DOI: 10.1371/journal.ppat.1003991. Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens

Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens

10.1371/journal.ppat.1003991

Crossref journal-article

Public Library of Science (PLoS)

PLoS Pathogens (340)

Bibliography

Lin, J.-S., Wu, H.-H., Hsu, P.-H., Ma, L.-S., Pang, Y.-Y., Tsai, M.-D., & Lai, E.-M. (2014). Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens. PLoS Pathogens, 10(3), e1003991.

Authors 7

Jer-Sheng Lin (first)
Hsin-Hui Wu (additional)
Pang-Hung Hsu (additional)
Lay-Sun Ma (additional)
Yin-Yuin Pang (additional)
Ming-Daw Tsai (additional)
Erh-Min Lai (additional)

References 59 Referenced 49

10.1186/1471-2164-10-104 / BMC Genomics / Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources? by F Boyer (2009)
10.1073/pnas.0706532104 / Proc Natl Acad Sci U S A / Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin by S Pukatzki (2007)
10.1016/j.tim.2010.09.001 / Trends Microbiol / What is type VI secretion doing in all those bugs? by S Schwarz (2010)
10.1016/j.chom.2009.12.007 / Cell Host Microbe / A type VI secretion system of <italic>Pseudomonas aeruginosa</italic> targets a toxin to bacteria by RD Hood (2010)
10.1016/j.chom.2012.04.007 / Cell Host Microbe / A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach by AB Russell (2012)
10.1111/mmi.12028 / Mol Microbiol / New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of <italic>Serratia marcescens</italic> by G English (2012)
10.1038/nature10846 / Nature / Type VI secretion requires a dynamic contractile phage tail-like structure by M Basler (2012)
10.1111/mmi.12147 / Mol Microbiol / ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion by N Kapitein (2013)
10.1038/emboj.2008.269 / EMBO J / Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion by G Bonemann (2009)
10.1146/annurev-micro-121809-151619 / Annu Rev Microbiol / Structure and Regulation of the Type VI Secretion System by JM Silverman (2012)
10.1371/journal.pone.0067647 / PLoS One / Systematic Dissection of the <italic>Agrobacterium</italic> Type VI secretion system reveals machinery and secreted components for subcomplex formation by JS Lin (2013)
10.1016/j.molcel.2013.07.025 / Mol Cell / Haemolysin coregulated protein Is an exported receptor and chaperone of type VI secretion substrates by JM Silverman (2013)
10.1111/j.1365-2958.2007.05993.x / Mol Microbiol / Dissection of a type VI secretion system in <italic>Edwardsiella tarda</italic> by J Zheng (2007)
10.1126/science.1222901 / Science / Type 6 secretion dynamics within and between bacterial cells by M Basler (2012)
10.1016/j.celrep.2012.11.027 / Cell Rep / Imaging type VI secretion-mediated bacterial killing by YR Brunet (2013)
10.1073/pnas.1213963109 / Proc Natl Acad Sci U S A / Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword by M Leroux (2012)
10.1016/j.cell.2013.01.042 / Cell / Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions by M Basler (2013)
10.1099/mic.0.2007/006585-0 / Microbiology / In vivo expression technology identifies a type VI secretion system locus in <italic>Burkholderia pseudomallei</italic> that is induced upon invasion of macrophages by G Shalom (2007)
10.1371/journal.pone.0023876 / PLoS One / Genetic analysis of anti-amoebae and anti-bacterial activities of the type VI secretion system in <italic>Vibrio cholerae</italic> by J Zheng (2011)
