DOI: 10.1261/rna.912608. Hammerhead redux: Does the new structure fit the old biochemical data?

Hammerhead redux: Does the new structure fit the old biochemical data?

10.1261/rna.912608

Crossref journal-article

Cold Spring Harbor Laboratory

RNA (246)

Abstract

The cleavage rates of 78 hammerhead ribozymes containing structurally conservative chemical modifications were collected from the literature and compared to the recently determined crystal structure of the Schistosoma mansoni hammerhead. With only a few exceptions, the biochemical data were consistent with the structure, indicating that the new structure closely resembles the transition state of the reaction. Since all the biochemical data were collected on minimal hammerheads that have a very different structure, the minimal hammerhead must be dynamic and occasionally adopt the quite different extended structure in order to cleave.

Bibliography

Nelson, J. A., & Uhlenbeck, O. C. (2008). Hammerhead redux: Does the new structure fit the old biochemical data? RNA, 14(4), 605â615.

Authors 2

Jennifer A. Nelson (first)
Olke C. Uhlenbeck (additional)

References 57 Referenced 53

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{'key': '2021112105472415000_14.4.605.18', 'first-page': '132', 'article-title': 'Complete identification of nonbridging phosphate oxygens involved in hammerhead cleavage', 'volume': '3', 'author': 'Knoll,', 'year': '1997', 'journal-title': 'RNA'} / RNA / Complete identification of nonbridging phosphate oxygens involved in hammerhead cleavage by Knoll, (1997)
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Dates

Type	When
Created	17 years, 6 months ago (Feb. 20, 2008, 9:23 p.m.)
Deposited	3 years, 9 months ago (Nov. 21, 2021, 8:53 a.m.)
Indexed	4 months, 2 weeks ago (April 12, 2025, 9:55 p.m.)
Issued	17 years, 6 months ago (Feb. 20, 2008)
Published	17 years, 6 months ago (Feb. 20, 2008)
Published Online	17 years, 6 months ago (Feb. 20, 2008)
Published Print	17 years, 5 months ago (April 1, 2008)

Funders 0

None

BibTeX

@article{Nelson_2008, title={Hammerhead redux: Does the new structure fit the old biochemical data?}, volume={14}, ISSN={1469-9001}, url={http://dx.doi.org/10.1261/rna.912608}, DOI={10.1261/rna.912608}, number={4}, journal={RNA}, publisher={Cold Spring Harbor Laboratory}, author={Nelson, Jennifer A. and Uhlenbeck, Olke C.}, year={2008}, month=feb, pages={605–615} }

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