DOI: 10.1242/jcs.114.2.377. Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology

Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology

10.1242/jcs.114.2.377

Crossref journal-article

The Company of Biologists

Journal of Cell Science (237)

Abstract

ABSTRACT The relative sizes of individual telomeres in cultured human cells under conditions of cell cycling, replicative quiescence, cell transformation and immortalization were determined using quantitative fluorescence in situ hybridization (Q-FISH) with a telomere-specific peptide nucleic acid (PNA) probe. Results obtained from analysis of telomere length profiles (TLPs), which display the distribution of relative telomere lengths for individual cells, confirmed telomere length heterogeneity at the single cell level and proportional shortening of telomere length during replicative aging of virus-transformed cells. TLPs also revealed that some telomeric ends of chromosomes are so closely juxtaposed within interphase nuclei that their fluorescent signals appear as a single spot. These telomeric associations (TAs) were far more prevalent in interphase nuclei of noncycling normal and virus-transformed cells than in their cycling counterparts. The number of interphase TAs per nucleus observed in late-passage E6/E7-transformed cells did not increase during progression to crisis, suggesting that telomere shortening does not increase the frequency of interphase TAs. Furthermore, interphase TAs were rarely observed in rapidly cycling, telomerase-positive, immortalized cells that exhibit somewhat shortened, but stabilized, telomere length through the activity of telomerase. Our overall results suggest that the number of interphase TAs is dependent more on whether or not cells are cycling than on telomere length, with TAs being most prominent in the nuclei of replicatively quiescent cells in which nonrandom (even preferred) chromosome spatial arrangements have been observed. We propose that interphase TAs may play a role in the generation and/or maintenance of nuclear architecture and chromosome positional stability in interphase nuclei, especially in cells with a prolonged G1/G0 phase and possibly in terminally differentiated cells.

Bibliography

Nagele, R. G., Velasco, A. Q., Anderson, W. J., McMahon, D. J., Thomson, Z., Fazekas, J., Wind, K., & Lee, H. (2001). Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology. Journal of Cell Science, 114(2), 377â388.

Authors 8

Robert G. Nagele (first)
Antonio Q. Velasco (additional)
William J. Anderson (additional)
Donald J. McMahon (additional)
Zabrina Thomson (additional)
Jessica Fazekas (additional)
Kelly Wind (additional)
Hsin-yi Lee (additional)

