DOI: 10.1523/jneurosci.0328-10.2010. RIM1α and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia

RIM1α and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia

10.1523/jneurosci.0328-10.2010

Crossref journal-article

Society for Neuroscience

The Journal of Neuroscience (393)

Abstract

Several presynaptic proteins involved in neurotransmitter release in the CNS have been implicated in schizophrenia in human clinical genetic studies, in postmortem studies, and in studies of putative animal models of schizophrenia. The presynaptic protein RIM1α mediates presynaptic plasticity and cognitive function. We now demonstrate that mice deficient in RIM1α exhibit abnormalities in multiple schizophrenia-relevant behavioral tasks including prepulse inhibition, response to psychotomimetic drugs, and social interaction. These schizophrenia-relevant behavioral findings are relatively selective to RIM1α-deficient mice, as mice bearing mutations in the RIM1α binding partners Rab3A or synaptotagmin 1 only show decreased prepulse inhibition. In addition to RIM1α's involvement in multiple behavioral abnormalities, these data suggest that alterations in presynaptic forms of short-term plasticity are linked to alterations in prepulse inhibition, a measure of sensorimotor gating.

Bibliography

Blundell, J., Kaeser, P. S., SÃ¼dhof, T. C., & Powell, C. M. (2010). RIM1Î± and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia. The Journal of Neuroscience, 30(15), 5326â5333.

Authors 4

Jacqueline Blundell (first)
Pascal S. Kaeser (additional)
Thomas C. Südhof (additional)
Craig M. Powell (additional)

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Dates

Type	When
Created	15 years, 4 months ago (April 14, 2010, 12:40 p.m.)
Deposited	2 years, 4 months ago (April 13, 2023, 3:54 p.m.)
Indexed	1 month ago (July 25, 2025, 6:10 a.m.)
Issued	15 years, 4 months ago (April 14, 2010)
Published	15 years, 4 months ago (April 14, 2010)
Published Online	15 years, 4 months ago (April 14, 2010)
Published Print	15 years, 4 months ago (April 14, 2010)

Funders 0

None

BibTeX

@article{Blundell_2010, title={RIM1α and Interacting Proteins Involved in Presynaptic Plasticity Mediate Prepulse Inhibition and Additional Behaviors Linked to Schizophrenia}, volume={30}, ISSN={1529-2401}, url={http://dx.doi.org/10.1523/jneurosci.0328-10.2010}, DOI={10.1523/jneurosci.0328-10.2010}, number={15}, journal={The Journal of Neuroscience}, publisher={Society for Neuroscience}, author={Blundell, Jacqueline and Kaeser, Pascal S. and Südhof, Thomas C. and Powell, Craig M.}, year={2010}, month=apr, pages={5326–5333} }

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