DOI: 10.1371/journal.pgen.1005092. Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis

Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis

10.1371/journal.pgen.1005092

Crossref journal-article

Public Library of Science (PLoS)

PLOS Genetics (340)

Bibliography

Chartier, A., Klein, P., Pierson, S., Barbezier, N., Gidaro, T., Casas, F., Carberry, S., Dowling, P., Maynadier, L., Bellec, M., Oloko, M., Jardel, C., Moritz, B., Dickson, G., Mouly, V., Ohlendieck, K., Butler-Browne, G., Trollet, C., & Simonelig, M. (2015). Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis. PLOS Genetics, 11(3), e1005092.

Authors 19

Aymeric Chartier (first)
Pierre Klein (additional)
Stéphanie Pierson (additional)
Nicolas Barbezier (additional)
Teresa Gidaro (additional)
François Casas (additional)
Steven Carberry (additional)
Paul Dowling (additional)
Laurie Maynadier (additional)
Maëlle Bellec (additional)
Martine Oloko (additional)
Claude Jardel (additional)
Bodo Moritz (additional)
George Dickson (additional)
Vincent Mouly (additional)
Kay Ohlendieck (additional)
Gillian Butler-Browne (additional)
Capucine Trollet (additional)
Martine Simonelig (additional)

References 73 Referenced 70

10.1126/science.1067122 / Science / Toxic proteins in neurodegenerative disease by JP Taylor (2002)
10.1016/j.cell.2013.07.038 / Cell / Altered ribostasis: RNA-protein granules in degenerative disorders by M Ramaswami (2013)
10.1002/ana.21948 / Annals of neurology / RNA-mediated neurodegeneration in repeat expansion disorders by PK Todd (2010)
10.1038/ng0298-164 / Nature Genetics / Short GCG expansions in the <italic>PABP2</italic> gene cause oculopharyngeal muscular dystrophy by B Brais (1998)
10.1016/j.bbadis.2006.10.003 / Biochim Biophys Acta / Oculopharyngeal muscular dystrophy: recent advances in the understanding of the molecular pathogenic mechanisms and treatment strategies by A Abu-Baker (2007)
10.1016/j.biocel.2006.01.016 / Int J Biochem Cell Biol / Oculopharyngeal muscular dystrophy: potential therapies for an aggregate-associated disorder by JE Davies (2006)
10.1007/BF00692226 / Acta Neuropathol (Berl) / Nuclear inclusions in oculopharyngeal dystrophy by FM Tome (1980)
10.1093/oxfordjournals.hmg.a018924 / Hum Mol Genet / Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein II aggregates which sequester poly(A) RNA by A Calado (2000)
10.1186/2044-5040-1-15 / Skeletal muscle / Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients by SY Anvar (2011)
10.1016/j.ajpath.2013.12.011 / The American journal of pathology / A Novel Feed-Forward Loop between ARIH2 E3-Ligase and PABPN1 Regulates Aging-Associated Muscle Degeneration by V Raz (2014)
10.1093/hmg/ddq559 / Human molecular genetics / Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy by JE Davies (2011)
10.1016/0092-8674(91)90119-J / Cell / A novel poly(A)-Binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation by E Wahle (1991)
10.1002/j.1460-2075.1993.tb05690.x / EMBO J / Assembly of a processive mRNA polyadenylation complex by S Bienroth (1993)
10.1093/emboj/cdg347 / The EMBO journal / Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA by Y Kerwitz (2003)
10.1074/jbc.M109.018226 / The Journal of biological chemistry / Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor by U Kuhn (2009)
10.1016/j.devcel.2005.09.002 / Dev Cell / An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila by B Benoit (2005)
10.1093/hmg/ddp569 / Human molecular genetics / Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis by LH Apponi (2010)
10.1371/journal.pgen.1003893 / PLoS genetics / The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay by SM Bresson (2013)
10.1371/journal.pgen.1003078 / PLoS genetics / Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1 by YB Beaulieu (2012)
10.1016/j.cell.2012.03.022 / Cell / The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites by M Jenal (2012)
10.1093/nar/gks655 / Nucleic acids research / Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation by E de Klerk (2012)
10.1002/emmm.201000109 / EMBO molecular medicine / Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy by N Barbezier (2011)
10.1038/sj.emboj.7601117 / Embo J / A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1 by A Chartier (2006)
10.1016/j.cub.2005.01.048 / Curr Biol / Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo by JL Semotok (2005)
10.1242/dev.02649 / Development / Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4 by S Zaessinger (2006)
10.1093/hmg/ddp101 / Hum Mol Genet / Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo by A Chartier (2009)
10.1186/gb-2007-8-7-r129 / Genome biology / FlyMine: an integrated database for Drosophila and Anopheles genomics by R Lyne (2007)
10.1101/gr.6940108 / Genome research / Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster by J Chen (2008)
10.1016/j.devcel.2007.12.002 / Developmental cell / Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila by GP Sykiotis (2008)
10.1124/mi.5.2.7 / Molecular interventions / Role of mitochondria in toxic oxidative stress by MW Fariss (2005)
10.1101/gad.1177604 / Genes & development / Transcriptional regulatory circuits controlling mitochondrial biogenesis and function by DP Kelly (2004)
10.1210/er.2002-0012 / Endocrine reviews / Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator by P Puigserver (2003)
10.1152/physrev.00025.2007 / Physiological reviews / Transcriptional paradigms in mammalian mitochondrial biogenesis and function by RC Scarpulla (2008)