References 81 Referenced 54

10.1093/nar/17.12.4611 / Nucl. Acids Res / Human telomeres contain at least three types of G-rich repeat distributed nonrandomly by Allshire (1989)
10.1073/pnas.89.21.10114 / Proc. Natl. Acad. Sci. USA / Telomere length predicts replicative capacity of human fibroblasts by Allsopp (1992)
10.1242/jcs.113.6.1033 / J. Cell Sci / Evidence for the coincident initiation of homolog pairing and synapsis during telomere-clustering (bouquet) stage of meiotic prophase by Bass (2000)
10.1093/oxfordjournals.aob.a088446 / Ann. Bot / Spatial separation of ancestral genomes in the wild grass Milium montianum Parl by Bennett (1992)
10.1002/jcb.240470204 / J. Cell. Biochem / The nuclear matrix: a heuristic model for investigating genomic organization and function in the cell nucleus by Bereszney (1991)
10.1242/jcs.100.1.219 / J. Cell Sci / Localization of centromeric satellite and telomeric DNA sequences in dorsal root ganglion neurons, in vitro by Billia (1991)
10.1038/350569a0 / Nature / Structure and function of telomeres by Blackburn (1991)
10.1016/S0092-8674(01)80006-4 / Cell / Telomere shortening and tumor formation by mouse cells lacking telomerase RNA by Blasco (1997)
10.1126/science.279.5349.349 / Science / Extension of life-span by introduction of telomerase into normal human cells by Bodnar (1998)
10.1016/S0960-9822(00)00312-2 / Curr. Biol / Re-modeling of nuclear architecture in quiescent and senescent human fibroblasts by Bridger (2000)
10.1007/BF01552798 / Chrom. Res / Parental genome separation and asynchronous centromere division in interspecific F1 hybrids in Lathyrus by Callimassia (1994)
10.1242/jcs.91.3.325 / J. Cell Sci / The prometaphase configuration and chromosome order in early mitosis by Chaly (1988)
{'key': '2024011500314446000_JOCES_114_2_377C13', 'first-page': '30', 'article-title': 'Symmetric chromosomal order in leukocytes indicated by DNA image cytometry and fluorescence in situ hybridization', 'volume': '19', 'author': 'Chaudhuri', 'year': '1997', 'journal-title': 'Anal. Quant. Cytol. Histol'} / Anal. Quant. Cytol. Histol / Symmetric chromosomal order in leukocytes indicated by DNA image cytometry and fluorescence in situ hybridization by Chaudhuri (1997)
10.3181/00379727-214-44075 / Proc. Soc. Exp. Biol. Med / Replicative senescence and cell immortality: The role of telomeres and telomerase by Chiu (1997)
{'key': '2024011500314446000_JOCES_114_2_377C15', 'first-page': '440', 'article-title': 'The rationale for an ordered arrangement of chromatin in the interphase nucleus', 'volume': '20', 'author': 'Comings', 'year': '1968', 'journal-title': 'Am. J. Hum. Genet'} / Am. J. Hum. Genet / The rationale for an ordered arrangement of chromatin in the interphase nucleus by Comings (1968)
10.1007/BF00273484 / Hum. Genet / Arrangement of chromatin in the nucleus by Comings (1980)
10.1073/pnas.67.4.1951 / Proc. Natl. Acad. Sci. USA / Identical linear order of chromosomes in both gametes of the Acoel Turbellarian polychoerus carmelensis: a preliminary note by Costello (1970)
10.1002/j.1460-2075.1992.tb05245.x / EMBO J / Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity by Counter (1992)
10.1242/jcs.110.21.2673 / J. Cell Sci / Scaffold attachments within the human genome by Craig (1997)
10.1083/jcb.145.6.1119 / J. Cell Biol / Differences in the localization and morphology of chromosomes in the human nucleus by Croft (1999)
10.1002/j.1460-2075.1992.tb05104.x / EMBO J / Human telomeres are attached to the nuclear matrix by De Lange (1992)
{'key': '2024011500314446000_JOCES_114_2_377C22', 'first-page': '518', 'article-title': 'Structure and variability of human chromosome ends', 'volume': '10', 'author': 'De Lange', 'year': '1990', 'journal-title': 'Mol. Cell. Biol'} / Mol. Cell. Biol / Structure and variability of human chromosome ends by De Lange (1990)
{'key': '2024011500314446000_JOCES_114_2_377C23', 'first-page': '265', 'article-title': 'Telomere dynamics and genome instability in human cancer', 'volume-title': 'In Telomeres', 'author': 'De Lange', 'year': '1995'} / In Telomeres / Telomere dynamics and genome instability in human cancer by De Lange (1995)
10.1038/sj.onc.1202797 / Oncogene / Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process by Ducray (1999)
{'key': '2024011500314446000_JOCES_114_2_377C25', 'volume-title': 'DNA and Chromosomes', 'author': 'DuPraw', 'year': '1970'} / DNA and Chromosomes by DuPraw (1970)
10.1038/365566a0 / Nature / PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules by Egholm (1993)
10.1016/0014-4827(91)90048-Y / Exp. Cell Res / Chromosome topology in mammalian interphase nuclei by Haaf (1991)
10.1083/jcb.144.4.589 / J. Cell Biol / Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice by Hande (1999)
10.1038/345458a0 / Nature / Telomeres shorten during aging of human fibroblasts by Harley (1990)
10.1016/0168-9525(89)90137-6 / Trends Genet / Human telomeres: fusion and interstitial sites by Hastie (1989)
10.1083/jcb.134.1.1 / J. Cell Biol / In situ analysis of changes in telomere size during replicative aging and cell transformation by Henderson (1996)
{'key': '2024011500314446000_JOCES_114_2_377C32', 'first-page': '51', 'article-title': 'Chromosome order – possible implications for development', 'volume': '83', 'author': 'Heslop-Harrison', 'year': '1984', 'journal-title': 'J. Embryol. Exp. Morphol'} / J. Embryol. Exp. Morphol / Chromosome order – possible implications for development by Heslop-Harrison (1984)
10.1038/23962 / Nature / Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells by Kiyono (1998)
10.1091/mbc.9.11.3147 / Mol. Biol. Cell / The three-dimensional study of chromosomes and upstream binding factor-immunolabeled nucleolar organizer regions demonstrates their nonrandom spatial arrangement during mitosis by Klein (1998)
10.1159/000015109 / Cytogenet. Cell Genet / Characteristics of chromosomes in polarized normal human bronchial cells provide a blueprint for nuclear organization by Koss (1998)
10.1093/hmg/5.5.685 / Hum. Mol. Genet / Heterogeneity in telomere length of human chromosomes by Lansdorp (1996)
10.1007/BF00212022 / Hum. Genet / The spatial localization of homologous chromosomes in human fibroblasts at mitosis by Leitch (1994)
10.1007/BF00365152 / Chromosoma / Parental genomes are separated throughout the cell cycle in a plant hybrid by Leitch (1991)
