DOI: 10.1378/chest.126.6.1802. Increased Activity of Matrix Metalloproteinase-8 and Matrix Metalloproteinase-9 in Induced Sputum From Patients With COPD

Increased Activity of Matrix Metalloproteinase-8 and Matrix Metalloproteinase-9 in Induced Sputum From Patients With COPD

10.1378/chest.126.6.1802

Crossref journal-article

Elsevier BV

Chest (78)

Bibliography

Vernooy, J. H. J., Lindeman, J. H. N., Jacobs, J. A., Hanemaaijer, R., & Wouters, E. F. M. (2004). Increased Activity of Matrix Metalloproteinase-8 and Matrix Metalloproteinase-9 in Induced Sputum From Patients With COPD. Chest, 126(6), 1802â1810.

Authors 5

Juanita H.J. Vernooy (first)
Jan H.N. Lindeman (additional)
Jan A. Jacobs (additional)
Roeland Hanemaaijer (additional)
Emiel F.M. Wouters (additional)

References 36 Referenced 151

10.1164/ajrccm.163.5.2101039 / Am J Respir Crit Care Med / Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary by Pauwels (2001)
10.1164/ajrccm.152.5.7582312 / Am J Respir Crit Care Med / Alveolar inflammation and its relation to emphysema in smokers by Finkelstein (1995)
10.1164/ajrccm.157.3.9709027 / Am J Respir Crit Care Med / CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease by Saetta (1998)
10.1034/j.1399-3003.1999.13d24.x / Eur Respir J / The cellular composition of induced sputum in chronic obstructive pulmonary disease by Peleman (1999)
10.1183/09031936.98.12020380 / Eur Respir J / Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease by Pesci (1998)
10.1164/ajrccm.153.2.8564092 / Am J Respir Crit Care Med / Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma by Keatings (1996)
10.1164/ajrccm.155.3.9117016 / Am J Respir Crit Care Med / Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1 by O’Shaughnessy (1997)
10.1164/rccm.2202023 / Am J Respir Crit Care Med / Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum by Vernooy (2002)
10.1046/j.1524-475X.1999.00442.x / Wound Repair Regen / Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors by Trengove (1999)
10.1074/jbc.M103220200 / J Biol Chem / Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor by Taggart (2001)
10.1172/JCI0213572 / J Clin Invest / Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis by Vandivier (2002)
10.1183/09031936.03.00040703 / Eur Respir J / Chronic obstructive pulmonary disease: molecular and cellular mechanisms by Barnes (2003)
10.1172/JCI0216550 / J Clin Invest / A confederacy of proteinases by Parks (2002)
10.1172/JCI10458 / J Clin Invest / Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema by Zheng (2000)
10.1378/chest.123.5.1633 / Chest / Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs by Selman (2003)
{'key': '10.1378/chest.126.6.1802_bib16', 'first-page': '1077', 'article-title': 'Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema', 'volume': '78', 'author': 'Ohnishi', 'year': '1998', 'journal-title': 'Lab Invest'} / Lab Invest / Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema by Ohnishi (1998)
10.1164/ajrccm.163.3.2001073 / Am J Respir Crit Care Med / Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema by Imai (2001)
10.1378/chest.117.3.684 / Chest / Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD by Segura-Valdez (2000)
10.1164/ajrccm.159.6.9809043 / Am J Respir Crit Care Med / Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema by Betsuyaku (1999)
{'key': '10.1378/chest.126.6.1802_bib20', 'series-title': 'Handbook for proteolytic enzymes', 'year': '1998'} / Handbook for proteolytic enzymes (1998)
10.1186/rr126 / Respir Res / Matrix metalloproteinases in lung biology by Parks (2001)
10.1016/S0022-2828(05)82390-9 / J Mol Cell Cardiol / Regulation of collagen degradation in the rat myocardium after infarction by Cleutjens (1995)
10.1016/S0140-6736(03)14416-9 / Lancet / Chronic obstructive pulmonary disease by Calverley (2003)
10.1186/rr85 / Respir Res / The role of collagenase in emphysema by Foronjy (2001)
10.1164/ajrccm.158.6.9803014 / Am J Respir Crit Care Med / Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis by Vignola (1998)
10.1159/000024452 / Int Arch Allergy Immunol / MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease by Cataldo (2000)
10.1053/rmed.2003.1493 / Respir Med / Sputum matrix metalloproteinase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects by Beeh (2003)
10.1136/thx.52.6.502 / Thorax / Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients by Finlay (1997)
10.1164/ajrccm.164.10.2104051 / Am J Respir Crit Care Med / Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique by Alexis (2001)
10.1378/chest.112.2.505 / Chest / Airway inflammation in COPD assessed by sputum levels of interleukin-8 by Yamamoto (1997)
10.1183/09031936.00.15110900 / Eur Respir J / Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD by Rutgers (2000)
10.1016/0014-5793(88)80817-2 / FEBS Lett / Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases by Okada (1988)
10.1152/ajplung.2001.281.4.L868 / Am J Physiol Lung Cell Mol Physiol / Synergistic neutrophil elastase-cytokine interaction degrades collagen in three-dimensional culture by Zhu (2001)
10.1074/jbc.270.28.16518 / J Biol Chem / Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase by Itoh (1995)
10.1165/ajrcmb.26.5.4685 / Am J Respir Cell Mol Biol / Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease by Russell (2002)
10.1152/ajplung.00020.2002 / Am J Physiol Lung Cell Mol Physiol / Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases by Russell (2002)

