DOI: 10.1371/journal.ppat.1002135. Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin

Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin

10.1371/journal.ppat.1002135

Crossref journal-article

Public Library of Science (PLoS)

PLoS Pathogens (340)

Bibliography

Iacovache, I., Degiacomi, M. T., Pernot, L., Ho, S., Schiltz, M., Dal Peraro, M., & van der Goot, F. G. (2011). Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin. PLoS Pathogens, 7(7), e1002135.

Authors 7

Ioan Iacovache (first)
Matteo T. Degiacomi (additional)
Lucile Pernot (additional)
Sylvia Ho (additional)
Marc Schiltz (additional)
Matteo Dal Peraro (additional)
F. Gisou van der Goot (additional)

References 30 Referenced 69

10.1016/j.ceb.2009.04.003 / Curr Opin Cell Biol / Membrane injury by pore-forming proteins. by M Bischofberger (2009)
10.1016/j.bbamem.2008.01.026 / Biochim Biophys Acta / Pore formation: an ancient yet complex form of attack. by I Iacovache (2008)
10.1074/jbc.273.49.32656 / J Biol Chem / The pore-forming toxin proaerolysin is processed by furin. by L Abrami (1998)
10.1128/JB.163.1.336-340.1985 / J Bacteriol / Activation of the hole forming toxin aerolysin by extracellular processing. by SP Howard (1985)
10.1038/367292a0 / Nature / Structure of the <italic>Aeromonas</italic> toxin proaerolysin in its water-soluble and membrane-channel states. by MW Parker (1994)
{'key': 'ref6', 'first-page': '608', 'article-title': 'Aerolysin and related Aeromonas toxins.', 'author': 'L Gurcel', 'year': '2005'} / Aerolysin and related Aeromonas toxins. by L Gurcel (2005)
10.1038/sj.emboj.7600959 / Embo J / A rivet model for channel formation by aerolysin-like pore-forming toxins. by I Iacovache (2006)
10.1021/ar020082r / Acc Chem Res / Molecular dynamics simulations of biomolecules. by M Karplus (2002)
10.1529/biophysj.104.058727 / Biophys J / Imaging alpha-hemolysin with molecular dynamics: ionic conductance, osmotic permeability, and the electrostatic potential map. by A Aksimentiev (2005)
10.1073/pnas.0502947102 / Proc Natl Acad Sci U S A / Orientation discrimination of single-stranded DNA inside the alpha-hemolysin membrane channel. by J Mathe (2005)
10.1021/bi00050a028 / Biochemistry / Protonation of His-132 promotes oligomerization of the channel-forming toxin Aerolysin. by JT Buckley (1995)
10.1107/S1744309110041035 / Acta Crystallogr Sect F Struct Biol Cryst Commun / Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in their proteolyzed forms. by L Pernot (2010)
10.1016/S0021-9258(18)43841-0 / J Biol Chem / The C-terminal peptide produced upon proteolytic activation of the cytolytic toxin aerolysin is not involved in channel formation. by FG van der Goot (1994)
10.1074/jbc.274.51.36722 / J Biol Chem / Increased stability upon heptamerization of the pore-forming toxin aerolysin. by C Lesieur (1999)
10.1016/j.jmb.2007.07.004 / J Mol Biol / Molecular principles of the interactions of disordered proteins. by B Meszaros (2007)
10.1021/bi00151a026 / Biochemistry / Spectroscopic study of the activation and oligomerization of the channel-forming toxin aerolysin: Identification of the site of proteolytic activation. by FG van der Goot (1992)
10.1046/j.1365-2958.1997.4541820.x / Mol Microbiol / The propeptide of Clostridium septicum alpha toxin functions as an intramolecular chaperone and is a potent inhibitor of alpha toxin- dependent cytolysis. by BR Sellman (1997)
10.1016/j.sbi.2008.10.005 / Curr Opin Struct Biol / The intramolecular chaperone-mediated protein folding. by YJ Chen (2008)
10.1016/S0021-9258(18)47646-6 / J Biol Chem / Requirement of pro-sequence for the production of active subtilisin E in Escherichia coli. by H Ikemura (1987)
10.1271/bbb.60.1551 / Biosci Biotechnol Biochem / Extracellular production of a Serratia marcescens serine protease in Escherichia coli. by Y Ohnishi (1996)
10.1093/emboj/16.24.7287 / EMBO J / Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain. by R Uellner (1997)
10.1074/jbc.M404369200 / J Biol Chem / The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of this monozinc aminopeptidase. by R Rozenfeld (2004)
10.1074/jbc.M204116200 / J Biol Chem / Sucrase is an intramolecular chaperone located at the C-terminal end of the sucrase-isomaltase enzyme complex. by R Jacob (2002)
10.1093/protein/12.9.713 / Protein Eng / Folding funnels and binding mechanisms. by B Ma (1999)
10.1073/pnas.96.18.9970 / Proc Natl Acad Sci U S A / Folding and binding cascades: shifts in energy landscapes. by CJ Tsai (1999)
10.1110/ps.9.1.10 / Protein Sci / Folding and binding cascades: dynamic landscapes and population shifts. by S Kumar (2000)
10.1002/jcc.20290 / J Comput Chem / The Amber biomolecular simulation programs. by DA Case (2005)
10.1002/jcc.20289 / J Comput Chem / Scalable molecular dynamics with NAMD. by JC Phillips (2005)
10.1063/1.1389854 / J Chem Phys / Optimized particle-mesh Ewald/multiple-time step integration for molecular dynamics simulations. by PF Batcho (2001)
10.1016/0263-7855(96)00018-5 / J Mol Graph / VMD: visual molecular dynamics. by W Humphrey (1996)

Dates

Type	When
Created	14 years, 1 month ago (July 14, 2011, 4:53 p.m.)
Deposited	3 years, 9 months ago (Nov. 27, 2021, 9:19 p.m.)
Indexed	1 month ago (July 30, 2025, 10:59 a.m.)
Issued	14 years, 1 month ago (July 14, 2011)
Published	14 years, 1 month ago (July 14, 2011)
Published Online	14 years, 1 month ago (July 14, 2011)

Funders 0

None

BibTeX

@article{Iacovache_2011, title={Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin}, volume={7}, ISSN={1553-7374}, url={http://dx.doi.org/10.1371/journal.ppat.1002135}, DOI={10.1371/journal.ppat.1002135}, number={7}, journal={PLoS Pathogens}, publisher={Public Library of Science (PLoS)}, author={Iacovache, Ioan and Degiacomi, Matteo T. and Pernot, Lucile and Ho, Sylvia and Schiltz, Marc and Dal Peraro, Matteo and van der Goot, F. Gisou}, editor={Roy, Craig R.}, year={2011}, month=jul, pages={e1002135} }

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