DOI: 10.1371/journal.pgen.1001173. DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes

DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes

10.1371/journal.pgen.1001173

Crossref journal-article

Public Library of Science (PLoS)

PLoS Genetics (340)

Bibliography

Drouin, S., LaramÃ©e, L., Jacques, P.-Ã., Forest, A., Bergeron, M., & Robert, F. (2010). DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes. PLoS Genetics, 6(10), e1001173.

Authors 6

Simon Drouin (first)
Louise Laramée (additional)
Pierre-Étienne Jacques (additional)
Audrey Forest (additional)
Maxime Bergeron (additional)
François Robert (additional)

References 78 Referenced 126

10.1146/annurev.biochem.76.052705.162114 / Annu Rev Biochem / Functions of site-specific histone acetylation and deacetylation. by MD Shahbazian (2007)
10.1038/nrm2346 / Nat Rev Mol Cell Biol / The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. by XJ Yang (2008)
10.1371/journal.pbio.1000189 / PLoS Biol / Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets. by H Wang (2009)
10.1371/journal.pbio.1000188 / PLoS Biol / Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. by D Huang (2009)
{'key': 'ref5', 'article-title': 'The SAGA and Rpd3 chromatin modification complexes dynamically regulate heat shock gene structure and expression.', 'author': 'SB Kremer', 'year': '2009', 'journal-title': 'J Biol Chem'} / J Biol Chem / The SAGA and Rpd3 chromatin modification complexes dynamically regulate heat shock gene structure and expression. by SB Kremer (2009)
10.1038/emboj.2009.270 / EMBO J / The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters. by S Takahata (2009)
10.1128/MCB.01253-07 / Mol Cell Biol / Activation of the G2/M-specific gene CLB2 requires multiple cell cycle signals. by J Veis (2007)
10.1128/MCB.02311-06 / Mol Cell Biol / Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes. by VM Sharma (2007)
10.1128/MCB.01661-06 / Mol Cell Biol / Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis. by T Inai (2007)
10.1016/j.molcel.2004.09.021 / Mol Cell / Global position and recruitment of HATs and HDACs in the yeast genome. by F Robert (2004)
10.1038/nature02258 / Nature / The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. by E De Nadal (2004)
10.1074/jbc.M308632200 / J Biol Chem / Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. by MJ Mallory (2003)
10.1128/MCB.21.6.2057-2069.2001 / Mol Cell Biol / Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast. by BK Washburn (2001)
10.1128/MCB.18.9.5121 / Mol Cell Biol / Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. by D Kadosh (1998)
10.1038/33952 / Nature / Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. by SE Rundlett (1998)
10.1016/S0092-8674(00)80217-2 / Cell / Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. by D Kadosh (1997)
10.1038/ng907 / Nat Genet / Genome-wide binding map of the histone deacetylase Rpd3 in yeast. by SK Kurdistani (2002)
10.1128/MCB.21.19.6450-6460.2001 / Mol Cell Biol / Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression. by TG Fazzio (2001)
10.1101/gad.12.6.797 / Genes Dev / Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. by D Kadosh (1998)
10.1093/nar/gkp233 / Nucleic Acids Res / Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. by J Zhou (2009)
10.1074/jbc.M102176200 / J Biol Chem / Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae. by R Loewith (2001)
10.1093/genetics/152.3.921 / Genetics / A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae. by ZW Sun (1999)
10.1073/pnas.93.25.14503 / Proc Natl Acad Sci U S A / HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. by SE Rundlett (1996)