10.1371/journal.pone.0006935 / PLoS One / Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4 by C Baltzer (2009)
10.1242/jcs.113.23.4263 / Journal of cell science / Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila by RP Herzig (2000)
10.1038/emboj.2009.330 / The EMBO journal / The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling by SK Tiefenbock (2010)
10.1016/j.cmet.2011.01.005 / Cell metabolism / The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth by JM Tennessen (2011)
10.1006/dbio.1995.1186 / Developmental biology / Monitoring development and pathology of Drosophila indirect flight muscles using green fluorescent protein by P Barthmaier (1995)
10.3389/fgene.2014.00143 / Frontiers in Genetics / Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects by C Temme (2014)
10.1038/sj.emboj.7600273 / EMBO J / A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila by C Temme (2004)
10.1261/rna.2145110 / Rna / Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation by C Temme (2010)
10.1242/dev.021444 / Development / PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila by P Benoit (2008)
10.1093/emboj/cdf633 / EMBO J / Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila by F Juge (2002)
10.1038/nsmb1100 / Nat Struct Mol Biol / PUF proteins bind Pop2p to regulate messenger RNAs by AC Goldstrohm (2006)
10.1242/dev.002212 / Development / Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline by LY Kadyrova (2007)
10.1083/jcb.200606054 / J Cell Biol / Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast by LJ Garcia-Rodriguez (2007)
10.1371/journal.pbio.0020079 / PLoS Biol / Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast by AP Gerber (2004)
10.1371/journal.pone.0002293 / PLoS One / Yeast mitochondrial biogenesis: a role for the PUF RNA-binding protein Puf3p in mRNA localization by Y Saint-Georges (2008)
10.1038/nature09465 / Nature / Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo by C Rouget (2010)
10.1371/journal.pgen.1003445 / PLoS genetics / Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy by M de Haro (2013)
10.1186/gb-2014-15-1-r4 / Genome biology / Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein by L Chen (2014)
10.1093/hmg/ddh101 / Hum Mol Genet / Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus by MT Berciano (2004)
10.1038/nm1242 / Nat Med / Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice by JE Davies (2005)
10.1093/hmg/ddq098 / Human molecular genetics / Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres by C Trollet (2010)
10.1038/nprot.2008.211 / Nature protocols / Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources by W Huang da (2009)
10.1038/nsmb1053 / Nature structural & molecular biology / Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p by T Aviv (2006)
10.1016/S1097-2765(03)00178-3 / Molecular cell / RNA recognition via the SAM domain of Smaug by JB Green (2003)
10.1097/NEN.0b013e3182854c07 / Journal of neuropathology and experimental neurology / Atrophy, fibrosis, and increased PAX7-positive cells in pharyngeal muscles of oculopharyngeal muscular dystrophy patients by T Gidaro (2013)
10.1016/j.neuron.2010.09.012 / Neuron / PolyQ disease: Too many Qs, too much function? by IH Kratter (2010)
10.1016/j.ajpath.2011.06.044 / The American journal of pathology / Modeling oculopharyngeal muscular dystrophy in myotube cultures reveals reduced accumulation of soluble mutant PABPN1 protein by V Raz (2011)
10.1038/35006074 / Nature / A Drosophila model of Parkinson's disease by MB Feany (2000)
10.1006/jmbi.2000.3572 / J Mol Biol / The nuclear poly(A) binding protein, PABP2, forms an oligomeric particle covering the length of the poly(A) tail by RW Keller (2000)
10.1038/nature02998 / Nature / Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death by M Arrasate (2004)
10.1083/jcb.201108159 / The Journal of cell biology / Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation by MV Baez (2011)
10.1016/j.neuron.2011.06.003 / Neuron / Mitochondria: the next (neurode)generation by EA Schon (2011)
10.1371/journal.pbio.1000298 / PLoS biology / PINK1 is selectively stabilized on impaired mitochondria to activate Parkin by DP Narendra (2010)
10.1016/j.cell.2011.10.018 / Cell / PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility by X Wang (2011)
10.1038/nature04779 / Nature / Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin by IE Clark (2006)
10.1038/nature04788 / Nature / Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin by J Park (2006)
{'key': 'ref70', 'first-page': '441', 'article-title': 'Analysis of poly(A) tail lengths by PCR: the PAT assay', 'volume': '118', 'author': 'FJ Salles', 'year': '1999', 'journal-title': 'Methods Mol Biol'} / Methods Mol Biol / Analysis of poly(A) tail lengths by PCR: the PAT assay by FJ Salles (1999)
10.1261/rna.031898.111 / RNA / ePAT: a simple method to tag adenylated RNA to measure poly(A)-tail length and other 3' RACE applications by A Janicke (2012)
10.1371/journal.pone.0005631 / PLoS One / Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging by F Casas (2009)
10.1093/nar/27.19.3771 / Nucleic Acids Res / The <italic>Drosophila</italic> poly(A)-binding protein II is ubiquitous throughout <italic>Drosophila</italic> development and has the same function in mRNA polyadenylation as its bovine homolog <italic>in vitro</italic> by B Benoit (1999)

