DOI: 10.1523/jneurosci.21-11-03904.2001. Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements

Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements

10.1523/jneurosci.21-11-03904.2001

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown. We found that cultured neurons from a key forebrain structure, the dorsal thalamus, develop a need for survival factors including brain-derived neurotrophic factor (BDNF) from their major target, the cerebral cortex, at the age at which they innervate it. Experimentsin vivohave shown that rates of dorsal thalamic cell death are reduced by increasing cortical levels of BDNF and are increased in mutant mice lacking functional BDNF receptors or thalamocortical projections; these experiments have also shown that an increase in the rates of dorsal thalamic cell death can be achieved by blocking BDNF in the cortex. We suggest that the onset of a requirement for cortex-derived neurotrophic factors initiates a competitive mechanism regulating programmed cell death among dorsal thalamic neurons.

Bibliography

Lotto, R. B., Asavaritikrai, P., Vali, L., & Price, D. J. (2001). Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements. The Journal of Neuroscience, 21(11), 3904â3910.

Authors 4

R. Beau Lotto (first)
Pundit Asavaritikrai (additional)
Leila Vali (additional)
David J. Price (additional)

References 39 Referenced 36

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Dates

Type	When
Created	7 years, 4 months ago (April 4, 2018, 9:30 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 9:57 a.m.)
Indexed	1 year, 9 months ago (Nov. 13, 2023, 11:44 a.m.)
Issued	24 years, 3 months ago (June 1, 2001)
Published	24 years, 3 months ago (June 1, 2001)
Published Online	24 years, 3 months ago (June 1, 2001)
Published Print	24 years, 3 months ago (June 1, 2001)

Funders 0

None

BibTeX

@article{Lotto_2001, title={Target-Derived Neurotrophic Factors Regulate the Death of Developing Forebrain Neurons after a Change in their Trophic Requirements}, volume={21}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.21-11-03904.2001}, DOI={10.1523/jneurosci.21-11-03904.2001}, number={11}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Lotto, R. Beau and Asavaritikrai, Pundit and Vali, Leila and Price, David J.}, year={2001}, month=jun, pages={3904–3910} }

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