10.1093/genetics/144.4.1343 / Genetics / Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. by D Vannier (1996)
10.1093/emboj/cdf498 / EMBO J / RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase. by JJ Sandmeier (2002)
10.1128/MCB.19.4.3184 / Mol Cell Biol / A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. by JS Smith (1999)
10.1128/MCB.26.10.3889-3901.2006 / Mol Cell Biol / Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast. by ML Oakes (2006)
10.1101/gad.1784309 / Genes Dev / Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. by SR Knott (2009)
10.1016/S1097-2765(02)00702-5 / Mol Cell / Histone acetylation regulates the time of replication origin firing. by M Vogelauer (2002)
10.1093/genetics/157.2.545 / Genetics / Coupling of Saccharomyces cerevisiae early meiotic gene expression to DNA replication depends upon RPD3 and SIN3. by TM Lamb (2001)
10.1128/MCB.24.11.4769-4780.2004 / Mol Cell Biol / The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae. by JG Aparicio (2004)
10.1016/j.dnarep.2008.04.009 / DNA Repair (Amst) / The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. by JD Merker (2008)
10.1007/s002940050434 / Curr Genet / RPD3 (REC3) mutations affect mitotic recombination in Saccharomyces cerevisiae. by EG Dora (1999)
10.1016/j.cell.2005.10.023 / Cell / Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription. by MJ Carrozza (2005)
10.1016/j.cell.2005.10.025 / Cell / Cotranscriptional set2 methylation of histone h3 lysine 36 recruits a repressive rpd3 complex. by MC Keogh (2005)
10.1371/journal.pone.0004886 / PLoS One / The Set2/Rpd3S pathway suppresses cryptic transcription without regard to gene length or transcription frequency. by CR Lickwar (2009)
10.1101/gad.1539307 / Genes Dev / Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription. by B Li (2007)
10.1016/j.molcel.2005.11.021 / Mol Cell / Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. by AA Joshi (2005)
10.1016/j.mrfmmm.2006.08.014 / Mutat Res / A site to remember: H3K36 methylation a mark for histone deacetylation. by JS Lee (2007)
10.1128/MCB.00164-08 / Mol Cell Biol / Different genetic functions for the Rpd3(L) and Rpd3(S) complexes suggest competition between NuA4 and Rpd3(S). by D Biswas (2008)
10.1016/S0092-8674(02)00746-8 / Cell / Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. by D Robyr (2002)
10.1534/genetics.109.111526 / Genetics / Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription. by TK Quan (2010)
10.1101/gad.12.3.343 / Genes Dev / DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. by T Wada (1998)
10.1016/j.molcel.2008.03.001 / Mol Cell / Poised polymerases: on your mark…get set…go! by DH Price (2008)
10.1038/nrm1981 / Nat Rev Mol Cell Biol / Breaking barriers to transcription elongation. by A Saunders (2006)
10.1101/gad.1235904 / Genes Dev / Elongation by RNA polymerase II: the short and long of it. by RJ Sims III (2004)
10.1128/MCB.23.21.7887-7901.2003 / Mol Cell Biol / In vivo evidence that defects in the transcriptional elongation factors RPB2, TFIIS, and SPT5 enhance upstream poly(A) site utilization. by Y Cui (2003)
10.1038/sj.emboj.7600687 / EMBO J / Npl3 is an antagonist of mRNA 3′ end formation by RNA polymerase II. by ME Bucheli (2005)
10.1074/jbc.M411108200 / J Biol Chem / Interaction between transcription elongation factors and mRNA 3′-end formation at the Saccharomyces cerevisiae GAL10-GAL7 locus. by CD Kaplan (2005)
10.1128/MCB.23.4.1368-1378.2003 / Mol Cell Biol / Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. by DL Lindstrom (2003)
