DOI: 10.1371/journal.pone.0063557. Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein

Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein

10.1371/journal.pone.0063557

Crossref journal-article

Public Library of Science (PLoS)

PLoS ONE (340)

Bibliography

Sarafian, T. A., Ryan, C. M., Souda, P., Masliah, E., Kar, U. K., Vinters, H. V., Mathern, G. W., Faull, K. F., Whitelegge, J. P., & Watson, J. B. (2013). Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human Î±-Synuclein. PLoS ONE, 8(5), e63557.

Authors 10

Theodore A. Sarafian (first)
Christopher M. Ryan (additional)
Puneet Souda (additional)
Eliezer Masliah (additional)
Upendra K. Kar (additional)
Harry V. Vinters (additional)
Gary W. Mathern (additional)
Kym F. Faull (additional)
Julian P. Whitelegge (additional)
Joseph B. Watson (additional)

References 79 Referenced 39

10.1016/0169-328X(91)90043-W / Brain Res Mol Brain Res / The rat brain synucleins: family of proteins transiently associated with neuronal membrane by L Maroteaux (1991)
10.1016/S0166-2236(97)01213-7 / Trends Neurosci / The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration, and disease by DF Clayton (1998)
10.1074/jbc.273.16.9443 / J Biol Chem / Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes by WS Davidson (1998)
10.1016/j.cell.2005.09.028 / Cell / Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration by S Chandra (2005)
10.1074/jbc.M504894200 / J Biol Chem / A combinatorial code for the interaction of alpha-synuclein with membranes by S Kubo (2005)
10.1073/pnas.0710685105 / Proc Natl Acad Sci USA / The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis by AD Gitler (2008)
10.1523/JNEUROSCI.3088-08.2008 / J Neurosci / Optical reporters for the conformation of α-synuclein reveal a specific interaction with mitochondria by K Nakamura (2008)
10.1016/j.bbamem.2011.11.024 / Biochemica and Biophysica ACTA / Interaction of α-synuclein with vesicles that mimic mitochondrial membranes by IG Zigoneanu (2012)
10.1523/JNEUROSCI.22-20-08797.2002 / J Neurosci / Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking -synuclein by DE Cabin (2002)
10.1523/JNEUROSCI.3821-06.2006 / Neurosci / α-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis by KE Larsen (2006)
10.1016/j.neuroscience.2009.01.021 / Neurosci / Alterations in corticostriatal synaptic plasticity in mice overexpressing human α-synuclein by JB Watson (2009)
10.1002/jnr.22327 / J Neurosci Res / Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway by N-P Wu (2010)
10.1016/j.neuron.2009.12.023 / Neuron / Increased expression of α-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis by VM Nemani (2010)
10.1146/annurev-genom-082410-101440 / Annu Rev Genomics Hum Genet / Recent advances in the genetics of Parkinson’s Disease by I Martin (2011)
10.1016/S0079-6123(10)83007-9 / Prog Brain Res / Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies by A Oueslati (2010)
10.1016/S0197-4580(02)00065-9 / Neurobiol Aging / Staging of brain pathology related to sporadic Parkinson’s disease by H Braak (2003)
10.1016/j.neuron.2004.10.023 / Neuron / Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease by C Paisan-Ruiz (2004)
10.1074/jbc.M710012200 / J Biol Chem / Mitochondrial import and accumulation of α-synuclein impair Complex I in human dopaminergic neuronal cultures and Parkinson’s Disease brain by L Devi (2008)
10.1111/j.1471-4159.1990.tb02325.x / J Neurochem / Mitochondrial Complex I deficiency in Parkinson’s disease by AHV Schapira (1990)
10.1016/S0896-6273(03)00568-3 / Neuron / Parkinson’s disease: mechanisms and models by W Dauer (2003)
10.1016/j.biopha.2008.01.017 / Biomed Pharmacotherapy / Glutathione and Parkinson’s Disease: Is this the elephant in the room? by GD Zeevalk (2008)
10.1016/j.nbd.2009.01.016 / Neurobiol Dis / A highly reproducible rotenone model of Parkinson's disease by JR Cannon (2009)
10.1016/j.neulet.2009.02.056 / Neurosci Lett / α-synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity by G Liu (2009)
10.1074/jbc.M109.061051 / J Biol Chem / The transgenic overexpression of α-synuclein and not its related pathology associates with complex I inhibition by V Loeb (2010)
10.1016/j.neulet.2010.09.061 / Neurosci Lett / Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo by SJ Chinta (2010)
10.1089/ars.2011.4200 / Antioxid Redox Signal / Mitochondrial dysfunction in genetic animal models of Parkinson's disease by A Trancikova (2012)
10.1016/S0002-9440(10)64553-1 / Am J Pathol / alpha-synuclein promotes mitochondrial deficit and oxidative stress by LJ Hsu (2000)
10.1523/JNEUROSCI.4308-05.2006 / J Neurosci / Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death by LJ Martin (2006)
10.1016/j.biocel.2011.01.014 / Int J Biochem Cell Biol / α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator by Y Zhu (2011)
10.1074/jbc.M110.213538 / J Biol Chem / Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein by K Nakamura (2011)
10.1002/jnr.10231 / J Neurosci Res / Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters by E Rockenstein (2002)
10.1523/JNEUROSCI.3080-04.2004 / J Neurosci / Early and progressive sensorimotor anomalies in mice overexpressing wild-type human α-synuclein by SM Fleming (2004)
10.1016/j.neuroscience.2006.07.005 / Neuroscience / Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype α-synuclein by SM Fleming (2006)
10.1111/j.1460-9568.2008.06346.x / Eur J Neurosci / Olfactory deficits in mice overexpressing human wildtype alpha-synuclein by SM Fleming (2008)
10.1002/jnr.22611 / J Neurosci Res / Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein by HA Lam (2011)
10.1016/S0165-0270(97)00120-9 / J Neurosci Methods / Isolation and characterization of synaptoneurosomes from single rat hippocampal slices by MW Johnson (1997)
10.1073/pnas.132197599 / Proc Natl Acad Sci USA / Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 —> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice by MK Lee (2002)
10.1016/S0896-6273(02)00682-7 / Neuron / Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein by BI Giasson (2002)
10.1073/pnas.0406976102 / Proc Natl Acad Sci USA / Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson’s disease-linked mutations by W Li (2005)
