DOI: 10.1523/jneurosci.0861-04.2004. A Seed for Alzheimer Amyloid in the Brain

A Seed for Alzheimer Amyloid in the Brain

10.1523/jneurosci.0861-04.2004

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

A fundamental question about the early pathogenesis of Alzheimer's disease (AD) concerns how toxic aggregates of amyloid β protein (Aβ) are formed from its nontoxic soluble form. We hypothesized previously that GM1 ganglioside-bound Aβ (GAβ) is involved in the process. We now examined this possibility using a novel monoclonal antibody raised against GAβ purified from an AD brain. Here, we report that GAβ has a conformation distinct from that of soluble Aβ and initiates Aβ aggregation by acting as a seed. Furthermore, GAβ generation in the brain was validated by both immunohistochemical and immunoprecipitation studies. These results imply a mechanism underlying the onset of AD and suggest that an endogenous seed can be a target of therapeutic strategy.

Bibliography

Hayashi, H., Kimura, N., Yamaguchi, H., Hasegawa, K., Yokoseki, T., Shibata, M., Yamamoto, N., Michikawa, M., Yoshikawa, Y., Terao, K., Matsuzaki, K., Lemere, C. A., Selkoe, D. J., Naiki, H., & Yanagisawa, K. (2004). A Seed for Alzheimer Amyloid in the Brain. The Journal of Neuroscience, 24(20), 4894â4902.

Authors 15

Hideki Hayashi (first)
Nobuyuki Kimura (additional)
Haruyasu Yamaguchi (additional)
Kazuhiro Hasegawa (additional)
Tatsuki Yokoseki (additional)
Masao Shibata (additional)
Naoki Yamamoto (additional)
Makoto Michikawa (additional)
Yasuhiro Yoshikawa (additional)
Keiji Terao (additional)
Katsumi Matsuzaki (additional)
Cynthia A. Lemere (additional)
Dennis J. Selkoe (additional)
Hironobu Naiki (additional)
Katsuhiko Yanagisawa (additional)

References 51 Referenced 215

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Dates

Type	When
Created	21 years, 3 months ago (May 19, 2004, 3:48 p.m.)
Deposited	1 year, 7 months ago (Jan. 13, 2024, 8:02 a.m.)
Indexed	3 weeks ago (Aug. 7, 2025, 4:53 a.m.)
Issued	21 years, 3 months ago (May 19, 2004)
Published	21 years, 3 months ago (May 19, 2004)
Published Online	21 years, 3 months ago (May 19, 2004)
Published Print	21 years, 3 months ago (May 19, 2004)

Funders 0

None

BibTeX

@article{Hayashi_2004, title={A Seed for Alzheimer Amyloid in the Brain}, volume={24}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.0861-04.2004}, DOI={10.1523/jneurosci.0861-04.2004}, number={20}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Hayashi, Hideki and Kimura, Nobuyuki and Yamaguchi, Haruyasu and Hasegawa, Kazuhiro and Yokoseki, Tatsuki and Shibata, Masao and Yamamoto, Naoki and Michikawa, Makoto and Yoshikawa, Yasuhiro and Terao, Keiji and Matsuzaki, Katsumi and Lemere, Cynthia A. and Selkoe, Dennis J. and Naiki, Hironobu and Yanagisawa, Katsuhiko}, year={2004}, month=may, pages={4894–4902} }

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