DOI: 10.1523/jneurosci.18-11-03991.1998. Binding of Serotonin to Receptors at Multiple Sites Is Required for Structural Plasticity Accompanying Long-Term Facilitation of<i>Aplysia</i>Sensorimotor Synapses

Binding of Serotonin to Receptors at Multiple Sites Is Required for Structural Plasticity Accompanying Long-Term Facilitation ofAplysiaSensorimotor Synapses

10.1523/jneurosci.18-11-03991.1998

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Long-term changes in the efficacy ofAplysiasensorimotor synapses accompany nonassociative and associative forms of behavioral plasticity. This synapse expresses long-term facilitation either with repeated applications of 5-hydroxytryptamine (5-HT) or with a single pairing of tetanus in the sensory neuron (SN) and bath application of 5-HT. We examined whether structural changes in the SN accompany all forms of long-term synaptic enhancement and the locations at which 5-HT must bind receptors to evoke long-term functional and/or structural changes. Pairing tetanus with one application of 5-HT evoked both functional and structural changes after 24 hr only when 5-HT application was temporally paired with the tetanus and activated receptors on both the SN cell body and terminal region. Repeated application of 5-HT to the terminal region alone failed to evoke any long-term change. Repeated applications of 5-HT to the SN cell body alone evoked a change in synaptic efficacy at 24 hr but failed to increase SN varicosities. Repeated applications of 5-HT to both the SN cell body and the terminal region evoked increases in both synaptic efficacy and the number of SN varicosities at 24 hr. The results indicate that different external stimuli can evoke equivalent forms of long-term synaptic facilitation with or without structural changes in the SNs. Changes in the number of SN varicosities can accompany different forms of long-term facilitation and require the activation of 5-HT receptors at multiple sites.

Bibliography

Sun, Z.-Y., & Schacher, S. (1998). Binding of Serotonin to Receptors at Multiple Sites Is Required for Structural Plasticity Accompanying Long-Term Facilitation ofAplysiaSensorimotor Synapses. The Journal of Neuroscience, 18(11), 3991â4000.

Authors 2

Zhong-Yi Sun (first)
Samuel Schacher (additional)

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Dates

Type	When
Created	7 years, 4 months ago (April 3, 2018, 9:35 a.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 7:54 a.m.)
Indexed	3 months ago (May 27, 2025, 1:46 a.m.)
Issued	27 years, 2 months ago (June 1, 1998)
Published	27 years, 2 months ago (June 1, 1998)
Published Online	27 years, 2 months ago (June 1, 1998)
Published Print	27 years, 2 months ago (June 1, 1998)

Funders 0

None

BibTeX

@article{Sun_1998, title={Binding of Serotonin to Receptors at Multiple Sites Is Required for Structural Plasticity Accompanying Long-Term Facilitation ofAplysiaSensorimotor Synapses}, volume={18}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.18-11-03991.1998}, DOI={10.1523/jneurosci.18-11-03991.1998}, number={11}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Sun, Zhong-Yi and Schacher, Samuel}, year={1998}, month=jun, pages={3991–4000} }

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