DOI: 10.1255/ejms.837. Electrospray Ionization Mass Spectrometry: A Major Tool to Investigate Reaction Mechanisms in Both Solution and the Gas Phase

Electrospray Ionization Mass Spectrometry: A Major Tool to Investigate Reaction Mechanisms in Both Solution and the Gas Phase

10.1255/ejms.837

Crossref journal-article

SAGE Publications

European Journal of Mass Spectrometry (179)

Abstract

Electrospray ionization mass spectrometry (ESI-MS), in conjunction with its tandem version ESI-MS/MS, is now established as a major tool to study reaction mechanisms in solution. This suitability results mainly from the ability of ESI to “fish” ions directly from solution to the gas phase environment of mass spectrometers. In this review, we summarize recent studies from our laboratory on the use of on-line monitoring by ESI-MS ion fishing of several types of reactions that permitted us to follow how these reactions progress as a function of both time and conditions using the ultra-high sensitivity and speed of ESI-MS to detect and even characterize transient reaction intermediates. We also show that the intrinsic reactivity of each key gaseous species fished by ESI can be further investigated via ESI-tandem mass spectrometry experiments, searching for the most active species via gas-phase ion/molecule reactions. In the gas-phase, solvent and counter-ion effects are absent. These studies often permit a detailed overview of major steps via the interception, characterization and reactivity investigation of key reaction players.

Bibliography

Eberlin, M. N. (2007). Electrospray Ionization Mass Spectrometry: A Major Tool to Investigate Reaction Mechanisms in Both Solution and the Gas Phase. European Journal of Mass Spectrometry, 13(1), 19â28.

Authors 1

Marcos N. Eberlin (first)

References 16 Referenced 179

10.1126/science.2675315
10.1016/j.ijms.2005.08.016
10.1002/anie.200353076
Eberlin M.N., Sabino A.A., Machado A.H.L., Correia C.R.D. “Probing the intrinsic reactivitiy of Heck reaction intermediates via gas-phase reactions and ESI-MS/MS”, submitted.
10.1002/anie.200460059
10.1002/poc.1066
Abella C.A.M., Benassi M., Santos L.S., Eberlin M.N., Coelho F. “The Mechanism of Tröger's Bases Formation Probed by Electrospray Ionization Mass Spectrometry”, J. Org. Chem. in press. doi: 10.1021/jo062556w (10.1021/jo062556w)
10.1021/om049805w
10.1002/rcm.2984
10.1021/jo048737k
10.1021/es047985v
10.1002/rcm.2523
10.1002/rcm.2574
Milagre C.D.F., Milagre H.M.S., Santos L.S., Lopes M.L.A., Moran P.J.S., Eberlin M.N., Rodrigues J.A.R. “Probing the mechanism of direct Mannich-type α-methylenation of ketoesters via electrospray ionization mass spectrometry”, J. Mass Spectrom. in press.
10.1016/j.tetlet.2006.09.037
Eberlin M.N., Santos L.S., Rosso G.B., Pilli R.A. “The mechanism of the Stille reaction investigated by electrospray ionization mass spectrometry”, J. Org. Chem., in press.

Dates

Type	When
Created	18 years, 2 months ago (June 12, 2007, 3:50 p.m.)
Deposited	5 months, 3 weeks ago (March 11, 2025, 6:18 a.m.)
Indexed	4 months ago (May 2, 2025, 9:10 a.m.)
Issued	18 years, 7 months ago (Feb. 1, 2007)
Published	18 years, 7 months ago (Feb. 1, 2007)
Published Online	18 years, 7 months ago (Feb. 1, 2007)
Published Print	18 years, 7 months ago (Feb. 1, 2007)

Funders 0

None

BibTeX

@article{Eberlin_2007, title={Electrospray Ionization Mass Spectrometry: A Major Tool to Investigate Reaction Mechanisms in Both Solution and the Gas Phase}, volume={13}, ISSN={1751-6838}, url={http://dx.doi.org/10.1255/ejms.837}, DOI={10.1255/ejms.837}, number={1}, journal={European Journal of Mass Spectrometry}, publisher={SAGE Publications}, author={Eberlin, Marcos N.}, year={2007}, month=feb, pages={19–28} }

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