Crossref journal-article
Public Library of Science (PLoS)
PLoS Genetics (340)
Bibliography

Budd, M. E., Tong, A. H. Y., Polaczek, P., Peng, X., Boone, C., & Campbell, J. L. (2005). A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability. PLoS Genetics, 1(6), e61.

Authors 6
  1. Martin E Budd (first)
  2. Amy Hin Yan Tong (additional)
  3. Piotr Polaczek (additional)
  4. Xiao Peng (additional)
  5. Charles Boone (additional)
  6. Judith L Campbell (additional)
References 121 Referenced 77
  1. 10.1073/pnas.80.21.6465 / Proc Natl Acad Sci U S A / Isolation of yeast DNA replication mutants using permeabilized cells. (1983)
  2. 10.1073/pnas.92.17.7642 / Proc Natl Acad Sci U S A / A new yeast gene required for DNA replication encodes a protein with homology to DNA helicases. (1995)
  3. 10.1074/jbc.270.45.26766 / J Biol Chem / DNA2 encodes a DNA helicase essential for replication of eukaryotic chromosomes. (1995)
  4. 10.1074/jbc.273.41.26880 / J Biol Chem / Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP. (1998)
  5. 10.1016/S0021-9258(17)34146-7 / J Biol Chem / Reconstitution of complete SV40 DNA replication with purified replication factors. (1994)
  6. 10.1002/j.1460-2075.1994.tb06373.x / EMBO J / The characterization of a mammalian DNA structure-specific endonuclease. (1994)
  7. 10.1128/MCB.17.4.2136 / Mol Cell Biol / A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function. (1997)
  8. 10.1093/genetics/151.4.1459 / Genetics / Dna2 mutants reveal interactions with DNA polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full DNA2 helicase activity is not essential for growth. (1999)
  9. 10.1074/jbc.M006513200 / J Biol Chem / Characterization of the enzymatic properties of the yeast Dna2 helicase/endonuclease suggests a new model for Okazaki fragment processing. (2000)
  10. 10.1074/jbc.M209801200 / J Biol Chem / Okazaki fragment maturation in yeast. I. Distribution of functions between Fen1 and Dna2. (2003)
  11. 10.1074/jbc.M209803200 / J Biol Chem / Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3′ to 5′ exonuclease activities of Pol delta in the creation of a ligatable nick. (2003)
  12. 10.1074/jbc.M313216200 / J Biol Chem / On the roles of Saccharomyces cerevisiae Dna2p and FEN1 in Okazaki fragment processing. (2004)
  13. 10.1038/35086609 / Nature / RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes. (2001)
  14. 10.1074/jbc.M409231200 / J Biol Chem / Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation. (2004)
  15. {'key': 'pgen-0010061-b015', 'first-page': '113', 'article-title': 'Regulation of the DNA replication fork: A way to fight genomic instability.', 'volume': '113', 'year': '2004', 'journal-title': 'Chromosoma'} / Chromosoma / Regulation of the DNA replication fork: A way to fight genomic instability. (2004)
  16. 10.1016/S0921-8777(99)00072-5 / Mutat Res / The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways. (2000)
  17. {'key': 'pgen-0010061-b017', 'first-page': '2002', 'article-title': 'Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication.', 'volume': '22', 'year': '2002', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication. (2002)
  18. 10.1126/science.1091317 / Science / Global mapping of the yeast genetic interaction network. (2004)
  19. 10.1126/science.1065810 / Science / Systematic genetic analysis with ordered arrays of yeast deletion mutants. (2001)
  20. 10.1128/MCB.21.9.3144-3158.2001 / Mol Cell Biol / Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. (2001)
  21. 10.1074/jbc.M909511199 / J Biol Chem / The nuclease activity of the yeast Dna2 protein, which is related to the RecB-like nucleases, is essential in vivo. (2000)
  22. 10.1038/384379a0 / Nature / Crystal structure of a DExx box DNA helicase. (1996)
  23. 10.1046/j.1365-2443.2003.00648.x / Genes Cells / Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability. (2003)
  24. 10.1093/genetics/155.4.1657 / Genetics / The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast. (2000)
  25. 10.1016/S0014-5793(97)01528-7 / FEBS Lett / Yeast RNase H(35) is the counterpart of the mammalian RNase HI and is evolutionarily related to prokaryotic RNase HII. (1998)
  26. 10.1007/s002940050362 / Curr Genet / Role of yeast Rth1 nuclease and its homologs in mutation avoidance, DNA repair, and DNA replication. (1998)
  27. 10.1073/pnas.94.14.7487 / Proc Natl Acad Sci U S A / Identification and characterization of Saccharomyuces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2. (1997)