10.1016/j.molcel.2010.07.003 / Mol Cell / Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. by CK Govind (2010)
10.1016/j.molcel.2009.02.018 / Mol Cell / Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. by H Qiu (2009)
10.1128/MCB.26.8.3029-3038.2006 / Mol Cell Biol / The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2. by Y Chu (2006)
10.1016/j.molcel.2006.06.014 / Mol Cell / Controlling the elongation phase of transcription with P-TEFb. by BM Peterlin (2006)
10.1016/j.molcel.2005.09.010 / Mol Cell / The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS. by A Wood (2005)
{'key': 'ref56', 'article-title': 'Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.', 'author': 'K Zhou', 'year': '2009', 'journal-title': 'Proc Natl Acad Sci U S A'} / Proc Natl Acad Sci U S A / Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5. by K Zhou (2009)
10.1128/MCB.00609-09 / Mol Cell Biol / Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. by Y Liu (2009)
10.1128/MCB.23.19.7005-7018.2003 / Mol Cell Biol / Bur1 kinase is required for efficient transcription elongation by RNA polymerase II. by MC Keogh (2003)
10.1038/nature00883 / Nature / Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. by ZW Sun (2002)
10.1074/jbc.C200433200 / J Biol Chem / Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. by HH Ng (2002)
10.1083/jcb.200906005 / J Cell Biol / Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. by S Nakanishi (2009)
10.1038/embor.2009.181 / EMBO Rep / Pervasive transcription constitutes a new level of eukaryotic genome regulation. by J Berretta (2009)
10.1038/nature05649 / Nature / Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. by SR Collins (2007)
10.1038/nature04532 / Nature / Proteome survey reveals modularity of the yeast cell machinery. by AC Gavin (2006)
10.1038/nature04670 / Nature / Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. by NJ Krogan (2006)
10.1073/pnas.0804424105 / Proc Natl Acad Sci U S A / A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin. by O Aygun (2008)
10.1074/mcp.M800447-MCP200 / Mol Cell Proteomics / A novel proteomics approach for the discovery of chromatin-associated protein networks. by JP Lambert (2009)
10.1006/jmbi.2001.4991 / J Mol Biol / The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9. by SB Lavoie (2001)
10.1093/emboj/19.14.3739 / EMBO J / Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. by M Arevalo-Rodriguez (2000)
10.1093/emboj/17.24.7395 / EMBO J / Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. by T Wada (1998)
10.1093/genetics/159.2.487 / Genetics / Genetic interactions of Spt4-Spt5 and TFIIS with the RNA polymerase II CTD and CTD modifying enzymes in Saccharomyces cerevisiae. by DL Lindstrom (2001)
10.1016/j.molcel.2009.01.029 / Mol Cell / TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. by L Viladevall (2009)
10.1128/MCB.26.8.3135-3148.2006 / Mol Cell Biol / The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II. by H Qiu (2006)
10.1126/science.290.5500.2306 / Science / Genome-wide location and function of DNA binding proteins. by B Ren (2000)
10.1371/journal.pgen.0020158 / PLoS Genet / Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters. by GJ Hogan (2006)
10.1073/pnas.95.25.14863 / Proc Natl Acad Sci U S A / Cluster analysis and display of genome-wide expression patterns. by MB Eisen (1998)
10.1093/bioinformatics/bth349 / Bioinformatics / Java Treeview–extensible visualization of microarray data. by AJ Saldanha (2004)
10.1016/j.molcel.2007.07.011 / Mol Cell / Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1. by A Rufiange (2007)