Dates

Type	When
Created	20 years, 8 months ago (Dec. 14, 2004, 5:42 p.m.)
Deposited	6 years, 7 months ago (Jan. 31, 2019, 5:23 a.m.)
Indexed	3 months ago (May 29, 2025, 9:09 a.m.)
Issued	20 years, 9 months ago (Dec. 1, 2004)
Published	20 years, 9 months ago (Dec. 1, 2004)
Published Print	20 years, 9 months ago (Dec. 1, 2004)

Funders 0

None

BibTeX

@article{Vernooy_2004, title={Increased Activity of Matrix Metalloproteinase-8 and Matrix Metalloproteinase-9 in Induced Sputum From Patients With COPD}, volume={126}, ISSN={0012-3692}, url={http://dx.doi.org/10.1378/chest.126.6.1802}, DOI={10.1378/chest.126.6.1802}, number={6}, journal={Chest}, publisher={Elsevier BV}, author={Vernooy, Juanita H.J. and Lindeman, Jan H.N. and Jacobs, Jan A. and Hanemaaijer, Roeland and Wouters, Emiel F.M.}, year={2004}, month=dec, pages={1802–1810} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        29
      ]
    ],
    "date-time": "2025-05-29T13:09:15Z",
    "timestamp": 1748524155934
  },
  "reference-count": 36,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            12,
            1
          ]
        ],
        "date-time": "2004-12-01T00:00:00Z",
        "timestamp": 1101859200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        12
      ]
    ]
  },
  "DOI": "10.1378/chest.126.6.1802",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        12,
        14
      ]
    ],
    "date-time": "2004-12-14T22:42:53Z",
    "timestamp": 1103064173000
  },
  "page": "1802-1810",
  "source": "Crossref",
  "is-referenced-by-count": 151,
  "title": "Increased Activity of Matrix Metalloproteinase-8 and Matrix Metalloproteinase-9 in Induced Sputum From Patients With COPD",
  "prefix": "10.1016",
  "volume": "126",
  "author": [
    {
      "given": "Juanita H.J.",
      "family": "Vernooy",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Jan H.N.",
      "family": "Lindeman",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jan A.",
      "family": "Jacobs",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Roeland",
      "family": "Hanemaaijer",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Emiel F.M.",
      "family": "Wouters",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1378/chest.126.6.1802_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "1256",
      "DOI": "10.1164/ajrccm.163.5.2101039",
      "article-title": "Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary",
      "volume": "163",
      "author": "Pauwels",
      "year": "2001",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "1666",
      "DOI": "10.1164/ajrccm.152.5.7582312",
      "article-title": "Alveolar inflammation and its relation to emphysema in smokers",
      "volume": "152",
      "author": "Finkelstein",
      "year": "1995",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "822",
      "DOI": "10.1164/ajrccm.157.3.9709027",
      "article-title": "CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease",
      "volume": "157",
      "author": "Saetta",
      "year": "1998",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "839",
      "DOI": "10.1034/j.1399-3003.1999.13d24.x",
      "article-title": "The cellular composition of induced sputum in chronic obstructive pulmonary disease",
      "volume": "13",
      "author": "Peleman",
      "year": "1999",
      "journal-title": "Eur Respir J"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "380",
      "DOI": "10.1183/09031936.98.12020380",
      "article-title": "Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease",
      "volume": "12",
      "author": "Pesci",
      "year": "1998",
      "journal-title": "Eur Respir J"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "530",
      "DOI": "10.1164/ajrccm.153.2.8564092",
      "article-title": "Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma",
      "volume": "153",
      "author": "Keatings",
      "year": "1996",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "852",
      "DOI": "10.1164/ajrccm.155.3.9117016",
      "article-title": "Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1",
      "volume": "155",
      "author": "O\u2019Shaughnessy",
      "year": "1997",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "1218",
      "DOI": "10.1164/rccm.2202023",
      "article-title": "Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum",
