DOI: 10.1371/journal.ppat.1000437. Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

10.1371/journal.ppat.1000437

Crossref journal-article

Public Library of Science (PLoS)

PLoS Pathogens (340)

Bibliography

Bushman, F. D., Malani, N., Fernandes, J., DâOrso, I., Cagney, G., Diamond, T. L., Zhou, H., Hazuda, D. J., Espeseth, A. S., KÃ¶nig, R., Bandyopadhyay, S., Ideker, T., Goff, S. P., Krogan, N. J., Frankel, A. D., Young, J. A. T., & Chanda, S. K. (2009). Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies. PLoS Pathogens, 5(5), e1000437.

Authors 17

Frederic D. Bushman (first)
Nirav Malani (additional)
Jason Fernandes (additional)
Iván D'Orso (additional)
Gerard Cagney (additional)
Tracy L. Diamond (additional)
Honglin Zhou (additional)
Daria J. Hazuda (additional)
Amy S. Espeseth (additional)
Renate König (additional)
Sourav Bandyopadhyay (additional)
Trey Ideker (additional)
Stephen P. Goff (additional)
Nevan J. Krogan (additional)
Alan D. Frankel (additional)
John A. T. Young (additional)
Sumit K. Chanda (additional)

References 62 Referenced 366

10.1016/S0076-6879(06)14028-8 / Methods Enzymol / High-content screening of functional genomic libraries. by DR Rines (2006)
10.1126/science.1152725 / Science / Identification of host proteins required for HIV infection through a functional genomic screen. by AL Brass (2008)
10.1016/j.cell.2008.07.032 / Cell / Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. by R Konig (2008)
10.1016/j.chom.2008.10.004 / Cell Host Microbe / Genome-scale RNAi screen for host factors required for HIV replication. by H Zhou (2008)
10.1016/j.cell.2008.10.007 / Cell / Knockdown screens to knockout HIV-1. by SP Goff (2008)
10.1016/S0959-437X(02)00290-3 / Curr Opin Genet Dev / RNAi: Nature abhors a double-strand. by G Hutvagner (2002)
10.1038/nmeth1089 / Nat Methods / A probability-based approach for the analysis of large-scale RNAi screens. by R Konig (2007)
10.1126/science.1143767 / Science / A whole-genome association study of major determinants for host control of HIV-1. by J Fellay (2007)
10.1128/JVI.01013-06 / J Virol / Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages. by E Chertova (2006)
10.1186/1742-4690-5-48 / Retrovirology / Host proteins interacting with the moloney murine leukemia virus integrase: Multiple transcriptional regulators and chromatin binding factors. by B Studamire (2008)
10.1093/nar/gkn708 / Nucleic Acids Res / Human immunodeficiency virus type 1, human protein interaction database at NCBI. by W Fu (2009)
10.1038/nature07151 / Nature / Drosophila RNAi screen identifies host genes important for influenza virus replication. by L Hao (2008)
10.1038/nature07207 / Nature / RNA interference screen for human genes associated with west nile virus infection. by MN Krishnan (2008)
10.1109/IEMBS.2006.260828 / Conf Proc IEEE Eng Med Biol Soc / Overlapping probabilities of top ranking gene lists, hypergeometric distribution, and stringency of gene selection criterion. by W Fury (2006)
10.1186/gb-2003-4-5-p3 / Genome Bio / Database for annotation, visualization, and integrated discovery. by G Dennis (2003)
10.1016/S0092-8674(00)80939-3 / Cell / A novel CDK9-associated C-type cyclin interacts directly with HIV-1 tat and mediates its high-affinity, loop-specific binding to TAR RNA. by P Wei (1998)
10.1016/j.cell.2004.09.029 / Cell / Requirement of DDX3 DEAD box RNA helicase for HIV-1 rev-RRE export function. by VS Yedavalli (2004)
10.1016/S0042-6822(03)00455-0 / Virology / Roles of host cell factors in circularization of retroviral DNA. by JM Kilzer (2003)
10.1016/S0092-8674(01)00506-2 / Cell / Tsg101 and the vacuolar protein sorting pathway are essential for hiv-1 budding. by JE Garrus (2001)
10.1016/S0960-9822(06)00335-6 / Curr Biol / The importin-beta family member Crm1p bridges the interaction between rev and the nuclear pore complex during nuclear export. by M Neville (1997)
10.1128/JVI.00580-08 / J Virol / Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. by PC Matthews (2008)
10.1126/science.1132319 / Science / An essential role for LEDGF/p75 in HIV integration. by M Llano (2006)
10.1371/journal.pone.0001340 / PLoS ONE / Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. by H Marshall (2007)
{'key': 'ref24', 'first-page': '960', 'article-title': 'Fusions of LEDGF/p75 to lambda repressor promote HIV DNA integration near lambda operators in vitro.', 'volume': '17', 'author': 'A Ciuffi', 'year': '2006', 'journal-title': 'Hum Gene Ther'} / Hum Gene Ther / Fusions of LEDGF/p75 to lambda repressor promote HIV DNA integration near lambda operators in vitro. by A Ciuffi (2006)
10.1128/JVI.78.17.9524-9537.2004 / J Virol / LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. by M Llano (2004)
10.1093/nar/gkl885 / Nucleic Acids Res / LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro. by P Cherepanov (2007)
10.1074/jbc.M209278200 / J Biol Chem / HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. by P Cherepanov (2003)
10.1074/jbc.M303594200 / J Biol Chem / LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. by G Maertens (2003)