Dates

Type	When
Created	10 years, 5 months ago (March 28, 2015, 10:26 p.m.)
Deposited	1 year, 2 months ago (June 7, 2024, 10:29 p.m.)
Indexed	1 week, 4 days ago (Aug. 21, 2025, 12:59 p.m.)
Issued	10 years, 5 months ago (March 27, 2015)
Published	10 years, 5 months ago (March 27, 2015)
Published Online	10 years, 5 months ago (March 27, 2015)

Funders 0

None

BibTeX

@article{Chartier_2015, title={Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis}, volume={11}, ISSN={1553-7404}, url={http://dx.doi.org/10.1371/journal.pgen.1005092}, DOI={10.1371/journal.pgen.1005092}, number={3}, journal={PLOS Genetics}, publisher={Public Library of Science (PLoS)}, author={Chartier, Aymeric and Klein, Pierre and Pierson, Stéphanie and Barbezier, Nicolas and Gidaro, Teresa and Casas, François and Carberry, Steven and Dowling, Paul and Maynadier, Laurie and Bellec, Maëlle and Oloko, Martine and Jardel, Claude and Moritz, Bodo and Dickson, George and Mouly, Vincent and Ohlendieck, Kay and Butler-Browne, Gillian and Trollet, Capucine and Simonelig, Martine}, editor={Lu, Bingwei}, year={2015}, month=mar, pages={e1005092} }