10.1128/MMBR.64.1.138-152.2000 / Micro. Molec. Biol. Rev / Higher levels of organization in the interphase nucleus of cycling and differentiated cells by Leitch (2000)
10.1016/0022-2836(92)90096-3 / J. Mol. Biol / Telomere end-replication problem and cell aging by Levy (1992)
10.1083/jcb.135.4.867 / J. Cell Biol / Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex by Luderus (1996)
10.1073/pnas.81.10.3123 / Proc. Natl. Acad. Sci. USA / Different central nervous system cell types display distinct and nonrandom arrangements of satellite DNA sequences by Manuelidis (1984)
10.1126/science.2274784 / Science / A view of interphase chromosomes by Manuelidis (1990)
10.1007/BF00303033 / Chromosoma / Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridization and three-dimensional reconstruction by Manuelidis (1988)
10.1006/excr.2000.4823 / Exp. Cell Res / Accumulation of short telomeres in human fibroblasts prior to replicative senescence by Martens (2000)
10.1242/jcs.112.11.1761 / J. Cell Sci / Homologous chromosome pairing in wheat by Martinez-Perez (1999)
10.1006/excr.1999.4793 / Exp. Cell Res / Nuclear topology of murine, cerebellar Purkinje neurons: changes as a function of development by Martou (2000)
10.1083/jcb.148.4.629 / J. Cell Biol / Spatial separation of parental genomes in preimplantation mouse embryos by Mayer (2000)
10.1093/genetics/26.2.234 / Genetics / The stability of broken ends of chromosomes in Zea mays by McClintock (1941)
10.1073/pnas.86.18.7049 / Proc. Natl. Acad. Sci. USA / Conservation of the human telomere sequence (TTAGGG)n among vertebrates by Meyne (1989)
10.1038/ng0796-350 / Nat. Genet / Accelerated telomere shortening in Ataxia Telangiectasia by Metcalfe (1996)
10.1016/0092-8674(84)90208-3 / Cell / Organization of the higher order chromatin loop: specific DNA attachment sites on nuclear scaffold by Mirkovitch (1984)
10.1007/BF00204924 / Hum. Genet / Chromosome arrangements in human fibroblasts at mitosis by Mosgoller (1991)
10.1128/jvi.63.10.4417-4421.1989 / J. Virol / The E6 and E7 genes of the human papilloma virus type 16 together are necessary and sufficient for transformation of primary human keratinocytes by Munger (1989)
10.1016/B978-0-12-185269-6.50035-7 / Meth. Neurosci / Computer-assisted three-dimensional reconstruction and dissection by Nagele (1992)
10.1126/science.270.5243.1831 / Science / Precise spatial positioning of chromosomes during prometaphase: evidence for chromosome order in human cells by Nagele (1995)
10.1007/s004120050315 / Chromosoma / Chromosome spatial order in human cells: evidence for early origin and faithful propagation by Nagele (1998)
10.1242/jcs.112.4.525 / J. Cell Sci / Chromosomes exhibit preferential positioning in nuclei of quiescent human cells by Nagele (1999)
10.1073/pnas.94.9.4446 / Proc. Natl. Acad. Sci. USA / The nuclear matrix revealed by eluting chromatin from a crosslinked nucleus by Nickerson (1977)
10.1023/A:1009253917125 / Chromosome Res / An anchorage nuclear structure for telomeric DNA repeats in HeLa cells by Pierron (1999)
10.1002/(SICI)1097-0320(19990801)36:4<267::AID-CYTO1>3.0.CO;2-O / Cytometry / Telomere length measurements using digital fluorescence microscopy by Poon (1999)
10.1016/0092-8674(93)90493-A / Cell / Loss of a yeast telomere: arrest, recovery and chromosome loss by Sandell (1993)
10.1242/jcs.101.1.13 / J. Cell Sci / Parental genome separation in reconstructions of somatic and premeiotic metaphases of Hordeum vulgare × H. bulbosum by Schwarzacher (1992)
10.1128/MCB.20.20.7773-7783.2000 / Mol. Cell Biol / Meiotic telomere distribution and sertoli cell nuclear architecture are altered in atm- and atm-p53-deficient mice by Scherthan (2000)
10.1007/s004120050263 / Chromosoma / Telomere length, chromatin structure, and chromosome fusigenic potential by Slijepcevic (1997)
10.1146/annurev.cb.09.110193.001405 / Annu. Rev. Cell Biol / Macromolecular domains within the cell nucleus by Spector (1993)
10.1006/excr.1998.4293 / Exp. Cell Res / Telomere dynamics in a human cancer cell line by Sprung (1999)
10.1016/S0027-5107(99)00115-3 / Mutat. Res / Telomere instability in a human cancer cell line by Sprung (1999)
10.1023/A:1009279918034 / Chromosome Res / Correlated positioning of homologous chromosomes in daughter fibroblast cells by Sun (1999)
10.1242/jcs.112.5.651 / J. Cell Sci / Bouquet formation in budding yeast; initiation of recombination is not required for meiotic telomere clustering by Trelles-Sticken (1999)
10.1016/S0092-8674(00)80932-0 / Cell / TRF2 protects human telomeres from end-to-end fusions by Van Steensel (1998)
10.1073/pnas.91.21.9857 / Proc. Natl. Acad. Sci. USA / Evidence for a mitotic clock in human hemopoietic stem cells: loss of telomeric DNA with age by Vaziri (1994)
10.1006/excr.1993.1068 / Exp. Cell Res / Cell cycle-dependent distribution of telomeres, centromeres and chromsomoe-specific subsatellite domains in the interphase nucleus of mouse lymphocytes by Vourc’h (1993)
10.1002/(SICI)1098-2264(199901)24:1<83::AID-GCC12>3.0.CO;2-C / Genes Chromosomes Cancer / Absence or low number of telomere repeats at junctions of dicentric chromosomes by Wan (1999)
10.1083/jcb.147.7.1409 / J. Cell Biol / Intranuclear anchoring of repetitive DNA sequences: centromeres, telomeres and ribosomal DNA by Weipoltshammer (1999)
{'key': '2024011500314446000_JOCES_114_2_377C76', 'first-page': '3088', 'article-title': 'Reversible cellular senescence: implications of normal human diploid fibroblasts', 'volume': '9', 'author': 'Wright', 'year': '1989', 'journal-title': 'Mol. Cell Biol'} / Mol. Cell Biol / Reversible cellular senescence: implications of normal human diploid fibroblasts by Wright (1989)
10.1006/excr.1999.4602 / Exp. Cell Res / Normal human telomeres are not late replicating by Wright (1999)
10.1093/carcin/17.7.1395 / Carcinogenesis / The human papillomavirus E6/E7 genes induce discordant changes in the expression of cell growth regulatory proteins by Xu (1996)
10.1146/annurev.ge.23.120189.003051 / Annu. Rev. Genet / Structure and function of telomeres by Zakian (1989)
10.1126/science.270.5242.1601 / Science / Telomeres: Beginning to understand the end by Zakian (1995)
10.1073/pnas.94.14.7423 / Proc. Natl. Acad. Sci. USA / Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats by Zijlmans (1997)

