Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians
10.1371/journal.pgen.0020132
Crossref journal-article
Public Library of Science (PLoS)
PLoS Genetics (340)
Bibliography

Pilia, G., Chen, W.-M., Scuteri, A., Orrú, M., Albai, G., Dei, M., Lai, S., Usala, G., Lai, M., Loi, P., Mameli, C., Vacca, L., Deiana, M., Olla, N., Masala, M., Cao, A., Najjar, S. S., Terracciano, A., Nedorezov, T., … Schlessinger, D. (2006). Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians. PLoS Genetics, 2(8), e132.

Authors 25
  1. Giuseppe Pilia (first)
  2. Wei-Min Chen (additional)
  3. Angelo Scuteri (additional)
  4. Marco Orrú (additional)
  5. Giuseppe Albai (additional)
  6. Mariano Dei (additional)
  7. Sandra Lai (additional)
  8. Gianluca Usala (additional)
  9. Monica Lai (additional)
  10. Paola Loi (additional)
  11. Cinzia Mameli (additional)
  12. Loredana Vacca (additional)
  13. Manila Deiana (additional)
  14. Nazario Olla (additional)
  15. Marco Masala (additional)
  16. Antonio Cao (additional)
  17. Samer S Najjar (additional)
  18. Antonio Terracciano (additional)
  19. Timur Nedorezov (additional)
  20. Alexei Sharov (additional)
  21. Alan B Zonderman (additional)
  22. Gonçalo R Abecasis (additional)
  23. Paul Costa (additional)
  24. Edward Lakatta (additional)
  25. David Schlessinger (additional)
References 70 Referenced 405
  1. 10.1038/35052543 / Nat Rev Genet / Association study designs for complex diseases. (2001)
  2. 10.1136/jmg.30.10.857 / J Med Genet / Disease gene mapping in isolated human populations: The example of Finland. (1993)
  3. 10.1038/35042049 / Nat Rev Genet / Use of population isolates for mapping complex traits. (2000)
  4. 10.1038/70501 / Nat Genet / Population choice in mapping genes for complex diseases. (1999)
  5. 10.1034/j.1399-0039.2000.560605.x / Tissue Antigens / The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations. (2000)
  6. 10.1038/81685 / Nat Genet / Y chromosome sequence variation and the history of human populations. (2000)
  7. 10.1002/ajpa.10265 / Am J Phys Anthropol / Peopling of three Mediterranean islands (Corsica, Sardinia, and Sicily) inferred by Y-chromosome biallelic variability. (2003)
  8. 10.1172/JCI110323 / J Clin Invest / Beta-zero thalassemia in Sardinia is caused by a nonsense mutation. (1981)
  9. 10.1016/S0022-3476(83)80771-9 / J Pediatr / Molecular mechanism accounting for milder types of thalassemia major. (1983)
  10. 10.1007/s004390050846 / Hum Genet / A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients. (1998)
  11. 10.1002/(SICI)1098-1004(199910)14:4<294::AID-HUMU4>3.0.CO;2-9 / Hum Mutat / Molecular characterization of Wilson disease in the Sardinian population—evidence of a founder effect. (1999)
  12. 10.1086/375628 / Am J Hum Genet / Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. (2003)
  13. 10.1159/000053368 / Hum Hered / Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population. (2001)
  14. 10.1161/01.HYP.34.2.201 / Hypertension / Arterial stiffness and the development of hypertension. The ARIC study. (1999)
  15. 10.1161/01.CIR.98.15.1504 / Circulation / Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. (1998)
  16. 10.1161/CIRCULATIONAHA.104.483628 / Circulation / Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. (2005)
  17. 10.1056/NEJM199502233320807 / N Engl J Med / Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. (1995)
  18. 10.1002/sim.4780141604 / Stat Med / Assessment of cardiovascular risk factors in the elderly: The Framingham Heart Study. (1995)
  19. 10.1161/01.CIR.0000133427.35111.67 / Circulation / Principles for national and regional guidelines on cardiovascular disease prevention: A scientific statement from the World Heart and Stroke Forum. (2004)
  20. 10.1146/annurev.ps.41.020190.002221 / Ann Rev Psychol / Personality structure: Emergence of the 5-factor model. (1990)
  21. McCraeRRCostaPTJ 2003 Personality in adulthood: A five-factor theory perspective. 2nd edition New York Guilford Press 268 p. (10.4324/9780203428412)
  22. 10.1161/01.CIR.99.16.2192 / Circulation / Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. (1999)
  23. 10.1111/j.1469-1809.1982.tb01588.x / Ann Hum Genet / Extensions of multivariate normal models for pedigree analysis. (1982)
  24. 10.1002/ajmg.1320140315 / Am J Med Genet / Extensions to pedigree analysis. IV. Covariance components models for multivariate traits. (1983)
  25. FalconerDS 1989 Introduction to quantitative genetics. 3rd edition London Longman Scientific and Technical 438 p.
  26. NealeMCCardonLR 1992 Methodology for genetic studies of twins and families Dordrecht (Netherlands) Kluwer Academic Publishers 496 p.