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      "first-page": "1991",
      "DOI": "10.1126/science.1067122",
      "article-title": "Toxic proteins in neurodegenerative disease",
      "volume": "296",
      "author": "JP Taylor",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "ref2",
      "doi-asserted-by": "crossref",
      "first-page": "727",
      "DOI": "10.1016/j.cell.2013.07.038",
      "article-title": "Altered ribostasis: RNA-protein granules in degenerative disorders",
      "volume": "154",
      "author": "M Ramaswami",
      "year": "2013",
      "journal-title": "Cell"
    },
    {
      "key": "ref3",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1002/ana.21948",
      "article-title": "RNA-mediated neurodegeneration in repeat expansion disorders",
      "volume": "67",
      "author": "PK Todd",
      "year": "2010",
      "journal-title": "Annals of neurology"
    },
    {
      "key": "ref4",
      "doi-asserted-by": "crossref",
      "first-page": "164",
      "DOI": "10.1038/ng0298-164",
      "article-title": "Short GCG expansions in the <italic>PABP2</italic> gene cause oculopharyngeal muscular dystrophy",
      "volume": "18",
      "author": "B Brais",
      "year": "1998",
      "journal-title": "Nature Genetics"
    },
    {
      "key": "ref5",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/j.bbadis.2006.10.003",
      "article-title": "Oculopharyngeal muscular dystrophy: recent advances in the understanding of the molecular pathogenic mechanisms and treatment strategies",
      "volume": "1772",
      "author": "A Abu-Baker",
      "year": "2007",
      "journal-title": "Biochim Biophys Acta"
    },
    {
      "key": "ref6",
      "doi-asserted-by": "crossref",
      "first-page": "1457",
      "DOI": "10.1016/j.biocel.2006.01.016",
      "article-title": "Oculopharyngeal muscular dystrophy: potential therapies for an aggregate-associated disorder",
      "volume": "38",
      "author": "JE Davies",
      "year": "2006",
      "journal-title": "Int J Biochem Cell Biol"
    },
    {
      "key": "ref7",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1007/BF00692226",
      "article-title": "Nuclear inclusions in oculopharyngeal dystrophy",
      "volume": "49",
      "author": "FM Tome",
      "year": "1980",
      "journal-title": "Acta Neuropathol (Berl)"
    },
    {
      "key": "ref8",
      "doi-asserted-by": "crossref",
      "first-page": "2321",
      "DOI": "10.1093/oxfordjournals.hmg.a018924",
      "article-title": "Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein II aggregates which sequester poly(A) RNA",
      "volume": "9",
      "author": "A Calado",
      "year": "2000",
      "journal-title": "Hum Mol Genet"
    },
    {
      "key": "ref9",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1186/2044-5040-1-15",
      "article-title": "Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients",
      "volume": "1",
      "author": "SY Anvar",
      "year": "2011",
      "journal-title": "Skeletal muscle"
    },
    {
      "key": "ref10",
      "doi-asserted-by": "crossref",
      "first-page": "1119",
      "DOI": "10.1016/j.ajpath.2013.12.011",
      "article-title": "A Novel Feed-Forward Loop between ARIH2 E3-Ligase and PABPN1 Regulates Aging-Associated Muscle Degeneration",
      "volume": "184",
      "author": "V Raz",
      "year": "2014",
      "journal-title": "The American journal of pathology"
    },
    {
      "key": "ref11",
      "doi-asserted-by": "crossref",
      "first-page": "1154",
      "DOI": "10.1093/hmg/ddq559",
      "article-title": "Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy",
      "volume": "20",
      "author": "JE Davies",
      "year": "2011",
      "journal-title": "Human molecular genetics"
    },
    {
      "key": "ref12",
      "doi-asserted-by": "crossref",
      "first-page": "759",
      "DOI": "10.1016/0092-8674(91)90119-J",
      "article-title": "A novel poly(A)-Binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation",
      "volume": "66",
      "author": "E Wahle",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "ref13",
      "doi-asserted-by": "crossref",
      "first-page": "585",
      "DOI": "10.1002/j.1460-2075.1993.tb05690.x",
      "article-title": "Assembly of a processive mRNA polyadenylation complex",
      "volume": "12",
      "author": "S Bienroth",
      "year": "1993",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref14",
      "doi-asserted-by": "crossref",
      "first-page": "3705",
      "DOI": "10.1093/emboj/cdg347",
      "article-title": "Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA",
      "volume": "22",
      "author": "Y Kerwitz",
      "year": "2003",
      "journal-title": "The EMBO journal"
    },
    {
      "key": "ref15",
      "doi-asserted-by": "crossref",
      "first-page": "22803",
      "DOI": "10.1074/jbc.M109.018226",
      "article-title": "Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor",
      "volume": "284",
      "author": "U Kuhn",
      "year": "2009",
