DOI: 10.1371/journal.pbio.0050233. Emergence of Large-Scale Cell Morphology and Movement from Local Actin Filament Growth Dynamics

Emergence of Large-Scale Cell Morphology and Movement from Local Actin Filament Growth Dynamics

10.1371/journal.pbio.0050233

Crossref journal-article

Public Library of Science (PLoS)

PLoS Biology (340)

Bibliography

Lacayo, C. I., Pincus, Z., VanDuijn, M. M., Wilson, C. A., Fletcher, D. A., Gertler, F. B., Mogilner, A., & Theriot, J. A. (2007). Emergence of Large-Scale Cell Morphology and Movement from Local Actin Filament Growth Dynamics. PLoS Biology, 5(9), e233.

Authors 8

Catherine I Lacayo (first)
Zachary Pincus (additional)
Martijn M VanDuijn (additional)
Cyrus A Wilson (additional)
Daniel A Fletcher (additional)
Frank B Gertler (additional)
Alex Mogilner (additional)
Julie A Theriot (additional)

References 59 Referenced 171

{'key': 'pbio-0050233-b001', 'first-page': '231', 'article-title': 'Control, exploitation and tolerance of intracellular noise[erratum appears in Nature. 9 January 2003 421:190].', 'volume': '420', 'year': '2002', 'journal-title': 'Nature'} / Nature / Control, exploitation and tolerance of intracellular noise[erratum appears in Nature. 9 January 2003 421:190]. (2002)
10.1016/j.devcel.2006.08.004 / Dev Cell / Quantitative modeling in cell biology: What is it good for? (2006)
10.1146/annurev.cellbio.19.050103.103356 / Annu Rev Cell Dev Biol / Ena/VASP proteins: Regulators of the actin cytoskeleton and cell migration. (2003)
10.1016/S0896-6273(04)00108-4 / Neuron / Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. (2004)
10.1016/S0092-8674(00)80884-3 / Cell / Negative regulation of fibroblast motility by Ena/VASP proteins. (2000)
10.1016/S0092-8674(02)00731-6 / Cell / Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. (2002)
10.1016/j.cell.2004.07.019 / Cell / Lamellipodial versus filopodial mode of the actin nanomachinery: Pivotal role of the filament barbed end. (2004)
10.1083/jcb.144.6.1245 / J Cell Biol / Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes. (1999)
10.1083/jcb.135.3.647 / Journal of Cell Biology / The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin. (1996)
10.1002/cm.10091 / Cell Motil Cytoskeleton / Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. (2003)
10.1074/jbc.M209107200 / J Biol Chem / Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium. (2002)
10.1093/emboj/18.1.37 / Embo J / The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. (1999)
10.1242/jcs.114.23.4307 / J Cell Sci / Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis. (2001)
10.1002/j.1460-2075.1995.tb07117.x / Embo J / A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells. (1995)
10.1016/S0960-9822(95)00104-7 / Curr Biol / The bacterial actin nucleator protein ActA of Listeria monocytogenes contains multiple binding sites for host microfilament proteins. (1995)
10.1002/j.1460-2075.1995.tb07146.x / Embo J / The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. (1995)
10.1091/mbc.e02-01-0058 / Molecular Biology of the Cell / Contribution of Ena/VASP proteins to intracellular motility of Listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization. (2002)
10.1038/44183 / Nature / Reconstitution of actin-based motility of Listeria and Shigella using pure proteins.[comment]. (1999)
10.1083/jcb.200106061 / J Cell Biol / Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility. (2001)
10.1074/jbc.M503957200 / J Biol Chem / Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. (2005)
10.1083/jcb.200303191 / J Cell Biol / How VASP enhances actin-based motility. (2003)
10.1021/bi010486b / Biochemistry / Listeria protein ActA mimics WASp family proteins: It activates filament barbed end branching by Arp2/3 complex. (2001)
10.1146/annurev.biochem.73.011303.073844 / Annu Rev Biochem / Crawling toward a unified model of cell mobility: Spatial and temporal regulation of actin dynamics. (2004)
10.1083/jcb.102.4.1384 / J Cell Biol / Motility of cultured fish epidermal cells in the presence and absence of direct current electric fields. (1986)
10.2307/1536726 / Biol Bull / Cell behavior in tissue cultures. (1924)
10.1083/jcb.129.5.1275 / J Cell Biol / Actin filament organization in the fish keratocyte lamellipodium. (1995)
10.1002/(SICI)1097-0169(1998)41:2<126::AID-CM4>3.0.CO;2-C / Cell Motil Cytoskeleton / Integrin involvement in keratocyte locomotion. (1998)
