DOI: 10.1523/jneurosci.17-24-09492.1997. Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons

Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons

10.1523/jneurosci.17-24-09492.1997

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

The mechanisms underlying the subcellular localization of neurotrophins and their receptors are poorly understood. We show that in cultured hippocampal neurons, the mRNAs for BDNF and TrkB have a somatodendritic localization, and we quantify the extent of their dendritic mRNA localization. In the dendrites the labeling covers on average the proximal 30% of the total dendritic length. On high potassium depolarization, the labeling of BDNF and TrkB mRNA extends on average to 68% of the dendritic length. This increase does not depend on new RNA synthesis, is inhibited by the Na+channel blocker tetrodotoxin, and involves the activation of glutamate receptors. Extracellular Ca2+, partly flowing through L-type Ca2+channels, is absolutely required for this process to occur. At the protein level, a brief stimulation of hippocampal neurons with 10 mmKCl leads to a marked increase of BDNF and TrkB immunofluorescence density in the distal portion of dendrites, which also occurs, even if at lower levels, when transport is inhibited by nocodazole. The protein synthesis inhibitor cycloheximide abolishes this increase. The activity-dependent modulation of mRNA targeting and protein accumulation in the dendrites may provide a mechanism for achieving a selective local regulation of the activity of neurotrophins and their receptors, close to their sites of action.

Bibliography

Tongiorgi, E., Righi, M., & Cattaneo, A. (1997). Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons. The Journal of Neuroscience, 17(24), 9492â9505.

Authors 3

Enrico Tongiorgi (first)
Massimo Righi (additional)
Antonino Cattaneo (additional)