Dates

Type	When
Created	4 years, 4 months ago (April 25, 2021, 2:42 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 7:32 p.m.)
Indexed	1 month, 2 weeks ago (July 12, 2025, 6:56 p.m.)
Issued	24 years, 7 months ago (Jan. 15, 2001)
Published	24 years, 7 months ago (Jan. 15, 2001)
Published Online	24 years, 7 months ago (Jan. 15, 2001)
Published Print	24 years, 7 months ago (Jan. 15, 2001)

Funders 0

None

BibTeX

@article{Nagele_2001, title={Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology}, volume={114}, ISSN={1477-9137}, url={http://dx.doi.org/10.1242/jcs.114.2.377}, DOI={10.1242/jcs.114.2.377}, number={2}, journal={Journal of Cell Science}, publisher={The Company of Biologists}, author={Nagele, Robert G. and Velasco, Antonio Q. and Anderson, William J. and McMahon, Donald J. and Thomson, Zabrina and Fazekas, Jessica and Wind, Kelly and Lee, Hsin-yi}, year={2001}, month=jan, pages={377–388} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        12
      ]
    ],
    "date-time": "2025-07-12T22:56:24Z",
    "timestamp": 1752360984661
  },
  "reference-count": 81,
  "publisher": "The Company of Biologists",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            1,
            15
          ]
        ],
        "date-time": "2001-01-15T00:00:00Z",
        "timestamp": 979516800000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://www.biologists.com/user-licence-1-1/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        1,
        15
      ]
    ]
  },
  "abstract": "<jats:title>ABSTRACT</jats:title>\n               <jats:p>The relative sizes of individual telomeres in cultured human cells under conditions of cell cycling, replicative quiescence, cell transformation and immortalization were determined using quantitative fluorescence in situ hybridization (Q-FISH) with a telomere-specific peptide nucleic acid (PNA) probe. Results obtained from analysis of telomere length profiles (TLPs), which display the distribution of relative telomere lengths for individual cells, confirmed telomere length heterogeneity at the single cell level and proportional shortening of telomere length during replicative aging of virus-transformed cells. TLPs also revealed that some telomeric ends of chromosomes are so closely juxtaposed within interphase nuclei that their fluorescent signals appear as a single spot. These telomeric associations (TAs) were far more prevalent in interphase nuclei of noncycling normal and virus-transformed cells than in their cycling counterparts. The number of interphase TAs per nucleus observed in late-passage E6/E7-transformed cells did not increase during progression to crisis, suggesting that telomere shortening does not increase the frequency of interphase TAs. Furthermore, interphase TAs were rarely observed in rapidly cycling, telomerase-positive, immortalized cells that exhibit somewhat shortened, but stabilized, telomere length through the activity of telomerase. Our overall results suggest that the number of interphase TAs is dependent more on whether or not cells are cycling than on telomere length, with TAs being most prominent in the nuclei of replicatively quiescent cells in which nonrandom (even preferred) chromosome spatial arrangements have been observed. We propose that interphase TAs may play a role in the generation and/or maintenance of nuclear architecture and chromosome positional stability in interphase nuclei, especially in cells with a prolonged G1/G0 phase and possibly in terminally differentiated cells.</jats:p>",
  "DOI": "10.1242/jcs.114.2.377",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2021,
        4,
        25
      ]
    ],
    "date-time": "2021-04-25T18:42:03Z",
    "timestamp": 1619376123000
  },
  "page": "377-388",
  "source": "Crossref",
  "is-referenced-by-count": 54,
  "title": "Telomere associations in interphase nuclei: possible role in maintenance of interphase chromosome topology",
  "prefix": "10.1242",
  "volume": "114",
  "author": [
    {
      "given": "Robert G.",
      "family": "Nagele",
      "sequence": "first",
      "affiliation": [
        {
          "name": "University of Medicine and Dentistry of New Jersey \u2013 School of Osteopathic Medicine 1 Department of Molecular Biology , , Stratford, New Jersey 08084, USA"
        }
      ]
    },
    {
      "given": "Antonio Q.",
      "family": "Velasco",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Rutgers University 2 Department of Biolog , , Camden, New Jersey, 08102, USA"
        }
      ]
    },
    {
      "given": "William J.",
      "family": "Anderson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Rutgers University 2 Department of Biolog , , Camden, New Jersey, 08102, USA"
        }
      ]
    },
    {
      "given": "Donald J.",
      "family": "McMahon",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Rutgers University 2 Department of Biolog , , Camden, New Jersey, 08102, USA"
        }
      ]
    },
    {
      "given": "Zabrina",
      "family": "Thomson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Rutgers University 2 Department of Biolog , , Camden, New Jersey, 08102, USA"
        }
      ]
    },
    {
      "given": "Jessica",
      "family": "Fazekas",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "University of Medicine and Dentistry of New Jersey \u2013 School of Osteopathic Medicine 1 Department of Molecular Biology , , Stratford, New Jersey 08084, USA"
        }
      ]
    },
    {
      "given": "Kelly",
      "family": "Wind",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "University of Medicine and Dentistry of New Jersey \u2013 School of Osteopathic Medicine 1 Department of Molecular Biology , , Stratford, New Jersey 08084, USA"
        }
      ]
    },
    {
      "given": "Hsin-yi",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Rutgers University 2 Department of Biolog , , Camden, New Jersey, 08102, USA"
        }
      ]
    }
  ],
  "member": "237",
  "published-online": {
    "date-parts": [
      [
        2001,
        1,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "2024011500314446000_JOCES_114_2_377C1",
      "doi-asserted-by": "publisher",
      "first-page": "4611",
      "DOI": "10.1093/nar/17.12.4611",
      "article-title": "Human telomeres contain at least three types of G-rich repeat distributed nonrandomly",
      "volume": "17",
      "author": "Allshire",
      "year": "1989",
      "journal-title": "Nucl. Acids Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C2",
      "doi-asserted-by": "publisher",
      "first-page": "10114",
      "DOI": "10.1073/pnas.89.21.10114",
      "article-title": "Telomere length predicts replicative capacity of human fibroblasts",
      "volume": "89",
      "author": "Allsopp",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C3",
      "doi-asserted-by": "publisher",
      "first-page": "1033",
      "DOI": "10.1242/jcs.113.6.1033",
      "article-title": "Evidence for the coincident initiation of homolog pairing and synapsis during telomere-clustering (bouquet) stage of meiotic prophase",
      "volume": "113",
      "author": "Bass",
      "year": "2000",