10.1016/j.expneurol.2009.03.006 / Exp Neurol / Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson’s Disease by H Büeler (2009)
10.1016/j.bbabio.2009.12.013 / Biochim Biophys Acta / Structure and function of mitochondrial supercomplexes by NV Dudkina (2010)
10.2174/156720508784533358 / Curr Alzheimer Res / Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders by F Rahimi (2008)
10.1038/nature10324 / Nature / α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation by T Bartels (2011)
10.1073/pnas.1113260108 / Proc Natl Acad Sci USA / A soluble α-synuclein construct forms a dynamic tetramer by W Wang (2011)
10.1074/jbc.M111.318949 / J Biol Chem / Alpha-synuclein in the central nervous system and from erythrocytes, mammalian cells and E. coli exists predominantly as a disordered monomer by B Fauvet (2012)
10.1126/science.1079469 / Science / Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis by R Kayed (2003)
Whitellegge JP (2009). Intact protein mass measurements and top-down mass spectrometry: Application to integral membrane proteins. In: D Barcelό, editor. Comprehensive analytical chemistry, Vol 52 , Protein mass spectrometry, Elsevier BV: Elsevier. Amsterdam, Netherlands pp.179–96.
10.1074/jbc.M600933200 / J Biol Chem / Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease by JP Anderson (2006)
10.1002/pro.2088 / Protein Sci / N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer by L Kang (2012)
10.1002/pro.2056 / Protein Sci / N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein by AJ Trexler (2012)
10.1021/ja208657z / J Am Chem Soc / Explaining the structural plasticity of α-synuclein by O Ullman (2011)
10.1523/JNEUROSCI.3545-12.2012 / J Neurosci / Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities by J Burré (2012)
10.1002/syn.20456 / Synapse / Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression by PO Fernagut (2007)
10.1016/j.febslet.2010.03.012 / FEBS Letters / α-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson’s disease by K Banerjee (2010)
10.1128/MCB.25.22.10190-10201.2005 / Molec Cell Biology / Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking α-synuclein by CE Ellis (2005)
10.1523/JNEUROSCI.23-08-03095.2003 / J Neurosci / Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration by AB Manning-Bog (2003)
10.1074/jbc.M900418200 / J Biol Chem / Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease by H Bayir (2009)
10.1016/j.mcn.2011.11.006 / Mol Cell Neurosci / Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression by JR McLean (2012)
10.1016/j.jneumeth.2012.09.005 / J Neurosci Methods / Synaptoneurosome micromethod for fractionation of mouse and human brain, and primary neuronal cultures by JW Chang (2012)
10.1016/j.neuroscience.2011.10.042 / Neuroscience / α-synuclein phosphorylation and truncation are normal events in the adult human brain by G Muntané (2012)
10.1523/JNEUROSCI.6513-10.2011 / J Neurosci / Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model by KW Lee (2011)
Graham JM (1993) Isolation of mitochondria, mitochondrial membranes, lysosomes, and Golgi membranes from rat liver. In: Methods in Molecular Biology Vol.19; Biomembrane Protocols; I Isolation and Analysis. Graham JM, Higgins JA, editors. Humana Press Inc., New York, New York. pp.29–40. (10.1385/0-89603-236-1:29)
10.1038/cdd.2011.53 / Cell Death and Differentiation / A deadly spread: cellular mechanisms of alpha-synuclein transfer by JA Steiner (2011)
10.1126/science.1213151 / Science / Atomic view of a toxic amyloid small oligomer by A Laganowsky (2012)
10.1111/j.1528-1167.2010.02777.x / Epilepsia / The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission by I Blümcke (2011)
10.1097/00005072-199710000-00004 / J Neuropathol Exp Neurol / Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia by JW Chang (1997)
10.1002/jnr.21040 / J Neurosci Res / Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes by JB Watson (2006)
10.1073/pnas.0712209105 / Proc Natl Acad Sci USA / Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria by C Vande Velde (2008)
10.1152/jn.00762.2011 / J Neurophysiol / A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease by DM Cummings (2012)
10.1074/jbc.M400255200 / J Biol Chem / Hsp70 reduces alpha-synuclein aggregation and toxicity by J Klucken (2004)
10.1152/ajplung.00371.2005 / Am J Physiol Lung Cell Mol Physiol / Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo by TA Sarafian (2006)
10.1371/journal.pone.0009532 / PLoS ONE / Disruption of astrocytes STAT3 signaling decreases mitochondrial function and increases oxidative stress In Vitro by TA Sarafian (2010)
Sasse J, Gallagher R (1991) Detection of proteins. In: Current Protocols in Molecular Biology, Vol 2, Ausubel FM, Brent R, Kingston RF, Moore DD, Seidman JG, et al., editors. John Wiley and Sons, New York, New York. pp. 10.6.1–10.6.8.
10.1016/j.febslet.2007.06.052 / FEBS Lett / The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11 by J Xie (2007)
10.1016/j.brainres.2010.03.044 / Brain Res / Cysteine string protein beta is prominently associated with nerve terminals and secretory organelles in mouse brain by CB Gundersen (2010)
10.1016/j.ijms.2007.08.008 / International Journal Mass Spectrometry / Protein-sequence polymorphisms and post-translational modifications in proteins from human saliva using top-down fourier-transform ion cyclotron resonance mass spectrometry by JP Whitelegge (2007)
10.1074/jbc.M707751200 / J Biol Chem / Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1 by BF Shaw (2008)
{'key': 'ref78', 'first-page': '868', 'article-title': 'Confident assignment of intact mass tags to human salivary cystatins using top-down fourier-transform ion cyclotron resonance mass spectrometry', 'volume': '21', 'author': 'CM Ryan', 'year': '2010', 'journal-title': 'J Am Soc Mass Spectrom'} / J Am Soc Mass Spectrom / Confident assignment of intact mass tags to human salivary cystatins using top-down fourier-transform ion cyclotron resonance mass spectrometry by CM Ryan (2010)
10.1074/mcp.M900516-MCP200 / Mol Cell Proteomics / Post-translational modifications of integral membrane proteins resolved by top-down Fourier-transform mass spectrometry with collisionally activated dissociation by CM Ryan (2010)

