DOI: 10.1242/jcs.1995.supplement_19.10. Recognition and processing of damaged DNA

Recognition and processing of damaged DNA

10.1242/jcs.1995.supplement_19.10

Crossref journal-article

The Company of Biologists

Journal of Cell Science (237)

Abstract

ABSTRACT Base excision-repair, which is required for correction of spontaneous hydrolytic and oxidative damage to DNA as well as lesions inflicted by alkylating agents, is a relatively well understood repair pathway. Mammalian factors involved in this pathway are reviewed, with emphasis on current uncertainties. Most DNA replication and repair enzymes in mammalian cell nuclei, e.g. DNA polymerases α, β, δ, and ε, have direct counterparts in yeast. In contrast, the abundant enzymes in mammalian cell nuclei that bind and are activated specifically by DNA strand interruptions, poly(ADP-ribose) polymerase and DNA-dependent protein kinase, have not been detected in yeast; nor has p53, which is elevated in response to DNA strand breaks. We have found a family of four distinct DNA ligases in human cell nuclei, whereas only a single DNA ligase has been detected in yeast. It would appear that the cellular responses to DNA strand breaks may differ markedly between higher and lower eukaryotes.

Bibliography

Lindahl, T. (1995). Recognition and processing of damaged DNA. Journal of Cell Science, 1995(Supplement_19), 73â77.

Authors 1

Tomas Lindahl (first)

References 33 Referenced 42

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{'key': '2024071019263562900_JOCES_1995_S19_73C3', 'first-page': '1605', 'article-title': 'Generation of single-nucleotide repair patches following excision of uracil residues from DNA', 'volume': '12', 'author': 'Dianov', 'year': '1992', 'journal-title': 'Mol. Cell. Biol'} / Mol. Cell. Biol / Generation of single-nucleotide repair patches following excision of uracil residues from DNA by Dianov (1992)
10.1016/S0960-9822(00)00245-1 / Curr. Biol / Reconstitution of the DNA base excisionrepair pathway by Dianov (1994)
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10.1073/pnas.87.8.2990 / Proc. Nat. Acad. Sci. USA / The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA by Gradwohl (1990)
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10.1074/jbc.270.16.9683 / J. Biol. Chem / Purification and characterization of DNA ligase III from bovine testes: Homology with DNA ligase II and Vaccinia DNA ligase by Husain (1995)
10.1016/S0021-9258(19)77695-9 / J. Biol. Chem / Complete enzymatic synthesis of DNA containing the SV4O origin of replication by Ishimi (1988)
10.1038/329131a0 / Nature / The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme by Jentsch (1987)
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10.1074/jbc.270.2.949 / J. Biol. Chem / DNA polymerase ß conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract by Singhal (1995)
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Dates

Type	When
Created	12 years, 3 months ago (May 23, 2013, 8:52 a.m.)
Deposited	1 year, 1 month ago (July 10, 2024, 3:27 p.m.)
Indexed	1 year, 1 month ago (July 10, 2024, 4:10 p.m.)
Issued	30 years, 7 months ago (Jan. 1, 1995)
Published	30 years, 7 months ago (Jan. 1, 1995)
Published Online	30 years, 7 months ago (Jan. 1, 1995)
Published Print	30 years, 7 months ago (Jan. 1, 1995)

Funders 0

None

BibTeX

@article{Lindahl_1995, title={Recognition and processing of damaged DNA}, volume={1995}, ISSN={1477-9137}, url={http://dx.doi.org/10.1242/jcs.1995.supplement_19.10}, DOI={10.1242/jcs.1995.supplement_19.10}, number={Supplement_19}, journal={Journal of Cell Science}, publisher={The Company of Biologists}, author={Lindahl, Tomas}, year={1995}, month=jan, pages={73–77} }

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