  27. 10.1001/jama.287.3.356 / JAMA / Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. (2002)
  28. AndersonDEMetterEJHougakuyHNajjarSS 2006 Suppressed anger is associated with increased arterial stiffness in older adults. Am J Hypertens In press. (10.1016/j.amjhyper.2006.04.018)
  29. 10.1177/174182670100800309 / J Cardiovasc Risk / The impact of emotions on coronary heart disease risk. (2001)
  30. 10.1007/s11883-006-0048-2 / Curr Atheroscler Rep / Behavioral cardiology: Recognizing and addressing the profound impact of psychosocial stress on cardiovascular health. (2006)
  31. 10.1161/CIRCULATIONAHA.104.530675 / Circulation / Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: The Framingham Heart Study. (2005)
  32. 10.1086/324025 / Am J Hum Genet / The genetic dissection of complex traits in a founder population. (2001)
  33. 10.1097/01.ASN.0000135972.13396.6F / J Am Soc Nephrol / Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: The Framingham Heart Study. (2004)
  34. 10.1093/clinchem/47.1.81 / Clin Chem / Evidence for a substantial genetic influence on biochemical liver function tests: Results from a population-based Danish twin study. (2001)
  35. {'key': 'pgen-0020132-b035', 'first-page': '1301', 'article-title': 'Broad and narrow heritabilities of quantitative traits in a founder population.', 'volume': '68', 'year': '2001', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Broad and narrow heritabilities of quantitative traits in a founder population. (2001)
  36. 10.1086/342929 / Am J Hum Genet / A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search. (2002)
  37. 10.1086/430133 / Am J Hum Genet / Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. (2005)
  38. 10.1375/twin.9.2.205 / Twin Res Hum Genet / Heritability and stability of resting blood pressure in Australian twins. (2006)
  39. 10.1037/0022-3514.74.6.1556 / J Pers Soc Psychol / Heritability of facet-level traits in a cross-cultural twin sample: Support for a hierarchical model of personality. (1998)
  40. 10.1111/j.1467-6494.1997.tb00324.x / J Pers / Genetic and environmental influences on personality: A study of twins reared together using the self- and peer-report NEO-FFI scales. (1997)
  41. BouchardTJJr. 1997 The genetics of personality. In: BlumKNobleEP Handbook of psychiatric genetics Boca Raton (Florida) CRC Press pp. 273 296
  42. 10.1006/jrpe.1998.2225 / J Res Pers / Heritabilities of common and measure-specific components of the Big Five personality factors. (1998)
  43. WallerNGLykkenDTTellegenA 1995 Occupational interests, leisure time interests, and personality: Three domains or one? Findings from the Minnesota Twin Registry. In: DawisRLubinskiD Assessing individual differences in human behavior: New concepts, methods, and findings Palo Alto (California) Davies-Black Publishing pp. 238 259
  44. 10.1023/A:1012294324713 / Behav Genet / Genes, evolution, and personality. (2001)
  45. 10.1159/000087971 / Hum Hered / The impact of pedigree structure on heritability estimates for pulse pressure in three studies. (2005)
  46. 10.1038/79866 / Nat Genet / How many diseases does it take to map a gene with SNPs? (2000)
  47. 10.1016/S0168-9525(02)00033-1 / Trends Genet / A polygenic basis for late-onset disease. (2003)
  48. {'key': 'pgen-0020132-b048', 'first-page': '233', 'article-title': 'Two point mutations are responsible for G6PD polymorphism in Sardinia.', 'volume': '44', 'year': '1989', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Two point mutations are responsible for G6PD polymorphism in Sardinia. (1989)
  49. 10.1002/(SICI)1096-8628(20000214)90:4<339::AID-AJMG15>3.0.CO;2-5 / Am J Med Genet / Mutations in the NSDHL gene, encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome. (2000)
  50. {'issue': '(Suppl 1)', 'key': 'pgen-0020132-b050', 'first-page': 'S96', 'article-title': 'A QTL genome scan of the metabolic syndrome and its component traits.', 'volume': '4', 'year': '2003', 'journal-title': 'BMC Genet'} / BMC Genet / A QTL genome scan of the metabolic syndrome and its component traits. (2003)
  51. 10.1111/j.2517-6161.1995.tb02031.x / J R Stat Soc Ser B / Controlling the false discovery rate: A practical and powerful approach to multiple testing. (1995)
  52. 10.1038/ng1456 / Nat Genet / Assessing genetic contributions to phenotypic differences among ‘racial' and ‘ethnic' groups. (2004)
  53. CostaPTJMcCraeRR 1992 Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) professional manual Odessa (Florida) Psychological Assessment Resources 101 p.