Dates

Type	When
Created	12 years, 3 months ago (May 7, 2013, 8:57 p.m.)
Deposited	1 year, 3 months ago (May 10, 2024, 5:21 a.m.)
Indexed	1 year, 1 month ago (July 11, 2024, 8:48 p.m.)
Issued	12 years, 3 months ago (May 7, 2013)
Published	12 years, 3 months ago (May 7, 2013)
Published Online	12 years, 3 months ago (May 7, 2013)

Funders 0

None

BibTeX

@article{Sarafian_2013, title={Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human α-Synuclein}, volume={8}, ISSN={1932-6203}, url={http://dx.doi.org/10.1371/journal.pone.0063557}, DOI={10.1371/journal.pone.0063557}, number={5}, journal={PLoS ONE}, publisher={Public Library of Science (PLoS)}, author={Sarafian, Theodore A. and Ryan, Christopher M. and Souda, Puneet and Masliah, Eliezer and Kar, Upendra K. and Vinters, Harry V. and Mathern, Gary W. and Faull, Kym F. and Whitelegge, Julian P. and Watson, Joseph B.}, editor={Moore, Darren J.}, year={2013}, month=may, pages={e63557} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        7,
        12
      ]
    ],
    "date-time": "2024-07-12T00:48:24Z",
    "timestamp": 1720745304375
  },
  "reference-count": 79,
  "publisher": "Public Library of Science (PLoS)",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2013,
            5,
            7
          ]
        ],
        "date-time": "2013-05-07T00:00:00Z",
        "timestamp": 1367884800000
      },
      "content-version": "unspecified",
      "delay-in-days": 0,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [
      "www.plosone.org"
    ],
    "crossmark-restriction": false
  },
  "DOI": "10.1371/journal.pone.0063557",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2013,
        5,
        8
      ]
    ],
    "date-time": "2013-05-08T00:57:11Z",
    "timestamp": 1367974631000
  },
  "page": "e63557",
  "update-policy": "http://dx.doi.org/10.1371/journal.pone.corrections_policy",
  "source": "Crossref",
  "is-referenced-by-count": 39,
  "title": "Impairment of Mitochondria in Adult Mouse Brain Overexpressing Predominantly Full-Length, N-Terminally Acetylated Human \u03b1-Synuclein",
  "prefix": "10.1371",
  "volume": "8",
  "author": [
    {
      "given": "Theodore A.",
      "family": "Sarafian",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Christopher M.",
      "family": "Ryan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Puneet",
      "family": "Souda",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Eliezer",
      "family": "Masliah",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Upendra K.",
      "family": "Kar",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Harry V.",
      "family": "Vinters",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Gary W.",
      "family": "Mathern",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Kym F.",
      "family": "Faull",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Julian P.",
      "family": "Whitelegge",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Joseph B.",
      "family": "Watson",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "340",
  "published-online": {
    "date-parts": [
      [
        2013,
        5,
        7
      ]
    ]
  },
  "reference": [
    {
      "key": "ref1",
      "doi-asserted-by": "crossref",
      "first-page": "35",
      "DOI": "10.1016/0169-328X(91)90043-W",
      "article-title": "The rat brain synucleins: family of proteins transiently associated with neuronal membrane",
      "volume": "11",
      "author": "L Maroteaux",
      "year": "1991",
      "journal-title": "Brain Res Mol Brain Res"
    },
    {
      "key": "ref2",
      "doi-asserted-by": "crossref",
      "first-page": "249",
      "DOI": "10.1016/S0166-2236(97)01213-7",
      "article-title": "The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration, and disease",
      "volume": "21",
      "author": "DF Clayton",
      "year": "1998",
      "journal-title": "Trends Neurosci"
    },
    {
      "key": "ref3",
      "doi-asserted-by": "crossref",
      "first-page": "9443",
      "DOI": "10.1074/jbc.273.16.9443",
      "article-title": "Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes",
      "volume": "273",
      "author": "WS Davidson",
      "year": "1998",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref4",
      "doi-asserted-by": "crossref",
      "first-page": "383",
      "DOI": "10.1016/j.cell.2005.09.028",
      "article-title": "Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration",
      "volume": "123",
      "author": "S Chandra",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "ref5",
      "doi-asserted-by": "crossref",
      "first-page": "31664",
      "DOI": "10.1074/jbc.M504894200",
      "article-title": "A combinatorial code for the interaction of alpha-synuclein with membranes",
      "volume": "280",
      "author": "S Kubo",
      "year": "2005",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref6",
      "doi-asserted-by": "crossref",
      "first-page": "145",
      "DOI": "10.1073/pnas.0710685105",
      "article-title": "The Parkinson&apos;s disease protein \u03b1-synuclein disrupts cellular Rab homeostasis",
      "volume": "105",
      "author": "AD Gitler",
      "year": "2008",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "ref7",
      "doi-asserted-by": "crossref",
      "first-page": "12305",
      "DOI": "10.1523/JNEUROSCI.3088-08.2008",
