DOI: 10.1515/bc.2006.023. Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma

Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma

10.1515/bc.2006.023

Crossref journal-article

Walter de Gruyter GmbH

Biological Chemistry (374)

Abstract

AbstractBlood coagulation factor XII (FXII, Hageman factor) is a plasma serine protease which is autoactivated following contact with negatively charged surfaces in a reaction involving plasma kallikrein and high-molecular-weight kininogen (contact phase activation). Active FXII has the ability to initiate blood clotting via the intrinsic pathway of coagulation and inflammatory reactions via the kallikrein-kinin system. Here we have determined FXII-mediated bradykinin formation and clotting in plasma. Western blotting analysis with specific antibodies against various parts of the contact factors revealed that limited activation of FXII is sufficient to promote plasma kallikrein activation, resulting in the conversion of high-molecular-weight kininogen and bradykinin generation. The presence of platelets significantly promoted FXII-initiated bradykinin formation. Similarly,in vitroclotting assays revealed that platelets critically promoted FXII-driven thrombin and fibrin formation. In summary, our data suggest that FXII-initiated protease cascades may proceed on platelet surfaces, with implications for inflammation and clotting.

Bibliography

Johne, J., Blume, C., Benz, P. M., PozgajovÃ¡, M., Ullrich, M., Schuh, K., Nieswandt, B., Walter, U., & RennÃ©, T. (2006). Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma. Biological Chemistry, 387(2), 173â178.

Authors 9

Julia Johne (first)
Constanze Blume (additional)
Peter M. Benz (additional)
Miroslava Pozgajová (additional)
Melanie Ullrich (additional)
Kai Schuh (additional)
Bernhard Nieswandt (additional)
Ulrich Walter (additional)
Thomas Renné (additional)

References 34 Referenced 51

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Dates

Type	When
Created	19 years, 6 months ago (Feb. 9, 2006, 6:02 a.m.)
Deposited	2 years, 4 months ago (May 6, 2023, 8:34 a.m.)
Indexed	1 year, 2 months ago (June 30, 2024, 10:29 a.m.)
Issued	19 years, 7 months ago (Feb. 1, 2006)
Published	19 years, 7 months ago (Feb. 1, 2006)
Published Print	19 years, 7 months ago (Feb. 1, 2006)

Funders 0

None

BibTeX

@article{Johne_2006, title={Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma}, volume={387}, ISSN={1437-4315}, url={http://dx.doi.org/10.1515/bc.2006.023}, DOI={10.1515/bc.2006.023}, number={2}, journal={Biological Chemistry}, publisher={Walter de Gruyter GmbH}, author={Johne, Julia and Blume, Constanze and Benz, Peter M. and Pozgajová, Miroslava and Ullrich, Melanie and Schuh, Kai and Nieswandt, Bernhard and Walter, Ulrich and Renné, Thomas}, year={2006}, month=feb, pages={173–178} }

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