DOI: 10.1523/jneurosci.19-21-09364.1999. Neuralization of the<i>Xenopus</i>Embryo by Inhibition of p300/ CREB-Binding Protein Function

Neuralization of theXenopusEmbryo by Inhibition of p300/ CREB-Binding Protein Function

10.1523/jneurosci.19-21-09364.1999

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

p300/ CREB-binding protein (CBP) is a transcriptional coactivator for a plethora of transcription factors and plays critical roles in signal transduction pathways. We report that the inhibition of p300/CBP function in theXenopusembryo abolishes non-neural tissue formation and, strikingly, initiates neural induction and primary neurogenesis in the entire embryo. The observed neuralization is achieved in the absence of anterior or posterior gene expression, suggesting that neural fate activation and anterior patterning may represent distinct molecular events. We further demonstrate that the neuralizing and anteriorizing activities of chordin and noggin are separable properties of these neural inducers. This study reveals that all embryonic cells possess intrinsic neuralizing capability and that p300/CBP function is essential for embryonic germ layer formation and neural fate suppression during vertebrate embryogenesis.

Bibliography

Kato, Y., Shi, Y., & He, X. (1999). Neuralization of theXenopusEmbryo by Inhibition of p300/ CREB-Binding Protein Function. The Journal of Neuroscience, 19(21), 9364â9373.

Authors 3

Yoichi Kato (first)
Yang Shi (additional)
Xi He (additional)

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Dates

Type	When
Created	7 years, 4 months ago (April 3, 2018, 10:20 p.m.)
Deposited	1 month, 3 weeks ago (July 3, 2025, 7:40 a.m.)
Indexed	1 month, 3 weeks ago (July 3, 2025, 8:10 a.m.)
Issued	25 years, 9 months ago (Nov. 1, 1999)
Published	25 years, 9 months ago (Nov. 1, 1999)
Published Online	25 years, 9 months ago (Nov. 1, 1999)
Published Print	25 years, 9 months ago (Nov. 1, 1999)

Funders 0

None

BibTeX

@article{Kato_1999, title={Neuralization of theXenopusEmbryo by Inhibition of p300/ CREB-Binding Protein Function}, volume={19}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.19-21-09364.1999}, DOI={10.1523/jneurosci.19-21-09364.1999}, number={21}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Kato, Yoichi and Shi, Yang and He, Xi}, year={1999}, month=nov, pages={9364–9373} }

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