      "journal-title": "J. Cell Sci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C4",
      "doi-asserted-by": "publisher",
      "first-page": "111",
      "DOI": "10.1093/oxfordjournals.aob.a088446",
      "article-title": "Spatial separation of ancestral genomes in the wild grass Milium montianum Parl",
      "volume": "70",
      "author": "Bennett",
      "year": "1992",
      "journal-title": "Ann. Bot"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C5",
      "doi-asserted-by": "publisher",
      "first-page": "109",
      "DOI": "10.1002/jcb.240470204",
      "article-title": "The nuclear matrix: a heuristic model for investigating genomic organization and function in the cell nucleus",
      "volume": "47",
      "author": "Bereszney",
      "year": "1991",
      "journal-title": "J. Cell. Biochem"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C6",
      "doi-asserted-by": "publisher",
      "first-page": "219",
      "DOI": "10.1242/jcs.100.1.219",
      "article-title": "Localization of centromeric satellite and telomeric DNA sequences in dorsal root ganglion neurons, in vitro",
      "volume": "100",
      "author": "Billia",
      "year": "1991",
      "journal-title": "J. Cell Sci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C7",
      "doi-asserted-by": "publisher",
      "first-page": "569",
      "DOI": "10.1038/350569a0",
      "article-title": "Structure and function of telomeres",
      "volume": "350",
      "author": "Blackburn",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C8",
      "doi-asserted-by": "publisher",
      "first-page": "25",
      "DOI": "10.1016/S0092-8674(01)80006-4",
      "article-title": "Telomere shortening and tumor formation by mouse cells lacking telomerase RNA",
      "volume": "91",
      "author": "Blasco",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C9",
      "doi-asserted-by": "publisher",
      "first-page": "349",
      "DOI": "10.1126/science.279.5349.349",
      "article-title": "Extension of life-span by introduction of telomerase into normal human cells",
      "volume": "279",
      "author": "Bodnar",
      "year": "1998",
      "journal-title": "Science"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C10",
      "doi-asserted-by": "publisher",
      "first-page": "149",
      "DOI": "10.1016/S0960-9822(00)00312-2",
      "article-title": "Re-modeling of nuclear architecture in quiescent and senescent human fibroblasts",
      "volume": "10",
      "author": "Bridger",
      "year": "2000",
      "journal-title": "Curr. Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C11",
      "doi-asserted-by": "publisher",
      "first-page": "383",
      "DOI": "10.1007/BF01552798",
      "article-title": "Parental genome separation and asynchronous centromere division in interspecific F1 hybrids in Lathyrus",
      "volume": "2",
      "author": "Callimassia",
      "year": "1994",
      "journal-title": "Chrom. Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C12",
      "doi-asserted-by": "publisher",
      "first-page": "325",
      "DOI": "10.1242/jcs.91.3.325",
      "article-title": "The prometaphase configuration and chromosome order in early mitosis",
      "volume": "91",
      "author": "Chaly",
      "year": "1988",
      "journal-title": "J. Cell Sci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C13",
      "first-page": "30",
      "article-title": "Symmetric chromosomal order in leukocytes indicated by DNA image cytometry and fluorescence in situ hybridization",
      "volume": "19",
      "author": "Chaudhuri",
      "year": "1997",
      "journal-title": "Anal. Quant. Cytol. Histol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C14",
      "doi-asserted-by": "publisher",
      "first-page": "99",
      "DOI": "10.3181/00379727-214-44075",
      "article-title": "Replicative senescence and cell immortality: The role of telomeres and telomerase",
      "volume": "214",
      "author": "Chiu",
      "year": "1997",
      "journal-title": "Proc. Soc. Exp. Biol. Med"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C15",
      "first-page": "440",
      "article-title": "The rationale for an ordered arrangement of chromatin in the interphase nucleus",
      "volume": "20",
      "author": "Comings",
      "year": "1968",
      "journal-title": "Am. J. Hum. Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C16",
      "doi-asserted-by": "publisher",
      "first-page": "131",
      "DOI": "10.1007/BF00273484",
      "article-title": "Arrangement of chromatin in the nucleus",
      "volume": "53",
      "author": "Comings",
      "year": "1980",
      "journal-title": "Hum. Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C17",
      "doi-asserted-by": "publisher",
      "first-page": "1951",
      "DOI": "10.1073/pnas.67.4.1951",
      "article-title": "Identical linear order of chromosomes in both gametes of the Acoel Turbellarian polychoerus carmelensis: a preliminary note",
      "volume": "67",
      "author": "Costello",
      "year": "1970",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C18",
      "doi-asserted-by": "publisher",
      "first-page": "1921",
      "DOI": "10.1002/j.1460-2075.1992.tb05245.x",
      "article-title": "Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity",
      "volume": "11",
      "author": "Counter",
      "year": "1992",
      "journal-title": "EMBO J"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C19",
      "doi-asserted-by": "publisher",
      "first-page": "2673",
      "DOI": "10.1242/jcs.110.21.2673",
      "article-title": "Scaffold attachments within the human genome",
      "volume": "110",
      "author": "Craig",
      "year": "1997",
      "journal-title": "J. Cell Sci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C20",
      "doi-asserted-by": "publisher",
      "first-page": "1119",
      "DOI": "10.1083/jcb.145.6.1119",
      "article-title": "Differences in the localization and morphology of chromosomes in the human nucleus",
      "volume": "145",
      "author": "Croft",
      "year": "1999",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C21",
      "doi-asserted-by": "publisher",
      "first-page": "717",
      "DOI": "10.1002/j.1460-2075.1992.tb05104.x",
      "article-title": "Human telomeres are attached to the nuclear matrix",
      "volume": "11",
      "author": "De Lange",
      "year": "1992",
      "journal-title": "EMBO J"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C22",
      "first-page": "518",
      "article-title": "Structure and variability of human chromosome ends",
      "volume": "10",
      "author": "De Lange",
      "year": "1990",
      "journal-title": "Mol. Cell. Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C23",
      "first-page": "265",
      "article-title": "Telomere dynamics and genome instability in human cancer",
      "volume-title": "In Telomeres",
      "author": "De Lange",
      "year": "1995"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C24",
      "doi-asserted-by": "publisher",
      "first-page": "4211",
      "DOI": "10.1038/sj.onc.1202797",