Dates

Type	When
Created	14 years, 10 months ago (Oct. 28, 2010, 4:55 p.m.)
Deposited	3 years, 9 months ago (Nov. 12, 2021, 3:48 p.m.)
Indexed	4 months, 1 week ago (April 22, 2025, 3:15 a.m.)
Issued	14 years, 10 months ago (Oct. 28, 2010)
Published	14 years, 10 months ago (Oct. 28, 2010)
Published Online	14 years, 10 months ago (Oct. 28, 2010)

Funders 0

None

BibTeX

@article{Drouin_2010, title={DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes}, volume={6}, ISSN={1553-7404}, url={http://dx.doi.org/10.1371/journal.pgen.1001173}, DOI={10.1371/journal.pgen.1001173}, number={10}, journal={PLoS Genetics}, publisher={Public Library of Science (PLoS)}, author={Drouin, Simon and Laramée, Louise and Jacques, Pierre-Étienne and Forest, Audrey and Bergeron, Maxime and Robert, François}, editor={Lieb, Jason D.}, year={2010}, month=oct, pages={e1001173} }

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      "article-title": "Functions of site-specific histone acetylation and deacetylation.",
      "volume": "76",
      "author": "MD Shahbazian",
      "year": "2007",
      "journal-title": "Annu Rev Biochem"
    },
    {
      "key": "ref2",
      "doi-asserted-by": "crossref",
      "first-page": "206",
      "DOI": "10.1038/nrm2346",
      "article-title": "The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.",
      "volume": "9",
      "author": "XJ Yang",
      "year": "2008",
      "journal-title": "Nat Rev Mol Cell Biol"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "e1000189",
      "DOI": "10.1371/journal.pbio.1000189",
      "article-title": "Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.",
      "volume": "7",
      "author": "H Wang",
      "year": "2009",
      "journal-title": "PLoS Biol"
    },
    {
      "key": "ref4",
      "doi-asserted-by": "crossref",
      "first-page": "e1000188",
      "DOI": "10.1371/journal.pbio.1000188",
      "article-title": "Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast.",
      "volume": "7",
      "author": "D Huang",
      "year": "2009",
      "journal-title": "PLoS Biol"
    },
    {
      "key": "ref5",
      "article-title": "The SAGA and Rpd3 chromatin modification complexes dynamically regulate heat shock gene structure and expression.",
      "author": "SB Kremer",
      "year": "2009",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref6",
      "doi-asserted-by": "crossref",
      "first-page": "3378",
      "DOI": "10.1038/emboj.2009.270",
      "article-title": "The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters.",
      "volume": "28",
      "author": "S Takahata",
      "year": "2009",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref7",
      "doi-asserted-by": "crossref",
      "first-page": "8364",
      "DOI": "10.1128/MCB.01253-07",
      "article-title": "Activation of the G2/M-specific gene CLB2 requires multiple cell cycle signals.",
      "volume": "27",
      "author": "J Veis",
      "year": "2007",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref8",
      "doi-asserted-by": "crossref",
      "first-page": "3199",
      "DOI": "10.1128/MCB.02311-06",
      "article-title": "Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes.",
      "volume": "27",
      "author": "VM Sharma",
      "year": "2007",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref9",
      "doi-asserted-by": "crossref",
      "first-page": "1254",
      "DOI": "10.1128/MCB.01661-06",
      "article-title": "Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis.",
      "volume": "27",
      "author": "T Inai",
      "year": "2007",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref10",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1016/j.molcel.2004.09.021",
      "article-title": "Global position and recruitment of HATs and HDACs in the yeast genome.",
      "volume": "16",
      "author": "F Robert",
      "year": "2004",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref11",
      "doi-asserted-by": "crossref",
      "first-page": "370",
      "DOI": "10.1038/nature02258",
      "article-title": "The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.",
      "volume": "427",
      "author": "E De Nadal",
      "year": "2004",
      "journal-title": "Nature"
    },
    {
      "key": "ref12",
      "doi-asserted-by": "crossref",
      "first-page": "44727",
      "DOI": "10.1074/jbc.M308632200",
      "article-title": "Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p.",
      "volume": "278",
      "author": "MJ Mallory",
      "year": "2003",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref13",
      "doi-asserted-by": "crossref",
      "first-page": "2057",
      "DOI": "10.1128/MCB.21.6.2057-2069.2001",
      "article-title": "Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast.",
      "volume": "21",
      "author": "BK Washburn",
      "year": "2001",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref14",
      "doi-asserted-by": "crossref",
      "first-page": "5121",
      "DOI": "10.1128/MCB.18.9.5121",
      "article-title": "Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo.",
      "volume": "18",
      "author": "D Kadosh",
