DOI: 10.1523/jneurosci.20-21-08012.2000. A Glia-Derived Signal Regulating Neuronal Differentiation

A Glia-Derived Signal Regulating Neuronal Differentiation

10.1523/jneurosci.20-21-08012.2000

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Astrocytes are present in large numbers in the nervous system, are associated with synapses, and propagate ionic signals. Astrocytes influence neuronal physiology by responding to and releasing neurotransmitters, but the mechanisms that establish the close interaction between these cells are not defined. Here we use hippocampal neurons in culture to demonstrate that vasoactive intestinal polypeptide (VIP) promotes neuronal differentiation through activity-dependent neurotrophic factor (ADNF), a protein secreted by VIP-stimulated astroglia. ADNF is produced by glial cells and acts directly on neurons to promote glutamate responses and morphological development. ADNF causes secretion of neurotrophin 3 (NT-3), and both proteins regulate NMDA receptor subunit 2A (NR2A) and NR2B. These data suggest that the VIP–ADNF–NT-3 neuronal–glial pathway regulates glutamate responses from an early stage in the synaptic development of excitatory neurons and may also contribute to the known effects of VIP on learning and behavior in the adult nervous system.

Bibliography

Blondel, O., Collin, C., McCarran, W. J., Zhu, S., Zamostiano, R., Gozes, I., Brenneman, D. E., & McKay, R. D. G. (2000). A Glia-Derived Signal Regulating Neuronal Differentiation. The Journal of Neuroscience, 20(21), 8012â8020.

Authors 8

Olivier Blondel (first)
Carlos Collin (additional)
William J. McCarran (additional)
Shiaoping Zhu (additional)
Rachel Zamostiano (additional)
Illana Gozes (additional)
Douglas E. Brenneman (additional)
Ronald D. G. McKay (additional)

References 49 Referenced 162

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Dates

Type	When
Created	7 years, 5 months ago (April 5, 2018, 11:10 a.m.)
Deposited	2 months ago (July 3, 2025, 9:04 a.m.)
Indexed	1 month, 4 weeks ago (July 7, 2025, 2:03 a.m.)
Issued	24 years, 10 months ago (Nov. 1, 2000)
Published	24 years, 10 months ago (Nov. 1, 2000)
Published Online	24 years, 10 months ago (Nov. 1, 2000)
Published Print	24 years, 10 months ago (Nov. 1, 2000)

Funders 0

None

BibTeX

@article{Blondel_2000, title={A Glia-Derived Signal Regulating Neuronal Differentiation}, volume={20}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.20-21-08012.2000}, DOI={10.1523/jneurosci.20-21-08012.2000}, number={21}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Blondel, Olivier and Collin, Carlos and McCarran, William J. and Zhu, Shiaoping and Zamostiano, Rachel and Gozes, Illana and Brenneman, Douglas E. and McKay, Ronald D. G.}, year={2000}, month=nov, pages={8012–8020} }

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