References 92 Referenced 280

10.1083/jcb.123.2.431
10.1016/0306-4522(91)90249-N
10.1016/0955-2235(90)90021-B
10.1006/mcne.1996.0009
10.1006/mcne.1996.0014
10.1016/S0959-4388(96)80017-1
10.1016/0306-4522(95)00321-9
10.1523/JNEUROSCI.10-06-01788.1990
10.1523/JNEUROSCI.16-24-07965.1996
10.1016/0165-3806(84)90167-6
10.1113/jphysiol.1997.sp021848
10.1073/pnas.89.20.9444
10.1097/00001756-199307000-00014
10.1016/0306-4522(94)00386-J
10.1111/j.1460-9568.1996.tb01287.x
10.1523/JNEUROSCI.15-06-04259.1995
10.1523/JNEUROSCI.17-07-02295.1997
10.1016/S0896-6273(00)80248-2
10.1523/JNEUROSCI.10-09-03056.1990
10.1242/jcs.1991.Supplement_15.11 / J Cell Sci / Intracellular organization of hippocampal neurons during the development of neuronal polarity. by Dotti (1991)
10.1016/0304-3940(93)90420-P
10.1016/0896-6273(92)90133-X
10.1111/j.1460-9568.1995.tb00703.x
10.1016/0169-328X(94)90077-9 / Mol Brain Res / An improved method detects differential NGF and BDNF gene expression in response to depolarization in cultured hippocampal neurons. by Elliott (1994)
10.1016/0166-2236(93)90041-J
10.1016/0896-6273(90)90090-3
10.1111/j.1460-9568.1992.tb00141.x
10.1523/JNEUROSCI.17-03-00951.1997
{'key': '2023041302372190000_17.24.9492.29', 'first-page': '195', 'article-title': 'Overexpression of Alzheimer’s PHF core tau fragments: implications for the tau truncation hypothesis.', 'volume': '2', 'author': 'Fasulo', 'year': '1996', 'journal-title': 'Alzheimer Res'} / Alzheimer Res / Overexpression of Alzheimer’s PHF core tau fragments: implications for the tau truncation hypothesis. by Fasulo (1996)
10.1523/JNEUROSCI.13-03-01010.1993
{'key': '2023041302372190000_17.24.9492.31', 'first-page': '11', 'article-title': 'Widespread expression of inositol 1,4,5-triphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system.', 'volume': '1', 'author': 'Furuichi', 'year': '1993', 'journal-title': 'Receptors Channels'} / Receptors Channels / Widespread expression of inositol 1,4,5-triphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system. by Furuichi (1993)
10.1038/336674a0
10.1523/JNEUROSCI.17-06-02006.1997
10.1006/mcne.1996.0017
10.1006/mcne.1995.1030
10.1006/mcne.1996.0594
10.1016/0896-6273(92)90184-F
10.1016/0896-6273(91)90234-Q
10.1016/0092-8674(95)90324-0
10.1126/science.7886457
10.1126/science.273.5280.1402
10.1083/jcb.93.3.576
10.1016/0006-8993(77)90882-4
10.1016/0896-6273(90)90341-C
10.1523/JNEUROSCI.14-03-01130.1994
10.1097/00001756-199412000-00007
10.1111/j.1460-9568.1994.tb00312.x
10.1523/JNEUROSCI.16-24-07812.1996
10.1073/pnas.90.14.6711
10.1073/pnas.92.19.8856
10.1073/pnas.93.22.12547
10.1523/JNEUROSCI.16-23-07428.1996
10.1038/341149a0
10.1097/00001756-199412300-00007
10.1073/pnas.92.17.8074
10.1002/neu.480251105 / J Neurobiol / Activity dependent and hormonal regulation of neurotrophin mRNA levels in the brain: implications for neuronal plasticity. by Lindholm (1994)
10.1016/0166-2236(94)90139-2
10.1073/pnas.92.12.5734
10.1038/363350a0
10.1016/0896-6273(95)90299-6 / Neuron / Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. by Lyford (1995)
10.1016/0888-7543(91)90436-I
10.1038/357134a0
10.1126/science.7539937
10.1523/JNEUROSCI.16-23-07428.1996
10.1016/0896-6273(93)90307-D
10.1128/MCB.11.1.143
10.1073/pnas.90.14.6439
10.1093/nar/11.6.1759
10.1016/0896-6273(92)90067-N
10.1016/S0896-6273(00)80140-3
10.1111/j.1460-9568.1997.tb01629.x
10.1523/JNEUROSCI.17-05-01691.1997
10.1016/0165-3806(93)90165-7 / Dev Brain Res / Expression of the members of the trk family in the developing postnatal rat brain. by Ringstedt (1993)
10.1007/BF00230416 / Exp Brain Res / Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus. by Schmidt-Kastner (1996)
10.1016/0306-4522(96)00093-0
10.1016/S0896-6273(00)81234-9
10.1523/JNEUROSCI.17-01-00190.1997 / J Neurosci / Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines in the immature and mature rat. by Spacek (1997)
10.1073/pnas.91.23.10766
10.1016/S0896-6273(01)80041-6
10.1523/JNEUROSCI.02-03-00284.1982
10.1126/science.270.5236.593
10.1523/JNEUROSCI.16-22-07171.1996
10.1016/0896-6273(93)90335-O
{'key': '2023041302372190000_17.24.9492.84', 'first-page': '125.17', 'article-title': 'NGF, BDNF and TrkB but not TrkA mRNAs are localized to the dendrites of rat neurons.', 'volume': '22', 'author': 'Tongiorgi', 'year': '1996', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / NGF, BDNF and TrkB but not TrkA mRNAs are localized to the dendrites of rat neurons. by Tongiorgi (1996)
{'key': '2023041302372190000_17.24.9492.85', 'first-page': '175', 'article-title': 'Subcellular localization of neurotrophins and neurotrophin receptors: implications for synaptic plasticity. Proceedings of the International Symposium of Neuroscience, Belém, Brasil.', 'volume': '56', 'author': 'Tongiorgi', 'year': '1996', 'journal-title': 'Rev Brasil Biol'} / Rev Brasil Biol / Subcellular localization of neurotrophins and neurotrophin receptors: implications for synaptic plasticity. Proceedings of the International Symposium of Neuroscience, Belém, Brasil. by Tongiorgi (1996)
10.1523/JNEUROSCI.12-03-00762.1992
10.1523/JNEUROSCI.16-19-05967.1996
10.1016/0006-8993(95)01191-9
10.1016/0014-4886(90)90068-4
10.1523/JNEUROSCI.14-03-01688.1994
10.1002/j.1460-2075.1990.tb07564.x / EMBO J / Activity-dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. by Zafra (1990)
10.1523/JNEUROSCI.12-12-04793.1992

Dates

Type	When
Created	7 years, 4 months ago (April 3, 2018, 9:35 a.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 7:43 a.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 1:26 a.m.)
Issued	27 years, 8 months ago (Dec. 15, 1997)
Published	27 years, 8 months ago (Dec. 15, 1997)
Published Online	27 years, 8 months ago (Dec. 15, 1997)
Published Print	27 years, 8 months ago (Dec. 15, 1997)

Funders 0

None

BibTeX

@article{Tongiorgi_1997, title={Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons}, volume={17}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.17-24-09492.1997}, DOI={10.1523/jneurosci.17-24-09492.1997}, number={24}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Tongiorgi, Enrico and Righi, Massimo and Cattaneo, Antonino}, year={1997}, month=dec, pages={9492–9505} }

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