10.1038/nm1329 / Nat Med / A role for LEDGF/p75 in targeting HIV DNA integration. by A Ciuffi (2005)
10.2741/1472 / Front Biosci / Human cell proteins and human immunodeficiency virus DNA integration. by F Turlure (2004)
10.1016/S0092-8674(00)81823-1 / Cell / Crystal structure of human cyclophillin A bound to the amino-terminal domain of HIV-1 capsid. by TR Gamble (1996)
10.1016/S0092-8674(03)00714-1 / Cell / The protein network of HIV budding. by UK von Schwedler (2003)
10.1186/1742-4690-2-63 / Retrovirology / DBR1 siRNA inhibition of HIV-1 replication. by Y Ye (2005)
10.1186/1471-2105-4-2 / BMC Bioinformatics / An automated method for finding molecular complexes in large protein interaction networks. by GD Bader (2003)
10.1128/JVI.72.5.3845-3850.1998 / J Virol / Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1. by O Schwartz (1998)
{'key': 'ref36', 'first-page': '3739', 'article-title': 'HIV cDNA metabolism studied by fluorescence-monitored PCR: Notable stability of two-LTR circles.', 'volume': '76', 'author': 'SL Butler', 'year': '2002', 'journal-title': 'J Virol'} / J Virol / HIV cDNA metabolism studied by fluorescence-monitored PCR: Notable stability of two-LTR circles. by SL Butler (2002)
10.1073/pnas.2036346100 / Proc Natl Acad Sci U S A / Association of the mediator complex with enhancers of active genes. by L Kuras (2003)
10.1073/pnas.0704138104 / Proc Natl Acad Sci U S A / The molecular basis of eukaryotic transcription. by RD Kornberg (2007)
10.2353/ajpath.2007.070017 / Am J Pathol / Gastrointestinal disease in SIV-infected rhesus macaques is characterized by proinflammatory dysregulation of the IL-6-JAK-STAT3 pathway. by M Mohan (2007)
10.1128/JVI.76.10.5108-5120.2002 / J Virol / Positive and negative modulation of human immunodeficiency virus type 1 rev function by cis and trans regulators of viral RNA splicing. by J Pongoski (2002)
{'key': 'ref41', 'first-page': '12625', 'article-title': 'Association of RNA helicase a with human immunodeficiency virus type 1 particles.', 'volume': '281(18)', 'author': 'BB Roy', 'year': '2006', 'journal-title': 'J Biol Chem'} / J Biol Chem / Association of RNA helicase a with human immunodeficiency virus type 1 particles. by BB Roy (2006)
10.1073/pnas.96.2.709 / Proc Natl Acad Sci U S A / A role for RNA helicase A in post-transcriptional regulation of HIV type 1. by J Li (1999)
10.1101/gad.1565107 / Genes Dev / LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. by MC Shun (2007)
10.1089/hum.2006.17.960 / Hum Gene Ther / Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factor. by A Ciuffi (2006)
10.1093/emboj/17.22.6723 / EMBO J / Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. by H Ge (1998)
10.1016/S0092-8674(02)00864-4 / Cell / HIV-1 integration in the human genome favors active genes and local hotspots. by AR Schroder (2002)
10.1371/journal.pbio.0020234 / PLoS Biol / Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. by RS Mitchell (2004)
10.1126/science.1083413 / Science / Transcription start regions in the human genome are favored targets for MLV integration. by X Wu (2003)
10.1128/JVI.65.4.2047-2055.1991 / J Virol / Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein. by PL Earl (1991)
10.1016/j.cub.2008.07.037 / Curr Biol / HIV-1 infection: Going nuclear with TNPO3/Transportin-SR2 and integrase. by J Luban (2008)
10.1016/j.cub.2008.07.079 / Curr Biol / Transportin-SR2 imports HIV into the nucleus. by F Christ (2008)
10.1091/mbc.E04-07-0583 / Mol Biol Cell / The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 vpr. by P Varadarajan (2005)
10.1128/JVI.73.1.120-127.1999 / J Virol / Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 rev. by AS Zolotukhin (1999)
10.1111/j.1471-4159.2006.03805.x / J Neurochem / Apolipoprotein A-I increases association of cytosolic cholesterol and caveolin-1 with microtubule cytoskeletons in rat astrocytes. by J Ito (2006)
10.1083/jcb.200203150 / J Cell Biol / Visualization of the intracellular behavior of HIV in living cells. by D McDonald (2002)
10.1038/nrd892 / Nat Rev Drug Discov / The druggable genome. by AL Hopkins (2002)
10.1517/14728222.8.6.587 / Expert Opin Ther Targets / The promise of genomics to identify novel therapeutic targets. by AP Orth (2004)
10.1016/S0166-3542(97)00025-9 / Antiviral Res / Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4. by D Schols (1997)
10.1128/JVI.01303-08 / J Virol / Baseline resistance of primary HIV-1 strains to the CXCR4 inhibitor AMD3100. by JE Harrison (2008)
10.1186/1742-4690-5-11 / Retrovirology / Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. by P Chugh (2008)
{'key': 'ref61', 'article-title': 'R: A language and environment for statistical computing.', 'year': '2006', 'journal-title': 'R Foundation for Statistical Computing'} / R Foundation for Statistical Computing / R: A language and environment for statistical computing. (2006)
10.1038/nature04670 / Nature / Global landscape of protein complexes in the yeast saccharomyces cerevisiae. by NJ Krogan (2006)