  54. {'key': 'pgen-0020132-b054', 'first-page': '1859', 'article-title': 'The Italian version of the NEO PI-R: Conceptual and empirical support for the use of targeted rotation.', 'volume': '35', 'year': '2005', 'journal-title': 'Pers Individ Dif'} / Pers Individ Dif / The Italian version of the NEO PI-R: Conceptual and empirical support for the use of targeted rotation. (2005)
  55. 10.1037/0022-3514.88.3.547 / J Pers Soc Psychol / Universal features of personality traits from the observer's perspective: Data from 50 cultures. (2005)
  56. {'key': 'pgen-0020132-b056', 'first-page': 'e545', 'article-title': 'CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Report from the laboratory science discussion group.', 'volume': '110', 'year': '2004', 'journal-title': 'Circulation'} / Circulation / CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Report from the laboratory science discussion group. (2004)
  57. 10.1097/00004872-200212000-00002 / J Hypertens / Carotid intima-media thickness, arterial stiffness and risk of cardiovascular disease: Current evidence. (2002)
  58. 10.1056/NEJM199901073400103 / N Engl J Med / Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. (1999)
  59. 10.1161/01.CIR.88.4.1456 / Circulation / Effects of age and aerobic capacity on arterial stiffness in healthy adults. (1993)
  60. 10.1093/bioinformatics/bti529 / Bioinformatics / PEDSTATS: Descriptive statistics, graphics and quality assessment for gene mapping data. (2005)
  61. 10.1086/338659 / Am J Hum Genet / A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size. (2002)
  62. 10.1086/426000 / Am J Hum Genet / Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. (2004)
  63. LiMBoehnkeMAbecasisGRSongP 2006 Quantitative trait linkage analysis using gaussian copulas. Genetics 173 DOI: 10.1534/genetics.105.054650 (10.1534/genetics.105.054650)
  64. LangeK 1997 Mathematical and statistical methods for genetic analysis. 2nd Edition New York Springer 361 p.
  65. GordonAD 1999 Classification. 2nd edition Boca Raton (Florida) Chapman and Hall/CRC 256 p.
  66. SearleSRCasellaGMcCullochCE 1992 Variance components New York John Wiley and Sons 501 p.
  67. 10.1093/biomet/73.1.13 / Biometrika / Longitudinal data analysis using generalized linear models. (1986)
  68. 10.1086/301844 / Am J Hum Genet / Multipoint quantitative-trait linkage analysis in general pedigrees. (1998)
  69. 10.1086/302698 / Am J Hum Genet / A general test of association for quantitative traits in nuclear families. (2000)
  70. 10.1214/aos/1176344136 / Ann Stat / Estimating the dimension of a model. (1978)
Dates
Type When
Created 19 years ago (Aug. 23, 2006, 2:06 p.m.)
Deposited 7 months, 3 weeks ago (Jan. 10, 2025, 9:59 a.m.)
Indexed 1 day, 8 hours ago (Sept. 4, 2025, 9:28 a.m.)
Issued 19 years ago (Aug. 25, 2006)
Published 19 years ago (Aug. 25, 2006)
Published Online 19 years ago (Aug. 25, 2006)
Funders 0

None

@article{Pilia_2006, title={Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians}, volume={2}, ISSN={1553-7404}, url={http://dx.doi.org/10.1371/journal.pgen.0020132}, DOI={10.1371/journal.pgen.0020132}, number={8}, journal={PLoS Genetics}, publisher={Public Library of Science (PLoS)}, author={Pilia, Giuseppe and Chen, Wei-Min and Scuteri, Angelo and Orrú, Marco and Albai, Giuseppe and Dei, Mariano and Lai, Sandra and Usala, Gianluca and Lai, Monica and Loi, Paola and Mameli, Cinzia and Vacca, Loredana and Deiana, Manila and Olla, Nazario and Masala, Marco and Cao, Antonio and Najjar, Samer S and Terracciano, Antonio and Nedorezov, Timur and Sharov, Alexei and Zonderman, Alan B and Abecasis, Gonçalo R and Costa, Paul and Lakatta, Edward and Schlessinger, David}, editor={Frankel, Wayne N}, year={2006}, month=aug, pages={e132} }