DOI: 10.1242/jcs.113.11.1903. Centromere clustering is a major determinant of yeast interphase nuclear organization

Centromere clustering is a major determinant of yeast interphase nuclear organization

10.1242/jcs.113.11.1903

Crossref journal-article

The Company of Biologists

Journal of Cell Science (237)

Abstract

ABSTRACT During interphase in the budding yeast, Saccharomyces cerevisiae, centromeres are clustered near one pole of the nucleus as a rosette with the spindle pole body at its hub. Opposite to the centromeric pole is the nucleolus. Chromosome arms extend outwards from the centromeric pole and are preferentially directed towards the opposite pole. Centromere clustering is reduced by the ndc10 mutation, which affects a kinetochore protein, and by the microtubule poison nocodazole. This suggests that clustering is actively maintained or enforced by the association of centromeres with microtubules throughout interphase. Unlike the Rabl-orientation known from many higher eukaryotes, centromere clustering in yeast is not only a relic of anaphase chromosome polarization, because it can be reconstituted without the passage of cells through anaphase. Within the rosette, homologous centromeres are not arranged in a particular order that would suggest somatic pairing or genome separation.

Bibliography

Jin, Q., Fuchs, J., & Loidl, J. (2000). Centromere clustering is a major determinant of yeast interphase nuclear organization. Journal of Cell Science, 113(11), 1903â1912.

Authors 3

Quan-wen Jin (first)
Jörg Fuchs (additional)
Josef Loidl (additional)

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Dates

Type	When
Created	4 years, 4 months ago (April 23, 2021, 11:04 p.m.)
Deposited	1 year, 1 month ago (July 10, 2024, 12:05 p.m.)
Indexed	1 week, 2 days ago (Aug. 20, 2025, 8:40 a.m.)
Issued	25 years, 2 months ago (June 1, 2000)
Published	25 years, 2 months ago (June 1, 2000)
Published Online	25 years, 2 months ago (June 1, 2000)
Published Print	25 years, 2 months ago (June 1, 2000)

Funders 0

None

BibTeX

@article{Jin_2000, title={Centromere clustering is a major determinant of yeast interphase nuclear organization}, volume={113}, ISSN={1477-9137}, url={http://dx.doi.org/10.1242/jcs.113.11.1903}, DOI={10.1242/jcs.113.11.1903}, number={11}, journal={Journal of Cell Science}, publisher={The Company of Biologists}, author={Jin, Quan-wen and Fuchs, Jörg and Loidl, Josef}, year={2000}, month=jun, pages={1903–1912} }

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