Dates

Type	When
Created	16 years, 3 months ago (May 28, 2009, 5:32 p.m.)
Deposited	5 years, 3 months ago (May 18, 2020, 5:20 p.m.)
Indexed	4 days, 8 hours ago (Aug. 24, 2025, 7:08 p.m.)
Issued	16 years, 3 months ago (May 29, 2009)
Published	16 years, 3 months ago (May 29, 2009)
Published Online	16 years, 3 months ago (May 29, 2009)

Funders 0

None

BibTeX

@article{Bushman_2009, title={Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies}, volume={5}, ISSN={1553-7374}, url={http://dx.doi.org/10.1371/journal.ppat.1000437}, DOI={10.1371/journal.ppat.1000437}, number={5}, journal={PLoS Pathogens}, publisher={Public Library of Science (PLoS)}, author={Bushman, Frederic D. and Malani, Nirav and Fernandes, Jason and D’Orso, Iván and Cagney, Gerard and Diamond, Tracy L. and Zhou, Honglin and Hazuda, Daria J. and Espeseth, Amy S. and König, Renate and Bandyopadhyay, Sourav and Ideker, Trey and Goff, Stephen P. and Krogan, Nevan J. and Frankel, Alan D. and Young, John A. T. and Chanda, Sumit K.}, editor={Rall, Glenn F.}, year={2009}, month=may, pages={e1000437} }