      "journal-title": "The Journal of biological chemistry"
    },
    {
      "key": "ref16",
      "doi-asserted-by": "crossref",
      "first-page": "511",
      "DOI": "10.1016/j.devcel.2005.09.002",
      "article-title": "An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila",
      "volume": "9",
      "author": "B Benoit",
      "year": "2005",
      "journal-title": "Dev Cell"
    },
    {
      "key": "ref17",
      "doi-asserted-by": "crossref",
      "first-page": "1058",
      "DOI": "10.1093/hmg/ddp569",
      "article-title": "Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis",
      "volume": "19",
      "author": "LH Apponi",
      "year": "2010",
      "journal-title": "Human molecular genetics"
    },
    {
      "key": "ref18",
      "doi-asserted-by": "crossref",
      "first-page": "e1003893",
      "DOI": "10.1371/journal.pgen.1003893",
      "article-title": "The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay",
      "volume": "9",
      "author": "SM Bresson",
      "year": "2013",
      "journal-title": "PLoS genetics"
    },
    {
      "key": "ref19",
      "doi-asserted-by": "crossref",
      "first-page": "e1003078",
      "DOI": "10.1371/journal.pgen.1003078",
      "article-title": "Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1",
      "volume": "8",
      "author": "YB Beaulieu",
      "year": "2012",
      "journal-title": "PLoS genetics"
    },
    {
      "key": "ref20",
      "doi-asserted-by": "crossref",
      "first-page": "538",
      "DOI": "10.1016/j.cell.2012.03.022",
      "article-title": "The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites",
      "volume": "149",
      "author": "M Jenal",
      "year": "2012",
      "journal-title": "Cell"
    },
    {
      "key": "ref21",
      "doi-asserted-by": "crossref",
      "first-page": "9089",
      "DOI": "10.1093/nar/gks655",
      "article-title": "Poly(A) binding protein nuclear 1 levels affect alternative polyadenylation",
      "volume": "40",
      "author": "E de Klerk",
      "year": "2012",
      "journal-title": "Nucleic acids research"
    },
    {
      "key": "ref22",
      "doi-asserted-by": "crossref",
      "first-page": "35",
      "DOI": "10.1002/emmm.201000109",
      "article-title": "Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy",
      "volume": "3",
      "author": "N Barbezier",
      "year": "2011",
      "journal-title": "EMBO molecular medicine"
    },
    {
      "key": "ref23",
      "doi-asserted-by": "crossref",
      "first-page": "2253",
      "DOI": "10.1038/sj.emboj.7601117",
      "article-title": "A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1",
      "volume": "25",
      "author": "A Chartier",
      "year": "2006",
      "journal-title": "Embo J"
    },
    {
      "key": "ref24",
      "doi-asserted-by": "crossref",
      "first-page": "284",
      "DOI": "10.1016/j.cub.2005.01.048",
      "article-title": "Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo",
      "volume": "15",
      "author": "JL Semotok",
      "year": "2005",
      "journal-title": "Curr Biol"
    },
    {
      "key": "ref25",
      "doi-asserted-by": "crossref",
      "first-page": "4573",
      "DOI": "10.1242/dev.02649",
      "article-title": "Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4",
      "volume": "133",
      "author": "S Zaessinger",
      "year": "2006",
      "journal-title": "Development"
    },
    {
      "key": "ref26",
      "doi-asserted-by": "crossref",
      "first-page": "1849",
      "DOI": "10.1093/hmg/ddp101",
      "article-title": "Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo",
      "volume": "18",
      "author": "A Chartier",
      "year": "2009",
      "journal-title": "Hum Mol Genet"
    },
    {
      "key": "ref27",
      "doi-asserted-by": "crossref",
      "first-page": "R129",
      "DOI": "10.1186/gb-2007-8-7-r129",
      "article-title": "FlyMine: an integrated database for Drosophila and Anopheles genomics",
      "volume": "8",
      "author": "R Lyne",
      "year": "2007",
      "journal-title": "Genome biology"
    },
    {
      "key": "ref28",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1101/gr.6940108",
      "article-title": "Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster",
      "volume": "18",
      "author": "J Chen",
      "year": "2008",
      "journal-title": "Genome research"
    },
    {
      "key": "ref29",
      "doi-asserted-by": "crossref",
      "first-page": "76",
      "DOI": "10.1016/j.devcel.2007.12.002",
      "article-title": "Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila",
      "volume": "14",
      "author": "GP Sykiotis",
      "year": "2008",
      "journal-title": "Developmental cell"
    },
    {
      "key": "ref30",
      "doi-asserted-by": "crossref",
      "first-page": "94",
      "DOI": "10.1124/mi.5.2.7",
      "article-title": "Role of mitochondria in toxic oxidative stress",
      "volume": "5",
      "author": "MW Fariss",
      "year": "2005",
      "journal-title": "Molecular interventions"
