DOI: 10.1523/jneurosci.16-13-04207.1996. Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1

Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1

10.1523/jneurosci.16-13-04207.1996

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

The linear transform model of functional magnetic resonance imaging (fMRI) hypothesizes that fMRI responses are proportional to local average neural activity averaged over a period of time. This work reports results from three empirical tests that support this hypothesis. First, fMRI responses in human primary visual cortex (V1) depend separably on stimulus timing and stimulus contrast. Second, responses to long-duration stimuli can be predicted from responses to shorter duration stimuli. Third, the noise in the fMRI data is independent of stimulus contrast and temporal period. Although these tests can not prove the correctness of the linear transform model, they might have been used to reject the model. Because the linear transform model is consistent with our data, we proceeded to estimate the temporal fMRI impulse–response function and the underlying (presumably neural) contrast–response function of human V1.

Bibliography

Boynton, G. M., Engel, S. A., Glover, G. H., & Heeger, D. J. (1996). Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1. The Journal of Neuroscience, 16(13), 4207â4221.

Authors 4

Geoffrey M. Boynton (first)
Stephen A. Engel (additional)
Gary H. Glover (additional)
David J. Heeger (additional)

References 36 Referenced 1,858

10.1152/jn.1982.48.1.217
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Atkinson KE (1988) Plots, transformations and regression. (Oxford UP, New York).
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10.1097/00004424-199201000-00012
10.1017/S0952523800006258
10.1126/science.8191289
10.1113/jphysiol.1981.sp013875
10.1016/0042-6989(83)90113-X
10.1016/0006-8993(86)90036-3
10.1016/0165-0270(94)90191-0
Engel SA, Wandell BA (1996) The spatial properties of the fmri signal in human visual cortex. Cereb Cortex, in press.
10.1016/0042-6989(93)90079-C
10.1002/hbm.460010207
10.1002/mrm.1910350312
10.1073/pnas.88.24.11559
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10.1152/jn.1993.70.5.1885 / J Neurophysiol / Modeling simple cell direction selectivity with normalized, half-squared, linear operators. by Heeger (1993)
Lange N, Zeger SL (1996) Non-linear Fourier analysis of magnetic resonance functional neuroimage time series. J R Stat Soc [B], in press.
10.1364/JOSA.70.001458
10.1007/BF00332911
10.1016/0042-6989(73)90201-0
10.1126/science.272.5261.551
10.1002/mrm.1910330323 / Magn Reson Med / BOLD-based functional MRI at 4 tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals. by Menon (1995)
10.1002/mrm.1910280204
{'key': '2023041302325939000_16.13.4207.26', 'first-page': '161', 'article-title': 'Functional MR imaging.', 'volume': '5', 'author': 'Moseley', 'year': '1995', 'journal-title': 'Funct Neuroimaging'} / Funct Neuroimaging / Functional MR imaging. by Moseley (1995)
10.1002/mrm.1910160103
10.1038/298266a0
10.1152/jn.1985.54.3.651 / J Neurophysiol / Contrast gain control in the cat’s visual system. by Ohzawa (1985)
{'key': '2023041302325939000_16.13.4207.30', 'first-page': '22', 'article-title': 'Contrast adaptation and masking in macaque V1.', 'volume': '21', 'author': 'Poirson', 'year': '1995', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr / Contrast adaptation and masking in macaque V1. by Poirson (1995)
10.1017/S0952523800003527
Savoy RL, Bandettini PA, O’Craven KM, Kwong KK, Davis TL, Baker JR, Weisskopf RM, Rosen BR (1995) Pushing the temporal resolution of fmri: studies of very brief visual stimuli, onset variability and asynchrony, and stimulus-correlated changes in noise. Program of SMR presented at 3d Annual Meeting, Nice, France.
10.1016/0042-6989(90)90123-3
10.1007/BF00237523 / Exp Brain Res / Nonlinearities of temporal summation in neurones in area 17 of the cat. by Tolhurst (1980)
10.1523/JNEUROSCI.15-04-03215.1995
10.1523/JNEUROSCI.11-08-02622.1991 / J Neurosci / Specialized vascularization of the primate visual cortex. by Zheng (1991)

Dates

Type	When
Created	7 years, 4 months ago (April 2, 2018, 2:35 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 6:47 a.m.)
Indexed	1 week, 4 days ago (Aug. 20, 2025, 9:19 a.m.)
Issued	29 years, 1 month ago (July 1, 1996)
Published	29 years, 1 month ago (July 1, 1996)
Published Online	29 years, 1 month ago (July 1, 1996)
Published Print	29 years, 1 month ago (July 1, 1996)

Funders 0

None

BibTeX

@article{Boynton_1996, title={Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1}, volume={16}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.16-13-04207.1996}, DOI={10.1523/jneurosci.16-13-04207.1996}, number={13}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Boynton, Geoffrey M. and Engel, Stephen A. and Glover, Gary H. and Heeger, David J.}, year={1996}, month=jul, pages={4207–4221} }

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