DOI: 10.1371/journal.pgen.1003613. The Conserved Intronic Cleavage and Polyadenylation Site of CstF-77 Gene Imparts Control of 3′ End Processing Activity through Feedback Autoregulation and by U1 snRNP

The Conserved Intronic Cleavage and Polyadenylation Site of CstF-77 Gene Imparts Control of 3′ End Processing Activity through Feedback Autoregulation and by U1 snRNP

10.1371/journal.pgen.1003613

Crossref journal-article

Public Library of Science (PLoS)

PLoS Genetics (340)

Bibliography

Luo, W., Ji, Z., Pan, Z., You, B., Hoque, M., Li, W., Gunderson, S. I., & Tian, B. (2013). The Conserved Intronic Cleavage and Polyadenylation Site of CstF-77 Gene Imparts Control of 3â² End Processing Activity through Feedback Autoregulation and by U1 snRNP. PLoS Genetics, 9(7), e1003613.

Authors 8

Wenting Luo (first)
Zhe Ji (additional)
Zhenhua Pan (additional)
Bei You (additional)
Mainul Hoque (additional)
Wencheng Li (additional)
Samuel I. Gunderson (additional)
Bin Tian (additional)

References 47 Referenced 45

10.1128/MMBR.63.2.405-445.1999 / Microbiol Mol Biol Rev / Formation of mRNA 3′ ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis by J Zhao (1999)
10.1101/gad.11.21.2755 / Genes Dev / Mechanism and regulation of mRNA polyadenylation by DF Colgan (1997)
10.1002/wrna.116 / Wiley Interdiscip Rev RNA / Signals for pre-mRNA cleavage and polyadenylation by B Tian (2011)
10.1101/gad.17268411 / Genes Dev / Ending the message: poly(A) signals then and now by NJ Proudfoot (2011)
10.1101/gad.1298605 / Genes Dev / Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition by K Venkataraman (2005)
10.1093/nar/gki158 / Nucleic Acids Res / A large-scale analysis of mRNA polyadenylation of human and mouse genes by B Tian (2005)
10.1038/nature07509 / Nature / Alternative isoform regulation in human tissue transcriptomes by ET Wang (2008)
10.1038/nmeth.2288 / Nat Methods / Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing by M Hoque (2013)
10.1101/gr.5532707 / Genome Res / Widespread mRNA polyadenylation events in introns indicate dynamic interplay between polyadenylation and splicing by B Tian (2007)
10.1016/S0092-8674(00)82000-0 / Cell / The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation by Y Takagaki (1996)
10.1007/s00018-007-7474-3 / Cell Mol Life Sci / Protein factors in pre-mRNA 3′-end processing by CR Mandel (2008)
10.1016/j.molcel.2008.12.028 / Mol Cell / Molecular architecture of the human pre-mRNA 3′ processing complex by Y Shi (2009)
10.1093/nar/28.2.520 / Nucleic Acids Res / The <italic>Drosophila</italic> homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the <italic>suppressor of forked</italic> gene by LS Hatton (2000)
10.1038/372471a0 / Nature / A polyadenylation factor subunit is the human homologue of the <italic>Drosophila suppressor of forked</italic> protein by Y Takagaki (1994)
10.1016/j.molcel.2007.01.034 / Mol Cell / Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors by Y Bai (2007)
10.1093/nar/gkm458 / Nucleic Acids Res / The structure of the CstF-77 homodimer provides insights into CstF assembly by P Legrand (2007)
10.1101/gad.9.21.2672 / Genes Dev / The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3′-end formation by KG Murthy (1995)
10.1038/385357a0 / Nature / The C-terminal domain of RNA polymerase II couples mRNA processing to transcription by S McCracken (1997)
10.1101/gad.7.2.241 / Genes Dev / Homology with <italic>Saccharomyces cerevisiae RNA14</italic> suggests that phenotypic suppression in <italic>Drosophila melanogaster</italic> by suppressor of forked occurs at the level of RNA stability by A Mitchelson (1993)
10.1093/genetics/142.4.1225 / Genetics / Interallelic complementation at the <italic>suppressor of forked</italic> locus of <italic>Drosophila</italic> reveals complementation between <italic>suppressor of forked</italic> proteins mutated in different regions by M Simonelig (1996)