      "year": "1998",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref15",
      "doi-asserted-by": "crossref",
      "first-page": "831",
      "DOI": "10.1038/33952",
      "article-title": "Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3.",
      "volume": "392",
      "author": "SE Rundlett",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "ref16",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1016/S0092-8674(00)80217-2",
      "article-title": "Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters.",
      "volume": "89",
      "author": "D Kadosh",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "ref17",
      "doi-asserted-by": "crossref",
      "first-page": "248",
      "DOI": "10.1038/ng907",
      "article-title": "Genome-wide binding map of the histone deacetylase Rpd3 in yeast.",
      "volume": "31",
      "author": "SK Kurdistani",
      "year": "2002",
      "journal-title": "Nat Genet"
    },
    {
      "key": "ref18",
      "doi-asserted-by": "crossref",
      "first-page": "6450",
      "DOI": "10.1128/MCB.21.19.6450-6460.2001",
      "article-title": "Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression.",
      "volume": "21",
      "author": "TG Fazzio",
      "year": "2001",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref19",
      "doi-asserted-by": "crossref",
      "first-page": "797",
      "DOI": "10.1101/gad.12.6.797",
      "article-title": "Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.",
      "volume": "12",
      "author": "D Kadosh",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref20",
      "doi-asserted-by": "crossref",
      "first-page": "3699",
      "DOI": "10.1093/nar/gkp233",
      "article-title": "Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation.",
      "volume": "37",
      "author": "J Zhou",
      "year": "2009",
      "journal-title": "Nucleic Acids Res"
    },
    {
      "key": "ref21",
      "doi-asserted-by": "crossref",
      "first-page": "24068",
      "DOI": "10.1074/jbc.M102176200",
      "article-title": "Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae.",
      "volume": "276",
      "author": "R Loewith",
      "year": "2001",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref22",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1093/genetics/152.3.921",
      "article-title": "A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae.",
      "volume": "152",
      "author": "ZW Sun",
      "year": "1999",
      "journal-title": "Genetics"
    },
    {
      "key": "ref23",
      "doi-asserted-by": "crossref",
      "first-page": "14503",
      "DOI": "10.1073/pnas.93.25.14503",
      "article-title": "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription.",
      "volume": "93",
      "author": "SE Rundlett",
      "year": "1996",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref24",
      "doi-asserted-by": "crossref",
      "first-page": "1343",
      "DOI": "10.1093/genetics/144.4.1343",
      "article-title": "Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae.",
      "volume": "144",
      "author": "D Vannier",
      "year": "1996",
      "journal-title": "Genetics"
    },
    {
      "key": "ref25",
      "doi-asserted-by": "crossref",
      "first-page": "4959",
      "DOI": "10.1093/emboj/cdf498",
      "article-title": "RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase.",
      "volume": "21",
      "author": "JJ Sandmeier",
      "year": "2002",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref26",
      "doi-asserted-by": "crossref",
      "first-page": "3184",
      "DOI": "10.1128/MCB.19.4.3184",
      "article-title": "A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.",
      "volume": "19",
      "author": "JS Smith",
      "year": "1999",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref27",
      "doi-asserted-by": "crossref",
      "first-page": "3889",
      "DOI": "10.1128/MCB.26.10.3889-3901.2006",
      "article-title": "Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast.",
      "volume": "26",
      "author": "ML Oakes",
      "year": "2006",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref28",
      "doi-asserted-by": "crossref",
      "first-page": "1077",
      "DOI": "10.1101/gad.1784309",
      "article-title": "Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae.",
      "volume": "23",
      "author": "SR Knott",
      "year": "2009",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref29",
      "doi-asserted-by": "crossref",
      "first-page": "1223",
      "DOI": "10.1016/S1097-2765(02)00702-5",
      "article-title": "Histone acetylation regulates the time of replication origin firing.",
      "volume": "10",
      "author": "M Vogelauer",
      "year": "2002",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref30",
      "doi-asserted-by": "crossref",
      "first-page": "545",
      "DOI": "10.1093/genetics/157.2.545",
      "article-title": "Coupling of Saccharomyces cerevisiae early meiotic gene expression to DNA replication depends upon RPD3 and SIN3.",
      "volume": "157",
      "author": "TM Lamb",
      "year": "2001",
      "journal-title": "Genetics"
    },
    {
      "key": "ref31",