10.1128/JB.00029-09 / J Bacteriol / An IcmF family protein, ImpL<sub>M</sub>, is an integral inner membrane protein interacting with ImpK<sub>L</sub>, and its walker a motif is required for type VI secretion system-mediated Hcp secretion in <italic>Agrobacterium tumefaciens</italic> by LS Ma (2009)
10.1371/journal.ppat.1002386 / PLoS Pathog / Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an <italic>Escherichia coli</italic> pathovar by C Felisberto-Rodrigues (2011)
10.1074/jbc.M111.301630 / J Biol Chem / IcmF family protein TssM exhibits ATPase activity and energizes type VI secretion by LS Ma (2012)
10.1074/jbc.M111.338731 / J Biol Chem / Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems by E Durand (2012)
10.1016/j.jmb.2012.04.003 / J Mol Biol / The structure of the conserved type six secretion protein TssL (DotU) from <italic>Francisella novicida</italic> by CS Robb (2012)
10.1098/rstb.2011.0209 / Philos Trans R Soc Lond B Biol Sci / Structural biology of type VI secretion systems by E Cascales (2012)
10.1038/embor.2008.131 / EMBO Rep / The type VI secretion toolkit by E Cascales (2008)
10.1111/j.1365-2958.2011.07889.x / Mol Microbiol / Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation by JM Silverman (2011)
10.1074/mcp.M113.030502 / Mol Cell Proteomics / Proteomic identification of novel secreted anti-bacterial toxins of the <italic>Serratia marcescens</italic> type VI secretion system by MJ Fritsch (2013)
10.1038/ncb1605 / Nat Cell Biol / Threonine phosphorylation post-translationally regulates protein secretion in <italic>Pseudomonas aeruginosa</italic> by JD Mougous (2007)
10.1111/j.1365-2958.2009.06701.x / Mol Microbiol / TagR promotes PpkA-catalysed type VI secretion activation in <italic>Pseudomonas aeruginosa</italic> by F Hsu (2009)
10.1111/j.1462-2920.2012.02816.x / Environ Microbiol / An ABC transporter and an outer membrane lipoprotein participate in posttranslational activation of type VI secretion in <italic>Pseudomonas aeruginosa</italic> by MG Casabona (2013)
10.1016/S0966-842X(02)02476-9 / Trends Microbiol / Bacterial FHA domains: neglected players in the phospho-threonine signalling game? by M Pallen (2002)
10.1016/S0014-5793(01)03294-X / FEBS Lett / The FHA domain by D Durocher (2002)
10.1016/S1097-2765(00)00114-3 / Mol Cell / The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms by D Durocher (2000)
10.1126/scisignal.151re12 / Sci Signal / Structure and function of the phosphothreonine-specific FHA domain by A Mahajan (2008)
10.1016/S0968-0004(00)89072-6 / Trends Biochem Sci / The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors by K Hofmann (1995)
10.1038/31159 / Nature / Deciphering the biology of <italic>Mycobacterium tuberculosis</italic> from the complete genome sequence by ST Cole (1998)
10.1074/jbc.M109.058834 / J Biol Chem / Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of <italic>Mycobacterium tuberculosis</italic> by M Gupta (2009)
{'key': 'ref39', 'first-page': 'ra7', 'article-title': 'A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria', 'volume': '5', 'author': 'CL Gee', 'year': '2012', 'journal-title': 'Sci Signal'} / Sci Signal / A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria by CL Gee (2012)
10.1371/journal.ppat.1002938 / PLoS Pathog / Acid-induced type VI secretion system is regulated by ExoR-ChvG/ChvI signaling cascade in <italic>Agrobacterium tumefaciens</italic> by CF Wu (2012)