10.1073/pnas.95.24.14302 / Proc Natl Acad Sci U S A / Autoregulation at the level of mRNA 3′ end formation of the suppressor of forked gene of Drosophila melanogaster is conserved in Drosophila virilis by A Audibert (1998)
10.1017/S1355838200001266 / RNA / Tissue-specific autoregulation of <italic>Drosophila suppressor of forked</italic> by alternative poly(A) site utilization leads to accumulation of the <italic>suppressor of forked</italic> protein in mitotically active cells by F Juge (2000)
10.1016/S0925-4773(99)00011-8 / Mech Dev / The suppressor of forked gene of Drosophila, which encodes a homologue of human CstF-77K involved in mRNA 3′-end processing, is required for progression through mitosis by A Audibert (1999)
10.1073/pnas.162191899 / Proc Natl Acad Sci U S A / Chimeric human CstF-77/<italic>Drosophila</italic> Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3′ end processing in <italic>Drosophila</italic> by B Benoit (2002)
10.1016/j.gene.2005.09.024 / Gene / An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism by Z Pan (2006)
10.1089/1066527041410418 / J Comput Biol / Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals by G Yeo (2004)
10.1101/gr.3715005 / Genome Res / Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes by A Siepel (2005)
10.1128/MCB.10.1.84 / Mol Cell Biol / Exon definition may facilitate splice site selection in RNAs with multiple exons by BL Robberson (1990)
10.1093/nar/18.19.5799 / Nucleic Acids Res / Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro by MD Sheets (1990)
10.1371/journal.pone.0008419 / PLoS One / Reprogramming of 3′ untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types by Z Ji (2009)
10.1073/pnas.0900028106 / Proc Natl Acad Sci U S A / Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development by Z Ji (2009)
10.1016/S1097-2765(00)80026-X / Mol Cell / U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase by SI Gunderson (1998)
10.1128/MCB.19.10.6796 / Mol Cell Biol / Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155 by BK Das (1999)
10.1126/science.273.5282.1706 / Science / Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected] by J Valcarcel (1996)
10.1038/nbt.1525 / Nat Biotechnol / Gene silencing by synthetic U1 adaptors by R Goraczniak (2009)
10.1016/j.cell.2012.05.029 / Cell / U1 snRNP determines mRNA length and regulates isoform expression by MG Berg (2012)
10.1073/pnas.83.23.8883 / Proc Natl Acad Sci U S A / Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intron by ML Peterson (1986)
10.1128/MCB.9.2.726 / Mol Cell Biol / The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice by ML Peterson (1989)
10.1128/MCB.24.14.6162-6171.2004 / Mol Cell Biol / U1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site by binding between the two downstream GU-rich regions by C Phillips (2004)
10.1038/ni.1786 / Nat Immunol / Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing by K Martincic (2009)
10.1093/emboj/cdg259 / EMBO J / Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein by JM Perez Canadillas (2003)
10.1073/pnas.1211101109 / Proc Natl Acad Sci U S A / Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation by C Yao (2012)
10.1038/msb.2011.69 / Mol Syst Biol / Transcriptional activity regulates alternative cleavage and polyadenylation by Z Ji (2011)
10.1093/nar/gkl870 / Nucleic Acids Res / PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes by JY Lee (2007)
10.1016/S1097-2765(03)00270-3 / Mol Cell / Pre-mRNA splicing: awash in a sea of proteins by MS Jurica (2003)
10.1093/nar/gkg599 / Nucleic Acids Research / Vienna RNA secondary structure server by IL Hofacker (2003)
10.1038/nprot.2008.211 / Nat Protoc / Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources by W Huang da (2009)

