D1Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+Conductance
10.1523/jneurosci.17-09-03334.1997
Crossref journal-article
Society for Neuroscience
The Journal of Neuroscience (393)
Abstract

Mostin vitrostudies of D1dopaminergic modulation of excitability in neostriatal medium spiny neurons have revealed inhibitory effects. Yet studies made in more intact preparations have shown that D1receptors can enhance or inhibit the responses to excitatory stimuli. One explanation for these differences is that the effects of D1receptors on excitability are dependent on changes in the membrane potential occurring in response to cortical inputs that are seen only in intact preparations. To test this hypothesis, we obtained voltage recordings from medium spiny neurons in slices and examined the impact of D1receptor stimulation at depolarized and hyperpolarized membrane potentials. As previously reported, evoked discharge was inhibited by D1agonists when holding at negative membrane potentials (approximately −80 mV). However, at more depolarized potentials (approximately −55 mV), D1agonists enhanced evoked activity. At these potentials, D1agonists or cAMP analogs prolonged or induced slow subthreshold depolarizations and increased the duration of barium- or TEA-induced Ca2+-dependent action potentials. Both effects were blocked by L-type Ca2+channel antagonists (nicardipine, calciseptine) and were occluded by the L-type channel agonist BayK 8644—arguing that the D1receptor-mediated effects on evoked activity at depolarized membrane potential were mediated by enhancement of L-type Ca2+currents. These results reconcile previousin vitroandin vivostudies by showing that D1dopamine receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization.

Bibliography

Hernández-López, S., Bargas, J., Surmeier, D. J., Reyes, A., & Galarraga, E. (1997). D1Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+Conductance. The Journal of Neuroscience, 17(9), 3334–3342.