      "article-title": "Optical reporters for the conformation of \u03b1-synuclein reveal a specific interaction with mitochondria",
      "volume": "28",
      "author": "K Nakamura",
      "year": "2008",
      "journal-title": "J Neurosci"
    },
    {
      "key": "ref8",
      "doi-asserted-by": "crossref",
      "first-page": "512",
      "DOI": "10.1016/j.bbamem.2011.11.024",
      "article-title": "Interaction of \u03b1-synuclein with vesicles that mimic mitochondrial membranes",
      "volume": "1818",
      "author": "IG Zigoneanu",
      "year": "2012",
      "journal-title": "Biochemica and Biophysica ACTA"
    },
    {
      "key": "ref9",
      "doi-asserted-by": "crossref",
      "first-page": "8797",
      "DOI": "10.1523/JNEUROSCI.22-20-08797.2002",
      "article-title": "Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking -synuclein",
      "volume": "22",
      "author": "DE Cabin",
      "year": "2002",
      "journal-title": "J Neurosci"
    },
    {
      "key": "ref10",
      "doi-asserted-by": "crossref",
      "first-page": "11915",
      "DOI": "10.1523/JNEUROSCI.3821-06.2006",
      "article-title": "\u03b1-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis",
      "volume": "26",
      "author": "KE Larsen",
      "year": "2006",
      "journal-title": "Neurosci"
    },
    {
      "key": "ref11",
      "doi-asserted-by": "crossref",
      "first-page": "501",
      "DOI": "10.1016/j.neuroscience.2009.01.021",
      "article-title": "Alterations in corticostriatal synaptic plasticity in mice overexpressing human \u03b1-synuclein",
      "volume": "159",
      "author": "JB Watson",
      "year": "2009",
      "journal-title": "Neurosci"
    },
    {
      "key": "ref12",
      "doi-asserted-by": "crossref",
      "first-page": "1764",
      "DOI": "10.1002/jnr.22327",
      "article-title": "Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway",
      "volume": "88",
      "author": "N-P Wu",
      "year": "2010",
      "journal-title": "J Neurosci Res"
    },
    {
      "key": "ref13",
      "doi-asserted-by": "crossref",
      "first-page": "66",
      "DOI": "10.1016/j.neuron.2009.12.023",
      "article-title": "Increased expression of \u03b1-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis",
      "volume": "65",
      "author": "VM Nemani",
      "year": "2010",
      "journal-title": "Neuron"
    },
    {
      "key": "ref14",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1146/annurev-genom-082410-101440",
      "article-title": "Recent advances in the genetics of Parkinson\u2019s Disease",
      "volume": "12",
      "author": "I Martin",
      "year": "2011",
      "journal-title": "Annu Rev Genomics Hum Genet"
    },
    {
      "key": "ref15",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1016/S0079-6123(10)83007-9",
      "article-title": "Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson&apos;s disease pathogenesis and therapies",
      "volume": "183",
      "author": "A Oueslati",
      "year": "2010",
      "journal-title": "Prog Brain Res"
    },
    {
      "key": "ref16",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1016/S0197-4580(02)00065-9",
      "article-title": "Staging of brain pathology related to sporadic Parkinson\u2019s disease",
      "volume": "24",
      "author": "H Braak",
      "year": "2003",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "ref17",
      "doi-asserted-by": "crossref",
      "first-page": "595",
      "DOI": "10.1016/j.neuron.2004.10.023",
      "article-title": "Cloning of the gene containing mutations that cause PARK8-linked Parkinson\u2019s disease",
      "volume": "44",
      "author": "C Paisan-Ruiz",
      "year": "2004",
      "journal-title": "Neuron"
    },
    {
      "key": "ref18",
      "doi-asserted-by": "crossref",
      "first-page": "9089",
      "DOI": "10.1074/jbc.M710012200",
      "article-title": "Mitochondrial import and accumulation of \u03b1-synuclein impair Complex I in human dopaminergic neuronal cultures and Parkinson\u2019s Disease brain",
      "volume": "283",
      "author": "L Devi",
      "year": "2008",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref19",
      "doi-asserted-by": "crossref",
      "first-page": "823",
      "DOI": "10.1111/j.1471-4159.1990.tb02325.x",
      "article-title": "Mitochondrial Complex I deficiency in Parkinson\u2019s disease",
      "volume": "54",
      "author": "AHV Schapira",
      "year": "1990",
      "journal-title": "J Neurochem"
    },
    {
      "key": "ref20",
      "doi-asserted-by": "crossref",
      "first-page": "889",
      "DOI": "10.1016/S0896-6273(03)00568-3",
      "article-title": "Parkinson\u2019s disease: mechanisms and models",
      "volume": "39",
      "author": "W Dauer",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "ref21",
      "doi-asserted-by": "crossref",
      "first-page": "236",
      "DOI": "10.1016/j.biopha.2008.01.017",
      "article-title": "Glutathione and Parkinson\u2019s Disease: Is this the elephant in the room?",
      "volume": "62",
      "author": "GD Zeevalk",
      "year": "2008",
      "journal-title": "Biomed Pharmacotherapy"
    },
    {
      "key": "ref22",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1016/j.nbd.2009.01.016",
      "article-title": "A highly reproducible rotenone model of Parkinson&apos;s disease",