  28. 10.1128/MCB.19.6.4143 / Mol Cell Biol / Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27. (1999)
  29. 10.1016/S1568-7864(02)00114-3 / DNA Repair (Amst) / Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae. (2002)
  30. 10.1073/pnas.0307796100 / Proc Natl Acad Sci U S A / ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing. (2004)
  31. 10.1016/S0960-9822(03)00578-5 / Curr Biol / Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. (2003)
  32. 10.1093/emboj/cdg406 / EMBO J / Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. (2003)
  33. 10.1101/gad.1252304 / Genes Dev / Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication. (2004)
  34. 10.1074/jbc.M310362200 / J Biol Chem / The Pol32 subunit of DNA polymerase delta contains separable domains for processive replication and proliferating cell nuclear antigen (PCNA) binding. (2004)
  35. 10.1074/jbc.M301610200 / J Biol Chem / Dna2 helicase/nuclease causes replicative fork stalling and double-strand breaks in the ribosomal DNA of Saccharomyces cerevisiae. (2003)
  36. 10.1128/MCB.22.12.4136-4146.2002 / Mol Cell Biol / Mutations in DNA replication genes reduce yeast life span. (2002)
  37. 10.1016/j.mrfmmm.2003.08.015 / Mutat Res / Evidence that yeast SGS1, DNA2, SRS2, and FOB1 interact to maintain rDNA stability. (2003)
  38. 10.1038/76055 / Nat Genet / Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases. (2000)
  39. 10.1093/genetics/157.1.103 / Genetics / Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. (2001)
  40. 10.1007/s00438-001-0605-x / Mol Genet Genomics / MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae. (2002)
  41. 10.1128/MMBR.66.4.630-670.2002 / Microbiol Mol Biol Rev / Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. (2002)
  42. 10.1128/MCB.24.21.9682-9694.2004 / Mol Cell Biol / The Mre11 nuclease is not required for 5′ to 3′ resection at multiple HO-induced double-strand breaks. (2004)
  43. 10.1091/mbc.8.12.2519 / Mol Biol Cell / Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase. (1997)
  44. 10.1038/ncb1101-958 / Nat Cell Biol / Mrc1 transduces signals of DNA replication stress to activiate Rad53. (2001)
  45. 10.1101/gad.1098303 / Genes Dev / Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. (2003)
  46. 10.1038/nature01900 / Nature / S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. (2003)
  47. 10.1128/MCB.24.8.3198-3212.2004 / Mol Cell Biol / Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: Viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities. (2004)
  48. 10.1016/j.cell.2004.08.015 / Cell / Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins. (2004)
  49. 10.1128/MCB.19.9.6065 / Mol Cell Biol / Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. (1999)
  50. {'key': 'pgen-0010061-b050', 'first-page': '5274', 'article-title': 'Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo.', 'volume': '12', 'year': '1992', 'journal-title': 'Mol Cell Biol'} / Mol Cell Biol / Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo. (1992)
  51. 10.1128/MCB.23.8.2733-2748.2003 / Mol Cell Biol / Saccharomyces cervisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion. (2003)
  52. 10.1093/genetics/155.4.1593 / Genetics / POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae. (2000)
  53. 10.1093/emboj/20.13.3506 / EMBO J / Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. (2001)
  54. 10.1128/MCB.24.9.3907-3917.2004 / Mol Cell Biol / Structural features of nucleosomes reorganized by yeast FACT and its HMG box component, Nhp6. (2004)
  55. 10.1093/genetics/162.4.1557 / Genetics / Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: Polymerase passage may degrade chromatin structure. (2002)
  56. 10.1128/MCB.24.21.9568-9579.2004 / Mol Cell Biol / A coordinated temporal interplay of nucleosome reorganization factor, sister chromatin cohesion factor, and DNA polymerase alpha facilitates DNA replication. (2004)
  57. 10.1073/pnas.84.9.2838 / Proc Natl Acad Sci U S A / Temperature sensitive mutants of yeast DNA polymerase I. (1987)
  58. 10.1093/emboj/18.22.6561 / EMBO J / Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. (1999)
  59. 10.1016/S1097-2765(03)00052-2 / Mol Cell / Histone deposition at the replication fork: A matter of urgency. (2003)