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      "DOI": "10.1016/S0076-6879(06)14028-8",
      "article-title": "High-content screening of functional genomic libraries.",
      "volume": "414",
      "author": "DR Rines",
      "year": "2006",
      "journal-title": "Methods Enzymol"
    },
    {
      "key": "ref2",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1126/science.1152725",
      "article-title": "Identification of host proteins required for HIV infection through a functional genomic screen.",
      "volume": "319(5865)",
      "author": "AL Brass",
      "year": "2008",
      "journal-title": "Science"
    },
    {
      "key": "ref3",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1016/j.cell.2008.07.032",
      "article-title": "Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.",
      "volume": "135(1)",
      "author": "R Konig",
      "year": "2008",
      "journal-title": "Cell"
    },
    {
      "key": "ref4",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1016/j.chom.2008.10.004",
      "article-title": "Genome-scale RNAi screen for host factors required for HIV replication.",
      "volume": "4(5)",
      "author": "H Zhou",
      "year": "2008",
      "journal-title": "Cell Host Microbe"
    },
    {
      "key": "ref5",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1016/j.cell.2008.10.007",
      "article-title": "Knockdown screens to knockout HIV-1.",
      "volume": "135(3)",
      "author": "SP Goff",
      "year": "2008",
      "journal-title": "Cell"
    },
    {
      "key": "ref6",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1016/S0959-437X(02)00290-3",
      "article-title": "RNAi: Nature abhors a double-strand.",
      "volume": "12(2)",
      "author": "G Hutvagner",
      "year": "2002",
      "journal-title": "Curr Opin Genet Dev"
    },
    {
      "key": "ref7",
      "doi-asserted-by": "crossref",
      "first-page": "847",
      "DOI": "10.1038/nmeth1089",
      "article-title": "A probability-based approach for the analysis of large-scale RNAi screens.",
      "volume": "4(10)",
      "author": "R Konig",
      "year": "2007",
      "journal-title": "Nat Methods"
    },
    {
      "key": "ref8",
      "doi-asserted-by": "crossref",
      "first-page": "944",
      "DOI": "10.1126/science.1143767",
      "article-title": "A whole-genome association study of major determinants for host control of HIV-1.",
      "volume": "317(5840)",
      "author": "J Fellay",
      "year": "2007",
      "journal-title": "Science"
    },
    {
      "key": "ref9",
      "doi-asserted-by": "crossref",
      "first-page": "9039",
      "DOI": "10.1128/JVI.01013-06",
      "article-title": "Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages.",
      "volume": "80(18)",
      "author": "E Chertova",
      "year": "2006",
      "journal-title": "J Virol"
    },
    {
      "key": "ref10",
      "doi-asserted-by": "crossref",
      "first-page": "48",
      "DOI": "10.1186/1742-4690-5-48",
      "article-title": "Host proteins interacting with the moloney murine leukemia virus integrase: Multiple transcriptional regulators and chromatin binding factors.",
      "volume": "5",
      "author": "B Studamire",
      "year": "2008",
      "journal-title": "Retrovirology"
    },
    {
      "key": "ref11",
      "doi-asserted-by": "crossref",
      "first-page": "D417",
      "DOI": "10.1093/nar/gkn708",
      "article-title": "Human immunodeficiency virus type 1, human protein interaction database at NCBI.",
      "volume": "37(Database issue)",
      "author": "W Fu",
      "year": "2009",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "ref12",
      "doi-asserted-by": "crossref",
      "first-page": "890",
      "DOI": "10.1038/nature07151",
      "article-title": "Drosophila RNAi screen identifies host genes important for influenza virus replication.",
      "volume": "454(7206)",
      "author": "L Hao",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "ref13",
      "doi-asserted-by": "crossref",
      "first-page": "242",
      "DOI": "10.1038/nature07207",