10.1007/s00249-003-0300-4 / Eur Biophys J / Analysis of actin dynamics at the leading edge of crawling cells: implications for the shape of keratocyte lamellipodia. (2003)
10.1038/362167a0 / Nature / Principles of locomotion for simple-shaped cells. (1993)
10.1091/mbc.e04-10-0860 / Mol Biol Cell / Slipping or gripping? Fluorescent speckle microscopy in fish keratocytes reveals two different mechanisms for generating a retrograde flow of actin. (2005)
10.1242/jeb.00706 / J Exp Biol / Influences of thermal acclimation and acute temperature change on the motility of epithelial wound-healing cells (keratocytes) of tropical, temperate and Antarctic fish. (2003)
10.1091/mbc.e02-10-0630 / Mol Biol Cell / Orientational order of the lamellipodial actin network as demonstrated in living motile cells. (2003)
10.1038/352126a0 / Nature / Actin microfilament dynamics in locomoting cells. (1991)
10.1002/j.1460-2075.1994.tb06318.x / Embo J / The ActA protein of Listeria monocytogenes acts as a nucleator inducing reorganization of the actin cytoskeleton. (1994)
10.1128/IAI.64.6.1929-1936.1996 / Infect Immun / The ActA polypeptides of Listeria ivanovii and Listeria monocytogenes harbor related binding sites for host microfilament proteins. (1996)
10.1091/mbc.e05-07-0644 / Mol Biol Cell / Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. (2006)
10.1016/S0960-9822(02)00725-X / Curr Biol / Ena/VASP proteins regulate cortical neuronal positioning. (2002)
10.1242/dev.02230 / Development / Regulation of somitogenesis by Ena/VASP proteins and FAK during Xenopus development. (2006)
10.1093/emboj/16.17.5433 / Embo J / A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. (1997)
10.1038/310058a0 / Nature / Persistent, directional motility of cells and cytoplasmic fragments in the absence of microtubules. (1984)
PincusZTheriotJA 2007 Comparison of quantitative methods for cell shape analysis. Journal of Microscopy In press. (10.1111/j.1365-2818.2007.01799.x)
10.1073/pnas.181338798 / Proc Natl Acad Sci U S A / Self-organization of a propulsive actin network as an evolutionary process. (2001)
10.1016/S0006-3495(02)73897-6 / Biophys J / Regulation of actin dynamics in rapidly moving cells: a quantitative analysis. (2002)
10.1083/jcb.200210174 / J Cell Biol / Mechanism of filopodia initiation by reorganization of a dendritic network. (2003)
10.1006/scel.1994.1020 / Semin Cell Biol / Lamellipodia architecture: Actin filament turnover and the lateral flow of actin filaments during motility. (1994)
10.1083/jcb.105.4.1473 / J Cell Biol / Effects of cytochalasin and phalloidin on actin. (1987)
10.1016/j.neuron.2004.05.015 / Neuron / Arp2/3 is a negative regulator of growth cone translocation. (2004)
10.1073/pnas.0511243103 / Proc Natl Acad Sci U S A / The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. (2006)
10.1038/13040 / Nat Cell Biol / VASP dynamics during lamellipodia protrusion. (1999)
10.1046/j.1365-2958.2003.03639.x / Molecular Microbiology / Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility. (2003)
10.1083/jcb.102.4.1400 / J Cell Biol / Effects of mechanical tension on protrusive activity and microfilament and intermediate filament organization in an epidermal epithelium moving in culture. (1986)
10.1016/S0006-3495(97)78209-2 / Biophys J / Electroporation-induced formation of individual calcium entry sites in the cell body and processes of adherent cells. (1997)
10.1016/S0165-0270(99)00112-0 / J Neurosci Methods / A versatile microporation technique for the transfection of cultured CNS neurons. (1999)
WesterfieldM 2000 The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio) Eugene (Oregon) University of Oregon Press 363
10.1083/jcb.138.2.375 / J Cell Biol / The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (1997)
10.1038/385265a0 / Nature / Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. (1997)
10.1083/jcb.91.3.695 / J Cell Biol / Organization of actin in the leading edge of cultured cells: Influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks. (1981)
10.1091/mbc.e03-10-0747 / Mol Biol Cell / Listeria monocytogenes actin-based motility varies depending on subcellular location: A kinematic probe for cytoarchitecture. (2004)
RosnerB 1995 Fundamentals of Biostatistics Belmont (California) Duxbury Press 688

