DOI: 10.1523/jneurosci.10-09-03087.1990. Nerve growth factor infusion into the denervated adult rat hippocampal formation promotes its cholinergic reinnervation

Nerve growth factor infusion into the denervated adult rat hippocampal formation promotes its cholinergic reinnervation

10.1523/jneurosci.10-09-03087.1990

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

The well-documented but little-understood failure of lengthy axonal regeneration after injury of the adult mammalian CNS may be caused by an insufficient availability of local growth-promoting factors. If so, identifying and supplying the missing factors may result in better central axonal regeneration. This hypothesis was tested in an adult rat CNS model in which peripheral nerve grafts were placed into a lesion cavity between the septum and hippocampal formation. Continuous infusion of nerve growth factor (NGF) into the dorsal hippocampal tissue dramatically enhanced and accelerated the regrowth and penetration of cholinergic axons into the hippocampal formation. Thus, NGF can overcome the apparent resistance of the hippocampal CNS tissue to cholinergic reinnervation.

Bibliography

Hagg, T., Vahlsing, H., Manthorpe, M., & Varon, S. (1990). Nerve growth factor infusion into the denervated adult rat hippocampal formation promotes its cholinergic reinnervation. The Journal of Neuroscience, 10(9), 3087â3092.

Authors 4

T Hagg (first)
HL Vahlsing (additional)
M Manthorpe (additional)
S Varon (additional)

References 0 Referenced 97

None

Dates

Type	When
Created	7 years, 5 months ago (March 30, 2018, 10:45 a.m.)
Deposited	2 years, 4 months ago (April 18, 2023, 9:50 a.m.)
Indexed	1 year, 2 months ago (July 3, 2024, 12:31 a.m.)
Issued	35 years ago (Sept. 1, 1990)
Published	35 years ago (Sept. 1, 1990)
Published Online	35 years ago (Sept. 1, 1990)
Published Print	35 years ago (Sept. 1, 1990)

Funders 0

None

BibTeX

@article{Hagg_1990, title={Nerve growth factor infusion into the denervated adult rat hippocampal formation promotes its cholinergic reinnervation}, volume={10}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.10-09-03087.1990}, DOI={10.1523/jneurosci.10-09-03087.1990}, number={9}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Hagg, T and Vahlsing, HL and Manthorpe, M and Varon, S}, year={1990}, month=sep, pages={3087–3092} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        7,
        3
      ]
    ],
    "date-time": "2024-07-03T04:31:16Z",
    "timestamp": 1719981076052
  },
  "reference-count": 0,
  "publisher": "Society for Neuroscience",
  "issue": "9",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1991,
            3,
            1
          ]
        ],
        "date-time": "1991-03-01T00:00:00Z",
        "timestamp": 667785600000
      },
      "content-version": "vor",
      "delay-in-days": 181,
      "URL": "https://creativecommons.org/licenses/by-nc-sa/4.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1990,
        9,
        1
      ]
    ]
  },
  "abstract": "<jats:p>The well-documented but little-understood failure of lengthy axonal regeneration after injury of the adult mammalian CNS may be caused by an insufficient availability of local growth-promoting factors. If so, identifying and supplying the missing factors may result in better central axonal regeneration. This hypothesis was tested in an adult rat CNS model in which peripheral nerve grafts were placed into a lesion cavity between the septum and hippocampal formation. Continuous infusion of nerve growth factor (NGF) into the dorsal hippocampal tissue dramatically enhanced and accelerated the regrowth and penetration of cholinergic axons into the hippocampal formation. Thus, NGF can overcome the apparent resistance of the hippocampal CNS tissue to cholinergic reinnervation.</jats:p>",
  "DOI": "10.1523/jneurosci.10-09-03087.1990",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2018,
        3,
        30
      ]
    ],
    "date-time": "2018-03-30T14:45:20Z",
    "timestamp": 1522421120000
  },
  "page": "3087-3092",
  "source": "Crossref",
  "is-referenced-by-count": 97,
  "title": "Nerve growth factor infusion into the denervated adult rat hippocampal formation promotes its cholinergic reinnervation",
  "prefix": "10.1523",
  "volume": "10",
  "author": [
    {
      "given": "T",
      "family": "Hagg",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "HL",
      "family": "Vahlsing",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M",
      "family": "Manthorpe",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "S",
      "family": "Varon",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "393",
  "published-online": {
    "date-parts": [
      [
        1990,
        9,
        1
      ]
    ]
  },
  "container-title": "The Journal of Neuroscience",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.10-09-03087.1990",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        4,
        18
      ]
    ],
    "date-time": "2023-04-18T13:50:38Z",
    "timestamp": 1681825838000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.10-09-03087.1990"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1990,
        9,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "9",
    "published-online": {
      "date-parts": [
        [
          1990,
          9,
          1
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          1990,
          9,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1523/JNEUROSCI.10-09-03087.1990"
  ],
  "URL": "http://dx.doi.org/10.1523/JNEUROSCI.10-09-03087.1990",
  "relation": {},
  "ISSN": [
    "0270-6474",
    "1529-2401"
  ],
  "subject": [],
  "container-title-short": "J. Neurosci.",
  "published": {
    "date-parts": [
      [
        1990,
        9,
        1
      ]
    ]
  }
}