10.1128/JB.01775-07 / J Bacteriol / Secretome analysis uncovers an Hcp-family protein secreted via a type VI secretion system in <italic>Agrobacterium tumefaciens</italic> by HY Wu (2008)
10.1096/fasebj.9.8.7768349 / FASEB J / Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification by SK Hanks (1995)
10.1021/bi201709w / Biochemistry / Structural delineation of MDC1-FHA domain binding with CHK2-pThr68 by HH Wu (2012)
10.1073/pnas.93.17.8889 / Proc Natl Acad Sci U S A / <italic>Agrobacterium tumefaciens</italic> VirB7 and VirB9 form a disulfide-linked protein complex by LB Anderson (1996)
10.1111/j.1365-2672.2008.03874.x / J Appl Microbiol / A citrate-inducible gene, encoding a putative tricarboxylate transporter, is downregulated by the organic solvent DMSO in <italic>Agrobacterium tumefaciens</italic> by AC Liu (2008)
10.1016/S0378-1119(02)00385-2 / Gene / An <italic>Agrobacterium</italic> gene involved in tumorigenesis encodes an outer membrane protein exposed on the bacterial cell surface by YH Jia (2002)
10.1128/jb.176.11.3102-3110.1994 / J Bacteriol / The response of a <italic>Bacillus subtilis</italic> temperature-sensitive <italic>sigA</italic> mutant to heat stress by BY Chang (1994)
10.1128/JB.01387-07 / J Bacteriol / Transcriptome profiling and functional analysis of <italic>Agrobacterium tumefaciens</italic> reveals a general conserved response to acidic conditions (pH 5.5) and a complex acid-mediated signaling involved in <italic>Agrobacterium</italic>-plant interactions by ZC Yuan (2008)
10.1073/pnas.192439499 / Proc Natl Acad Sci U S A / A global pH sensor: <italic>Agrobacterium</italic> sensor protein ChvG regulates acid-inducible genes on its two chromosomes and Ti plasmid by L Li (2002)
10.1128/JB.187.17.6039-6045.2005 / J Bacteriol / Phosphoenolpyruvate carboxykinase is an acid-induced, chromosomally encoded virulence factor in <italic>Agrobacterium tumefaciens</italic> by P Liu (2005)
10.1016/j.molcel.2008.05.013 / Mol Cell / Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade by H Lee (2008)
10.1534/genetics.108.095539 / Genetics / Recruitment of <italic>Saccharomyces cerevisiae</italic> Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain by PL Palmbos (2008)
10.1126/science.1128393 / Science / A virulence locus of <italic>Pseudomonas aeruginosa</italic> encodes a protein secretion apparatus by JD Mougous (2006)
10.1094/Phyto-60-969 / Phytopathology / Selective media for isolation of <italic>Agrobacterium</italic>, <italic>Corynebacterium</italic>, <italic>Erwinia</italic>, <italic>Pseudomonas</italic>, and <italic>Xanthomonas</italic> by CI Kado (1970)
10.1128/jb.62.3.293-300.1951 / J Bacteriol / Studies on lysogenesis. I. The mode of phage liberation by lysogenic <italic>Escherichia coli</italic> by G Bertani (1951)
10.1128/JB.180.10.2711-2717.1998 / J Bacteriol / Processed VirB2 is the major subunit of the promiscuous pilus of <italic>Agrobacterium tumefaciens</italic> by EM Lai (1998)
10.1016/0378-1119(93)90611-6 / Gene / Versatile suicide vectors which allow direct selection for gene replacement in gram-negative bacteria by J Quandt (1993)
10.1016/0003-2697(92)90061-B / Anal Biochem / In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis by J Rosenfeld (1992)
10.1006/abio.1995.1070 / Anal Biochem / Improvement of an “In-Gel” digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing by U Hellman (1995)

