DOI: 10.1523/jneurosci.1299-04.2004. The Invulnerability of Adult Neurons: A Critical Role for p73

The Invulnerability of Adult Neurons: A Critical Role for p73

10.1523/jneurosci.1299-04.2004

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Here, we investigated the intracellular mechanisms that underlie the relative invulnerability of adult versus developing dorsal root ganglion (DRG) sensory neurons. In culture, adult neurons were resistant to stimuli that caused apoptosis of their neonatal counterparts. In both adult and neonatal neurons, death stimuli induced the apoptotic c-Jun N-terminal protein kinase (JNK) pathway, but JNK activation only caused death of neonatal neurons, indicating that adult neurons have a downstream block to apoptosis. Expression of the dominant-inhibitory p53 family member, ΔNp73, rescued JNK-induced apoptosis of neonatal neurons, suggesting that it might participate in the downstream apoptotic block in adult neurons. To test this possibility, we examined adult DRG neurons cultured from p73+/- mice. Adult p73+/- DRG neurons were more vulnerable to apoptotic stimuli than their p73+/+ counterparts, and invulnerability could be restored to the p73+/- neurons by increased expression of ΔNp73. Moreover, although DRG neuron development was normal in p73+/- animalsin vivo, axotomy caused death of adult p73+/- but not p73+/+ DRG neurons. Thus, one way adult neurons become invulnerable is to enhance endogenous survival pathways, and one critical component of these survival pathways is p73.

Bibliography

Walsh, G. S., Orike, N., Kaplan, D. R., & Miller, F. D. (2004). The Invulnerability of Adult Neurons: A Critical Role for p73. The Journal of Neuroscience, 24(43), 9638â9647.

Authors 4

Gregory S. Walsh (first)
Nina Orike (additional)
David R. Kaplan (additional)
Freda D. Miller (additional)

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Dates

Type	When
Created	20 years, 10 months ago (Oct. 27, 2004, 9:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 2:37 p.m.)
Indexed	1 year, 2 months ago (May 31, 2024, 4:25 a.m.)
Issued	20 years, 10 months ago (Oct. 27, 2004)
Published	20 years, 10 months ago (Oct. 27, 2004)
Published Online	20 years, 10 months ago (Oct. 27, 2004)
Published Print	20 years, 10 months ago (Oct. 27, 2004)

Funders 0

None

BibTeX

@article{Walsh_2004, title={The Invulnerability of Adult Neurons: A Critical Role for p73}, volume={24}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.1299-04.2004}, DOI={10.1523/jneurosci.1299-04.2004}, number={43}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Walsh, Gregory S. and Orike, Nina and Kaplan, David R. and Miller, Freda D.}, year={2004}, month=oct, pages={9638–9647} }

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