Authors 5
  1. Salvador Hernández-López (first)
  2. José Bargas (additional)
  3. D. James Surmeier (additional)
  4. Arturo Reyes (additional)
  5. Elvira Galarraga (additional)
References 69 Referenced 392
  1. 10.1016/0006-8993(87)90094-1
  2. Alexander GE (1995) Basal ganglia. in The handbook of brain theory and neural networks, ed Arbib MA (MIT, Cambridge, MA), pp 139–144.
  3. 10.1093/cercor/3.1.26
  4. 10.1016/0006-8993(88)91614-9
  5. 10.1523/JNEUROSCI.16-18-05567.1996 / J Neurosci / Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons. by Avery (1996)
  6. Bargas J Galarraga E (1995) Ion channels: keys to neuronal specialization. in The handbook of brain theory and neural networks, ed Arbib MA (MIT, Cambridge, MA), pp 496–501.
  7. 10.1007/BF00250260 / Exp Brain Res / Electrotonic properties of neostriatal neurons are modulated by extracellular potassium. by Bargas (1988)
  8. 10.1007/BF00248538 / Exp Brain Res / An early outward conductance modulates the firing latency and frequency of neostriatal neurons of the rat brain. by Bargas (1989)
  9. 10.1016/0006-8993(91)90700-6
  10. 10.1523/JNEUROSCI.14-11-06667.1994
  11. 10.1523/JNEUROSCI.15-12-07821.1995
  12. 10.1152/jn.1992.68.3.767 / J Neurophysiol / Dopamine and glutamate agonists stimulate neuron-specific expression of c-fos-like protein in the striatum. by Berretta (1992)
  13. 10.1016/0306-4522(87)90239-9
  14. 10.1111/j.1460-9568.1992.tb00885.x
  15. 10.1073/pnas.90.20.9576
  16. 10.1152/jn.1995.74.3.1343 / J Neurophysiol / Persistent Na+ conductance in medium-sized neostriatal neurons: characterization using infrared videomicroscopy and whole-cell patch-clamp recordings. by Cepeda (1995)
  17. 10.1016/0306-4522(87)90054-6
  18. 10.1016/0006-8993(86)90976-5
  19. 10.1016/0922-4106(91)90001-X
  20. 10.1111/j.1471-4159.1992.tb11358.x / J Neurochem / D1 dopamine receptor activation of multiple transcription factor genes in rat striatum. by Cole (1992)
  21. 10.1523/JNEUROSCI.15-03-01704.1995
  22. 10.1152/jn.1994.72.5.2246 / J Neurophysiol / Patterns of excitatory and inhibitory synaptic transmission in the rat neostriatum as revealed by 4-AP. by Flores-Hernández (1994)
  23. 10.1002/(SICI)1098-2396(199702)25:2<185::AID-SYN9>3.0.CO;2-8
  24. 10.1007/BF00248539 / Exp Brain Res / The role of calcium in the repetitive firing of neostriatal neurons. by Galarraga (1989)
  25. 10.1007/BF00227194 / Exp Brain Res / Subthreshold rectification in neostriatal spiny projection neurons. by Galarraga (1994)
  26. 10.1146/annurev.ne.15.030192.001441
  27. 10.1016/0006-8993(74)90686-6
  28. 10.1097/00001756-199601310-00019 / NeuroReport / Dopamine modulates the afterhyperpolarization in neostriatal neurons. by Hernández-López (1996)
  29. {'key': '2023041302352803000_17.9.3334.29', 'first-page': '411', 'article-title': 'Ion mechanisms for dopaminergic excitation in neostriatal neurons.', 'volume': '22', 'author': 'Hernández-López', 'year': '1996', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Ion mechanisms for dopaminergic excitation in neostriatal neurons. by Hernández-López (1996)
  30. 10.1016/0006-8993(80)90896-3
  31. 10.1523/JNEUROSCI.15-07-05222.1995 / J Neurosci / Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents. by Hersch (1995)
  32. 10.1016/0165-0270(88)90114-8
  33. 10.1113/jphysiol.1993.sp019769
  34. 10.1113/jphysiol.1988.sp017059
  35. 10.1523/JNEUROSCI.08-11-04340.1988
  36. 10.1523/JNEUROSCI.10-07-02318.1990
  37. 10.1038/357244a0
  38. 10.1152/jn.1989.62.5.1052 / J Neurophysiol / Intracellular recording of identified neostriatal patch and matrix spiny cells in a slice preparation preserving cortical inputs. by Kawaguchi (1989)
  39. 10.1523/JNEUROSCI.13-12-05301.1993
  40. {'key': '2023041302352803000_17.9.3334.40', 'first-page': '54', 'article-title': 'Active membrane properties of rat neostriatal neurons in an in vitro slice preparation.', 'volume': '60', 'author': 'Kita', 'year': '1985', 'journal-title': 'Exp Brain Res'} / Exp Brain Res / Active membrane properties of rat neostriatal neurons in an in vitro slice preparation. by Kita (1985)
  41. 10.1007/BF00235003 / Exp Brain Res / Excitatory nature of dopamine in the nigro-caudate pathway. by Kitai (1976)
  42. 10.1152/jn.1996.75.1.142 / J Neurophysiol / Dopaminergic modulation of glutamate-induced excitations of neurons in the neostriatum and nucleus accumbens of awake, unrestrained rats. by Kiyatkin (1996)
  43. 10.1152/jn.1996.75.1.154 / J Neurophysiol / Propagation of action potentials in the dendrites of neurons from spinal cord slices in cultures. by Larkum (1996)
  44. 10.1126/science.3059497
  45. 10.1113/jphysiol.1984.sp015378
  46. 10.1126/science.275.5297.209
  47. 10.1016/0006-8993(85)90954-0
  48. 10.1126/science.2456612
  49. 10.1152/physrev.1990.70.2.513 / Physiol Rev / Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. by Nicoll (1990)
  50. 10.1523/JNEUROSCI.15-06-04449.1995
  51. 10.1152/jn.1996.76.2.1180 / J Neurophysiol / Isolation and characterization of a persistent potassium current in neostriatal neurons. by Nisenbaum (1996)
  52. 10.1016/0006-8993(78)90095-1
  53. 10.1007/BF00228552 / Exp Brain Res / Inhibitory action of dopamine involves a subthreshold Cs+-sensitive conductance in neostriatal neurons. by Pacheco-Cano (1996)
  54. 10.1152/jn.1992.68.1.287 / J Neurophysiol / Charybdotoxin and apamin sensitivity of the calcium-dependent repolarization and the afterhyperpolarization in neostriatal neurons. by Pineda (1992)
  55. 10.1523/JNEUROSCI.13-11-04609.1993
  56. 10.1007/BF00247499 / Exp Brain Res / An after hyperpolarization recorded in striatal cells “in vitro”: effect of dopamine administration. by Rutherford (1988)
  57. 10.1113/jphysiol.1995.sp020570
  58. 10.1016/0165-6147(92)90025-2
  59. Sibley DR (1995) Molecular biology of dopamine receptors. in Molecular and cellular mechanisms of neostriatal function, eds Ariano MA Surmeier DJ (Landes, Austin, TX), pp 255–272.
  60. 10.1523/JNEUROSCI.13-12-05066.1993
  61. 10.1016/0304-3940(91)90188-Y
  62. 10.1073/pnas.89.21.10178
  63. 10.1016/0896-6273(95)90294-5
  64. 10.1523/JNEUROSCI.16-20-06579.1996
  65. 10.1016/0006-8993(86)90760-2
  66. 10.1016/S0079-6123(08)61352-7
  67. 10.1523/JNEUROSCI.16-07-02397.1996
  68. 10.1016/S0079-6123(08)63820-0 / Prog Brain Res / The cerebellar norepinephrine system: inhibition, modulation, and gating. by Woodward (1991)
  69. 10.1523/JNEUROSCI.16-05-01922.1996
Dates
Type When
Created 7 years, 5 months ago (April 2, 2018, 7:20 p.m.)
Deposited 2 years, 4 months ago (April 13, 2023, 7:16 a.m.)
Indexed 2 weeks, 5 days ago (Aug. 19, 2025, 6:06 a.m.)
Issued 28 years, 4 months ago (May 1, 1997)
Published 28 years, 4 months ago (May 1, 1997)
Published Online 28 years, 4 months ago (May 1, 1997)
Published Print 28 years, 4 months ago (May 1, 1997)
Funders 0

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@article{Hern_ndez_L_pez_1997, title={D1Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+Conductance}, volume={17}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.17-09-03334.1997}, DOI={10.1523/jneurosci.17-09-03334.1997}, number={9}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Hernández-López, Salvador and Bargas, José and Surmeier, D. James and Reyes, Arturo and Galarraga, Elvira}, year={1997}, month=may, pages={3334–3342} }