, R. B., Asavaritikrai, P., Vali, L., & Price, D. J. (2001). Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements. The Journal of Neuroscience, 21(11), 3904â3910.

Authors 4

R. Beau Lotto (first)
Pundit Asavaritikrai (additional)
Leila Vali (additional)
David J. Price (additional)

References 39 Referenced 36

10.1523/JNEUROSCI.17-10-03623.1997
10.1523/JNEUROSCI.14-03-01795.1994
10.1016/0092-8674(92)90531-G
10.1111/j.1460-9568.1997.tb01685.x
Burek MJ Oppenheim RW (1998) Cellular interactions that regulate programmed cell death in the developing vertebrate nervous system. in Cell death and diseases of the nervous system, eds Koliatsos V Ratan R (Humana, Totowa, NJ), pp 223–246. (10.1007/978-1-4612-1602-5_8)
10.1016/0896-6273(92)90023-7 / Neuron / Neurotrophin receptors: a window into neuronal differentiation. by Chao (1992)
10.1016/0165-3806(87)90235-5
10.1016/S0959-4388(97)80128-6
10.1016/0014-4886(92)90163-K
10.1083/jcb.119.3.493
10.1016/S0960-9822(02)00442-6
10.1126/science.7907431
10.1016/S0092-8674(00)81509-3
10.1002/(SICI)1096-9861(19990531)408:2<147::AID-CNE1>3.0.CO;2-L
10.1038/bjc.1972.33
10.1016/S0092-8674(05)80088-1
10.1038/368249a0
10.1111/j.1460-9568.1995.tb01067.x
Lotto RB Price DJ (1997) Thalamus: dispersed neuron culture. in The neuron in culture. International Brain Research Organization handbook series: methods in the neurosciences, ed Haynes LW (Wiley, Chichester, UK), pp 525–530.
10.1111/j.1460-9568.1997.tb00761.x
10.1016/S0079-6123(08)62405-X / Prog Brain Res / The neurotrophic hypothesis and the cholinergic basal forebrain projection. by Lucidi-Phillipi (1993)
10.1016/0306-4522(96)00200-X / Neuroscience / Trophic and outgrowth-promoting effects of K+-induced depolarization on developing thalamic cells in organotypic culture. by Magowan (1996)
10.1016/0896-6273(90)90089-X
10.1016/0896-6273(95)90171-X
10.1016/0896-6273(95)90172-8
Molnar Z (1998) Development of thalamocortical connections. (Springer, Berlin).
10.1146/annurev.ne.14.030191.002321
10.1016/S0896-6273(00)81004-1
Price DJ Willshaw DA (2000) Mechanisms of cortical development. (Oxford UP, Oxford). (10.1093/acprof:oso/9780192624277.001.0001)
10.1016/0306-4522(94)90433-2
10.1016/0165-3806(93)90165-7 / Dev Brain Res / Expression of members of the trk family in the developing postnatal rat-brain. by Ringstedt (1993)
10.1523/JNEUROSCI.15-01-00477.1995
10.1016/0092-8674(94)90048-5
10.1002/cne.903630209
10.1242/dev.122.11.3453 / Development / Forebrain patterning defects in Small eye mutant mice. by Stoykova (1996)
{'key': '2023041302483751000_21.11.3904.36', 'first-page': '371', 'article-title': 'K252a is a selective inhibitor of the tyrosine protein-kinase activity of the trk family of oncogenes and neurotrophin receptors.', 'volume': '7', 'author': 'Tapley', 'year': '1992', 'journal-title': 'Oncogene'} / Oncogene / K252a is a selective inhibitor of the tyrosine protein-kinase activity of the trk family of oncogenes and neurotrophin receptors. by Tapley (1992)
10.1242/dev.124.8.1573 / Development / Roles of Pax-6 in murine diencephalic development. by Warren (1997)
10.1093/cercor/9.6.627
10.1016/S0896-6273(00)80367-0

Dates

Type	When
Created	7 years, 5 months ago (April 4, 2018, 9:30 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 9:57 a.m.)
Indexed	1 year, 9 months ago (Nov. 13, 2023, 11:44 a.m.)
Issued	24 years, 3 months ago (June 1, 2001)
Published	24 years, 3 months ago (June 1, 2001)
Published Online	24 years, 3 months ago (June 1, 2001)
Published Print	24 years, 3 months ago (June 1, 2001)