Dates

Type	When
Created	11 years, 5 months ago (March 13, 2014, 5:05 p.m.)
Deposited	3 years, 4 months ago (March 29, 2022, 6:40 p.m.)
Indexed	1 week, 2 days ago (Aug. 20, 2025, 8:43 a.m.)
Issued	11 years, 5 months ago (March 13, 2014)
Published	11 years, 5 months ago (March 13, 2014)
Published Online	11 years, 5 months ago (March 13, 2014)

Funders 0

None

BibTeX

@article{Lin_2014, title={Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens}, volume={10}, ISSN={1553-7374}, url={http://dx.doi.org/10.1371/journal.ppat.1003991}, DOI={10.1371/journal.ppat.1003991}, number={3}, journal={PLoS Pathogens}, publisher={Public Library of Science (PLoS)}, author={Lin, Jer-Sheng and Wu, Hsin-Hui and Hsu, Pang-Hung and Ma, Lay-Sun and Pang, Yin-Yuin and Tsai, Ming-Daw and Lai, Erh-Min}, editor={Mougous, Joseph D.}, year={2014}, month=mar, pages={e1003991} }

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      "author": "F Boyer",
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      "volume": "104",
      "author": "S Pukatzki",
      "year": "2007",
      "journal-title": "Proc Natl Acad Sci U S A"
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      "article-title": "What is type VI secretion doing in all those bugs?",
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      "author": "S Schwarz",
      "year": "2010",
      "journal-title": "Trends Microbiol"
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      "first-page": "25",
      "DOI": "10.1016/j.chom.2009.12.007",
      "article-title": "A type VI secretion system of <italic>Pseudomonas aeruginosa</italic> targets a toxin to bacteria",
      "volume": "7",
      "author": "RD Hood",
      "year": "2010",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "ref5",
      "doi-asserted-by": "crossref",
      "first-page": "538",
      "DOI": "10.1016/j.chom.2012.04.007",
      "article-title": "A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach",
      "volume": "11",
      "author": "AB Russell",
      "year": "2012",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "ref6",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1111/mmi.12028",
      "article-title": "New secreted toxins and immunity proteins encoded within the type VI secretion system gene cluster of <italic>Serratia marcescens</italic>",
      "volume": "86",
      "author": "G English",
      "year": "2012",
      "journal-title": "Mol Microbiol"
    },
    {
      "key": "ref7",
      "doi-asserted-by": "crossref",
      "first-page": "182",
      "DOI": "10.1038/nature10846",
      "article-title": "Type VI secretion requires a dynamic contractile phage tail-like structure",
      "volume": "483",
      "author": "M Basler",
      "year": "2012",
      "journal-title": "Nature"
    },
    {
      "key": "ref8",
      "doi-asserted-by": "crossref",
      "first-page": "1013",
      "DOI": "10.1111/mmi.12147",
      "article-title": "ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion",
      "volume": "87",
      "author": "N Kapitein",
      "year": "2013",
      "journal-title": "Mol Microbiol"
    },
    {
      "key": "ref9",
      "doi-asserted-by": "crossref",
      "first-page": "315",
      "DOI": "10.1038/emboj.2008.269",
      "article-title": "Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion",
      "volume": "28",
      "author": "G Bonemann",
      "year": "2009",
      "journal-title": "EMBO J"
    },
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      "key": "ref10",
      "doi-asserted-by": "crossref",
      "first-page": "453",
      "DOI": "10.1146/annurev-micro-121809-151619",
      "article-title": "Structure and Regulation of the Type VI Secretion System",
      "volume": "66",
      "author": "JM Silverman",
      "year": "2012",
      "journal-title": "Annu Rev Microbiol"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "e67647",
      "DOI": "10.1371/journal.pone.0067647",
      "article-title": "Systematic Dissection of the <italic>Agrobacterium</italic> Type VI secretion system reveals machinery and secreted components for subcomplex formation",
      "volume": "8",
      "author": "JS Lin",
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      "first-page": "584",
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      "article-title": "Haemolysin coregulated protein Is an exported receptor and chaperone of type VI secretion substrates",