      "doi-asserted-by": "crossref",
      "first-page": "4769",
      "DOI": "10.1128/MCB.24.11.4769-4780.2004",
      "article-title": "The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae.",
      "volume": "24",
      "author": "JG Aparicio",
      "year": "2004",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref32",
      "doi-asserted-by": "crossref",
      "first-page": "1298",
      "DOI": "10.1016/j.dnarep.2008.04.009",
      "article-title": "The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae.",
      "volume": "7",
      "author": "JD Merker",
      "year": "2008",
      "journal-title": "DNA Repair (Amst)"
    },
    {
      "key": "ref33",
      "doi-asserted-by": "crossref",
      "first-page": "68",
      "DOI": "10.1007/s002940050434",
      "article-title": "RPD3 (REC3) mutations affect mitotic recombination in Saccharomyces cerevisiae.",
      "volume": "35",
      "author": "EG Dora",
      "year": "1999",
      "journal-title": "Curr Genet"
    },
    {
      "key": "ref34",
      "doi-asserted-by": "crossref",
      "first-page": "581",
      "DOI": "10.1016/j.cell.2005.10.023",
      "article-title": "Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription.",
      "volume": "123",
      "author": "MJ Carrozza",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "ref35",
      "doi-asserted-by": "crossref",
      "first-page": "593",
      "DOI": "10.1016/j.cell.2005.10.025",
      "article-title": "Cotranscriptional set2 methylation of histone h3 lysine 36 recruits a repressive rpd3 complex.",
      "volume": "123",
      "author": "MC Keogh",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "ref36",
      "doi-asserted-by": "crossref",
      "first-page": "e4886",
      "DOI": "10.1371/journal.pone.0004886",
      "article-title": "The Set2/Rpd3S pathway suppresses cryptic transcription without regard to gene length or transcription frequency.",
      "volume": "4",
      "author": "CR Lickwar",
      "year": "2009",
      "journal-title": "PLoS One"
    },
    {
      "key": "ref37",
      "doi-asserted-by": "crossref",
      "first-page": "1422",
      "DOI": "10.1101/gad.1539307",
      "article-title": "Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription.",
      "volume": "21",
      "author": "B Li",
      "year": "2007",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref38",
      "doi-asserted-by": "crossref",
      "first-page": "971",
      "DOI": "10.1016/j.molcel.2005.11.021",
      "article-title": "Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation.",
      "volume": "20",
      "author": "AA Joshi",
      "year": "2005",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref39",
      "doi-asserted-by": "crossref",
      "first-page": "130",
      "DOI": "10.1016/j.mrfmmm.2006.08.014",
      "article-title": "A site to remember: H3K36 methylation a mark for histone deacetylation.",
      "volume": "618",
      "author": "JS Lee",
      "year": "2007",
      "journal-title": "Mutat Res"
    },
    {
      "key": "ref40",
      "doi-asserted-by": "crossref",
      "first-page": "4445",
      "DOI": "10.1128/MCB.00164-08",
      "article-title": "Different genetic functions for the Rpd3(L) and Rpd3(S) complexes suggest competition between NuA4 and Rpd3(S).",
      "volume": "28",
      "author": "D Biswas",
      "year": "2008",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref41",
      "doi-asserted-by": "crossref",
      "first-page": "437",
      "DOI": "10.1016/S0092-8674(02)00746-8",
      "article-title": "Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases.",
      "volume": "109",
      "author": "D Robyr",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "ref42",
      "doi-asserted-by": "crossref",
      "first-page": "321",
      "DOI": "10.1534/genetics.109.111526",
      "article-title": "Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription.",
      "volume": "184",
      "author": "TK Quan",
      "year": "2010",
      "journal-title": "Genetics"
    },
    {
      "key": "ref43",
      "doi-asserted-by": "crossref",
      "first-page": "343",
      "DOI": "10.1101/gad.12.3.343",
      "article-title": "DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.",
      "volume": "12",
      "author": "T Wada",
      "year": "1998",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref44",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.1016/j.molcel.2008.03.001",
      "article-title": "Poised polymerases: on your mark\u2026get set\u2026go!",
      "volume": "30",
      "author": "DH Price",
      "year": "2008",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref45",
      "doi-asserted-by": "crossref",
      "first-page": "557",
      "DOI": "10.1038/nrm1981",
      "article-title": "Breaking barriers to transcription elongation.",
      "volume": "7",
      "author": "A Saunders",
      "year": "2006",
      "journal-title": "Nat Rev Mol Cell Biol"
    },
    {
      "key": "ref46",
      "doi-asserted-by": "crossref",
      "first-page": "2437",
      "DOI": "10.1101/gad.1235904",
      "article-title": "Elongation by RNA polymerase II: the short and long of it.",
      "volume": "18",
      "author": "RJ Sims III",