      "article-title": "Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process",
      "volume": "18",
      "author": "Ducray",
      "year": "1999",
      "journal-title": "Oncogene"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C25",
      "volume-title": "DNA and Chromosomes",
      "author": "DuPraw",
      "year": "1970"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C26",
      "doi-asserted-by": "publisher",
      "first-page": "566",
      "DOI": "10.1038/365566a0",
      "article-title": "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules",
      "volume": "365",
      "author": "Egholm",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C27",
      "doi-asserted-by": "publisher",
      "first-page": "325",
      "DOI": "10.1016/0014-4827(91)90048-Y",
      "article-title": "Chromosome topology in mammalian interphase nuclei",
      "volume": "192",
      "author": "Haaf",
      "year": "1991",
      "journal-title": "Exp. Cell Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C28",
      "doi-asserted-by": "publisher",
      "first-page": "589",
      "DOI": "10.1083/jcb.144.4.589",
      "article-title": "Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice",
      "volume": "144",
      "author": "Hande",
      "year": "1999",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C29",
      "doi-asserted-by": "publisher",
      "first-page": "458",
      "DOI": "10.1038/345458a0",
      "article-title": "Telomeres shorten during aging of human fibroblasts",
      "volume": "345",
      "author": "Harley",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C30",
      "doi-asserted-by": "publisher",
      "first-page": "326",
      "DOI": "10.1016/0168-9525(89)90137-6",
      "article-title": "Human telomeres: fusion and interstitial sites",
      "volume": "5",
      "author": "Hastie",
      "year": "1989",
      "journal-title": "Trends Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C31",
      "doi-asserted-by": "publisher",
      "first-page": "1",
      "DOI": "10.1083/jcb.134.1.1",
      "article-title": "In situ analysis of changes in telomere size during replicative aging and cell transformation",
      "volume": "134",
      "author": "Henderson",
      "year": "1996",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C32",
      "first-page": "51",
      "article-title": "Chromosome order \u2013 possible implications for development",
      "volume": "83",
      "author": "Heslop-Harrison",
      "year": "1984",
      "journal-title": "J. Embryol. Exp. Morphol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C33",
      "doi-asserted-by": "publisher",
      "first-page": "84",
      "DOI": "10.1038/23962",
      "article-title": "Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells",
      "volume": "396",
      "author": "Kiyono",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C34",
      "doi-asserted-by": "publisher",
      "first-page": "3147",
      "DOI": "10.1091/mbc.9.11.3147",
      "article-title": "The three-dimensional study of chromosomes and upstream binding factor-immunolabeled nucleolar organizer regions demonstrates their nonrandom spatial arrangement during mitosis",
      "volume": "9",
      "author": "Klein",
      "year": "1998",
      "journal-title": "Mol. Biol. Cell"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C35",
      "doi-asserted-by": "publisher",
      "first-page": "230",
      "DOI": "10.1159/000015109",
      "article-title": "Characteristics of chromosomes in polarized normal human bronchial cells provide a blueprint for nuclear organization",
      "volume": "82",
      "author": "Koss",
      "year": "1998",
      "journal-title": "Cytogenet. Cell Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C36",
      "doi-asserted-by": "publisher",
      "first-page": "685",
      "DOI": "10.1093/hmg/5.5.685",
      "article-title": "Heterogeneity in telomere length of human chromosomes",
      "volume": "5",
      "author": "Lansdorp",
      "year": "1996",
      "journal-title": "Hum. Mol. Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C37",
      "doi-asserted-by": "publisher",
      "first-page": "275",
      "DOI": "10.1007/BF00212022",
      "article-title": "The spatial localization of homologous chromosomes in human fibroblasts at mitosis",
      "volume": "93",
      "author": "Leitch",
      "year": "1994",
      "journal-title": "Hum. Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C38",
      "doi-asserted-by": "publisher",
      "first-page": "206",
      "DOI": "10.1007/BF00365152",
      "article-title": "Parental genomes are separated throughout the cell cycle in a plant hybrid",
      "volume": "101",
      "author": "Leitch",
      "year": "1991",
      "journal-title": "Chromosoma"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C39",
      "doi-asserted-by": "publisher",
      "first-page": "138",
      "DOI": "10.1128/MMBR.64.1.138-152.2000",
      "article-title": "Higher levels of organization in the interphase nucleus of cycling and differentiated cells",
      "volume": "64",
      "author": "Leitch",
      "year": "2000",
      "journal-title": "Micro. Molec. Biol. Rev"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C40",
      "doi-asserted-by": "publisher",
      "first-page": "951",
      "DOI": "10.1016/0022-2836(92)90096-3",
      "article-title": "Telomere end-replication problem and cell aging",
      "volume": "225",
      "author": "Levy",
      "year": "1992",
      "journal-title": "J. Mol. Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C41",
      "doi-asserted-by": "publisher",
      "first-page": "867",
      "DOI": "10.1083/jcb.135.4.867",
      "article-title": "Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex",
      "volume": "135",
      "author": "Luderus",
      "year": "1996",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C42",
      "doi-asserted-by": "publisher",
      "first-page": "3123",
      "DOI": "10.1073/pnas.81.10.3123",
      "article-title": "Different central nervous system cell types display distinct and nonrandom arrangements of satellite DNA sequences",
      "volume": "81",
      "author": "Manuelidis",
      "year": "1984",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C43",
      "doi-asserted-by": "publisher",
      "first-page": "1533",
      "DOI": "10.1126/science.2274784",
      "article-title": "A view of interphase chromosomes",
      "volume": "250",
      "author": "Manuelidis",
      "year": "1990",
      "journal-title": "Science"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C44",
      "doi-asserted-by": "publisher",
      "first-page": "397",
      "DOI": "10.1007/BF00303033",
      "article-title": "Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridization and three-dimensional reconstruction",
      "volume": "96",
      "author": "Manuelidis",
      "year": "1988",
      "journal-title": "Chromosoma"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C45",
      "doi-asserted-by": "publisher",
      "first-page": "291",
      "DOI": "10.1006/excr.2000.4823",