      "volume": "51",
      "author": "JM Silverman",
      "year": "2013",
      "journal-title": "Mol Cell"
    },
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      "first-page": "1192",
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      "article-title": "Dissection of a type VI secretion system in <italic>Edwardsiella tarda</italic>",
      "volume": "66",
      "author": "J Zheng",
      "year": "2007",
      "journal-title": "Mol Microbiol"
    },
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      "key": "ref14",
      "doi-asserted-by": "crossref",
      "first-page": "815",
      "DOI": "10.1126/science.1222901",
      "article-title": "Type 6 secretion dynamics within and between bacterial cells",
      "volume": "337",
      "author": "M Basler",
      "year": "2012",
      "journal-title": "Science"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "1",
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      "article-title": "Imaging type VI secretion-mediated bacterial killing",
      "volume": "3",
      "author": "YR Brunet",
      "year": "2013",
      "journal-title": "Cell Rep"
    },
    {
      "key": "ref16",
      "doi-asserted-by": "crossref",
      "first-page": "19804",
      "DOI": "10.1073/pnas.1213963109",
      "article-title": "Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword",
      "volume": "109",
      "author": "M Leroux",
      "year": "2012",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref17",
      "doi-asserted-by": "crossref",
      "first-page": "884",
      "DOI": "10.1016/j.cell.2013.01.042",
      "article-title": "Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions",
      "volume": "152",
      "author": "M Basler",
      "year": "2013",
      "journal-title": "Cell"
    },
    {
      "key": "ref18",
      "doi-asserted-by": "crossref",
      "first-page": "2689",
      "DOI": "10.1099/mic.0.2007/006585-0",
      "article-title": "In vivo expression technology identifies a type VI secretion system locus in <italic>Burkholderia pseudomallei</italic> that is induced upon invasion of macrophages",
      "volume": "153",
      "author": "G Shalom",
      "year": "2007",
      "journal-title": "Microbiology"
    },
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      "key": "ref19",
      "doi-asserted-by": "crossref",
      "first-page": "e23876",
      "DOI": "10.1371/journal.pone.0023876",
      "article-title": "Genetic analysis of anti-amoebae and anti-bacterial activities of the type VI secretion system in <italic>Vibrio cholerae</italic>",
      "volume": "6",
      "author": "J Zheng",
      "year": "2011",
      "journal-title": "PLoS One"
    },
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      "key": "ref20",
      "doi-asserted-by": "crossref",
      "first-page": "4316",
      "DOI": "10.1128/JB.00029-09",
      "article-title": "An IcmF family protein, ImpL<sub>M</sub>, is an integral inner membrane protein interacting with ImpK<sub>L</sub>, and its walker a motif is required for type VI secretion system-mediated Hcp secretion in <italic>Agrobacterium tumefaciens</italic>",
      "volume": "191",
      "author": "LS Ma",
      "year": "2009",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "ref21",
      "doi-asserted-by": "crossref",
      "first-page": "e1002386",
      "DOI": "10.1371/journal.ppat.1002386",
      "article-title": "Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an <italic>Escherichia coli</italic> pathovar",
      "volume": "7",
      "author": "C Felisberto-Rodrigues",
      "year": "2011",
      "journal-title": "PLoS Pathog"
    },
    {
      "key": "ref22",
      "doi-asserted-by": "crossref",
      "first-page": "15610",
      "DOI": "10.1074/jbc.M111.301630",
      "article-title": "IcmF family protein TssM exhibits ATPase activity and energizes type VI secretion",
      "volume": "287",
      "author": "LS Ma",
      "year": "2012",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref23",
      "doi-asserted-by": "crossref",
      "first-page": "14157",
      "DOI": "10.1074/jbc.M111.338731",
      "article-title": "Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems",
      "volume": "287",
      "author": "E Durand",
      "year": "2012",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref24",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1016/j.jmb.2012.04.003",