Funders 0

None

BibTeX

@article{Lotto_2001, title={Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements}, volume={21}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.21-11-03904.2001}, DOI={10.1523/jneurosci.21-11-03904.2001}, number={11}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Lotto, R. Beau and Asavaritikrai, Pundit and Vali, Leila and Price, David J.}, year={2001}, month=jun, pages={3904–3910} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        11,
        13
      ]
    ],
    "date-time": "2023-11-13T16:44:10Z",
    "timestamp": 1699893850736
  },
  "reference-count": 39,
  "publisher": "Society for Neuroscience",
  "issue": "11",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            12,
            1
          ]
        ],
        "date-time": "2001-12-01T00:00:00Z",
        "timestamp": 1007164800000
      },
      "content-version": "vor",
      "delay-in-days": 183,
      "URL": "https://creativecommons.org/licenses/by-nc-sa/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        6,
        1
      ]
    ]
  },
  "abstract": "<jats:p>Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown. We found that cultured neurons from a key forebrain structure, the dorsal thalamus, develop a need for survival factors including brain-derived neurotrophic factor (BDNF) from their major target, the cerebral cortex, at the age at which they innervate it. Experiments<jats:italic>in vivo</jats:italic>have shown that rates of dorsal thalamic cell death are reduced by increasing cortical levels of BDNF and are increased in mutant mice lacking functional BDNF receptors or thalamocortical projections; these experiments have also shown that an increase in the rates of dorsal thalamic cell death can be achieved by blocking BDNF in the cortex. We suggest that the onset of a requirement for cortex-derived neurotrophic factors initiates a competitive mechanism regulating programmed cell death among dorsal thalamic neurons.</jats:p>",
  "DOI": "10.1523/jneurosci.21-11-03904.2001",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2018,
        4,
        5
      ]
    ],
    "date-time": "2018-04-05T01:30:23Z",
    "timestamp": 1522891823000
  },
  "page": "3904-3910",
  "source": "Crossref",
  "is-referenced-by-count": 36,
  "title": "Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements",
  "prefix": "10.1523",
  "volume": "21",
  "author": [
    {
      "given": "R. Beau",
      "family": "Lotto",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Pundit",
      "family": "Asavaritikrai",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Leila",
      "family": "Vali",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "David J.",
      "family": "Price",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "393",
  "published-online": {
    "date-parts": [
      [
        2001,
        6,
        1
      ]
    ]
  },
  "reference": [
    {
      "key": "2023041302483751000_21.11.3904.1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.17-10-03623.1997"
    },
    {
      "key": "2023041302483751000_21.11.3904.2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.14-03-01795.1994"
    },
    {
      "key": "2023041302483751000_21.11.3904.3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90531-G"
    },
    {
      "key": "2023041302483751000_21.11.3904.4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1460-9568.1997.tb01685.x"
    },
    {
      "key": "2023041302483751000_21.11.3904.5",
      "doi-asserted-by": "crossref",
      "unstructured": "Burek MJ Oppenheim RW (1998) Cellular interactions that regulate programmed cell death in the developing vertebrate nervous system. in Cell death and diseases of the nervous system, eds Koliatsos V Ratan R (Humana, Totowa, NJ), pp 223\u2013246.",
      "DOI": "10.1007/978-1-4612-1602-5_8"
    },
    {
      "key": "2023041302483751000_21.11.3904.6",
      "doi-asserted-by": "crossref",
      "first-page": "583",
      "DOI": "10.1016/0896-6273(92)90023-7",
      "article-title": "Neurotrophin receptors: a window into neuronal differentiation.",
      "volume": "4",
      "author": "Chao",
      "year": "1992",
      "journal-title": "Neuron"
    },
    {
      "key": "2023041302483751000_21.11.3904.7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0165-3806(87)90235-5"
    },
    {
      "key": "2023041302483751000_21.11.3904.8",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0959-4388(97)80128-6"
    },
    {
      "key": "2023041302483751000_21.11.3904.9",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-4886(92)90163-K"
    },
    {
      "key": "2023041302483751000_21.11.3904.10",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.119.3.493"
    },
    {
      "key": "2023041302483751000_21.11.3904.11",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(02)00442-6"
    },
    {
      "key": "2023041302483751000_21.11.3904.12",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7907431"
    },
    {
      "key": "2023041302483751000_21.11.3904.13",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81509-3"
    },
    {
      "key": "2023041302483751000_21.11.3904.14",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1096-9861(19990531)408:2<147::AID-CNE1>3.0.CO;2-L"
    },
    {
      "key": "2023041302483751000_21.11.3904.15",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/bjc.1972.33"
    },
    {
      "key": "2023041302483751000_21.11.3904.16",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(05)80088-1"
    },
    {
      "key": "2023041302483751000_21.11.3904.17",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/368249a0"
    },
    {