      "article-title": "RNA interference screen for human genes associated with west nile virus infection.",
      "volume": "455(7210)",
      "author": "MN Krishnan",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "ref14",
      "doi-asserted-by": "crossref",
      "first-page": "5531",
      "DOI": "10.1109/IEMBS.2006.260828",
      "article-title": "Overlapping probabilities of top ranking gene lists, hypergeometric distribution, and stringency of gene selection criterion.",
      "volume": "1",
      "author": "W Fury",
      "year": "2006",
      "journal-title": "Conf Proc IEEE Eng Med Biol Soc"
    },
    {
      "key": "ref15",
      "doi-asserted-by": "crossref",
      "first-page": "P3",
      "DOI": "10.1186/gb-2003-4-5-p3",
      "article-title": "Database for annotation, visualization, and integrated discovery.",
      "volume": "4",
      "author": "G Dennis",
      "year": "2003",
      "journal-title": "Genome Bio"
    },
    {
      "key": "ref16",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1016/S0092-8674(00)80939-3",
      "article-title": "A novel CDK9-associated C-type cyclin interacts directly with HIV-1 tat and mediates its high-affinity, loop-specific binding to TAR RNA.",
      "volume": "92",
      "author": "P Wei",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "ref17",
      "doi-asserted-by": "crossref",
      "first-page": "381",
      "DOI": "10.1016/j.cell.2004.09.029",
      "article-title": "Requirement of DDX3 DEAD box RNA helicase for HIV-1 rev-RRE export function.",
      "volume": "119(3)",
      "author": "VS Yedavalli",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "ref18",
      "doi-asserted-by": "crossref",
      "first-page": "460",
      "DOI": "10.1016/S0042-6822(03)00455-0",
      "article-title": "Roles of host cell factors in circularization of retroviral DNA.",
      "volume": "314",
      "author": "JM Kilzer",
      "year": "2003",
      "journal-title": "Virology"
    },
    {
      "key": "ref19",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1016/S0092-8674(01)00506-2",
      "article-title": "Tsg101 and the vacuolar protein sorting pathway are essential for hiv-1 budding.",
      "volume": "107(1)",
      "author": "JE Garrus",
      "year": "2001",
      "journal-title": "Cell"
    },
    {
      "key": "ref20",
      "doi-asserted-by": "crossref",
      "first-page": "767",
      "DOI": "10.1016/S0960-9822(06)00335-6",
      "article-title": "The importin-beta family member Crm1p bridges the interaction between rev and the nuclear pore complex during nuclear export.",
      "volume": "7(10)",
      "author": "M Neville",
      "year": "1997",
      "journal-title": "Curr Biol"
    },
    {
      "key": "ref21",
      "doi-asserted-by": "crossref",
      "first-page": "8548",
      "DOI": "10.1128/JVI.00580-08",
      "article-title": "Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.",
      "volume": "82(17)",
      "author": "PC Matthews",
      "year": "2008",
      "journal-title": "J Virol"
    },
    {
      "key": "ref22",
      "doi-asserted-by": "crossref",
      "first-page": "461",
      "DOI": "10.1126/science.1132319",
      "article-title": "An essential role for LEDGF/p75 in HIV integration.",
      "volume": "314(5798)",
      "author": "M Llano",
      "year": "2006",
      "journal-title": "Science"
    },
    {
      "key": "ref23",
      "doi-asserted-by": "crossref",
      "first-page": "e1340",
      "DOI": "10.1371/journal.pone.0001340",
      "article-title": "Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.",
      "volume": "2(12)",
      "author": "H Marshall",
      "year": "2007",
      "journal-title": "PLoS ONE"
    },
    {
      "key": "ref24",
      "first-page": "960",
      "article-title": "Fusions of LEDGF/p75 to lambda repressor promote HIV DNA integration near lambda operators in vitro.",
      "volume": "17",
      "author": "A Ciuffi",
      "year": "2006",
      "journal-title": "Hum Gene Ther"
    },
    {
      "key": "ref25",
      "doi-asserted-by": "crossref",
      "first-page": "9524",
      "DOI": "10.1128/JVI.78.17.9524-9537.2004",