  60. 10.1007/BF00352525 / Mol Gen Genet / Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3, and rad52 mutations. (1981)
  61. 10.1002/j.1460-2075.1991.tb07754.x / EMBO J / Yeast RAD6 encoded ubiquitin conjugating enayme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. (1991)
  62. 10.1016/S1097-2765(02)00802-X / Mol Cell / Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. (2003)
  63. 10.1101/gad.8.7.811 / Genes Dev / Specific complex formation between yeast RAD6 and RAD18 proteins: A potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. (1994)
  64. 10.1093/emboj/19.13.3388 / EMBO J / Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. (2000)
  65. 10.1016/S1097-2765(02)00826-2 / Mol Cell / A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. (2003)
  66. 10.1074/jbc.C300270200 / J Biol Chem / The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. (2003)
  67. 10.1016/S1097-2765(02)00702-5 / Mol Cell / Histone acetylation regulates the time of replication origin firing. (2002)
  68. 10.1128/MCB.24.11.4769-4780.2004 / Mol Cell Biol / The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae. (2004)
  69. 10.1038/83673 / Nat Genet / SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. (2001)
  70. 10.1016/S0092-8674(01)00227-6 / Cell / Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. (2001)
  71. 10.1038/35082608 / Nature / Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. (2001)
  72. 10.1073/pnas.1232239100 / Proc Natl Acad Sci U S A / Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability. (2003)
  73. 10.1073/pnas.0407010101 / Proc Natl Acad Sci U S A / Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae. (2004)
  74. 10.1038/ng1359 / Nat Genet / Recombination and the Tel1 and Mec1 checkpoints differentially effect genome rearrangements driven by telomere dysfunction in yeast. (2004)
  75. 10.1128/MCB.24.8.3213-3226.2004 / Mol Cell Biol / Requirement of Rrm3 helicase for repair of spontaneous DNA lesions in cells lacking Srs2 or Sgs1 helicase. (2004)
  76. 10.1038/nature03239 / Nature / Interaction network containing conserved and essential protein complexes in Escherichia coli. (2005)
  77. 10.1128/MCB.19.12.8361 / Mol Cell Biol / Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. (1999)
  78. 10.1016/j.molcel.2003.08.010 / Mol Cell / Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. (2003)
  79. 10.1073/pnas.0401263101 / Proc Natl Acad Sci U S A / A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. (2004)
  80. 10.1038/nature03329 / Nature / Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. (2005)
  81. 10.1073/pnas.091095198 / Proc Natl Acad Sci U S A / The 3′-5′ exonuclease of DNA polymerase delta can substitute for the 5′ flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. (2001)
  82. 10.1007/s002940000149 / Curr Genet / POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathway. (2000)
  83. 10.1093/nar/gkh963 / Nucleic Acids Res / Genetics of lagging strand DNA synthesis and maturation in fission yeast: Suppression analysis links the Dna2-Cdc24 complex to DNA polymerase delta. (2004)
  84. 10.1016/j.molcel.2004.09.017 / Mol Cell / Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. (2004)
  85. 10.1074/jbc.M400142200 / J Biol Chem / Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p. (2004)
  86. 10.1016/j.dnarep.2004.11.010 / DNA Repair (Amst) / Genetic network interactions among replication repair and nuclear pore deficiencies in yeast. (2005)
  87. 10.1016/S0092-8674(00)81846-2 / Cell / A novel mutation avoidance mechanism dependent on Saccharomyces cerevisiae RAD27 is distinct from DNA mismatch repair. (1997)
  88. 10.1146/annurev.biochem.73.012803.092453 / Annu Rev Biochem / Flap endonuclease 1: A central component of DNA metabolism. (2004)
  89. 10.1126/science.7618086 / Science / Requirement for the yeast RTH1 5′ to 3′ exonuclease for the stability of simple repetitive DNA. (1995)
  90. 10.1128/MCB.23.21.7849-7860.2003 / Mol Cell Biol / Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. (2003)
  91. 10.1093/emboj/cdf310 / EMBO J / Instability of the human minisatellite CEB1 in rad27Δ and dna2–1 replication-deficient yeast cells. (2002)
  92. 10.1038/ng1258 / Nat Genet / DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray. (2003)
  93. 10.1101/gad.322605 / Genes Dev / Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. (2005)
  94. 10.1073/pnas.1431624100 / Proc Natl Acad Sci U S A / The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants. (2003)