    },
    {
      "key": "ref31",
      "doi-asserted-by": "crossref",
      "first-page": "357",
      "DOI": "10.1101/gad.1177604",
      "article-title": "Transcriptional regulatory circuits controlling mitochondrial biogenesis and function",
      "volume": "18",
      "author": "DP Kelly",
      "year": "2004",
      "journal-title": "Genes & development"
    },
    {
      "key": "ref32",
      "doi-asserted-by": "crossref",
      "first-page": "78",
      "DOI": "10.1210/er.2002-0012",
      "article-title": "Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator",
      "volume": "24",
      "author": "P Puigserver",
      "year": "2003",
      "journal-title": "Endocrine reviews"
    },
    {
      "key": "ref33",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1152/physrev.00025.2007",
      "article-title": "Transcriptional paradigms in mammalian mitochondrial biogenesis and function",
      "volume": "88",
      "author": "RC Scarpulla",
      "year": "2008",
      "journal-title": "Physiological reviews"
    },
    {
      "key": "ref34",
      "doi-asserted-by": "crossref",
      "first-page": "e6935",
      "DOI": "10.1371/journal.pone.0006935",
      "article-title": "Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4",
      "volume": "4",
      "author": "C Baltzer",
      "year": "2009",
      "journal-title": "PLoS One"
    },
    {
      "issue": "Pt 23",
      "key": "ref35",
      "doi-asserted-by": "crossref",
      "first-page": "4263",
      "DOI": "10.1242/jcs.113.23.4263",
      "article-title": "Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila",
      "volume": "113",
      "author": "RP Herzig",
      "year": "2000",
      "journal-title": "Journal of cell science"
    },
    {
      "key": "ref36",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1038/emboj.2009.330",
      "article-title": "The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling",
      "volume": "29",
      "author": "SK Tiefenbock",
      "year": "2010",
      "journal-title": "The EMBO journal"
    },
    {
      "key": "ref37",
      "doi-asserted-by": "crossref",
      "first-page": "139",
      "DOI": "10.1016/j.cmet.2011.01.005",
      "article-title": "The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth",
      "volume": "13",
      "author": "JM Tennessen",
      "year": "2011",
      "journal-title": "Cell metabolism"
    },
    {
      "key": "ref38",
      "doi-asserted-by": "crossref",
      "first-page": "770",
      "DOI": "10.1006/dbio.1995.1186",
      "article-title": "Monitoring development and pathology of Drosophila indirect flight muscles using green fluorescent protein",
      "volume": "169",
      "author": "P Barthmaier",
      "year": "1995",
      "journal-title": "Developmental biology"
    },
    {
      "key": "ref39",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.3389/fgene.2014.00143",
      "article-title": "Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects",
      "volume": "5",
      "author": "C Temme",
      "year": "2014",
      "journal-title": "Frontiers in Genetics"
    },
    {
      "key": "ref40",
      "doi-asserted-by": "crossref",
      "first-page": "2862",
      "DOI": "10.1038/sj.emboj.7600273",
      "article-title": "A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila",
      "volume": "23",
      "author": "C Temme",
      "year": "2004",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref41",
      "doi-asserted-by": "crossref",
      "first-page": "1356",
      "DOI": "10.1261/rna.2145110",
      "article-title": "Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation",
      "volume": "16",
      "author": "C Temme",
      "year": "2010",
      "journal-title": "Rna"
    },
    {
      "key": "ref42",
      "doi-asserted-by": "crossref",
      "first-page": "1969",
      "DOI": "10.1242/dev.021444",
      "article-title": "PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila",
      "volume": "135",
      "author": "P Benoit",
      "year": "2008",
      "journal-title": "Development"
    },
    {
      "key": "ref43",
      "doi-asserted-by": "crossref",
      "first-page": "6603",
      "DOI": "10.1093/emboj/cdf633",
      "article-title": "Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila",
      "volume": "21",
      "author": "F Juge",
      "year": "2002",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref44",
      "doi-asserted-by": "crossref",
      "first-page": "533",
      "DOI": "10.1038/nsmb1100",
      "article-title": "PUF proteins bind Pop2p to regulate messenger RNAs",
      "volume": "13",
      "author": "AC Goldstrohm",
      "year": "2006",
      "journal-title": "Nat Struct Mol Biol"
    },
    {
      "key": "ref45",
      "doi-asserted-by": "crossref",
      "first-page": "1519",
      "DOI": "10.1242/dev.002212",
      "article-title": "Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline",
      "volume": "134",
      "author": "LY Kadyrova",
      "year": "2007",
      "journal-title": "Development"
    },