      "volume": "34",
      "author": "JR Cannon",
      "year": "2009",
      "journal-title": "Neurobiol Dis"
    },
    {
      "key": "ref23",
      "doi-asserted-by": "crossref",
      "first-page": "187",
      "DOI": "10.1016/j.neulet.2009.02.056",
      "article-title": "\u03b1-synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity",
      "volume": "454",
      "author": "G Liu",
      "year": "2009",
      "journal-title": "Neurosci Lett"
    },
    {
      "key": "ref24",
      "doi-asserted-by": "crossref",
      "first-page": "7334",
      "DOI": "10.1074/jbc.M109.061051",
      "article-title": "The transgenic overexpression of \u03b1-synuclein and not its related pathology associates with complex I inhibition",
      "volume": "285",
      "author": "V Loeb",
      "year": "2010",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref25",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1016/j.neulet.2010.09.061",
      "article-title": "Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo",
      "volume": "486",
      "author": "SJ Chinta",
      "year": "2010",
      "journal-title": "Neurosci Lett"
    },
    {
      "key": "ref26",
      "doi-asserted-by": "crossref",
      "first-page": "896",
      "DOI": "10.1089/ars.2011.4200",
      "article-title": "Mitochondrial dysfunction in genetic animal models of Parkinson&apos;s disease",
      "volume": "16",
      "author": "A Trancikova",
      "year": "2012",
      "journal-title": "Antioxid Redox Signal"
    },
    {
      "key": "ref27",
      "doi-asserted-by": "crossref",
      "first-page": "401",
      "DOI": "10.1016/S0002-9440(10)64553-1",
      "article-title": "alpha-synuclein promotes mitochondrial deficit and oxidative stress",
      "volume": "157",
      "author": "LJ Hsu",
      "year": "2000",
      "journal-title": "Am J Pathol"
    },
    {
      "key": "ref28",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1523/JNEUROSCI.4308-05.2006",
      "article-title": "Parkinson&apos;s disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death",
      "volume": "26",
      "author": "LJ Martin",
      "year": "2006",
      "journal-title": "J Neurosci"
    },
    {
      "key": "ref29",
      "doi-asserted-by": "crossref",
      "first-page": "732",
      "DOI": "10.1016/j.biocel.2011.01.014",
      "article-title": "\u03b1-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator",
      "volume": "43",
      "author": "Y Zhu",
      "year": "2011",
      "journal-title": "Int J Biochem Cell Biol"
    },
    {
      "key": "ref30",
      "doi-asserted-by": "crossref",
      "first-page": "20710",
      "DOI": "10.1074/jbc.M110.213538",
      "article-title": "Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein",
      "volume": "286",
      "author": "K Nakamura",
      "year": "2011",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref31",
      "doi-asserted-by": "crossref",
      "first-page": "568",
      "DOI": "10.1002/jnr.10231",
      "article-title": "Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters",
      "volume": "68",
      "author": "E Rockenstein",
      "year": "2002",
      "journal-title": "J Neurosci Res"
    },
    {
      "key": "ref32",
      "doi-asserted-by": "crossref",
      "first-page": "9434",
      "DOI": "10.1523/JNEUROSCI.3080-04.2004",
      "article-title": "Early and progressive sensorimotor anomalies in mice overexpressing wild-type human \u03b1-synuclein",
      "volume": "24",
      "author": "SM Fleming",
      "year": "2004",
      "journal-title": "J Neurosci"
    },
    {
      "key": "ref33",
      "doi-asserted-by": "crossref",
      "first-page": "1245",
      "DOI": "10.1016/j.neuroscience.2006.07.005",
      "article-title": "Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype \u03b1-synuclein",
      "volume": "142",
      "author": "SM Fleming",
      "year": "2006",
      "journal-title": "Neuroscience"
    },
    {
      "key": "ref34",
      "doi-asserted-by": "crossref",
      "first-page": "247",
      "DOI": "10.1111/j.1460-9568.2008.06346.x",
      "article-title": "Olfactory deficits in mice overexpressing human wildtype alpha-synuclein",
      "volume": "28",
      "author": "SM Fleming",
      "year": "2008",
      "journal-title": "Eur J Neurosci"
    },
    {
      "key": "ref35",
      "doi-asserted-by": "crossref",
      "first-page": "1091",
      "DOI": "10.1002/jnr.22611",
      "article-title": "Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human \u03b1-synuclein",
      "volume": "89",
      "author": "HA Lam",
      "year": "2011",
      "journal-title": "J Neurosci Res"
    },
    {
      "key": "ref36",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1016/S0165-0270(97)00120-9",
      "article-title": "Isolation and characterization of synaptoneurosomes from single rat hippocampal slices",
      "volume": "77",
      "author": "MW Johnson",
      "year": "1997",
      "journal-title": "J Neurosci Methods"
    },
    {
      "key": "ref37",
      "doi-asserted-by": "crossref",
      "first-page": "8968",
      "DOI": "10.1073/pnas.132197599",
      "article-title": "Human alpha-synuclein-harboring familial Parkinson&apos;s disease-linked Ala-53 \u2014&gt; Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice",
      "volume": "99",
      "author": "MK Lee",
