DOI: 10.1523/jneurosci.20-07-02470.2000. Mechanisms of Cannabinoid Inhibition of GABA<sub>A</sub>Synaptic Transmission in the Hippocampus

Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus

10.1523/jneurosci.20-07-02470.2000

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

The localization of cannabinoid (CB) receptors to GABAergic interneurons in the hippocampus indicates that CBs may modulate GABAergic function and thereby mediate some of the disruptive effects of marijuana on spatial memory and sensory processing. To investigate the possible mechanisms through which CB receptors may modulate GABAergic neurotransmission in the hippocampus, whole-cell voltage-clamp recordings were performed on CA1 pyramidal neurons in rat brain slices. Stimulus-evoked GABAAreceptor-mediated IPSCs were reduced in a concentration-dependent manner by the CB receptor agonist WIN 55,212–2 (EC50of 138 nm). This effect was blocked by the CB1 receptor antagonist SR141716A (1 μm) but not by the opioid antagonist naloxone. In contrast, evoked GABAB-mediated IPSCs were insensitive to the CB agonist. WIN 55,212–2 also reduced the frequency of spontaneous, action potential-dependent IPSCs (sIPSCs), without altering action potential-independent miniature IPSCs (mIPSCs), measured while sodium channels were blocked by tetrodotoxin (TTX). Blockade of voltage-dependent calcium channels (VDCCs) by cadmium also eliminated the effect of WIN 55,212–2 on sIPSCs. Depolarization of inhibitory terminals with elevated extracellular potassium caused a large increase in the frequency of mIPSCs that was inhibited by both cadmium and WIN 55,212–2. The presynaptic effect of WIN 55,212–2 was also investigated using the potassium channel blockers barium and 4-aminopyridine. Neither of these agents significantly altered the effect of WIN 55,212–2 on evoked IPSCs. Together, these data suggest that presynaptic CB1 receptors reduce GABAA- but not GABAB-mediated synaptic inhibition of CA1 pyramidal neurons by inhibiting VDCCs located on inhibitory nerve terminals.

Bibliography

Hoffman, A. F., & Lupica, C. R. (2000). Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus. The Journal of Neuroscience, 20(7), 2470â2479.

Authors 2

Alexander F. Hoffman (first)
Carl R. Lupica (additional)

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Dates

Type	When
Created	7 years, 4 months ago (April 4, 2018, 10:11 p.m.)
Deposited	1 month, 4 weeks ago (July 3, 2025, 8:47 a.m.)
Indexed	3 days, 5 hours ago (Aug. 29, 2025, 6:15 a.m.)
Issued	25 years, 5 months ago (April 1, 2000)
Published	25 years, 5 months ago (April 1, 2000)
Published Online	25 years, 5 months ago (April 1, 2000)
Published Print	25 years, 5 months ago (April 1, 2000)

Funders 0

None

BibTeX

@article{Hoffman_2000, title={Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus}, volume={20}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.20-07-02470.2000}, DOI={10.1523/jneurosci.20-07-02470.2000}, number={7}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Hoffman, Alexander F. and Lupica, Carl R.}, year={2000}, month=apr, pages={2470–2479} }

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  "abstract": "<jats:p>The localization of cannabinoid (CB) receptors to GABAergic interneurons in the hippocampus indicates that CBs may modulate GABAergic function and thereby mediate some of the disruptive effects of marijuana on spatial memory and sensory processing. To investigate the possible mechanisms through which CB receptors may modulate GABAergic neurotransmission in the hippocampus, whole-cell voltage-clamp recordings were performed on CA1 pyramidal neurons in rat brain slices. Stimulus-evoked GABA<jats:sub>A</jats:sub>receptor-mediated IPSCs were reduced in a concentration-dependent manner by the CB receptor agonist WIN 55,212\u20132 (EC<jats:sub>50</jats:sub>of 138 n<jats:sc>m</jats:sc>). This effect was blocked by the CB1 receptor antagonist SR141716A (1 \u03bc<jats:sc>m</jats:sc>) but not by the opioid antagonist naloxone. In contrast, evoked GABA<jats:sub>B</jats:sub>-mediated IPSCs were insensitive to the CB agonist. WIN 55,212\u20132 also reduced the frequency of spontaneous, action potential-dependent IPSCs (sIPSCs), without altering action potential-independent miniature IPSCs (mIPSCs), measured while sodium channels were blocked by tetrodotoxin (TTX). Blockade of voltage-dependent calcium channels (VDCCs) by cadmium also eliminated the effect of WIN 55,212\u20132 on sIPSCs. Depolarization of inhibitory terminals with elevated extracellular potassium caused a large increase in the frequency of mIPSCs that was inhibited by both cadmium and WIN 55,212\u20132. The presynaptic effect of WIN 55,212\u20132 was also investigated using the potassium channel blockers barium and 4-aminopyridine. Neither of these agents significantly altered the effect of WIN 55,212\u20132 on evoked IPSCs. Together, these data suggest that presynaptic CB1 receptors reduce GABA<jats:sub>A</jats:sub>- but not GABA<jats:sub>B</jats:sub>-mediated synaptic inhibition of CA1 pyramidal neurons by inhibiting VDCCs located on inhibitory nerve terminals.</jats:p>",
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