DOI: 10.1523/jneurosci.1181-04.2004. High-Frequency Stimulation Induces Ethanol-Sensitive Long-Term Potentiation at Glutamatergic Synapses in the Dorsolateral Bed Nucleus of the Stria Terminalis

High-Frequency Stimulation Induces Ethanol-Sensitive Long-Term Potentiation at Glutamatergic Synapses in the Dorsolateral Bed Nucleus of the Stria Terminalis

10.1523/jneurosci.1181-04.2004

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Anatomical and functional data support a critical role for the bed nucleus of the stria terminalis (BNST) in the interaction between stress and alcohol/substance abuse. We report here that neurons of the dorsal anterolateral BNST respond to glutamatergic synaptic input in a synchronized way, such that an interpretable extracellular synaptic field potential can be readily measured. High-frequency stimulation of these glutamatergic inputs evoked NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). We found that an early portion of this LTP is reduced by acute exposure to ethanol in a GABAAreceptor-dependent manner. This effect of ethanol is accompanied by a significant and reversible dose-dependent attenuation of isolated NMDAR signaling and is mimicked by incomplete NMDAR blockade.

Bibliography

Weitlauf, C., Egli, R. E., Grueter, B. A., & Winder, D. G. (2004). High-Frequency Stimulation Induces Ethanol-Sensitive Long-Term Potentiation at Glutamatergic Synapses in the Dorsolateral Bed Nucleus of the Stria Terminalis. The Journal of Neuroscience, 24(25), 5741â5747.

Authors 4

Carl Weitlauf (first)
Regula E. Egli (additional)
Brad A. Grueter (additional)
Danny G. Winder (additional)

References 33 Referenced 64

10.1097/01.ALC.0000089956.43262.17 / Alcohol Clin Exp Res (2003)
10.1111/j.1749-6632.1999.tb09284.x
10.1523/JNEUROSCI.22-12-05239.2002 / J Neurosci (2002)
10.1016/0006-8993(90)90359-J
10.1523/JNEUROSCI.20-20-j0002.2000 / J Neurosci (2000)
10.1016/0006-8993(95)00210-H
10.1002/cne.10949
10.1152/jn.00228.2003
10.1523/JNEUROSCI.19-20-j0006.1999 / J Neurosci (1999)
10.1523/JNEUROSCI.23-01-00023.2003 / J Neurosci (2003)
Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. San Diego: Academic.
10.1523/JNEUROSCI.21-16-j0003.2001 / J Neurosci (2001)
10.1523/JNEUROSCI.22-12-05173.2002 / J Neurosci (2002)
10.1038/35094560
10.1007/s002130000411
10.1126/science.2467382
10.1523/JNEUROSCI.23-11-04406.2003 / J Neurosci (2003)
10.1016/S0091-3057(01)00748-1
10.1016/S0741-8329(99)00021-X
10.1111/j.1749-6632.1999.tb09304.x
10.1073/pnas.0437926100
10.1523/JNEUROSCI.5077-03.2004
10.1016/S0896-6273(03)00021-7
10.1023/A:1026021307833
{'key': '2023041303071479000_24.25.5741.25', 'first-page': '264', 'volume': '41', 'year': '1981', 'journal-title': 'Exp Brain Res'} / Exp Brain Res (1981)
10.1016/0006-8993(80)90058-X
10.1016/S0169-328X(01)00161-9 / Brain Res Mol Brain Res (2001)
10.1016/0306-3623(86)90144-8
10.1523/JNEUROSCI.17-23-09375.1997 / J Neurosci (1997)
10.1016/S0014-2999(03)01282-2
10.1073/pnas.2435171100
10.1073/pnas.93.10.5049
10.2174/1566524023361961

Dates

Type	When
Created	21 years, 2 months ago (June 23, 2004, 2:38 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 12:11 p.m.)
Indexed	4 weeks ago (Aug. 5, 2025, 8:50 a.m.)
Issued	21 years, 2 months ago (June 23, 2004)
Published	21 years, 2 months ago (June 23, 2004)
Published Online	21 years, 2 months ago (June 23, 2004)
Published Print	21 years, 2 months ago (June 23, 2004)

Funders 0

None

BibTeX

@article{Weitlauf_2004, title={High-Frequency Stimulation Induces Ethanol-Sensitive Long-Term Potentiation at Glutamatergic Synapses in the Dorsolateral Bed Nucleus of the Stria Terminalis}, volume={24}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.1181-04.2004}, DOI={10.1523/jneurosci.1181-04.2004}, number={25}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Weitlauf, Carl and Egli, Regula E. and Grueter, Brad A. and Winder, Danny G.}, year={2004}, month=jun, pages={5741–5747} }

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