      "article-title": "Accumulation of short telomeres in human fibroblasts prior to replicative senescence",
      "volume": "256",
      "author": "Martens",
      "year": "2000",
      "journal-title": "Exp. Cell Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C46",
      "doi-asserted-by": "publisher",
      "first-page": "1761",
      "DOI": "10.1242/jcs.112.11.1761",
      "article-title": "Homologous chromosome pairing in wheat",
      "volume": "112",
      "author": "Martinez-Perez",
      "year": "1999",
      "journal-title": "J. Cell Sci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C47",
      "doi-asserted-by": "publisher",
      "first-page": "131",
      "DOI": "10.1006/excr.1999.4793",
      "article-title": "Nuclear topology of murine, cerebellar Purkinje neurons: changes as a function of development",
      "volume": "256",
      "author": "Martou",
      "year": "2000",
      "journal-title": "Exp. Cell Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C48",
      "doi-asserted-by": "publisher",
      "first-page": "629",
      "DOI": "10.1083/jcb.148.4.629",
      "article-title": "Spatial separation of parental genomes in preimplantation mouse embryos",
      "volume": "148",
      "author": "Mayer",
      "year": "2000",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C49",
      "doi-asserted-by": "publisher",
      "first-page": "234",
      "DOI": "10.1093/genetics/26.2.234",
      "article-title": "The stability of broken ends of chromosomes in Zea mays",
      "volume": "26",
      "author": "McClintock",
      "year": "1941",
      "journal-title": "Genetics"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C50",
      "doi-asserted-by": "publisher",
      "first-page": "7049",
      "DOI": "10.1073/pnas.86.18.7049",
      "article-title": "Conservation of the human telomere sequence (TTAGGG)n among vertebrates",
      "volume": "86",
      "author": "Meyne",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C51",
      "doi-asserted-by": "publisher",
      "first-page": "350",
      "DOI": "10.1038/ng0796-350",
      "article-title": "Accelerated telomere shortening in Ataxia Telangiectasia",
      "volume": "13",
      "author": "Metcalfe",
      "year": "1996",
      "journal-title": "Nat. Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C52",
      "doi-asserted-by": "publisher",
      "first-page": "223",
      "DOI": "10.1016/0092-8674(84)90208-3",
      "article-title": "Organization of the higher order chromatin loop: specific DNA attachment sites on nuclear scaffold",
      "volume": "39",
      "author": "Mirkovitch",
      "year": "1984",
      "journal-title": "Cell"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C53",
      "doi-asserted-by": "publisher",
      "first-page": "27",
      "DOI": "10.1007/BF00204924",
      "article-title": "Chromosome arrangements in human fibroblasts at mitosis",
      "volume": "88",
      "author": "Mosgoller",
      "year": "1991",
      "journal-title": "Hum. Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C54",
      "doi-asserted-by": "publisher",
      "first-page": "4417",
      "DOI": "10.1128/jvi.63.10.4417-4421.1989",
      "article-title": "The E6 and E7 genes of the human papilloma virus type 16 together are necessary and sufficient for transformation of primary human keratinocytes",
      "volume": "63",
      "author": "Munger",
      "year": "1989",
      "journal-title": "J. Virol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C55",
      "doi-asserted-by": "publisher",
      "first-page": "492",
      "DOI": "10.1016/B978-0-12-185269-6.50035-7",
      "article-title": "Computer-assisted three-dimensional reconstruction and dissection",
      "volume": "10",
      "author": "Nagele",
      "year": "1992",
      "journal-title": "Meth. Neurosci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C56",
      "doi-asserted-by": "publisher",
      "first-page": "1831",
      "DOI": "10.1126/science.270.5243.1831",
      "article-title": "Precise spatial positioning of chromosomes during prometaphase: evidence for chromosome order in human cells",
      "volume": "270",
      "author": "Nagele",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C57",
      "doi-asserted-by": "publisher",
      "first-page": "330",
      "DOI": "10.1007/s004120050315",
      "article-title": "Chromosome spatial order in human cells: evidence for early origin and faithful propagation",
      "volume": "107",
      "author": "Nagele",
      "year": "1998",
      "journal-title": "Chromosoma"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C58",
      "doi-asserted-by": "publisher",
      "first-page": "525",
      "DOI": "10.1242/jcs.112.4.525",
      "article-title": "Chromosomes exhibit preferential positioning in nuclei of quiescent human cells",
      "volume": "112",
      "author": "Nagele",
      "year": "1999",
      "journal-title": "J. Cell Sci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C59",
      "doi-asserted-by": "publisher",
      "first-page": "4446",
      "DOI": "10.1073/pnas.94.9.4446",
      "article-title": "The nuclear matrix revealed by eluting chromatin from a crosslinked nucleus",
      "volume": "94",
      "author": "Nickerson",
      "year": "1977",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C60",
      "doi-asserted-by": "publisher",
      "first-page": "581",
      "DOI": "10.1023/A:1009253917125",
      "article-title": "An anchorage nuclear structure for telomeric DNA repeats in HeLa cells",
      "volume": "7",
      "author": "Pierron",
      "year": "1999",
      "journal-title": "Chromosome Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C61",
      "doi-asserted-by": "publisher",
      "first-page": "267",
      "DOI": "10.1002/(SICI)1097-0320(19990801)36:4&lt;267::AID-CYTO1&gt;3.0.CO;2-O",
      "article-title": "Telomere length measurements using digital fluorescence microscopy",
      "volume": "36",
      "author": "Poon",
      "year": "1999",
      "journal-title": "Cytometry"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C62",
      "doi-asserted-by": "publisher",
      "first-page": "729",
      "DOI": "10.1016/0092-8674(93)90493-A",
      "article-title": "Loss of a yeast telomere: arrest, recovery and chromosome loss",
      "volume": "75",
      "author": "Sandell",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C63",
      "doi-asserted-by": "publisher",
      "first-page": "13",
      "DOI": "10.1242/jcs.101.1.13",
      "article-title": "Parental genome separation in reconstructions of somatic and premeiotic metaphases of Hordeum vulgare \u00d7 H. bulbosum",
      "volume": "101",
      "author": "Schwarzacher",
      "year": "1992",
      "journal-title": "J. Cell Sci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C64",
      "doi-asserted-by": "publisher",
      "first-page": "7773",
      "DOI": "10.1128/MCB.20.20.7773-7783.2000",
      "article-title": "Meiotic telomere distribution and sertoli cell nuclear architecture are altered in atm- and atm-p53-deficient mice",
      "volume": "20",
      "author": "Scherthan",
      "year": "2000",
      "journal-title": "Mol. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C65",