Dates

Type	When
Created	12 years, 1 month ago (July 11, 2013, 4:44 p.m.)
Deposited	3 years, 6 months ago (Feb. 28, 2022, 8:57 a.m.)
Indexed	2 months, 1 week ago (June 24, 2025, 2:40 p.m.)
Issued	12 years, 1 month ago (July 11, 2013)
Published	12 years, 1 month ago (July 11, 2013)
Published Online	12 years, 1 month ago (July 11, 2013)

Funders 0

None

BibTeX

@article{Luo_2013, title={The Conserved Intronic Cleavage and Polyadenylation Site of CstF-77 Gene Imparts Control of 3′ End Processing Activity through Feedback Autoregulation and by U1 snRNP}, volume={9}, ISSN={1553-7404}, url={http://dx.doi.org/10.1371/journal.pgen.1003613}, DOI={10.1371/journal.pgen.1003613}, number={7}, journal={PLoS Genetics}, publisher={Public Library of Science (PLoS)}, author={Luo, Wenting and Ji, Zhe and Pan, Zhenhua and You, Bei and Hoque, Mainul and Li, Wencheng and Gunderson, Samuel I. and Tian, Bin}, editor={Liang Tong}, year={2013}, month=jul, pages={e1003613} }

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      "author": "J Zhao",
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      "author": "DF Colgan",
      "year": "1997",
      "journal-title": "Genes Dev"
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    {
      "key": "ref3",
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      "first-page": "385",
      "DOI": "10.1002/wrna.116",
      "article-title": "Signals for pre-mRNA cleavage and polyadenylation",
      "volume": "3",
      "author": "B Tian",
      "year": "2011",
      "journal-title": "Wiley Interdiscip Rev RNA"
    },
    {
      "key": "ref4",
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      "first-page": "1770",
      "DOI": "10.1101/gad.17268411",
      "article-title": "Ending the message: poly(A) signals then and now",
      "volume": "25",
      "author": "NJ Proudfoot",
      "year": "2011",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref5",
      "doi-asserted-by": "crossref",
      "first-page": "1315",
      "DOI": "10.1101/gad.1298605",
      "article-title": "Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition",
      "volume": "19",
      "author": "K Venkataraman",
      "year": "2005",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref6",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1093/nar/gki158",
      "article-title": "A large-scale analysis of mRNA polyadenylation of human and mouse genes",
      "volume": "33",
      "author": "B Tian",
      "year": "2005",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "ref7",
      "doi-asserted-by": "crossref",
      "first-page": "470",
      "DOI": "10.1038/nature07509",
      "article-title": "Alternative isoform regulation in human tissue transcriptomes",
      "volume": "456",
      "author": "ET Wang",
      "year": "2008",
      "journal-title": "Nature"
    },
    {
      "key": "ref8",
      "doi-asserted-by": "crossref",
      "first-page": "133",
      "DOI": "10.1038/nmeth.2288",
      "article-title": "Analysis of alternative cleavage and polyadenylation by 3\u2032 region extraction and deep sequencing",
      "volume": "10",
      "author": "M Hoque",
      "year": "2013",
      "journal-title": "Nat Methods"
    },
    {
      "key": "ref9",
      "doi-asserted-by": "crossref",
      "first-page": "156",
      "DOI": "10.1101/gr.5532707",
      "article-title": "Widespread mRNA polyadenylation events in introns indicate dynamic interplay between polyadenylation and splicing",
      "volume": "17",
      "author": "B Tian",
      "year": "2007",
      "journal-title": "Genome Res"
    },
    {
      "key": "ref10",
      "doi-asserted-by": "crossref",
      "first-page": "941",
      "DOI": "10.1016/S0092-8674(00)82000-0",
      "article-title": "The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation",
      "volume": "87",
      "author": "Y Takagaki",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "ref11",
      "doi-asserted-by": "crossref",
      "first-page": "1099",
      "DOI": "10.1007/s00018-007-7474-3",
      "article-title": "Protein factors in pre-mRNA 3\u2032-end processing",
      "volume": "65",
      "author": "CR Mandel",
      "year": "2008",
      "journal-title": "Cell Mol Life Sci"
    },
    {
      "key": "ref12",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1016/j.molcel.2008.12.028",
      "article-title": "Molecular architecture of the human pre-mRNA 3\u2032 processing complex",
      "volume": "33",
      "author": "Y Shi",
      "year": "2009",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref13",
      "doi-asserted-by": "crossref",
      "first-page": "520",
      "DOI": "10.1093/nar/28.2.520",
      "article-title": "The <italic>Drosophila</italic> homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the <italic>suppressor of forked</italic> gene",
      "volume": "28",
      "author": "LS Hatton",
      "year": "2000",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "ref14",
      "doi-asserted-by": "crossref",
      "first-page": "471",
      "DOI": "10.1038/372471a0",
      "article-title": "A polyadenylation factor subunit is the human homologue of the <italic>Drosophila suppressor of forked</italic> protein",
      "volume": "372",
      "author": "Y Takagaki",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "ref15",
      "doi-asserted-by": "crossref",
      "first-page": "863",
      "DOI": "10.1016/j.molcel.2007.01.034",
      "article-title": "Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors",
      "volume": "25",
      "author": "Y Bai",
      "year": "2007",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref16",