Dates

Type	When
Created	18 years ago (Aug. 23, 2007, 7:57 a.m.)
Deposited	4 years ago (Aug. 22, 2021, 3:39 a.m.)
Indexed	3 weeks, 3 days ago (Aug. 3, 2025, 6:58 p.m.)
Issued	18 years ago (Aug. 28, 2007)
Published	18 years ago (Aug. 28, 2007)
Published Online	18 years ago (Aug. 28, 2007)

Funders 0

None

BibTeX

@article{Lacayo_2007, title={Emergence of Large-Scale Cell Morphology and Movement from Local Actin Filament Growth Dynamics}, volume={5}, ISSN={1545-7885}, url={http://dx.doi.org/10.1371/journal.pbio.0050233}, DOI={10.1371/journal.pbio.0050233}, number={9}, journal={PLoS Biology}, publisher={Public Library of Science (PLoS)}, author={Lacayo, Catherine I and Pincus, Zachary and VanDuijn, Martijn M and Wilson, Cyrus A and Fletcher, Daniel A and Gertler, Frank B and Mogilner, Alex and Theriot, Julie A}, editor={Alberts, Jonathan B}, year={2007}, month=aug, pages={e233} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        3
      ]
    ],
    "date-time": "2025-08-03T22:58:36Z",
    "timestamp": 1754261916626
  },
  "reference-count": 59,
  "publisher": "Public Library of Science (PLoS)",
  "issue": "9",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            8,
            28
          ]
        ],
        "date-time": "2007-08-28T00:00:00Z",
        "timestamp": 1188259200000
      },
      "content-version": "unspecified",
      "delay-in-days": 0,
      "URL": "http://creativecommons.org/licenses/by/4.0/"
    }
  ],
  "content-domain": {
    "domain": [
      "www.plosbiology.org"
    ],
    "crossmark-restriction": false
  },
  "DOI": "10.1371/journal.pbio.0050233",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        8,
        23
      ]
    ],
    "date-time": "2007-08-23T11:57:54Z",
    "timestamp": 1187870274000
  },
  "page": "e233",
  "update-policy": "http://dx.doi.org/10.1371/journal.pbio.corrections_policy",
  "source": "Crossref",
  "is-referenced-by-count": 171,
  "title": "Emergence of Large-Scale Cell Morphology and Movement from Local Actin Filament Growth Dynamics",
  "prefix": "10.1371",
  "volume": "5",
  "author": [
    {
      "given": "Catherine I",
      "family": "Lacayo",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Zachary",
      "family": "Pincus",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Martijn M",
      "family": "VanDuijn",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Cyrus A",
      "family": "Wilson",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Daniel A",
      "family": "Fletcher",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Frank B",
      "family": "Gertler",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alex",
      "family": "Mogilner",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Julie A",
      "family": "Theriot",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "340",
  "published-online": {
    "date-parts": [
      [
        2007,
        8,
        28
      ]
    ]
  },
  "reference": [
    {
      "key": "pbio-0050233-b001",
      "first-page": "231",
      "article-title": "Control, exploitation and tolerance of intracellular noise[erratum appears in Nature. 9 January 2003 421:190].",
      "volume": "420",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "pbio-0050233-b002",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1016/j.devcel.2006.08.004",
      "article-title": "Quantitative modeling in cell biology: What is it good for?",
      "volume": "11",
      "year": "2006",
      "journal-title": "Dev Cell"
    },
    {
      "key": "pbio-0050233-b003",
      "doi-asserted-by": "crossref",
      "first-page": "541",
      "DOI": "10.1146/annurev.cellbio.19.050103.103356",
      "article-title": "Ena/VASP proteins: Regulators of the actin cytoskeleton and cell migration.",
      "volume": "19",
      "year": "2003",
      "journal-title": "Annu Rev Cell Dev Biol"
    },
    {
      "key": "pbio-0050233-b004",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1016/S0896-6273(04)00108-4",
      "article-title": "Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.",
      "volume": "42",
      "year": "2004",
      "journal-title": "Neuron"
    },
    {
      "key": "pbio-0050233-b005",
      "doi-asserted-by": "crossref",
      "first-page": "717",
      "DOI": "10.1016/S0092-8674(00)80884-3",
      "article-title": "Negative regulation of fibroblast motility by Ena/VASP proteins.",
      "volume": "101",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "pbio-0050233-b006",
      "doi-asserted-by": "crossref",
      "first-page": "509",