      "year": "2004",
      "journal-title": "Genes Dev"
    },
    {
      "key": "ref47",
      "doi-asserted-by": "crossref",
      "first-page": "7887",
      "DOI": "10.1128/MCB.23.21.7887-7901.2003",
      "article-title": "In vivo evidence that defects in the transcriptional elongation factors RPB2, TFIIS, and SPT5 enhance upstream poly(A) site utilization.",
      "volume": "23",
      "author": "Y Cui",
      "year": "2003",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref48",
      "doi-asserted-by": "crossref",
      "first-page": "2150",
      "DOI": "10.1038/sj.emboj.7600687",
      "article-title": "Npl3 is an antagonist of mRNA 3\u2032 end formation by RNA polymerase II.",
      "volume": "24",
      "author": "ME Bucheli",
      "year": "2005",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref49",
      "doi-asserted-by": "crossref",
      "first-page": "913",
      "DOI": "10.1074/jbc.M411108200",
      "article-title": "Interaction between transcription elongation factors and mRNA 3\u2032-end formation at the Saccharomyces cerevisiae GAL10-GAL7 locus.",
      "volume": "280",
      "author": "CD Kaplan",
      "year": "2005",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref50",
      "doi-asserted-by": "crossref",
      "first-page": "1368",
      "DOI": "10.1128/MCB.23.4.1368-1378.2003",
      "article-title": "Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins.",
      "volume": "23",
      "author": "DL Lindstrom",
      "year": "2003",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref51",
      "doi-asserted-by": "crossref",
      "first-page": "234",
      "DOI": "10.1016/j.molcel.2010.07.003",
      "article-title": "Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes.",
      "volume": "39",
      "author": "CK Govind",
      "year": "2010",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref52",
      "doi-asserted-by": "crossref",
      "first-page": "752",
      "DOI": "10.1016/j.molcel.2009.02.018",
      "article-title": "Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters.",
      "volume": "33",
      "author": "H Qiu",
      "year": "2009",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref53",
      "doi-asserted-by": "crossref",
      "first-page": "3029",
      "DOI": "10.1128/MCB.26.8.3029-3038.2006",
      "article-title": "The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.",
      "volume": "26",
      "author": "Y Chu",
      "year": "2006",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref54",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1016/j.molcel.2006.06.014",
      "article-title": "Controlling the elongation phase of transcription with P-TEFb.",
      "volume": "23",
      "author": "BM Peterlin",
      "year": "2006",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref55",
      "doi-asserted-by": "crossref",
      "first-page": "589",
      "DOI": "10.1016/j.molcel.2005.09.010",
      "article-title": "The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS.",
      "volume": "20",
      "author": "A Wood",
      "year": "2005",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref56",
      "article-title": "Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.",
      "author": "K Zhou",
      "year": "2009",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref57",
      "doi-asserted-by": "crossref",
      "first-page": "4852",
      "DOI": "10.1128/MCB.00609-09",
      "article-title": "Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.",
      "volume": "29",
      "author": "Y Liu",
      "year": "2009",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref58",
      "doi-asserted-by": "crossref",
      "first-page": "7005",
      "DOI": "10.1128/MCB.23.19.7005-7018.2003",
      "article-title": "Bur1 kinase is required for efficient transcription elongation by RNA polymerase II.",
      "volume": "23",
      "author": "MC Keogh",
      "year": "2003",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref59",
      "doi-asserted-by": "crossref",
      "first-page": "104",
      "DOI": "10.1038/nature00883",
      "article-title": "Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast.",
      "volume": "418",
      "author": "ZW Sun",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "ref60",
      "doi-asserted-by": "crossref",
      "first-page": "34655",
      "DOI": "10.1074/jbc.C200433200",
      "article-title": "Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.",
      "volume": "277",
      "author": "HH Ng",
      "year": "2002",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "ref61",
      "doi-asserted-by": "crossref",
      "first-page": "371",
      "DOI": "10.1083/jcb.200906005",
      "article-title": "Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.",
      "volume": "186",
      "author": "S Nakanishi",
      "year": "2009",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "ref62",
      "doi-asserted-by": "crossref",
      "first-page": "973",
      "DOI": "10.1038/embor.2009.181",
      "article-title": "Pervasive transcription constitutes a new level of eukaryotic genome regulation.",
      "volume": "10",
      "author": "J Berretta",
