DOI: 10.1523/jneurosci.18-01-00026.1998. Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence

Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence

10.1523/jneurosci.18-01-00026.1998

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

This study characterizes the differential targeting of recently synthesized immediate early gene (IEG) mRNAs to neuronal cell bodies versus dendrites and tests the hypothesis that this targeting is based on signals in the encoded proteins. A single electroconvulsive seizure induces the expression of a number of IEG mRNAs in granule cells of the dentate gyrus. Most of these IEG mRNAs remain in the cell body, including two that are characterized in the present study (the mRNAs for NGFI-A and COX-2). In contrast, the mRNA forArcmoved rapidly into dendrites at an apparent rate of ∼300 μm/hr. Inhibiting protein synthesis with cycloheximide did not disrupt the differential mRNA sorting, demonstrating that the differential targeting of mRNAs is not dependent on translation.

Bibliography

Wallace, C. S., Lyford, G. L., Worley, P. F., & Steward, O. (1998). Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence. The Journal of Neuroscience, 18(1), 26â35.

Authors 4

Christopher S. Wallace (first)
Gregory L. Lyford (additional)
Paul F. Worley (additional)
Oswald Steward (additional)

References 38 Referenced 146

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Dates

Type	When
Created	7 years, 4 months ago (April 3, 2018, 11:06 a.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 7:37 a.m.)
Indexed	3 weeks, 5 days ago (July 27, 2025, 3:52 a.m.)
Issued	27 years, 7 months ago (Jan. 1, 1998)
Published	27 years, 7 months ago (Jan. 1, 1998)
Published Online	27 years, 7 months ago (Jan. 1, 1998)
Published Print	27 years, 7 months ago (Jan. 1, 1998)

Funders 0

None

BibTeX

@article{Wallace_1998, title={Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence}, volume={18}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.18-01-00026.1998}, DOI={10.1523/jneurosci.18-01-00026.1998}, number={1}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Wallace, Christopher S. and Lyford, Gregory L. and Worley, Paul F. and Steward, Oswald}, year={1998}, month=jan, pages={26–35} }

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