      "DOI": "10.1016/S0092-8674(02)00731-6",
      "article-title": "Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility.",
      "volume": "109",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "pbio-0050233-b007",
      "doi-asserted-by": "crossref",
      "first-page": "363",
      "DOI": "10.1016/j.cell.2004.07.019",
      "article-title": "Lamellipodial versus filopodial mode of the actin nanomachinery: Pivotal role of the filament barbed end.",
      "volume": "118",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "pbio-0050233-b008",
      "doi-asserted-by": "crossref",
      "first-page": "1245",
      "DOI": "10.1083/jcb.144.6.1245",
      "article-title": "Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes.",
      "volume": "144",
      "year": "1999",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b009",
      "doi-asserted-by": "crossref",
      "first-page": "647",
      "DOI": "10.1083/jcb.135.3.647",
      "article-title": "The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin.",
      "volume": "135",
      "year": "1996",
      "journal-title": "Journal of Cell Biology"
    },
    {
      "key": "pbio-0050233-b010",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1002/cm.10091",
      "article-title": "Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton.",
      "volume": "54",
      "year": "2003",
      "journal-title": "Cell Motil Cytoskeleton"
    },
    {
      "key": "pbio-0050233-b011",
      "doi-asserted-by": "crossref",
      "first-page": "49877",
      "DOI": "10.1074/jbc.M209107200",
      "article-title": "Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium.",
      "volume": "277",
      "year": "2002",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "pbio-0050233-b012",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1093/emboj/18.1.37",
      "article-title": "The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.",
      "volume": "18",
      "year": "1999",
      "journal-title": "Embo J"
    },
    {
      "key": "pbio-0050233-b013",
      "doi-asserted-by": "crossref",
      "first-page": "4307",
      "DOI": "10.1242/jcs.114.23.4307",
      "article-title": "Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis.",
      "volume": "114",
      "year": "2001",
      "journal-title": "J Cell Sci"
    },
    {
      "key": "pbio-0050233-b014",
      "doi-asserted-by": "crossref",
      "first-page": "1314",
      "DOI": "10.1002/j.1460-2075.1995.tb07117.x",
      "article-title": "A focal adhesion factor directly linking intracellularly motile Listeria monocytogenes and Listeria ivanovii to the actin-based cytoskeleton of mammalian cells.",
      "volume": "14",
      "year": "1995",
      "journal-title": "Embo J"
    },
    {
      "key": "pbio-0050233-b015",
      "doi-asserted-by": "crossref",
      "first-page": "517",
      "DOI": "10.1016/S0960-9822(95)00104-7",
      "article-title": "The bacterial actin nucleator protein ActA of Listeria monocytogenes contains multiple binding sites for host microfilament proteins.",
      "volume": "5",
      "year": "1995",
      "journal-title": "Curr Biol"
    },
    {
      "key": "pbio-0050233-b016",
      "doi-asserted-by": "crossref",
      "first-page": "1583",
      "DOI": "10.1002/j.1460-2075.1995.tb07146.x",
      "article-title": "The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.",
      "volume": "14",
      "year": "1995",
      "journal-title": "Embo J"
    },
    {
      "key": "pbio-0050233-b017",
      "doi-asserted-by": "crossref",
      "first-page": "2383",
      "DOI": "10.1091/mbc.e02-01-0058",
      "article-title": "Contribution of Ena/VASP proteins to intracellular motility of Listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization.",
      "volume": "13",
      "year": "2002",
      "journal-title": "Molecular Biology of the Cell"
    },
    {
      "key": "pbio-0050233-b018",
      "doi-asserted-by": "crossref",
      "first-page": "613",
      "DOI": "10.1038/44183",
      "article-title": "Reconstitution of actin-based motility of Listeria and Shigella using pure proteins.[comment].",
      "volume": "401",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "pbio-0050233-b019",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1083/jcb.200106061",
      "article-title": "Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility.",
      "volume": "155",
      "year": "2001",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b020",
      "doi-asserted-by": "crossref",
      "first-page": "28653",
      "DOI": "10.1074/jbc.M503957200",