      "article-title": "LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes.",
      "volume": "78(17)",
      "author": "M Llano",
      "year": "2004",
      "journal-title": "J Virol"
    },
    {
      "key": "ref26",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1093/nar/gkl885",
      "article-title": "LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.",
      "volume": "35(1)",
      "author": "P Cherepanov",
      "year": "2007",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "ref27",
      "doi-asserted-by": "crossref",
      "first-page": "372",
      "DOI": "10.1074/jbc.M209278200",
      "article-title": "HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.",
      "volume": "278",
      "author": "P Cherepanov",
      "year": "2003",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref28",
      "doi-asserted-by": "crossref",
      "first-page": "33528",
      "DOI": "10.1074/jbc.M303594200",
      "article-title": "LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.",
      "volume": "278",
      "author": "G Maertens",
      "year": "2003",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref29",
      "doi-asserted-by": "crossref",
      "first-page": "1287",
      "DOI": "10.1038/nm1329",
      "article-title": "A role for LEDGF/p75 in targeting HIV DNA integration.",
      "volume": "11(12)",
      "author": "A Ciuffi",
      "year": "2005",
      "journal-title": "Nat Med"
    },
    {
      "key": "ref30",
      "doi-asserted-by": "crossref",
      "first-page": "3187",
      "DOI": "10.2741/1472",
      "article-title": "Human cell proteins and human immunodeficiency virus DNA integration.",
      "volume": "9",
      "author": "F Turlure",
      "year": "2004",
      "journal-title": "Front Biosci"
    },
    {
      "key": "ref31",
      "doi-asserted-by": "crossref",
      "first-page": "1285",
      "DOI": "10.1016/S0092-8674(00)81823-1",
      "article-title": "Crystal structure of human cyclophillin A bound to the amino-terminal domain of HIV-1 capsid.",
      "volume": "87",
      "author": "TR Gamble",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "ref32",
      "doi-asserted-by": "crossref",
      "first-page": "701",
      "DOI": "10.1016/S0092-8674(03)00714-1",
      "article-title": "The protein network of HIV budding.",
      "volume": "114(6)",
      "author": "UK von Schwedler",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "ref33",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1186/1742-4690-2-63",
      "article-title": "DBR1 siRNA inhibition of HIV-1 replication.",
      "volume": "2",
      "author": "Y Ye",
      "year": "2005",
      "journal-title": "Retrovirology"
    },
    {
      "key": "ref34",
      "doi-asserted-by": "crossref",
      "first-page": "2",
      "DOI": "10.1186/1471-2105-4-2",
      "article-title": "An automated method for finding molecular complexes in large protein interaction networks.",
      "volume": "4",
      "author": "GD Bader",
      "year": "2003",
      "journal-title": "BMC Bioinformatics"
    },
    {
      "key": "ref35",
      "doi-asserted-by": "crossref",
      "first-page": "3845",
      "DOI": "10.1128/JVI.72.5.3845-3850.1998",
      "article-title": "Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1.",
      "volume": "72",
      "author": "O Schwartz",
      "year": "1998",
      "journal-title": "J Virol"
    },
    {
      "key": "ref36",
      "first-page": "3739",
      "article-title": "HIV cDNA metabolism studied by fluorescence-monitored PCR: Notable stability of two-LTR circles.",
      "volume": "76",
      "author": "SL Butler",
      "year": "2002",
      "journal-title": "J Virol"
    },
    {
      "key": "ref37",
      "doi-asserted-by": "crossref",
      "first-page": "13887",
      "DOI": "10.1073/pnas.2036346100",
      "article-title": "Association of the mediator complex with enhancers of active genes.",
      "volume": "100(24)",
      "author": "L Kuras",
      "year": "2003",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref38",
      "doi-asserted-by": "crossref",
      "first-page": "12955",