    {
      "key": "ref46",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1083/jcb.200606054",
      "article-title": "Puf3p, a Pumilio family RNA binding protein, localizes to mitochondria and regulates mitochondrial biogenesis and motility in budding yeast",
      "volume": "176",
      "author": "LJ Garcia-Rodriguez",
      "year": "2007",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "ref47",
      "doi-asserted-by": "crossref",
      "first-page": "E79",
      "DOI": "10.1371/journal.pbio.0020079",
      "article-title": "Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast",
      "volume": "2",
      "author": "AP Gerber",
      "year": "2004",
      "journal-title": "PLoS Biol"
    },
    {
      "key": "ref48",
      "doi-asserted-by": "crossref",
      "first-page": "e2293",
      "DOI": "10.1371/journal.pone.0002293",
      "article-title": "Yeast mitochondrial biogenesis: a role for the PUF RNA-binding protein Puf3p in mRNA localization",
      "volume": "3",
      "author": "Y Saint-Georges",
      "year": "2008",
      "journal-title": "PLoS One"
    },
    {
      "key": "ref49",
      "doi-asserted-by": "crossref",
      "first-page": "1128",
      "DOI": "10.1038/nature09465",
      "article-title": "Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo",
      "volume": "467",
      "author": "C Rouget",
      "year": "2010",
      "journal-title": "Nature"
    },
    {
      "key": "ref50",
      "doi-asserted-by": "crossref",
      "first-page": "e1003445",
      "DOI": "10.1371/journal.pgen.1003445",
      "article-title": "Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy",
      "volume": "9",
      "author": "M de Haro",
      "year": "2013",
      "journal-title": "PLoS genetics"
    },
    {
      "key": "ref51",
      "doi-asserted-by": "crossref",
      "first-page": "R4",
      "DOI": "10.1186/gb-2014-15-1-r4",
      "article-title": "Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein",
      "volume": "15",
      "author": "L Chen",
      "year": "2014",
      "journal-title": "Genome biology"
    },
    {
      "key": "ref52",
      "doi-asserted-by": "crossref",
      "first-page": "829",
      "DOI": "10.1093/hmg/ddh101",
      "article-title": "Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus",
      "volume": "13",
      "author": "MT Berciano",
      "year": "2004",
      "journal-title": "Hum Mol Genet"
    },
    {
      "key": "ref53",
      "doi-asserted-by": "crossref",
      "first-page": "672",
      "DOI": "10.1038/nm1242",
      "article-title": "Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice",
      "volume": "11",
      "author": "JE Davies",
      "year": "2005",
      "journal-title": "Nat Med"
    },
    {
      "key": "ref54",
      "doi-asserted-by": "crossref",
      "first-page": "2191",
      "DOI": "10.1093/hmg/ddq098",
      "article-title": "Molecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres",
      "volume": "19",
      "author": "C Trollet",
      "year": "2010",
      "journal-title": "Human molecular genetics"
    },
    {
      "key": "ref55",
      "doi-asserted-by": "crossref",
      "first-page": "44",
      "DOI": "10.1038/nprot.2008.211",
      "article-title": "Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources",
      "volume": "4",
      "author": "W Huang da",
      "year": "2009",
      "journal-title": "Nature protocols"
    },
    {
      "key": "ref56",
      "doi-asserted-by": "crossref",
      "first-page": "168",
      "DOI": "10.1038/nsmb1053",
      "article-title": "Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p",
      "volume": "13",
      "author": "T Aviv",
      "year": "2006",
      "journal-title": "Nature structural & molecular biology"
    },
    {
      "key": "ref57",
      "doi-asserted-by": "crossref",
      "first-page": "1537",
      "DOI": "10.1016/S1097-2765(03)00178-3",
      "article-title": "RNA recognition via the SAM domain of Smaug",
      "volume": "11",
      "author": "JB Green",
      "year": "2003",
      "journal-title": "Molecular cell"
    },
    {
      "key": "ref58",
      "doi-asserted-by": "crossref",
      "first-page": "234",
      "DOI": "10.1097/NEN.0b013e3182854c07",
      "article-title": "Atrophy, fibrosis, and increased PAX7-positive cells in pharyngeal muscles of oculopharyngeal muscular dystrophy patients",
      "volume": "72",
      "author": "T Gidaro",
      "year": "2013",
      "journal-title": "Journal of neuropathology and experimental neurology"
    },
    {
      "key": "ref59",
      "doi-asserted-by": "crossref",
      "first-page": "897",
      "DOI": "10.1016/j.neuron.2010.09.012",
      "article-title": "PolyQ disease: Too many Qs, too much function?",
      "volume": "67",
      "author": "IH Kratter",
      "year": "2010",
      "journal-title": "Neuron"
    },
    {
      "key": "ref60",
      "doi-asserted-by": "crossref",
      "first-page": "1988",
      "DOI": "10.1016/j.ajpath.2011.06.044",
