DOI: 10.1242/jeb.172.1.67. Molecular genetics of the yeast vacuolar H+-ATPase

Molecular genetics of the yeast vacuolar H+-ATPase

10.1242/jeb.172.1.67

Crossref journal-article

The Company of Biologists

Journal of Experimental Biology (237)

Abstract

ABSTRACT The yeast vacuolar proton-translocating ATPase was discovered in 1981 as the first member of the V-ATPases, which are now known to be ubiquitously distributed in eukaryotic vacuo-lysosomal organelles and archaebacteria. Nine VMA genes that are indispensable for expression of vacuolar ATPase activity have been identified in the yeast Saccharomyces cerevisiae. VMA1, VMA2, VMA3, VMA5 and VMA6 were cloned and characterized on the basis of partial amino acid sequences determined with the purified subunits. Genetic and biochemical studies of the yeast Pet–cls mutants have demonstrated that they are related to vma defects. Based on this evidence, VMA11 (CLS9), VMA 12 (CLS10) and VMA 13 (CLS11) were isolated from a yeast genomic DNA library by complementation of the vmal 1, vma!2 and vma!3 mutations, respectively. This article summarizes currently available information on the VMA genes and the molecular biological functions of the VMA gene products.

Bibliography

Anraku, Y., Hirata, R., Wada, Y., & Ohya, Y. (1992). Molecular genetics of the yeast vacuolar H+-ATPase. Journal of Experimental Biology, 172(1), 67â81.

Authors 4

Yasuhiro Anraku (first)
Ryogo Hirata (additional)
Yoh Wada (additional)
Yoshikazu Ohya (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 24, 2021, 11:34 p.m.)
Deposited	2 years, 3 months ago (May 11, 2023, 11:27 p.m.)
Indexed	2 months ago (June 27, 2025, 6:40 a.m.)
Issued	32 years, 10 months ago (Nov. 1, 1992)
Published	32 years, 10 months ago (Nov. 1, 1992)
Published Online	32 years, 10 months ago (Nov. 1, 1992)
Published Print	32 years, 10 months ago (Nov. 1, 1992)

Funders 0

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BibTeX

@article{Anraku_1992, title={Molecular genetics of the yeast vacuolar H+-ATPase}, volume={172}, ISSN={1477-9145}, url={http://dx.doi.org/10.1242/jeb.172.1.67}, DOI={10.1242/jeb.172.1.67}, number={1}, journal={Journal of Experimental Biology}, publisher={The Company of Biologists}, author={Anraku, Yasuhiro and Hirata, Ryogo and Wada, Yoh and Ohya, Yoshikazu}, year={1992}, month=nov, pages={67–81} }

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