DOI: 10.1523/jneurosci.13-04-01751.1993. Odorants differentially enhance phosphoinositide turnover and adenylyl cyclase in olfactory receptor neuronal cultures

Odorants differentially enhance phosphoinositide turnover and adenylyl cyclase in olfactory receptor neuronal cultures

10.1523/jneurosci.13-04-01751.1993

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Both the cAMP and the phosphoinositide (PI) second messenger systems have been implicated in olfactory signal transduction. We have developed a primary culture system of mammalian olfactory receptor neurons (ORNs; Ronnett et al., 1991a) to permit analysis of odorant- induced second messenger system activation in the intact ORN. The ability of a series of odorants to stimulate PI turnover and adenylyl cyclase was examined. All odorants stimulated both second messenger systems, although with differential potencies. Stimulation of PI turnover desensitized upon reexposure of cultures to odorant. The enhancement by single odorants of both adenylyl cyclase and PI turnover, but to varying degrees, affords a mechanism for increased specificity in olfactory signal transduction.

Bibliography

Ronnett, G., Cho, H., Hester, L., Wood, S., & Snyder, S. (1993). Odorants differentially enhance phosphoinositide turnover and adenylyl cyclase in olfactory receptor neuronal cultures. The Journal of Neuroscience, 13(4), 1751â1758.

Authors 5

GV Ronnett (first)
H Cho (additional)
LD Hester (additional)
SF Wood (additional)
SH Snyder (additional)

References 0 Referenced 78

None

Dates

Type	When
Created	7 years, 5 months ago (March 30, 2018, 9:10 p.m.)
Deposited	2 years, 4 months ago (April 18, 2023, 9:55 a.m.)
Indexed	4 weeks, 2 days ago (Aug. 3, 2025, 12:09 a.m.)
Issued	32 years, 5 months ago (April 1, 1993)
Published	32 years, 5 months ago (April 1, 1993)
Published Online	32 years, 5 months ago (April 1, 1993)
Published Print	32 years, 5 months ago (April 1, 1993)

Funders 0

None

BibTeX

@article{Ronnett_1993, title={Odorants differentially enhance phosphoinositide turnover and adenylyl cyclase in olfactory receptor neuronal cultures}, volume={13}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.13-04-01751.1993}, DOI={10.1523/jneurosci.13-04-01751.1993}, number={4}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Ronnett, GV and Cho, H and Hester, LD and Wood, SF and Snyder, SH}, year={1993}, month=apr, pages={1751–1758} }

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