  95. 10.1093/hmg/ddh234 / Hum Mol Genet / In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. (2004)
  96. 10.1016/S1568-7864(02)00002-2 / DNA Repair (Amst) / Defending genome integrity during S-phase: Putative roles for RecQ helicases and topoisomerases. (2002)
  97. 10.1007/s004380051116 / Mol Gen Genet / RecQ and RecJ process blocked replication forks prior to resumption of replication in UV-irradiated Escherichia coli. (1999)
  98. 10.1093/genetics/124.4.817 / Genetics / The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway. (1990)
  99. 10.1038/nature01585 / Nature / The Srs2 helicase prevents recombination by disruption Rad51 nucleorotein filaments. (2003)
  100. 10.1038/nature01577 / Nature / DNA helicase Srs2 disrupts the Rad51 presynaptic filament. (2003)
  101. 10.1101/gad.1033702 / Genes Dev / To fire or not to fire: Origin activation in Saccharomyces cerevisiae ribosomal DNA. (2002)
  102. 10.1101/gad.982902 / Genes Dev / Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. (2002)
  103. 10.1016/S1097-2765(03)00456-8 / Mol Cell / The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes. (2003)
  104. 10.1128/MCB.24.9.4019-4031.2004 / Mol Cell Biol / Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. (2004)
  105. 10.1074/jbc.M110662200 / J Biol Chem / Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate. (2002)
  106. {'key': 'pgen-0010061-b106', 'first-page': '207', 'article-title': 'DNA replication-dependent nuclear dynamics of the Mre11 complex.', 'volume': '1', 'year': '2003', 'journal-title': 'Mol Cancer Res'} / Mol Cancer Res / DNA replication-dependent nuclear dynamics of the Mre11 complex. (2003)
  107. 10.1128/MCB.24.21.9557-9567.2004 / Mol Cell Biol / Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. (2004)
  108. 10.1016/S0960-9822(01)00271-8 / Curr Biol / Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. (2001)
  109. 10.1016/S0092-8674(04)00414-3 / Cell / SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast. (2004)
  110. 10.1128/MCB.17.7.4178 / Mol Cell Biol / The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein. (1997)
  111. 10.1016/S0960-9822(99)80160-2 / Curr Biol / A DNA unwinding factor involved in DNA replication in cell-free extracts of Xenopus eggs. (1999)
  112. 10.1038/22350 / Nature / The chromatin-specific transcrition elongation factor FACT comprises human ST16 and SSRP1 proteins. (1999)
  113. 10.1016/S0092-8674(00)80903-4 / Cell / FACT, a factor that facilitates transcript elongation through nucleosomes. (1998)
  114. 10.1073/pnas.221596698 / Proc Natl Acad Sci U S A / A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. (2002)
  115. 10.1074/jbc.C200023200 / J Biol Chem / COMPASS, a histone H3 (lysine 4) methyltransferase required for telomeric silencing of gene expression. (2002)
  116. 10.1534/genetics.103.024851 / Genetics / The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae. (2004)
  117. 10.1101/gad.9.23.2888 / Genes Dev / The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. (1995)
  118. 10.1093/nar/gkg422 / Nucleic Acids Res / Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro. (2003)
  119. GuthrieCFinkG 1991 Guide to yeast genetics and molecular biology New York Academic Press 933 p.
  120. 10.1007/BF02451799 / Chromosoma / Roles of POL3, POL2 and PMS1 genes in maintaining accurate DNA replication. (1992)
  121. 10.1002/(SICI)1097-0061(200004)16:6<553::AID-YEA554>3.0.CO;2-7 / Yeast / A counterselection for the tryptohpan pathway in yeast: 5-fluoroanthranilic acid resistance. (2000)
Dates
Type When
Created 19 years, 9 months ago (Nov. 28, 2005, 4:18 p.m.)
Deposited 4 years, 1 month ago (July 20, 2021, 9:46 a.m.)
Indexed 1 year, 1 month ago (Aug. 3, 2024, 3:34 p.m.)
Issued 19 years, 9 months ago (Dec. 2, 2005)
Published 19 years, 9 months ago (Dec. 2, 2005)
Published Online 19 years, 9 months ago (Dec. 2, 2005)
Funders 0

None

@article{Budd_2005, title={A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability}, volume={1}, ISSN={1553-7404}, url={http://dx.doi.org/10.1371/journal.pgen.0010061}, DOI={10.1371/journal.pgen.0010061}, number={6}, journal={PLoS Genetics}, publisher={Public Library of Science (PLoS)}, author={Budd, Martin E and Tong, Amy Hin Yan and Polaczek, Piotr and Peng, Xiao and Boone, Charles and Campbell, Judith L}, editor={Snyder, Michael}, year={2005}, month=dec, pages={e61} }