DOI: 10.1259/bjr.70.832.9166070. Bolus dynamics: theoretical and experimental aspects.

Bolus dynamics: theoretical and experimental aspects.

10.1259/bjr.70.832.9166070

Crossref journal-article

Oxford University Press (OUP)

The British Journal of Radiology (286)

Abstract

This paper analyses the arterial enhancement produced by short intravenous boluses of iodinated contrast medium, with particular attention to the differences between various types of contrast media. A theoretical discussion is presented, followed by a small experimental study. The characteristics of the arterial time-attenuation curve are a function of the rate of contrast medium transit to the extracellular fluid (ECF), osmolality driven transit of water from the ECF into the plasma, direct effects on the heart and pulmonary circulation, the distribution of transit times in the cardiopulmonary circulation and recirculation. Theory predicts that while differences in peak arterial attenuation/peak height (PH) will be small, alterations in the areas under the time-attenuation curve (AUC) will reflect early-phase rate constants in the absence of major inotropic effects. The AUC should be higher for non-ionic than ionic media reflecting these lower rate constants. An experimental study on three healthy dogs confirmed these theoretical observations, with a slightly higher PH (6.5% higher) using a non-ionic medium but a substantially higher AUC (22% higher). (Differences significant at the 5% level, two-tailed paired t-test.) Our theoretical predictions and experimental findings suggest non-ionic media produce superior vascular enhancement, particularly shortly after injection. Possible clinical implications, particularly in dynamic enhanced computed tomography, are discussed.

Bibliography

Blomley, M. J., & Dawson, P. (1997). Bolus dynamics: theoretical and experimental aspects. The British Journal of Radiology, 70(832), 351â359.

Authors 2

M J Blomley (first)
P Dawson (additional)

References 24 Referenced 67

10.1007/978-3-642-69733-3
10.1097/00004424-199311001-00023
10.1259/0007-1285-64-761-409
10.1097/00004424-199212002-00008
{'key': 'p_5', 'first-page': '424', 'volume': '19', 'author': 'Blomley MJK', 'year': '1995', 'journal-title': 'JCAT'} / JCAT by Blomley MJK (1995)
10.1097/00004424-198307000-00004
10.1161/01.RES.14.6.502
10.1177/028418517701800304 / Acta Radiol by Dean PB (1977)
10.1177/028418517701800408 / Acta Radiol by Dean PB (1977)
10.1148/121.2.379 / Radiology by Kormano M (1976)
10.1161/01.CIR.84.5.2071
{'key': 'p_12', 'first-page': '178', 'volume': '4', 'author': 'Gardeur D', 'year': '1980', 'journal-title': 'JCAT'} / JCAT by Gardeur D (1980)
10.1097/00004424-197707000-00009
10.1097/00004424-198511000-00016
10.1097/00004424-198307000-00015
10.1007/978-3-642-69515-5_11
10.1148/radiology.142.3.7063684 / Radiology by Higgins CB (1982)
10.1007/978-3-642-69515-5_4
{'key': 'p_19', 'first-page': '753', 'volume': '26', 'author': 'Hine A', 'year': '1985', 'journal-title': 'Br J Radiol'} / Br J Radiol by Hine A (1985)
10.1097/00004424-198509000-00018
10.1148/radiology.190.3.8115618 / Radiology by Chambers TP (1994)
10.1148/radiology.193.1.8090915 / Radiology by Dawson P (1994)
10.1148/radiology.170.3.2916011 / Radiology by Foley WD (1989)
10.1148/radiology.153.2.6484168 / Radiology by Claussen CD (1984)

Dates

Type	When
Created	11 years, 2 months ago (June 12, 2014, 9:57 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 11:18 a.m.)
Indexed	1 year, 7 months ago (Jan. 12, 2024, 7:15 p.m.)
Issued	28 years, 4 months ago (April 1, 1997)
Published	28 years, 4 months ago (April 1, 1997)
Published Online	11 years, 2 months ago (May 29, 2014)
Published Print	28 years, 4 months ago (April 1, 1997)

Funders 0

None

BibTeX

@article{Blomley_1997, title={Bolus dynamics: theoretical and experimental aspects.}, volume={70}, ISSN={0007-1285}, url={http://dx.doi.org/10.1259/bjr.70.832.9166070}, DOI={10.1259/bjr.70.832.9166070}, number={832}, journal={The British Journal of Radiology}, publisher={Oxford University Press (OUP)}, author={Blomley, M J and Dawson, P}, year={1997}, month=apr, pages={351–359} }

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