      "year": "2002",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "ref38",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1016/S0896-6273(02)00682-7",
      "article-title": "Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein",
      "volume": "34",
      "author": "BI Giasson",
      "year": "2002",
      "journal-title": "Neuron"
    },
    {
      "key": "ref39",
      "doi-asserted-by": "crossref",
      "first-page": "2162",
      "DOI": "10.1073/pnas.0406976102",
      "article-title": "Aggregation promoting C-terminal truncation of \u03b1-synuclein is a normal cellular process and is enhanced by the familial Parkinson\u2019s disease-linked mutations",
      "volume": "102",
      "author": "W Li",
      "year": "2005",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "ref40",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1016/j.expneurol.2009.03.006",
      "article-title": "Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson\u2019s Disease",
      "volume": "218",
      "author": "H B\u00fceler",
      "year": "2009",
      "journal-title": "Exp Neurol"
    },
    {
      "key": "ref41",
      "doi-asserted-by": "crossref",
      "first-page": "664",
      "DOI": "10.1016/j.bbabio.2009.12.013",
      "article-title": "Structure and function of mitochondrial supercomplexes",
      "volume": "1797",
      "author": "NV Dudkina",
      "year": "2010",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "ref42",
      "doi-asserted-by": "crossref",
      "first-page": "319",
      "DOI": "10.2174/156720508784533358",
      "article-title": "Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer&apos;s disease and related disorders",
      "volume": "5",
      "author": "F Rahimi",
      "year": "2008",
      "journal-title": "Curr Alzheimer Res"
    },
    {
      "key": "ref43",
      "doi-asserted-by": "crossref",
      "first-page": "107",
      "DOI": "10.1038/nature10324",
      "article-title": "\u03b1-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation",
      "volume": "477",
      "author": "T Bartels",
      "year": "2011",
      "journal-title": "Nature"
    },
    {
      "key": "ref44",
      "doi-asserted-by": "crossref",
      "first-page": "17797",
      "DOI": "10.1073/pnas.1113260108",
      "article-title": "A soluble \u03b1-synuclein construct forms a dynamic tetramer",
      "volume": "108",
      "author": "W Wang",
      "year": "2011",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "ref45",
      "doi-asserted-by": "crossref",
      "first-page": "15345",
      "DOI": "10.1074/jbc.M111.318949",
      "article-title": "Alpha-synuclein in the central nervous system and from erythrocytes, mammalian cells and E. coli exists predominantly as a disordered monomer",
      "volume": "287",
      "author": "B Fauvet",
      "year": "2012",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref46",
      "doi-asserted-by": "crossref",
      "first-page": "486",
      "DOI": "10.1126/science.1079469",
      "article-title": "Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis",
      "volume": "300",
      "author": "R Kayed",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "ref47",
      "unstructured": "Whitellegge JP (2009). Intact protein mass measurements and top-down mass spectrometry: Application to integral membrane proteins. In: D Barcel\u03cc, editor. Comprehensive analytical chemistry, Vol 52 , Protein mass spectrometry, Elsevier BV: Elsevier. Amsterdam, Netherlands pp.179\u201396."
    },
    {
      "key": "ref48",
      "doi-asserted-by": "crossref",
      "first-page": "29739",
      "DOI": "10.1074/jbc.M600933200",
      "article-title": "Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease",
      "volume": "281",
      "author": "JP Anderson",
      "year": "2006",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref49",
      "doi-asserted-by": "crossref",
      "first-page": "911",
      "DOI": "10.1002/pro.2088",
      "article-title": "N-terminal acetylation of \u03b1-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer",
      "volume": "21",
      "author": "L Kang",
      "year": "2012",
      "journal-title": "Protein Sci"
    },
    {
      "key": "ref50",
      "doi-asserted-by": "crossref",
      "first-page": "601",
      "DOI": "10.1002/pro.2056",
      "article-title": "N-terminal acetylation is critical for forming \u03b1-helical oligomer of \u03b1-synuclein",
      "volume": "21",
      "author": "AJ Trexler",
      "year": "2012",
      "journal-title": "Protein Sci"
    },
    {
      "key": "ref51",
      "doi-asserted-by": "crossref",
      "first-page": "19536",
      "DOI": "10.1021/ja208657z",
      "article-title": "Explaining the structural plasticity of \u03b1-synuclein",
      "volume": "133",
      "author": "O Ullman",
      "year": "2011",
      "journal-title": "J Am Chem Soc"
    },
    {
      "key": "ref52",
      "doi-asserted-by": "crossref",
      "first-page": "15227",
      "DOI": "10.1523/JNEUROSCI.3545-12.2012",
      "article-title": "Systematic mutagenesis of \u03b1-synuclein reveals distinct sequence requirements for physiological and pathological activities",
      "volume": "32",
      "author": "J Burr\u00e9",
      "year": "2012",
      "journal-title": "J Neurosci"
    },
    {
      "key": "ref53",
      "doi-asserted-by": "crossref",