      "volume": "166",
      "author": "Vernooy",
      "year": "2002",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "442",
      "DOI": "10.1046/j.1524-475X.1999.00442.x",
      "article-title": "Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors",
      "volume": "7",
      "author": "Trengove",
      "year": "1999",
      "journal-title": "Wound Repair Regen"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "33345",
      "DOI": "10.1074/jbc.M103220200",
      "article-title": "Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor",
      "volume": "276",
      "author": "Taggart",
      "year": "2001",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "661",
      "DOI": "10.1172/JCI0213572",
      "article-title": "Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis",
      "volume": "109",
      "author": "Vandivier",
      "year": "2002",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "672",
      "DOI": "10.1183/09031936.03.00040703",
      "article-title": "Chronic obstructive pulmonary disease: molecular and cellular mechanisms",
      "volume": "22",
      "author": "Barnes",
      "year": "2003",
      "journal-title": "Eur Respir J"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1172/JCI0216550",
      "article-title": "A confederacy of proteinases",
      "volume": "110",
      "author": "Parks",
      "year": "2002",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "1081",
      "DOI": "10.1172/JCI10458",
      "article-title": "Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema",
      "volume": "106",
      "author": "Zheng",
      "year": "2000",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "1633",
      "DOI": "10.1378/chest.123.5.1633",
      "article-title": "Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs",
      "volume": "123",
      "author": "Selman",
      "year": "2003",
      "journal-title": "Chest"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib16",
      "first-page": "1077",
      "article-title": "Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema",
      "volume": "78",
      "author": "Ohnishi",
      "year": "1998",
      "journal-title": "Lab Invest"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "786",
      "DOI": "10.1164/ajrccm.163.3.2001073",
      "article-title": "Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema",
      "volume": "163",
      "author": "Imai",
      "year": "2001",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "684",
      "DOI": "10.1378/chest.117.3.684",
      "article-title": "Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD",
      "volume": "117",
      "author": "Segura-Valdez",
      "year": "2000",
      "journal-title": "Chest"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "1985",
      "DOI": "10.1164/ajrccm.159.6.9809043",
      "article-title": "Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema",
      "volume": "159",
      "author": "Betsuyaku",
      "year": "1999",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib20",
      "series-title": "Handbook for proteolytic enzymes",
      "year": "1998"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "DOI": "10.1186/rr126",
      "article-title": "Matrix metalloproteinases in lung biology",
      "volume": "2",
      "author": "Parks",
      "year": "2001",
      "journal-title": "Respir Res"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "1281",
      "DOI": "10.1016/S0022-2828(05)82390-9",
      "article-title": "Regulation of collagen degradation in the rat myocardium after infarction",
      "volume": "27",
      "author": "Cleutjens",
      "year": "1995",
      "journal-title": "J Mol Cell Cardiol"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "1053",
      "DOI": "10.1016/S0140-6736(03)14416-9",
      "article-title": "Chronic obstructive pulmonary disease",
      "volume": "362",
      "author": "Calverley",
      "year": "2003",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "348",
      "DOI": "10.1186/rr85",
      "article-title": "The role of collagenase in emphysema",
      "volume": "2",
      "author": "Foronjy",
      "year": "2001",
      "journal-title": "Respir Res"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "1945",
      "DOI": "10.1164/ajrccm.158.6.9803014",