      "article-title": "The structure of the conserved type six secretion protein TssL (DotU) from <italic>Francisella novicida</italic>",
      "volume": "419",
      "author": "CS Robb",
      "year": "2012",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "ref25",
      "doi-asserted-by": "crossref",
      "first-page": "1102",
      "DOI": "10.1098/rstb.2011.0209",
      "article-title": "Structural biology of type VI secretion systems",
      "volume": "367",
      "author": "E Cascales",
      "year": "2012",
      "journal-title": "Philos Trans R Soc Lond B Biol Sci"
    },
    {
      "key": "ref26",
      "doi-asserted-by": "crossref",
      "first-page": "735",
      "DOI": "10.1038/embor.2008.131",
      "article-title": "The type VI secretion toolkit",
      "volume": "9",
      "author": "E Cascales",
      "year": "2008",
      "journal-title": "EMBO Rep"
    },
    {
      "key": "ref27",
      "doi-asserted-by": "crossref",
      "first-page": "1277",
      "DOI": "10.1111/j.1365-2958.2011.07889.x",
      "article-title": "Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation",
      "volume": "82",
      "author": "JM Silverman",
      "year": "2011",
      "journal-title": "Mol Microbiol"
    },
    {
      "key": "ref28",
      "doi-asserted-by": "crossref",
      "first-page": "2739",
      "DOI": "10.1074/mcp.M113.030502",
      "article-title": "Proteomic identification of novel secreted anti-bacterial toxins of the <italic>Serratia marcescens</italic> type VI secretion system",
      "volume": "12",
      "author": "MJ Fritsch",
      "year": "2013",
      "journal-title": "Mol Cell Proteomics"
    },
    {
      "key": "ref29",
      "doi-asserted-by": "crossref",
      "first-page": "797",
      "DOI": "10.1038/ncb1605",
      "article-title": "Threonine phosphorylation post-translationally regulates protein secretion in <italic>Pseudomonas aeruginosa</italic>",
      "volume": "9",
      "author": "JD Mougous",
      "year": "2007",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "ref30",
      "doi-asserted-by": "crossref",
      "first-page": "1111",
      "DOI": "10.1111/j.1365-2958.2009.06701.x",
      "article-title": "TagR promotes PpkA-catalysed type VI secretion activation in <italic>Pseudomonas aeruginosa</italic>",
      "volume": "72",
      "author": "F Hsu",
      "year": "2009",
      "journal-title": "Mol Microbiol"
    },
    {
      "key": "ref31",
      "doi-asserted-by": "crossref",
      "first-page": "471",
      "DOI": "10.1111/j.1462-2920.2012.02816.x",
      "article-title": "An ABC transporter and an outer membrane lipoprotein participate in posttranslational activation of type VI secretion in <italic>Pseudomonas aeruginosa</italic>",
      "volume": "15",
      "author": "MG Casabona",
      "year": "2013",
      "journal-title": "Environ Microbiol"
    },
    {
      "key": "ref32",
      "doi-asserted-by": "crossref",
      "first-page": "556",
      "DOI": "10.1016/S0966-842X(02)02476-9",
      "article-title": "Bacterial FHA domains: neglected players in the phospho-threonine signalling game?",
      "volume": "10",
      "author": "M Pallen",
      "year": "2002",
      "journal-title": "Trends Microbiol"
    },
    {
      "key": "ref33",
      "doi-asserted-by": "crossref",
      "first-page": "58",
      "DOI": "10.1016/S0014-5793(01)03294-X",
      "article-title": "The FHA domain",
      "volume": "513",
      "author": "D Durocher",
      "year": "2002",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "ref34",
      "doi-asserted-by": "crossref",
      "first-page": "1169",
      "DOI": "10.1016/S1097-2765(00)00114-3",
      "article-title": "The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms",
      "volume": "6",
      "author": "D Durocher",
      "year": "2000",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref35",
      "doi-asserted-by": "crossref",
      "first-page": "re12",
      "DOI": "10.1126/scisignal.151re12",
      "article-title": "Structure and function of the phosphothreonine-specific FHA domain",
      "volume": "1",
      "author": "A Mahajan",
      "year": "2008",
      "journal-title": "Sci Signal"
    },
    {
      "key": "ref36",
      "doi-asserted-by": "crossref",
      "first-page": "347",
      "DOI": "10.1016/S0968-0004(00)89072-6",
      "article-title": "The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors",