      "article-title": "Modeling oculopharyngeal muscular dystrophy in myotube cultures reveals reduced accumulation of soluble mutant PABPN1 protein",
      "volume": "179",
      "author": "V Raz",
      "year": "2011",
      "journal-title": "The American journal of pathology"
    },
    {
      "key": "ref61",
      "doi-asserted-by": "crossref",
      "first-page": "394",
      "DOI": "10.1038/35006074",
      "article-title": "A Drosophila model of Parkinson&apos;s disease",
      "volume": "404",
      "author": "MB Feany",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "ref62",
      "doi-asserted-by": "crossref",
      "first-page": "569",
      "DOI": "10.1006/jmbi.2000.3572",
      "article-title": "The nuclear poly(A) binding protein, PABP2, forms an oligomeric particle covering the length of the poly(A) tail",
      "volume": "297",
      "author": "RW Keller",
      "year": "2000",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "ref63",
      "doi-asserted-by": "crossref",
      "first-page": "805",
      "DOI": "10.1038/nature02998",
      "article-title": "Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death",
      "volume": "431",
      "author": "M Arrasate",
      "year": "2004",
      "journal-title": "Nature"
    },
    {
      "key": "ref64",
      "doi-asserted-by": "crossref",
      "first-page": "1141",
      "DOI": "10.1083/jcb.201108159",
      "article-title": "Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation",
      "volume": "195",
      "author": "MV Baez",
      "year": "2011",
      "journal-title": "The Journal of cell biology"
    },
    {
      "key": "ref65",
      "doi-asserted-by": "crossref",
      "first-page": "1033",
      "DOI": "10.1016/j.neuron.2011.06.003",
      "article-title": "Mitochondria: the next (neurode)generation",
      "volume": "70",
      "author": "EA Schon",
      "year": "2011",
      "journal-title": "Neuron"
    },
    {
      "key": "ref66",
      "doi-asserted-by": "crossref",
      "first-page": "e1000298",
      "DOI": "10.1371/journal.pbio.1000298",
      "article-title": "PINK1 is selectively stabilized on impaired mitochondria to activate Parkin",
      "volume": "8",
      "author": "DP Narendra",
      "year": "2010",
      "journal-title": "PLoS biology"
    },
    {
      "key": "ref67",
      "doi-asserted-by": "crossref",
      "first-page": "893",
      "DOI": "10.1016/j.cell.2011.10.018",
      "article-title": "PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility",
      "volume": "147",
      "author": "X Wang",
      "year": "2011",
      "journal-title": "Cell"
    },
    {
      "key": "ref68",
      "doi-asserted-by": "crossref",
      "first-page": "1162",
      "DOI": "10.1038/nature04779",
      "article-title": "Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin",
      "volume": "441",
      "author": "IE Clark",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "ref69",
      "doi-asserted-by": "crossref",
      "first-page": "1157",
      "DOI": "10.1038/nature04788",
      "article-title": "Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin",
      "volume": "441",
      "author": "J Park",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "ref70",
      "first-page": "441",
      "article-title": "Analysis of poly(A) tail lengths by PCR: the PAT assay",
      "volume": "118",
      "author": "FJ Salles",
      "year": "1999",
      "journal-title": "Methods Mol Biol"
    },
    {
      "key": "ref71",
      "doi-asserted-by": "crossref",
      "first-page": "1289",
      "DOI": "10.1261/rna.031898.111",
      "article-title": "ePAT: a simple method to tag adenylated RNA to measure poly(A)-tail length and other 3&apos; RACE applications",
      "volume": "18",
      "author": "A Janicke",
      "year": "2012",
      "journal-title": "RNA"
    },
    {
      "key": "ref72",
      "doi-asserted-by": "crossref",
      "first-page": "e5631",
      "DOI": "10.1371/journal.pone.0005631",
      "article-title": "Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging",
      "volume": "4",
      "author": "F Casas",
      "year": "2009",
      "journal-title": "PLoS One"
    },
    {
      "key": "ref73",
      "doi-asserted-by": "crossref",
      "first-page": "3771",
      "DOI": "10.1093/nar/27.19.3771",
      "article-title": "The <italic>Drosophila</italic> poly(A)-binding protein II is ubiquitous throughout <italic>Drosophila</italic> development and has the same function in mRNA polyadenylation as its bovine homolog <italic>in vitro</italic>",
      "volume": "27",
      "author": "B Benoit",
      "year": "1999",
      "journal-title": "Nucleic Acids Res"
    }
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    "issue": "3",
    "published-online": {
      "date-parts": [
        [
          2015,
          3,
          27
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1371/journal.pgen.1005092",
  "relation": {},
  "ISSN": [
    "1553-7404"
  ],
  "subject": [],
  "container-title-short": "PLoS Genet",
  "published": {
    "date-parts": [
      [
        2015,
        3,
        27
      ]
    ]
  }
}