      "article-title": "Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins.",
      "volume": "280",
      "year": "2005",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "pbio-0050233-b021",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1083/jcb.200303191",
      "article-title": "How VASP enhances actin-based motility.",
      "volume": "163",
      "year": "2003",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b022",
      "doi-asserted-by": "crossref",
      "first-page": "11390",
      "DOI": "10.1021/bi010486b",
      "article-title": "Listeria protein ActA mimics WASp family proteins: It activates filament barbed end branching by Arp2/3 complex.",
      "volume": "40",
      "year": "2001",
      "journal-title": "Biochemistry"
    },
    {
      "key": "pbio-0050233-b023",
      "doi-asserted-by": "crossref",
      "first-page": "209",
      "DOI": "10.1146/annurev.biochem.73.011303.073844",
      "article-title": "Crawling toward a unified model of cell mobility: Spatial and temporal regulation of actin dynamics.",
      "volume": "73",
      "year": "2004",
      "journal-title": "Annu Rev Biochem"
    },
    {
      "key": "pbio-0050233-b024",
      "doi-asserted-by": "crossref",
      "first-page": "1384",
      "DOI": "10.1083/jcb.102.4.1384",
      "article-title": "Motility of cultured fish epidermal cells in the presence and absence of direct current electric fields.",
      "volume": "102",
      "year": "1986",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b025",
      "doi-asserted-by": "crossref",
      "first-page": "252",
      "DOI": "10.2307/1536726",
      "article-title": "Cell behavior in tissue cultures.",
      "volume": "46",
      "year": "1924",
      "journal-title": "Biol Bull"
    },
    {
      "key": "pbio-0050233-b026",
      "doi-asserted-by": "crossref",
      "first-page": "1275",
      "DOI": "10.1083/jcb.129.5.1275",
      "article-title": "Actin filament organization in the fish keratocyte lamellipodium.",
      "volume": "129",
      "year": "1995",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b027",
      "doi-asserted-by": "crossref",
      "first-page": "126",
      "DOI": "10.1002/(SICI)1097-0169(1998)41:2<126::AID-CM4>3.0.CO;2-C",
      "article-title": "Integrin involvement in keratocyte locomotion.",
      "volume": "41",
      "year": "1998",
      "journal-title": "Cell Motil Cytoskeleton"
    },
    {
      "key": "pbio-0050233-b028",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1007/s00249-003-0300-4",
      "article-title": "Analysis of actin dynamics at the leading edge of crawling cells: implications for the shape of keratocyte lamellipodia.",
      "volume": "32",
      "year": "2003",
      "journal-title": "Eur Biophys J"
    },
    {
      "key": "pbio-0050233-b029",
      "doi-asserted-by": "crossref",
      "first-page": "167",
      "DOI": "10.1038/362167a0",
      "article-title": "Principles of locomotion for simple-shaped cells.",
      "volume": "362",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "pbio-0050233-b030",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1091/mbc.e04-10-0860",
      "article-title": "Slipping or gripping? Fluorescent speckle microscopy in fish keratocytes reveals two different mechanisms for generating a retrograde flow of actin.",
      "volume": "16",
      "year": "2005",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "pbio-0050233-b031",
      "doi-asserted-by": "crossref",
      "first-page": "4539",
      "DOI": "10.1242/jeb.00706",
      "article-title": "Influences of thermal acclimation and acute temperature change on the motility of epithelial wound-healing cells (keratocytes) of tropical, temperate and Antarctic fish.",
      "volume": "206",
      "year": "2003",
      "journal-title": "J Exp Biol"
    },
    {
      "key": "pbio-0050233-b032",
      "doi-asserted-by": "crossref",
      "first-page": "4667",
      "DOI": "10.1091/mbc.e02-10-0630",
      "article-title": "Orientational order of the lamellipodial actin network as demonstrated in living motile cells.",
      "volume": "14",
      "year": "2003",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "pbio-0050233-b033",
      "doi-asserted-by": "crossref",
      "first-page": "126",
      "DOI": "10.1038/352126a0",
      "article-title": "Actin microfilament dynamics in locomoting cells.",
      "volume": "352",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "pbio-0050233-b034",
      "doi-asserted-by": "crossref",
      "first-page": "758",