      "DOI": "10.1073/pnas.0704138104",
      "article-title": "The molecular basis of eukaryotic transcription.",
      "volume": "104(32)",
      "author": "RD Kornberg",
      "year": "2007",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref39",
      "doi-asserted-by": "crossref",
      "first-page": "1952",
      "DOI": "10.2353/ajpath.2007.070017",
      "article-title": "Gastrointestinal disease in SIV-infected rhesus macaques is characterized by proinflammatory dysregulation of the IL-6-JAK-STAT3 pathway.",
      "volume": "171(6)",
      "author": "M Mohan",
      "year": "2007",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "ref40",
      "doi-asserted-by": "crossref",
      "first-page": "5108",
      "DOI": "10.1128/JVI.76.10.5108-5120.2002",
      "article-title": "Positive and negative modulation of human immunodeficiency virus type 1 rev function by cis and trans regulators of viral RNA splicing.",
      "volume": "76(10)",
      "author": "J Pongoski",
      "year": "2002",
      "journal-title": "J Virol"
    },
    {
      "key": "ref41",
      "first-page": "12625",
      "article-title": "Association of RNA helicase a with human immunodeficiency virus type 1 particles.",
      "volume": "281(18)",
      "author": "BB Roy",
      "year": "2006",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref42",
      "doi-asserted-by": "crossref",
      "first-page": "709",
      "DOI": "10.1073/pnas.96.2.709",
      "article-title": "A role for RNA helicase A in post-transcriptional regulation of HIV type 1.",
      "volume": "96(2)",
      "author": "J Li",
      "year": "1999",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref43",
      "doi-asserted-by": "crossref",
      "first-page": "1767",
      "DOI": "10.1101/gad.1565107",
      "article-title": "LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration.",
      "volume": "21(14)",
      "author": "MC Shun",
      "year": "2007",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref44",
      "doi-asserted-by": "crossref",
      "first-page": "960",
      "DOI": "10.1089/hum.2006.17.960",
      "article-title": "Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factor.",
      "volume": "17(9)",
      "author": "A Ciuffi",
      "year": "2006",
      "journal-title": "Hum Gene Ther"
    },
    {
      "key": "ref45",
      "doi-asserted-by": "crossref",
      "first-page": "6723",
      "DOI": "10.1093/emboj/17.22.6723",
      "article-title": "Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.",
      "volume": "17",
      "author": "H Ge",
      "year": "1998",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref46",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1016/S0092-8674(02)00864-4",
      "article-title": "HIV-1 integration in the human genome favors active genes and local hotspots.",
      "volume": "110(4)",
      "author": "AR Schroder",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "ref47",
      "doi-asserted-by": "crossref",
      "first-page": "e234",
      "DOI": "10.1371/journal.pbio.0020234",
      "article-title": "Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.",
      "volume": "2(8)",
      "author": "RS Mitchell",
      "year": "2004",
      "journal-title": "PLoS Biol"
    },
    {
      "key": "ref48",
      "doi-asserted-by": "crossref",
      "first-page": "1749",
      "DOI": "10.1126/science.1083413",
      "article-title": "Transcription start regions in the human genome are favored targets for MLV integration.",
      "volume": "300(5626)",
      "author": "X Wu",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "ref49",
      "doi-asserted-by": "crossref",
      "first-page": "2047",
      "DOI": "10.1128/JVI.65.4.2047-2055.1991",
      "article-title": "Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein.",
      "volume": "65(4)",
      "author": "PL Earl",
      "year": "1991",
      "journal-title": "J Virol"
    },
    {
      "key": "ref50",
      "doi-asserted-by": "crossref",
      "first-page": "R710",
      "DOI": "10.1016/j.cub.2008.07.037",
      "article-title": "HIV-1 infection: Going nuclear with TNPO3/Transportin-SR2 and integrase.",