      "doi-asserted-by": "publisher",
      "first-page": "413",
      "DOI": "10.1007/s004120050263",
      "article-title": "Telomere length, chromatin structure, and chromosome fusigenic potential",
      "volume": "106",
      "author": "Slijepcevic",
      "year": "1997",
      "journal-title": "Chromosoma"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C66",
      "doi-asserted-by": "publisher",
      "first-page": "265",
      "DOI": "10.1146/annurev.cb.09.110193.001405",
      "article-title": "Macromolecular domains within the cell nucleus",
      "volume": "9",
      "author": "Spector",
      "year": "1993",
      "journal-title": "Annu. Rev. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C67",
      "doi-asserted-by": "publisher",
      "first-page": "29",
      "DOI": "10.1006/excr.1998.4293",
      "article-title": "Telomere dynamics in a human cancer cell line",
      "volume": "247",
      "author": "Sprung",
      "year": "1999",
      "journal-title": "Exp. Cell Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C68",
      "doi-asserted-by": "publisher",
      "first-page": "209",
      "DOI": "10.1016/S0027-5107(99)00115-3",
      "article-title": "Telomere instability in a human cancer cell line",
      "volume": "429",
      "author": "Sprung",
      "year": "1999",
      "journal-title": "Mutat. Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C69",
      "doi-asserted-by": "publisher",
      "first-page": "603",
      "DOI": "10.1023/A:1009279918034",
      "article-title": "Correlated positioning of homologous chromosomes in daughter fibroblast cells",
      "volume": "7",
      "author": "Sun",
      "year": "1999",
      "journal-title": "Chromosome Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C70",
      "doi-asserted-by": "publisher",
      "first-page": "651",
      "DOI": "10.1242/jcs.112.5.651",
      "article-title": "Bouquet formation in budding yeast; initiation of recombination is not required for meiotic telomere clustering",
      "volume": "112",
      "author": "Trelles-Sticken",
      "year": "1999",
      "journal-title": "J. Cell Sci"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C71",
      "doi-asserted-by": "publisher",
      "first-page": "401",
      "DOI": "10.1016/S0092-8674(00)80932-0",
      "article-title": "TRF2 protects human telomeres from end-to-end fusions",
      "volume": "92",
      "author": "Van Steensel",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C72",
      "doi-asserted-by": "publisher",
      "first-page": "9857",
      "DOI": "10.1073/pnas.91.21.9857",
      "article-title": "Evidence for a mitotic clock in human hemopoietic stem cells: loss of telomeric DNA with age",
      "volume": "91",
      "author": "Vaziri",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C73",
      "doi-asserted-by": "publisher",
      "first-page": "142",
      "DOI": "10.1006/excr.1993.1068",
      "article-title": "Cell cycle-dependent distribution of telomeres, centromeres and chromsomoe-specific subsatellite domains in the interphase nucleus of mouse lymphocytes",
      "volume": "205",
      "author": "Vourc\u2019h",
      "year": "1993",
      "journal-title": "Exp. Cell Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C74",
      "doi-asserted-by": "publisher",
      "first-page": "83",
      "DOI": "10.1002/(SICI)1098-2264(199901)24:1&lt;83::AID-GCC12&gt;3.0.CO;2-C",
      "article-title": "Absence or low number of telomere repeats at junctions of dicentric chromosomes",
      "volume": "24",
      "author": "Wan",
      "year": "1999",
      "journal-title": "Genes Chromosomes Cancer"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C75",
      "doi-asserted-by": "publisher",
      "first-page": "1409",
      "DOI": "10.1083/jcb.147.7.1409",
      "article-title": "Intranuclear anchoring of repetitive DNA sequences: centromeres, telomeres and ribosomal DNA",
      "volume": "147",
      "author": "Weipoltshammer",
      "year": "1999",
      "journal-title": "J. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C76",
      "first-page": "3088",
      "article-title": "Reversible cellular senescence: implications of normal human diploid fibroblasts",
      "volume": "9",
      "author": "Wright",
      "year": "1989",
      "journal-title": "Mol. Cell Biol"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C77",
      "doi-asserted-by": "publisher",
      "first-page": "492",
      "DOI": "10.1006/excr.1999.4602",
      "article-title": "Normal human telomeres are not late replicating",
      "volume": "251",
      "author": "Wright",
      "year": "1999",
      "journal-title": "Exp. Cell Res"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C78",
      "doi-asserted-by": "publisher",
      "first-page": "1395",
      "DOI": "10.1093/carcin/17.7.1395",
      "article-title": "The human papillomavirus E6/E7 genes induce discordant changes in the expression of cell growth regulatory proteins",
      "volume": "17",
      "author": "Xu",
      "year": "1996",
      "journal-title": "Carcinogenesis"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C79",
      "doi-asserted-by": "publisher",
      "first-page": "579",
      "DOI": "10.1146/annurev.ge.23.120189.003051",
      "article-title": "Structure and function of telomeres",
      "volume": "23",
      "author": "Zakian",
      "year": "1989",
      "journal-title": "Annu. Rev. Genet"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C80",
      "doi-asserted-by": "publisher",
      "first-page": "1601",
      "DOI": "10.1126/science.270.5242.1601",
      "article-title": "Telomeres: Beginning to understand the end",
      "volume": "270",
      "author": "Zakian",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "2024011500314446000_JOCES_114_2_377C81",
      "doi-asserted-by": "publisher",
      "first-page": "7423",
      "DOI": "10.1073/pnas.94.14.7423",
      "article-title": "Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats",
      "volume": "94",
      "author": "Zijlmans",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    }
  ],
  "container-title": "Journal of Cell Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.biologists.com/jcs/article-pdf/114/2/377/3354244/joces_114_2_377.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://journals.biologists.com/jcs/article-pdf/114/2/377/3354244/joces_114_2_377.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        15
      ]
    ],
    "date-time": "2024-01-15T00:32:21Z",
    "timestamp": 1705278741000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.biologists.com/jcs/article/114/2/377/26554/Telomere-associations-in-interphase-nuclei"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        1,
        15
      ]
    ]
  },
  "references-count": 81,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2001,
          1,
          15
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1242/jcs.114.2.377",
  "relation": {},
  "ISSN": [
    "0021-9533",
    "1477-9137"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2001,
        1,
        15
      ]
    ]
  }
}