      "DOI": "10.1002/j.1460-2075.1994.tb06318.x",
      "article-title": "The ActA protein of Listeria monocytogenes acts as a nucleator inducing reorganization of the actin cytoskeleton.",
      "volume": "13",
      "year": "1994",
      "journal-title": "Embo J"
    },
    {
      "key": "pbio-0050233-b035",
      "doi-asserted-by": "crossref",
      "first-page": "1929",
      "DOI": "10.1128/IAI.64.6.1929-1936.1996",
      "article-title": "The ActA polypeptides of Listeria ivanovii and Listeria monocytogenes harbor related binding sites for host microfilament proteins.",
      "volume": "64",
      "year": "1996",
      "journal-title": "Infect Immun"
    },
    {
      "key": "pbio-0050233-b036",
      "doi-asserted-by": "crossref",
      "first-page": "1085",
      "DOI": "10.1091/mbc.e05-07-0644",
      "article-title": "Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts.",
      "volume": "17",
      "year": "2006",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "pbio-0050233-b037",
      "doi-asserted-by": "crossref",
      "first-page": "565",
      "DOI": "10.1016/S0960-9822(02)00725-X",
      "article-title": "Ena/VASP proteins regulate cortical neuronal positioning.",
      "volume": "12",
      "year": "2002",
      "journal-title": "Curr Biol"
    },
    {
      "key": "pbio-0050233-b038",
      "doi-asserted-by": "crossref",
      "first-page": "685",
      "DOI": "10.1242/dev.02230",
      "article-title": "Regulation of somitogenesis by Ena/VASP proteins and FAK during Xenopus development.",
      "volume": "133",
      "year": "2006",
      "journal-title": "Development"
    },
    {
      "key": "pbio-0050233-b039",
      "doi-asserted-by": "crossref",
      "first-page": "5433",
      "DOI": "10.1093/emboj/16.17.5433",
      "article-title": "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.",
      "volume": "16",
      "year": "1997",
      "journal-title": "Embo J"
    },
    {
      "key": "pbio-0050233-b040",
      "doi-asserted-by": "crossref",
      "first-page": "58",
      "DOI": "10.1038/310058a0",
      "article-title": "Persistent, directional motility of cells and cytoplasmic fragments in the absence of microtubules.",
      "volume": "310",
      "year": "1984",
      "journal-title": "Nature"
    },
    {
      "key": "pbio-0050233-b041",
      "doi-asserted-by": "crossref",
      "unstructured": "PincusZTheriotJA 2007 Comparison of quantitative methods for cell shape analysis. Journal of Microscopy In press.",
      "DOI": "10.1111/j.1365-2818.2007.01799.x"
    },
    {
      "key": "pbio-0050233-b042",
      "doi-asserted-by": "crossref",
      "first-page": "11324",
      "DOI": "10.1073/pnas.181338798",
      "article-title": "Self-organization of a propulsive actin network as an evolutionary process.",
      "volume": "98",
      "year": "2001",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "pbio-0050233-b043",
      "doi-asserted-by": "crossref",
      "first-page": "1237",
      "DOI": "10.1016/S0006-3495(02)73897-6",
      "article-title": "Regulation of actin dynamics in rapidly moving cells: a quantitative analysis.",
      "volume": "83",
      "year": "2002",
      "journal-title": "Biophys J"
    },
    {
      "key": "pbio-0050233-b044",
      "doi-asserted-by": "crossref",
      "first-page": "409",
      "DOI": "10.1083/jcb.200210174",
      "article-title": "Mechanism of filopodia initiation by reorganization of a dendritic network.",
      "volume": "160",
      "year": "2003",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b045",
      "doi-asserted-by": "crossref",
      "first-page": "157",
      "DOI": "10.1006/scel.1994.1020",
      "article-title": "Lamellipodia architecture: Actin filament turnover and the lateral flow of actin filaments during motility.",
      "volume": "5",
      "year": "1994",
      "journal-title": "Semin Cell Biol"
    },
    {
      "key": "pbio-0050233-b046",
      "doi-asserted-by": "crossref",
      "first-page": "1473",
      "DOI": "10.1083/jcb.105.4.1473",
      "article-title": "Effects of cytochalasin and phalloidin on actin.",
      "volume": "105",
      "year": "1987",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b047",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1016/j.neuron.2004.05.015",
      "article-title": "Arp2/3 is a negative regulator of growth cone translocation.",
      "volume": "43",
      "year": "2004",
      "journal-title": "Neuron"
    },
    {
      "key": "pbio-0050233-b048",
      "doi-asserted-by": "crossref",
      "first-page": "7694",