      "year": "2009",
      "journal-title": "EMBO Rep"
    },
    {
      "key": "ref63",
      "doi-asserted-by": "crossref",
      "first-page": "806",
      "DOI": "10.1038/nature05649",
      "article-title": "Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.",
      "volume": "446",
      "author": "SR Collins",
      "year": "2007",
      "journal-title": "Nature"
    },
    {
      "key": "ref64",
      "doi-asserted-by": "crossref",
      "first-page": "631",
      "DOI": "10.1038/nature04532",
      "article-title": "Proteome survey reveals modularity of the yeast cell machinery.",
      "volume": "440",
      "author": "AC Gavin",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "ref65",
      "doi-asserted-by": "crossref",
      "first-page": "637",
      "DOI": "10.1038/nature04670",
      "article-title": "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.",
      "volume": "440",
      "author": "NJ Krogan",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "ref66",
      "doi-asserted-by": "crossref",
      "first-page": "8580",
      "DOI": "10.1073/pnas.0804424105",
      "article-title": "A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin.",
      "volume": "105",
      "author": "O Aygun",
      "year": "2008",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref67",
      "doi-asserted-by": "crossref",
      "first-page": "870",
      "DOI": "10.1074/mcp.M800447-MCP200",
      "article-title": "A novel proteomics approach for the discovery of chromatin-associated protein networks.",
      "volume": "8",
      "author": "JP Lambert",
      "year": "2009",
      "journal-title": "Mol Cell Proteomics"
    },
    {
      "key": "ref68",
      "doi-asserted-by": "crossref",
      "first-page": "675",
      "DOI": "10.1006/jmbi.2001.4991",
      "article-title": "The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.",
      "volume": "312",
      "author": "SB Lavoie",
      "year": "2001",
      "journal-title": "J Mol Biol"
    },
    {
      "key": "ref69",
      "doi-asserted-by": "crossref",
      "first-page": "3739",
      "DOI": "10.1093/emboj/19.14.3739",
      "article-title": "Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.",
      "volume": "19",
      "author": "M Arevalo-Rodriguez",
      "year": "2000",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref70",
      "doi-asserted-by": "crossref",
      "first-page": "7395",
      "DOI": "10.1093/emboj/17.24.7395",
      "article-title": "Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.",
      "volume": "17",
      "author": "T Wada",
      "year": "1998",
      "journal-title": "EMBO J"
    },
    {
      "key": "ref71",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.1093/genetics/159.2.487",
      "article-title": "Genetic interactions of Spt4-Spt5 and TFIIS with the RNA polymerase II CTD and CTD modifying enzymes in Saccharomyces cerevisiae.",
      "volume": "159",
      "author": "DL Lindstrom",
      "year": "2001",
      "journal-title": "Genetics"
    },
    {
      "key": "ref72",
      "doi-asserted-by": "crossref",
      "first-page": "738",
      "DOI": "10.1016/j.molcel.2009.01.029",
      "article-title": "TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.",
      "volume": "33",
      "author": "L Viladevall",
      "year": "2009",
      "journal-title": "Mol Cell"
    },
    {
      "key": "ref73",
      "doi-asserted-by": "crossref",
      "first-page": "3135",
      "DOI": "10.1128/MCB.26.8.3135-3148.2006",
      "article-title": "The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II.",
      "volume": "26",
      "author": "H Qiu",
      "year": "2006",
      "journal-title": "Mol Cell Biol"
    },
    {
      "key": "ref74",
      "doi-asserted-by": "crossref",
      "first-page": "2306",
      "DOI": "10.1126/science.290.5500.2306",
      "article-title": "Genome-wide location and function of DNA binding proteins.",
      "volume": "290",
      "author": "B Ren",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "ref75",
      "doi-asserted-by": "crossref",
      "first-page": "e158",
      "DOI": "10.1371/journal.pgen.0020158",
      "article-title": "Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters.",
      "volume": "2",
      "author": "GJ Hogan",
      "year": "2006",
      "journal-title": "PLoS Genet"
    },
    {
      "key": "ref76",
      "doi-asserted-by": "crossref",
      "first-page": "14863",
      "DOI": "10.1073/pnas.95.25.14863",
      "article-title": "Cluster analysis and display of genome-wide expression patterns.",
      "volume": "95",
      "author": "MB Eisen",
      "year": "1998",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "ref77",
      "doi-asserted-by": "crossref",
      "first-page": "3246",
      "DOI": "10.1093/bioinformatics/bth349",
      "article-title": "Java Treeview\u2013extensible visualization of microarray data.",
      "volume": "20",
      "author": "AJ Saldanha",
      "year": "2004",
      "journal-title": "Bioinformatics"
    },
    {
      "key": "ref78",
      "doi-asserted-by": "crossref",
      "first-page": "393",
      "DOI": "10.1016/j.molcel.2007.07.011",
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