      "first-page": "991",
      "DOI": "10.1002/syn.20456",
      "article-title": "Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression",
      "volume": "61",
      "author": "PO Fernagut",
      "year": "2007",
      "journal-title": "Synapse"
    },
    {
      "key": "ref54",
      "doi-asserted-by": "crossref",
      "first-page": "1571",
      "DOI": "10.1016/j.febslet.2010.03.012",
      "article-title": "\u03b1-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson\u2019s disease",
      "volume": "584",
      "author": "K Banerjee",
      "year": "2010",
      "journal-title": "FEBS Letters"
    },
    {
      "key": "ref55",
      "doi-asserted-by": "crossref",
      "first-page": "10190",
      "DOI": "10.1128/MCB.25.22.10190-10201.2005",
      "article-title": "Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking \u03b1-synuclein",
      "volume": "25",
      "author": "CE Ellis",
      "year": "2005",
      "journal-title": "Molec Cell Biology"
    },
    {
      "key": "ref56",
      "doi-asserted-by": "crossref",
      "first-page": "3095",
      "DOI": "10.1523/JNEUROSCI.23-08-03095.2003",
      "article-title": "Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration",
      "volume": "23",
      "author": "AB Manning-Bog",
      "year": "2003",
      "journal-title": "J Neurosci"
    },
    {
      "key": "ref57",
      "doi-asserted-by": "crossref",
      "first-page": "15951",
      "DOI": "10.1074/jbc.M900418200",
      "article-title": "Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease",
      "volume": "284",
      "author": "H Bayir",
      "year": "2009",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref58",
      "doi-asserted-by": "crossref",
      "first-page": "230",
      "DOI": "10.1016/j.mcn.2011.11.006",
      "article-title": "Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson&apos;s disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression",
      "volume": "49",
      "author": "JR McLean",
      "year": "2012",
      "journal-title": "Mol Cell Neurosci"
    },
    {
      "key": "ref59",
      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.1016/j.jneumeth.2012.09.005",
      "article-title": "Synaptoneurosome micromethod for fractionation of mouse and human brain, and primary neuronal cultures",
      "volume": "211",
      "author": "JW Chang",
      "year": "2012",
      "journal-title": "J Neurosci Methods"
    },
    {
      "key": "ref60",
      "doi-asserted-by": "crossref",
      "first-page": "106",
      "DOI": "10.1016/j.neuroscience.2011.10.042",
      "article-title": "\u03b1-synuclein phosphorylation and truncation are normal events in the adult human brain",
      "volume": "200",
      "author": "G Muntan\u00e9",
      "year": "2012",
      "journal-title": "Neuroscience"
    },
    {
      "key": "ref61",
      "doi-asserted-by": "crossref",
      "first-page": "6963",
      "DOI": "10.1523/JNEUROSCI.6513-10.2011",
      "article-title": "Enhanced phosphatase activity attenuates \u03b1-synucleinopathy in a mouse model",
      "volume": "31",
      "author": "KW Lee",
      "year": "2011",
      "journal-title": "J Neurosci"
    },
    {
      "key": "ref62",
      "doi-asserted-by": "crossref",
      "unstructured": "Graham JM (1993) Isolation of mitochondria, mitochondrial membranes, lysosomes, and Golgi membranes from rat liver. In: Methods in Molecular Biology Vol.19; Biomembrane Protocols; I Isolation and Analysis. Graham JM, Higgins JA, editors. Humana Press Inc., New York, New York. pp.29\u201340.",
      "DOI": "10.1385/0-89603-236-1:29"
    },
    {
      "key": "ref63",
      "doi-asserted-by": "crossref",
      "first-page": "1425",
      "DOI": "10.1038/cdd.2011.53",
      "article-title": "A deadly spread: cellular mechanisms of alpha-synuclein transfer",
      "volume": "18",
      "author": "JA Steiner",
      "year": "2011",
      "journal-title": "Cell Death and Differentiation"
    },
    {
      "key": "ref64",
      "doi-asserted-by": "crossref",
      "first-page": "1228",
      "DOI": "10.1126/science.1213151",
      "article-title": "Atomic view of a toxic amyloid small oligomer",
      "volume": "335",
      "author": "A Laganowsky",
      "year": "2012",
      "journal-title": "Science"
    },
    {
      "key": "ref65",
      "doi-asserted-by": "crossref",
      "first-page": "158",
      "DOI": "10.1111/j.1528-1167.2010.02777.x",
      "article-title": "The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission",
      "volume": "52",
      "author": "I Bl\u00fcmcke",
      "year": "2011",
      "journal-title": "Epilepsia"
    },
    {
      "key": "ref66",
      "doi-asserted-by": "crossref",
      "first-page": "1105",
      "DOI": "10.1097/00005072-199710000-00004",
      "article-title": "Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia",
      "volume": "56",
      "author": "JW Chang",
      "year": "1997",
      "journal-title": "J Neuropathol Exp Neurol"
    },
    {
      "key": "ref67",
      "doi-asserted-by": "crossref",
      "first-page": "1564",
      "DOI": "10.1002/jnr.21040",
      "article-title": "Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes",
      "volume": "84",
      "author": "JB Watson",
      "year": "2006",
      "journal-title": "J Neurosci Res"
    },
    {
      "key": "ref68",
      "doi-asserted-by": "crossref",