      "doi-asserted-by": "crossref",
      "first-page": "4515",
      "DOI": "10.1093/nar/gkm458",
      "article-title": "The structure of the CstF-77 homodimer provides insights into CstF assembly",
      "volume": "35",
      "author": "P Legrand",
      "year": "2007",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "ref17",
      "doi-asserted-by": "crossref",
      "first-page": "2672",
      "DOI": "10.1101/gad.9.21.2672",
      "article-title": "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3\u2032-end formation",
      "volume": "9",
      "author": "KG Murthy",
      "year": "1995",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref18",
      "doi-asserted-by": "crossref",
      "first-page": "357",
      "DOI": "10.1038/385357a0",
      "article-title": "The C-terminal domain of RNA polymerase II couples mRNA processing to transcription",
      "volume": "385",
      "author": "S McCracken",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "ref19",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1101/gad.7.2.241",
      "article-title": "Homology with <italic>Saccharomyces cerevisiae RNA14</italic> suggests that phenotypic suppression in <italic>Drosophila melanogaster</italic> by suppressor of forked occurs at the level of RNA stability",
      "volume": "7",
      "author": "A Mitchelson",
      "year": "1993",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref20",
      "doi-asserted-by": "crossref",
      "first-page": "1225",
      "DOI": "10.1093/genetics/142.4.1225",
      "article-title": "Interallelic complementation at the <italic>suppressor of forked</italic> locus of <italic>Drosophila</italic> reveals complementation between <italic>suppressor of forked</italic> proteins mutated in different regions",
      "volume": "142",
      "author": "M Simonelig",
      "year": "1996",
      "journal-title": "Genetics"
    },
    {
      "key": "ref21",
      "doi-asserted-by": "crossref",
      "first-page": "14302",
      "DOI": "10.1073/pnas.95.24.14302",
      "article-title": "Autoregulation at the level of mRNA 3\u2032 end formation of the suppressor of forked gene of Drosophila melanogaster is conserved in Drosophila virilis",
      "volume": "95",
      "author": "A Audibert",
      "year": "1998",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref22",
      "doi-asserted-by": "crossref",
      "first-page": "1529",
      "DOI": "10.1017/S1355838200001266",
      "article-title": "Tissue-specific autoregulation of <italic>Drosophila suppressor of forked</italic> by alternative poly(A) site utilization leads to accumulation of the <italic>suppressor of forked</italic> protein in mitotically active cells",
      "volume": "6",
      "author": "F Juge",
      "year": "2000",
      "journal-title": "RNA"
    },
    {
      "key": "ref23",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1016/S0925-4773(99)00011-8",
      "article-title": "The suppressor of forked gene of Drosophila, which encodes a homologue of human CstF-77K involved in mRNA 3\u2032-end processing, is required for progression through mitosis",
      "volume": "82",
      "author": "A Audibert",
      "year": "1999",
      "journal-title": "Mech Dev"
    },
    {
      "key": "ref24",
      "doi-asserted-by": "crossref",
      "first-page": "10593",
      "DOI": "10.1073/pnas.162191899",
      "article-title": "Chimeric human CstF-77/<italic>Drosophila</italic> Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3\u2032 end processing in <italic>Drosophila</italic>",
      "volume": "99",
      "author": "B Benoit",
      "year": "2002",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref25",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1016/j.gene.2005.09.024",
      "article-title": "An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism",
      "volume": "366",
      "author": "Z Pan",
      "year": "2006",
      "journal-title": "Gene"
    },
    {
      "key": "ref26",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1089/1066527041410418",
      "article-title": "Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals",
      "volume": "11",
      "author": "G Yeo",
      "year": "2004",
      "journal-title": "J Comput Biol"
    },
    {
      "key": "ref27",
      "doi-asserted-by": "crossref",
      "first-page": "1034",
      "DOI": "10.1101/gr.3715005",
      "article-title": "Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes",
      "volume": "15",
      "author": "A Siepel",
      "year": "2005",
      "journal-title": "Genome Res"
    },
    {
      "key": "ref28",
      "doi-asserted-by": "crossref",
      "first-page": "84",
      "DOI": "10.1128/MCB.10.1.84",
      "article-title": "Exon definition may facilitate splice site selection in RNAs with multiple exons",
      "volume": "10",
      "author": "BL Robberson",
      "year": "1990",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref29",
      "doi-asserted-by": "crossref",
      "first-page": "5799",
      "DOI": "10.1093/nar/18.19.5799",
      "article-title": "Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro",
      "volume": "18",
      "author": "MD Sheets",
      "year": "1990",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "ref30",
      "doi-asserted-by": "crossref",
      "first-page": "e8419",
      "DOI": "10.1371/journal.pone.0008419",
      "article-title": "Reprogramming of 3\u2032 untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types",
      "volume": "4",
      "author": "Z Ji",
      "year": "2009",