      "volume": "20",
      "author": "K Hofmann",
      "year": "1995",
      "journal-title": "Trends Biochem Sci"
    },
    {
      "key": "ref37",
      "doi-asserted-by": "crossref",
      "first-page": "537",
      "DOI": "10.1038/31159",
      "article-title": "Deciphering the biology of <italic>Mycobacterium tuberculosis</italic> from the complete genome sequence",
      "volume": "393",
      "author": "ST Cole",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "ref38",
      "doi-asserted-by": "crossref",
      "first-page": "34723",
      "DOI": "10.1074/jbc.M109.058834",
      "article-title": "Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of <italic>Mycobacterium tuberculosis</italic>",
      "volume": "284",
      "author": "M Gupta",
      "year": "2009",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref39",
      "first-page": "ra7",
      "article-title": "A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria",
      "volume": "5",
      "author": "CL Gee",
      "year": "2012",
      "journal-title": "Sci Signal"
    },
    {
      "key": "ref40",
      "doi-asserted-by": "crossref",
      "first-page": "e1002938",
      "DOI": "10.1371/journal.ppat.1002938",
      "article-title": "Acid-induced type VI secretion system is regulated by ExoR-ChvG/ChvI signaling cascade in <italic>Agrobacterium tumefaciens</italic>",
      "volume": "8",
      "author": "CF Wu",
      "year": "2012",
      "journal-title": "PLoS Pathog"
    },
    {
      "key": "ref41",
      "doi-asserted-by": "crossref",
      "first-page": "2841",
      "DOI": "10.1128/JB.01775-07",
      "article-title": "Secretome analysis uncovers an Hcp-family protein secreted via a type VI secretion system in <italic>Agrobacterium tumefaciens</italic>",
      "volume": "190",
      "author": "HY Wu",
      "year": "2008",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "ref42",
      "doi-asserted-by": "crossref",
      "first-page": "576",
      "DOI": "10.1096/fasebj.9.8.7768349",
      "article-title": "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification",
      "volume": "9",
      "author": "SK Hanks",
      "year": "1995",
      "journal-title": "FASEB J"
    },
    {
      "key": "ref43",
      "doi-asserted-by": "crossref",
      "first-page": "575",
      "DOI": "10.1021/bi201709w",
      "article-title": "Structural delineation of MDC1-FHA domain binding with CHK2-pThr68",
      "volume": "51",
      "author": "HH Wu",
      "year": "2012",
      "journal-title": "Biochemistry"
    },
    {
      "key": "ref44",
      "doi-asserted-by": "crossref",
      "first-page": "8889",
      "DOI": "10.1073/pnas.93.17.8889",
      "article-title": "<italic>Agrobacterium tumefaciens</italic> VirB7 and VirB9 form a disulfide-linked protein complex",
      "volume": "93",
      "author": "LB Anderson",
      "year": "1996",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref45",
      "doi-asserted-by": "crossref",
      "first-page": "1372",
      "DOI": "10.1111/j.1365-2672.2008.03874.x",
      "article-title": "A citrate-inducible gene, encoding a putative tricarboxylate transporter, is downregulated by the organic solvent DMSO in <italic>Agrobacterium tumefaciens</italic>",
      "volume": "105",
      "author": "AC Liu",
      "year": "2008",
      "journal-title": "J Appl Microbiol"
    },
    {
      "key": "ref46",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1016/S0378-1119(02)00385-2",
      "article-title": "An <italic>Agrobacterium</italic> gene involved in tumorigenesis encodes an outer membrane protein exposed on the bacterial cell surface",
      "volume": "284",
      "author": "YH Jia",
      "year": "2002",
      "journal-title": "Gene"
    },
    {
      "key": "ref47",
      "doi-asserted-by": "crossref",
      "first-page": "3102",
      "DOI": "10.1128/jb.176.11.3102-3110.1994",
      "article-title": "The response of a <italic>Bacillus subtilis</italic> temperature-sensitive <italic>sigA</italic> mutant to heat stress",
      "volume": "176",
      "author": "BY Chang",
      "year": "1994",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "ref48",
      "doi-asserted-by": "crossref",
      "first-page": "494",
      "DOI": "10.1128/JB.01387-07",
      "article-title": "Transcriptome profiling and functional analysis of <italic>Agrobacterium tumefaciens</italic> reveals a general conserved response to acidic conditions (pH 5.5) and a complex acid-mediated signaling involved in <italic>Agrobacterium</italic>-plant interactions",