      "DOI": "10.1073/pnas.0511243103",
      "article-title": "The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation.",
      "volume": "103",
      "year": "2006",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "pbio-0050233-b049",
      "doi-asserted-by": "crossref",
      "first-page": "321",
      "DOI": "10.1038/13040",
      "article-title": "VASP dynamics during lamellipodia protrusion.",
      "volume": "1",
      "year": "1999",
      "journal-title": "Nat Cell Biol"
    },
    {
      "key": "pbio-0050233-b050",
      "doi-asserted-by": "crossref",
      "first-page": "1361",
      "DOI": "10.1046/j.1365-2958.2003.03639.x",
      "article-title": "Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility.",
      "volume": "49",
      "year": "2003",
      "journal-title": "Molecular Microbiology"
    },
    {
      "key": "pbio-0050233-b051",
      "doi-asserted-by": "crossref",
      "first-page": "1400",
      "DOI": "10.1083/jcb.102.4.1400",
      "article-title": "Effects of mechanical tension on protrusive activity and microfilament and intermediate filament organization in an epidermal epithelium moving in culture.",
      "volume": "102",
      "year": "1986",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b052",
      "doi-asserted-by": "crossref",
      "first-page": "1785",
      "DOI": "10.1016/S0006-3495(97)78209-2",
      "article-title": "Electroporation-induced formation of individual calcium entry sites in the cell body and processes of adherent cells.",
      "volume": "73",
      "year": "1997",
      "journal-title": "Biophys J"
    },
    {
      "key": "pbio-0050233-b053",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1016/S0165-0270(99)00112-0",
      "article-title": "A versatile microporation technique for the transfection of cultured CNS neurons.",
      "volume": "93",
      "year": "1999",
      "journal-title": "J Neurosci Methods"
    },
    {
      "key": "pbio-0050233-b054",
      "unstructured": "WesterfieldM 2000 The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio) Eugene (Oregon) University of Oregon Press 363"
    },
    {
      "key": "pbio-0050233-b055",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1083/jcb.138.2.375",
      "article-title": "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.",
      "volume": "138",
      "year": "1997",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b056",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1038/385265a0",
      "article-title": "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.",
      "volume": "385",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "pbio-0050233-b057",
      "doi-asserted-by": "crossref",
      "first-page": "695",
      "DOI": "10.1083/jcb.91.3.695",
      "article-title": "Organization of actin in the leading edge of cultured cells: Influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks.",
      "volume": "91",
      "year": "1981",
      "journal-title": "J Cell Biol"
    },
    {
      "key": "pbio-0050233-b058",
      "doi-asserted-by": "crossref",
      "first-page": "2164",
      "DOI": "10.1091/mbc.e03-10-0747",
      "article-title": "Listeria monocytogenes actin-based motility varies depending on subcellular location: A kinematic probe for cytoarchitecture.",
      "volume": "15",
      "year": "2004",
      "journal-title": "Mol Biol Cell"
    },
    {
      "key": "pbio-0050233-b059",
      "unstructured": "RosnerB 1995 Fundamentals of Biostatistics Belmont (California) Duxbury Press 688"
    }
  ],
  "container-title": "PLoS Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://dx.plos.org/10.1371/journal.pbio.0050233",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        8,
        22
      ]
    ],
    "date-time": "2021-08-22T07:39:29Z",
    "timestamp": 1629617969000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://dx.plos.org/10.1371/journal.pbio.0050233"
    }
  },
  "subtitle": [],
  "editor": [
    {
      "given": "Jonathan B",
      "family": "Alberts",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        8,
        28
      ]
    ]
  },
  "references-count": 59,
  "journal-issue": {
    "issue": "9",
    "published-online": {
      "date-parts": [
        [
          2007,
          8,
          28
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1371/journal.pbio.0050233",
  "relation": {},
  "ISSN": [
    "1545-7885"
  ],
  "subject": [],
  "container-title-short": "PLoS Biol",
  "published": {
    "date-parts": [
      [
        2007,
        8,
        28
      ]
    ]
  }
}