      "volume": "18(16)",
      "author": "J Luban",
      "year": "2008",
      "journal-title": "Curr Biol"
    },
    {
      "key": "ref51",
      "doi-asserted-by": "crossref",
      "first-page": "1192",
      "DOI": "10.1016/j.cub.2008.07.079",
      "article-title": "Transportin-SR2 imports HIV into the nucleus.",
      "volume": "18(16)",
      "author": "F Christ",
      "year": "2008",
      "journal-title": "Curr Biol"
    },
    {
      "key": "ref52",
      "doi-asserted-by": "crossref",
      "first-page": "1823",
      "DOI": "10.1091/mbc.E04-07-0583",
      "article-title": "The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 vpr.",
      "volume": "16(4)",
      "author": "P Varadarajan",
      "year": "2005",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "ref53",
      "doi-asserted-by": "crossref",
      "first-page": "120",
      "DOI": "10.1128/JVI.73.1.120-127.1999",
      "article-title": "Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 rev.",
      "volume": "73(1)",
      "author": "AS Zolotukhin",
      "year": "1999",
      "journal-title": "J Virol"
    },
    {
      "key": "ref54",
      "doi-asserted-by": "crossref",
      "first-page": "1034",
      "DOI": "10.1111/j.1471-4159.2006.03805.x",
      "article-title": "Apolipoprotein A-I increases association of cytosolic cholesterol and caveolin-1 with microtubule cytoskeletons in rat astrocytes.",
      "volume": "97(4)",
      "author": "J Ito",
      "year": "2006",
      "journal-title": "J Neurochem"
    },
    {
      "key": "ref55",
      "doi-asserted-by": "crossref",
      "first-page": "441",
      "DOI": "10.1083/jcb.200203150",
      "article-title": "Visualization of the intracellular behavior of HIV in living cells.",
      "volume": "159(3)",
      "author": "D McDonald",
      "year": "2002",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "ref56",
      "doi-asserted-by": "crossref",
      "first-page": "727",
      "DOI": "10.1038/nrd892",
      "article-title": "The druggable genome.",
      "volume": "1(9)",
      "author": "AL Hopkins",
      "year": "2002",
      "journal-title": "Nat Rev Drug Discov"
    },
    {
      "key": "ref57",
      "doi-asserted-by": "crossref",
      "first-page": "587",
      "DOI": "10.1517/14728222.8.6.587",
      "article-title": "The promise of genomics to identify novel therapeutic targets.",
      "volume": "8(6)",
      "author": "AP Orth",
      "year": "2004",
      "journal-title": "Expert Opin Ther Targets"
    },
    {
      "key": "ref58",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.1016/S0166-3542(97)00025-9",
      "article-title": "Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.",
      "volume": "35(3)",
      "author": "D Schols",
      "year": "1997",
      "journal-title": "Antiviral Res"
    },
    {
      "key": "ref59",
      "doi-asserted-by": "crossref",
      "first-page": "11695",
      "DOI": "10.1128/JVI.01303-08",
      "article-title": "Baseline resistance of primary HIV-1 strains to the CXCR4 inhibitor AMD3100.",
      "volume": "82(23)",
      "author": "JE Harrison",
      "year": "2008",
      "journal-title": "J Virol"
    },
    {
      "key": "ref60",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1186/1742-4690-5-11",
      "article-title": "Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.",
      "volume": "5",
      "author": "P Chugh",
      "year": "2008",
      "journal-title": "Retrovirology"
    },
    {
      "key": "ref61",
      "article-title": "R: A language and environment for statistical computing.",
      "year": "2006",
      "journal-title": "R Foundation for Statistical Computing"
    },
    {
      "key": "ref62",
      "doi-asserted-by": "crossref",
      "first-page": "637",
      "DOI": "10.1038/nature04670",
      "article-title": "Global landscape of protein complexes in the yeast saccharomyces cerevisiae.",
      "volume": "440(7084)",
      "author": "NJ Krogan",
      "year": "2006",
      "journal-title": "Nature"
    }
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