      "journal-title": "PLoS One"
    },
    {
      "key": "ref31",
      "doi-asserted-by": "crossref",
      "first-page": "7028",
      "DOI": "10.1073/pnas.0900028106",
      "article-title": "Progressive lengthening of 3\u2032 untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development",
      "volume": "106",
      "author": "Z Ji",
      "year": "2009",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref32",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1016/S1097-2765(00)80026-X",
      "article-title": "U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase",
      "volume": "1",
      "author": "SI Gunderson",
      "year": "1998",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref33",
      "doi-asserted-by": "crossref",
      "first-page": "6796",
      "DOI": "10.1128/MCB.19.10.6796",
      "article-title": "Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155",
      "volume": "19",
      "author": "BK Das",
      "year": "1999",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref34",
      "doi-asserted-by": "crossref",
      "first-page": "1706",
      "DOI": "10.1126/science.273.5282.1706",
      "article-title": "Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected]",
      "volume": "273",
      "author": "J Valcarcel",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "ref35",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1038/nbt.1525",
      "article-title": "Gene silencing by synthetic U1 adaptors",
      "volume": "27",
      "author": "R Goraczniak",
      "year": "2009",
      "journal-title": "Nat Biotechnol"
    },
    {
      "key": "ref36",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1016/j.cell.2012.05.029",
      "article-title": "U1 snRNP determines mRNA length and regulates isoform expression",
      "volume": "150",
      "author": "MG Berg",
      "year": "2012",
      "journal-title": "Cell"
    },
    {
      "key": "ref37",
      "doi-asserted-by": "crossref",
      "first-page": "8883",
      "DOI": "10.1073/pnas.83.23.8883",
      "article-title": "Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intron",
      "volume": "83",
      "author": "ML Peterson",
      "year": "1986",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref38",
      "doi-asserted-by": "crossref",
      "first-page": "726",
      "DOI": "10.1128/MCB.9.2.726",
      "article-title": "The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice",
      "volume": "9",
      "author": "ML Peterson",
      "year": "1989",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref39",
      "doi-asserted-by": "crossref",
      "first-page": "6162",
      "DOI": "10.1128/MCB.24.14.6162-6171.2004",
      "article-title": "U1A inhibits cleavage at the immunoglobulin M heavy-chain secretory poly(A) site by binding between the two downstream GU-rich regions",
      "volume": "24",
      "author": "C Phillips",
      "year": "2004",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref40",
      "doi-asserted-by": "crossref",
      "first-page": "1102",
      "DOI": "10.1038/ni.1786",
      "article-title": "Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing",
      "volume": "10",
      "author": "K Martincic",
      "year": "2009",
      "journal-title": "Nat Immunol"
    },
    {
      "key": "ref41",
      "doi-asserted-by": "crossref",
      "first-page": "2821",
      "DOI": "10.1093/emboj/cdg259",
      "article-title": "Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein",
      "volume": "22",
      "author": "JM Perez Canadillas",
      "year": "2003",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref42",
      "doi-asserted-by": "crossref",
      "first-page": "18773",
      "DOI": "10.1073/pnas.1211101109",
      "article-title": "Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation",
      "volume": "109",
      "author": "C Yao",
      "year": "2012",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref43",
      "doi-asserted-by": "crossref",
      "first-page": "534",
      "DOI": "10.1038/msb.2011.69",
      "article-title": "Transcriptional activity regulates alternative cleavage and polyadenylation",
      "volume": "7",
      "author": "Z Ji",
      "year": "2011",
      "journal-title": "Mol Syst Biol"
    },
    {
      "key": "ref44",
      "doi-asserted-by": "crossref",
      "first-page": "D165",
      "DOI": "10.1093/nar/gkl870",
      "article-title": "PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes",
      "volume": "35",
      "author": "JY Lee",
      "year": "2007",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "ref45",
      "doi-asserted-by": "crossref",
      "first-page": "5",
      "DOI": "10.1016/S1097-2765(03)00270-3",
      "article-title": "Pre-mRNA splicing: awash in a sea of proteins",
      "volume": "12",
      "author": "MS Jurica",
      "year": "2003",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref46",
      "doi-asserted-by": "crossref",
      "first-page": "3429",
      "DOI": "10.1093/nar/gkg599",
      "article-title": "Vienna RNA secondary structure server",
      "volume": "31",
      "author": "IL Hofacker",
      "year": "2003",
      "journal-title": "Nucleic Acids Research"
    },
    {
      "key": "ref47",
      "doi-asserted-by": "crossref",
      "first-page": "44",
      "DOI": "10.1038/nprot.2008.211",
      "article-title": "Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources",
      "volume": "4",
      "author": "W Huang da",
      "year": "2009",
      "journal-title": "Nat Protoc"
    }
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