      "first-page": "4022",
      "DOI": "10.1073/pnas.0712209105",
      "article-title": "Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria",
      "volume": "105",
      "author": "C Vande Velde",
      "year": "2008",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "ref69",
      "doi-asserted-by": "crossref",
      "first-page": "677",
      "DOI": "10.1152/jn.00762.2011",
      "article-title": "A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington&apos;s disease",
      "volume": "107",
      "author": "DM Cummings",
      "year": "2012",
      "journal-title": "J Neurophysiol"
    },
    {
      "key": "ref70",
      "doi-asserted-by": "crossref",
      "first-page": "25497",
      "DOI": "10.1074/jbc.M400255200",
      "article-title": "Hsp70 reduces alpha-synuclein aggregation and toxicity",
      "volume": "279",
      "author": "J Klucken",
      "year": "2004",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref71",
      "doi-asserted-by": "crossref",
      "first-page": "L1202",
      "DOI": "10.1152/ajplung.00371.2005",
      "article-title": "Inhaled marijuana smoke disrupts mitochondrial energetics in pulmonary epithelial cells in vivo",
      "volume": "290",
      "author": "TA Sarafian",
      "year": "2006",
      "journal-title": "Am J Physiol Lung Cell Mol Physiol"
    },
    {
      "key": "ref72",
      "doi-asserted-by": "crossref",
      "first-page": "e9532",
      "DOI": "10.1371/journal.pone.0009532",
      "article-title": "Disruption of astrocytes STAT3 signaling decreases mitochondrial function and increases oxidative stress In Vitro",
      "volume": "5(3)",
      "author": "TA Sarafian",
      "year": "2010",
      "journal-title": "PLoS ONE"
    },
    {
      "key": "ref73",
      "unstructured": "Sasse J, Gallagher R (1991) Detection of proteins. In: Current Protocols in Molecular Biology, Vol 2, Ausubel FM, Brent R, Kingston RF, Moore DD, Seidman JG, et al., editors. John Wiley and Sons, New York, New York. pp. 10.6.1\u201310.6.8."
    },
    {
      "key": "ref74",
      "doi-asserted-by": "crossref",
      "first-page": "3545",
      "DOI": "10.1016/j.febslet.2007.06.052",
      "article-title": "The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11",
      "volume": "581",
      "author": "J Xie",
      "year": "2007",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "ref75",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/j.brainres.2010.03.044",
      "article-title": "Cysteine string protein beta is prominently associated with nerve terminals and secretory organelles in mouse brain",
      "volume": "1332",
      "author": "CB Gundersen",
      "year": "2010",
      "journal-title": "Brain Res"
    },
    {
      "key": "ref76",
      "doi-asserted-by": "crossref",
      "first-page": "190",
      "DOI": "10.1016/j.ijms.2007.08.008",
      "article-title": "Protein-sequence polymorphisms and post-translational modifications in proteins from human saliva using top-down fourier-transform ion cyclotron resonance mass spectrometry",
      "volume": "268",
      "author": "JP Whitelegge",
      "year": "2007",
      "journal-title": "International Journal Mass Spectrometry"
    },
    {
      "key": "ref77",
      "doi-asserted-by": "crossref",
      "first-page": "8340",
      "DOI": "10.1074/jbc.M707751200",
      "article-title": "Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1",
      "volume": "283",
      "author": "BF Shaw",
      "year": "2008",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref78",
      "first-page": "868",
      "article-title": "Confident assignment of intact mass tags to human salivary cystatins using top-down fourier-transform ion cyclotron resonance mass spectrometry",
      "volume": "21",
      "author": "CM Ryan",
      "year": "2010",
      "journal-title": "J Am Soc Mass Spectrom"
    },
    {
      "key": "ref79",
      "doi-asserted-by": "crossref",
      "first-page": "791",
      "DOI": "10.1074/mcp.M900516-MCP200",
      "article-title": "Post-translational modifications of integral membrane proteins resolved by top-down Fourier-transform mass spectrometry with collisionally activated dissociation",
      "volume": "9",
      "author": "CM Ryan",
      "year": "2010",
      "journal-title": "Mol Cell Proteomics"
    }
  ],
  "container-title": "PLoS ONE",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://dx.plos.org/10.1371/journal.pone.0063557",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        5,
        10
      ]
    ],
    "date-time": "2024-05-10T09:21:37Z",
    "timestamp": 1715332897000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://dx.plos.org/10.1371/journal.pone.0063557"
    }
  },
  "subtitle": [],
  "editor": [
    {
      "given": "Darren J.",
      "family": "Moore",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2013,
        5,
        7
      ]
    ]
  },
  "references-count": 79,
  "journal-issue": {
    "issue": "5",
    "published-online": {
      "date-parts": [
        [
          2013,
          5,
          7
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1371/journal.pone.0063557",
  "relation": {},
  "ISSN": [
    "1932-6203"
  ],
  "subject": [],
  "container-title-short": "PLoS ONE",
  "published": {
    "date-parts": [
      [
        2013,
        5,
        7
      ]
    ]
  }
}