      "article-title": "Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis",
      "volume": "158",
      "author": "Vignola",
      "year": "1998",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "259",
      "DOI": "10.1159/000024452",
      "article-title": "MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease",
      "volume": "123",
      "author": "Cataldo",
      "year": "2000",
      "journal-title": "Int Arch Allergy Immunol"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "634",
      "DOI": "10.1053/rmed.2003.1493",
      "article-title": "Sputum matrix metalloproteinase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects",
      "volume": "97",
      "author": "Beeh",
      "year": "2003",
      "journal-title": "Respir Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "502",
      "DOI": "10.1136/thx.52.6.502",
      "article-title": "Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients",
      "volume": "52",
      "author": "Finlay",
      "year": "1997",
      "journal-title": "Thorax"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "1964",
      "DOI": "10.1164/ajrccm.164.10.2104051",
      "article-title": "Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique",
      "volume": "164",
      "author": "Alexis",
      "year": "2001",
      "journal-title": "Am J Respir Crit Care Med"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "505",
      "DOI": "10.1378/chest.112.2.505",
      "article-title": "Airway inflammation in COPD assessed by sputum levels of interleukin-8",
      "volume": "112",
      "author": "Yamamoto",
      "year": "1997",
      "journal-title": "Chest"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "109",
      "DOI": "10.1183/09031936.00.15110900",
      "article-title": "Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD",
      "volume": "15",
      "author": "Rutgers",
      "year": "2000",
      "journal-title": "Eur Respir J"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1016/0014-5793(88)80817-2",
      "article-title": "Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases",
      "volume": "229",
      "author": "Okada",
      "year": "1988",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "L868",
      "DOI": "10.1152/ajplung.2001.281.4.L868",
      "article-title": "Synergistic neutrophil elastase-cytokine interaction degrades collagen in three-dimensional culture",
      "volume": "281",
      "author": "Zhu",
      "year": "2001",
      "journal-title": "Am J Physiol Lung Cell Mol Physiol"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "16518",
      "DOI": "10.1074/jbc.270.28.16518",
      "article-title": "Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase",
      "volume": "270",
      "author": "Itoh",
      "year": "1995",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "602",
      "DOI": "10.1165/ajrcmb.26.5.4685",
      "article-title": "Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease",
      "volume": "26",
      "author": "Russell",
      "year": "2002",
      "journal-title": "Am J Respir Cell Mol Biol"
    },
    {
      "key": "10.1378/chest.126.6.1802_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "L867",
      "DOI": "10.1152/ajplung.00020.2002",
      "article-title": "Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases",
      "volume": "283",
      "author": "Russell",
      "year": "2002",
      "journal-title": "Am J Physiol Lung Cell Mol Physiol"
    }
  ],
  "container-title": "Chest",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0012369215314264?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0012369215314264?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        1,
        31
      ]
    ],
    "date-time": "2019-01-31T10:23:23Z",
    "timestamp": 1548930203000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0012369215314264"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        12
      ]
    ]
  },
  "references-count": 36,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2004,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "S0012369215314264"
  ],
  "URL": "http://dx.doi.org/10.1378/chest.126.6.1802",
  "relation": {},
  "ISSN": [
    "0012-3692"
  ],
  "subject": [],
  "container-title-short": "Chest",
  "published": {
    "date-parts": [
      [
        2004,
        12
      ]
    ]
  }
}