      "key": "2023041302483751000_21.11.3904.18",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1460-9568.1995.tb01067.x"
    },
    {
      "key": "2023041302483751000_21.11.3904.19",
      "unstructured": "Lotto RB Price DJ (1997) Thalamus: dispersed neuron culture. in The neuron in culture. International Brain Research Organization handbook series: methods in the neurosciences, ed Haynes LW (Wiley, Chichester, UK), pp 525\u2013530."
    },
    {
      "key": "2023041302483751000_21.11.3904.20",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1460-9568.1997.tb00761.x"
    },
    {
      "key": "2023041302483751000_21.11.3904.21",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1016/S0079-6123(08)62405-X",
      "article-title": "The neurotrophic hypothesis and the cholinergic basal forebrain projection.",
      "volume": "98",
      "author": "Lucidi-Phillipi",
      "year": "1993",
      "journal-title": "Prog Brain Res"
    },
    {
      "key": "2023041302483751000_21.11.3904.22",
      "doi-asserted-by": "crossref",
      "first-page": "1045",
      "DOI": "10.1016/0306-4522(96)00200-X",
      "article-title": "Trophic and outgrowth-promoting effects of K+-induced depolarization on developing thalamic cells in organotypic culture.",
      "volume": "74",
      "author": "Magowan",
      "year": "1996",
      "journal-title": "Neuroscience"
    },
    {
      "key": "2023041302483751000_21.11.3904.23",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(90)90089-X"
    },
    {
      "key": "2023041302483751000_21.11.3904.24",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(95)90171-X"
    },
    {
      "key": "2023041302483751000_21.11.3904.25",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(95)90172-8"
    },
    {
      "key": "2023041302483751000_21.11.3904.26",
      "unstructured": "Molnar Z (1998) Development of thalamocortical connections. (Springer, Berlin)."
    },
    {
      "key": "2023041302483751000_21.11.3904.27",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.ne.14.030191.002321"
    },
    {
      "key": "2023041302483751000_21.11.3904.28",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0896-6273(00)81004-1"
    },
    {
      "key": "2023041302483751000_21.11.3904.29",
      "doi-asserted-by": "crossref",
      "unstructured": "Price DJ Willshaw DA (2000) Mechanisms of cortical development. (Oxford UP, Oxford).",
      "DOI": "10.1093/acprof:oso/9780192624277.001.0001"
    },
    {
      "key": "2023041302483751000_21.11.3904.30",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0306-4522(94)90433-2"
    },
    {
      "key": "2023041302483751000_21.11.3904.31",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1016/0165-3806(93)90165-7",
      "article-title": "Expression of members of the trk family in the developing postnatal rat-brain.",
      "volume": "72",
      "author": "Ringstedt",
      "year": "1993",
      "journal-title": "Dev Brain Res"
    },
    {
      "key": "2023041302483751000_21.11.3904.32",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.15-01-00477.1995"
    },
    {
      "key": "2023041302483751000_21.11.3904.33",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(94)90048-5"
    },
    {
      "key": "2023041302483751000_21.11.3904.34",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/cne.903630209"
    },
    {
      "key": "2023041302483751000_21.11.3904.35",
      "doi-asserted-by": "crossref",
      "first-page": "3453",
      "DOI": "10.1242/dev.122.11.3453",
      "article-title": "Forebrain patterning defects in Small eye mutant mice.",
      "volume": "122",
      "author": "Stoykova",
      "year": "1996",
      "journal-title": "Development"
    },
    {
      "key": "2023041302483751000_21.11.3904.36",
      "first-page": "371",
      "article-title": "K252a is a selective inhibitor of the tyrosine protein-kinase activity of the trk family of oncogenes and neurotrophin receptors.",
      "volume": "7",
      "author": "Tapley",
      "year": "1992",
      "journal-title": "Oncogene"
    },
    {
      "key": "2023041302483751000_21.11.3904.37",
      "doi-asserted-by": "crossref",
      "first-page": "1573",
      "DOI": "10.1242/dev.124.8.1573",
      "article-title": "Roles of Pax-6 in murine diencephalic development.",
      "volume": "124",
      "author": "Warren",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "2023041302483751000_21.11.3904.38",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/cercor/9.6.627"
    },
    {
      "key": "2023041302483751000_21.11.3904.39",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0896-6273(00)80367-0"
    }
  ],
  "container-title": "The Journal of Neuroscience",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.21-11-03904.2001",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        13
      ]
    ],
    "date-time": "2023-04-13T13:57:29Z",
    "timestamp": 1681394249000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.21-11-03904.2001"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        6,
        1
      ]
    ]
  },
  "references-count": 39,
  "journal-issue": {
    "issue": "11",
    "published-online": {
      "date-parts": [
        [
          2001,
          6,
          1
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          2001,
          6,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1523/JNEUROSCI.21-11-03904.2001"
  ],
  "URL": "http://dx.doi.org/10.1523/JNEUROSCI.21-11-03904.2001",
  "relation": {},
  "ISSN": [
    "0270-6474",
    "1529-2401"
  ],
  "subject": [],
  "container-title-short": "J. Neurosci.",
  "published": {
    "date-parts": [
      [
        2001,
        6,
        1
      ]
    ]
  }
}