DOI: 10.1242/jcs.114.10.1811. Cyclin specificity: how many wheels do you need on a unicycle?

Cyclin specificity: how many wheels do you need on a unicycle?

10.1242/jcs.114.10.1811

Crossref journal-article

The Company of Biologists

Journal of Cell Science (237)

Abstract

ABSTRACT Cyclin-dependent kinase (CDK) activity is essential for eukaryotic cell cycle events. Multiple cyclins activate CDKs in all eukaryotes, but it is unclear whether multiple cyclins are really required for cell cycle progression. It has been argued that cyclins may predominantly act as simple enzymatic activators of CDKs; in opposition to this idea, it has been argued that cyclins might target the activated CDK to particular substrates or inhibitors. Such targeting might occur through a combination of factors, including temporal expression, protein associations, and subcellular localization.

Bibliography

Miller, M. E., & Cross, F. R. (2001). Cyclin specificity: how many wheels do you need on a unicycle? Journal of Cell Science, 114(10), 1811â1820.

Authors 2

Mary E. Miller (first)
Frederick R. Cross (additional)

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Dates

Type	When
Created	4 years, 3 months ago (April 25, 2021, 7:27 p.m.)
Deposited	1 year, 7 months ago (Jan. 14, 2024, 8:02 p.m.)
Indexed	5 months ago (March 22, 2025, 7:31 a.m.)
Issued	24 years, 3 months ago (May 15, 2001)
Published	24 years, 3 months ago (May 15, 2001)
Published Online	24 years, 3 months ago (May 15, 2001)
Published Print	24 years, 3 months ago (May 15, 2001)

Funders 0

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BibTeX

@article{Miller_2001, title={Cyclin specificity: how many wheels do you need on a unicycle?}, volume={114}, ISSN={1477-9137}, url={http://dx.doi.org/10.1242/jcs.114.10.1811}, DOI={10.1242/jcs.114.10.1811}, number={10}, journal={Journal of Cell Science}, publisher={The Company of Biologists}, author={Miller, Mary E. and Cross, Frederick R.}, year={2001}, month=may, pages={1811–1820} }

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