      "volume": "190",
      "author": "ZC Yuan",
      "year": "2008",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "ref49",
      "doi-asserted-by": "crossref",
      "first-page": "12369",
      "DOI": "10.1073/pnas.192439499",
      "article-title": "A global pH sensor: <italic>Agrobacterium</italic> sensor protein ChvG regulates acid-inducible genes on its two chromosomes and Ti plasmid",
      "volume": "99",
      "author": "L Li",
      "year": "2002",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref50",
      "doi-asserted-by": "crossref",
      "first-page": "6039",
      "DOI": "10.1128/JB.187.17.6039-6045.2005",
      "article-title": "Phosphoenolpyruvate carboxykinase is an acid-induced, chromosomally encoded virulence factor in <italic>Agrobacterium tumefaciens</italic>",
      "volume": "187",
      "author": "P Liu",
      "year": "2005",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "ref51",
      "doi-asserted-by": "crossref",
      "first-page": "767",
      "DOI": "10.1016/j.molcel.2008.05.013",
      "article-title": "Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade",
      "volume": "30",
      "author": "H Lee",
      "year": "2008",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref52",
      "doi-asserted-by": "crossref",
      "first-page": "1809",
      "DOI": "10.1534/genetics.108.095539",
      "article-title": "Recruitment of <italic>Saccharomyces cerevisiae</italic> Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain",
      "volume": "180",
      "author": "PL Palmbos",
      "year": "2008",
      "journal-title": "Genetics"
    },
    {
      "key": "ref53",
      "doi-asserted-by": "crossref",
      "first-page": "1526",
      "DOI": "10.1126/science.1128393",
      "article-title": "A virulence locus of <italic>Pseudomonas aeruginosa</italic> encodes a protein secretion apparatus",
      "volume": "312",
      "author": "JD Mougous",
      "year": "2006",
      "journal-title": "Science"
    },
    {
      "key": "ref54",
      "doi-asserted-by": "crossref",
      "first-page": "969",
      "DOI": "10.1094/Phyto-60-969",
      "article-title": "Selective media for isolation of <italic>Agrobacterium</italic>, <italic>Corynebacterium</italic>, <italic>Erwinia</italic>, <italic>Pseudomonas</italic>, and <italic>Xanthomonas</italic>",
      "volume": "60",
      "author": "CI Kado",
      "year": "1970",
      "journal-title": "Phytopathology"
    },
    {
      "key": "ref55",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1128/jb.62.3.293-300.1951",
      "article-title": "Studies on lysogenesis. I. The mode of phage liberation by lysogenic <italic>Escherichia coli</italic>",
      "volume": "62",
      "author": "G Bertani",
      "year": "1951",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "ref56",
      "doi-asserted-by": "crossref",
      "first-page": "2711",
      "DOI": "10.1128/JB.180.10.2711-2717.1998",
      "article-title": "Processed VirB2 is the major subunit of the promiscuous pilus of <italic>Agrobacterium tumefaciens</italic>",
      "volume": "180",
      "author": "EM Lai",
      "year": "1998",
      "journal-title": "J Bacteriol"
    },
    {
      "key": "ref57",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1016/0378-1119(93)90611-6",
      "article-title": "Versatile suicide vectors which allow direct selection for gene replacement in gram-negative bacteria",
      "volume": "127",
      "author": "J Quandt",
      "year": "1993",
      "journal-title": "Gene"
    },
    {
      "key": "ref58",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/0003-2697(92)90061-B",
      "article-title": "In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis",
      "volume": "203",
      "author": "J Rosenfeld",
      "year": "1992",
      "journal-title": "Anal Biochem"
    },
    {
      "key": "ref59",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1006/abio.1995.1070",
      "article-title": "Improvement of an \u201cIn-Gel\u201d digestion procedure for the micropreparation of internal protein fragments for amino acid sequencing",
      "volume": "224",
      "author": "U Hellman",
      "year": "1995",
      "journal-title": "Anal Biochem"
    }
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